立体选择性合成2-呋喃甲酰基-3-芳基-4-乙氧羰基-5-甲基-反式-2,3-二氢呋喃

溴化呋喃甲酰基甲基三苯鉮1与2-乙酰基-3-芳基丙烯酸乙酯2以碳酸钾为碱，在四氢呋喃中室温反应，可以较好的收率、高立体选择性地生成反-2-呋喃甲酰基-3-芳基-4-乙氧羰基-5-甲基-2,3-二氢呋喃3。产物结构均经波谱予以确定。本文还提出了生成产物的可能机理。     

立体选择性合成2-(a-噻吩甲酰基)-3-取代苯基-4-乙氧羰基-5-甲基-反式-2,3-二氢呋喃

溴化(a-噻吩甲酰基)甲基三苯鉮1与3-取代苯甲叉基-2,4-戊二酮 2以碳酸钾为碱,在苯中55℃条件下反应,可以较好的收率、高立体选择性地生成反-2-(a-噻吩甲酰基)-3-取代苯基-4-乙氧羰基-5-甲基-2,3-二氢呋喃3。产物结构均经波谱予以确定。本文还提出了生成产物的可能机理。     

顺-1-苯甲酰基-2-芳基取代的环丙烷衍生物的立体选择性合成

烯烃与苯甲酰基亚甲基三苯基胂（１）反应,顺利生成顺－１－苯甲酰基－２－芳基取代的环丙烷衍生物。反应不生成反式异构体。副产物三苯基胂可回收。如改用叶立德（１）对应的溴盐,在四氢呋喃或乙腈中于Ｋ２ＣＯ２存在下反应可获得相同的产物。     

L-苏式二氢鞘氨醇的立体选择性合成

二氢鞘氨醇（ＤＨＳ）是２－氨基－１，３－二羟基的饱和长链氨基醇化合物，是构成鞘脂类（包括鞘磷脂和糖鞘脂）的主链部分．由于鞘脂类在自然界中来源稀少，又很难得到纯品．因此，作为鞘脂类主链部分的二氢鞘氨醇的合成有重要的意义［１］．二氢鞘氨醇有两个手性碳，共...     

碘催化亚胺与二氢呋喃反应合成四氢喹啉衍生物

碘催化N-苯基苄基亚胺与二氢呋喃反应合成了四氢喹啉衍生物,其结构经~1H NMR,~(13)C NMR和HR-MS表征.     

新型3-C-支链呋喃核糖衍生物的立体选择性合成

在KF存在下,3-氧化木糖与亲核试剂发生加成反应,立体选择性地合成了4个新型3-C-支链呋喃核糖衍生物(2～5,其中4用生物方法脱苯甲酰基保护得6),其结构经1H NMR, IR, HR-MS表征;2的绝对构型由X-射线单晶衍射分析确证.     

聚乙烯负载氮叶立德催化的二氢呋喃衍生物的高选择性合成

利用（O-NX）TiCl3非茂聚烯烃催化剂实现了乙烯和4-(10-十一烯)-吡啶的共聚合反应,成功将吡啶基团负载在聚乙烯上,在5mol%负载的吡啶和1mol%卟啉铁的催化作用下,此聚合物作为负载型催化剂可以高效地催化重氮化合物与双拉电子Michael受体的反应,高产率、高非对映选择性地得到二氢呋喃衍生物. 催化剂至少可以回收3次,反应收率均大于90%. 该催化反应具有分离和纯化方便、催化剂可回收利用、催化剂无挥发性的特点.     

meso-四苯基-2,3-二氢卟啉-2,3-二醇的合成

研究了一种关于meso-四苯基-2,3-二氢卟啉-2,3-二醇的避免使用昂贵且剧毒的四氧化锇的合成方法,整个合成过程中所用试剂廉价易得,反应操作简单.该合成方法可同时得到顺、反两种目标产物异构体.     

胂叶立德与具有对三氟甲基苯基及双吸电子基团烯烃的反应研究

鉮盐1以碳酸钾为碱分别与含对三氟甲基苯基及双吸电子基团的烯烃2或3反应, 高产率、高立体选择性地合成了含对三氟甲基苯基的顺-1,2-环丙烷衍生物4或顺-2,3-二氢呋喃衍生物5, 并对其产物结构进行了确证.     

顺式-和反式-2,5-二取代四氢呋喃的立体选择性合成

内酯与有机锂试剂发生亲核加成反应,再在酸催化下用NaBH3CN还原,反应的立体选择性可能是由氢负离子在中间体氧鎓离子位阻最小的一侧进攻所引起.所得的三环化合物经热分解和加氢反应,制备顺式和反式-2,5-二取代四氢呋喃.     

A Highly Stereoselective Synthesis of 2－Carbomethoxy－3－aryl－4－carboethoxy－5－methyl－cis－2，3－dihydrofurans

ＡＨｉｇｈｌｙＳｔｅｒｅｏｓｅｌｅｃｔｉｖｅＳｙｎｔｈｅｓｉｓｏｆ２－Ｃａｒｂｏｍｅｔｈｏｘｙ－３－ａｒｙｌ－４－ｃａｒｂｏｅｔｈｏｘｙ－５－ｍｅｔｈｙｌ－ｃｉｓ－２，３－ｄｉｈｙｄｒｏｆｕｒａｎｓＤＩＮＧＷｅｉ－ｙｕ；ＣＨＥＮＹａ－ｌｉ；ＺＨＡＮＧ...     

Stereoselective Synthesis of cis-1, 2-cyclopropane Derivatives

IntroductionNumeroussyntheticmethodsofcyclopropanationhavebeenstudied[l1,butmostofthemarenon-stereoselective,oritsproductisthethermodynamicallystableonewithl,2-transconfiguration.Thestereoselectivesynthesesof1,2-cisisomersofcyclopropanederivativesareseldomseeninliterature.Hereinastere-oselectivecycloporpanationviathereactionofarsenicylidewithe1ectrondefi-cientalkenesisreportedinthispaper.ResultsandDiscussionCarbomethoxymethylenetriphenylarl,oritsarsoniumbromideinthepresenceofK,CO,reactswith2…     

Modification of Metal Complex on the StereoselectiveHydrogenation of 2,3-Butanedione

Nanoscopic metal clusters, because of their substantial difference from metal atoms and bulk metals in size and structure, have attracted great interest especially in the field of catalysis1. It is well known that additives can markedly affect the properties of metal catalysts. The effect of metal ions has been well studied in the field of heterogeneous catalysis2. However, the study of metal complex effect is scarce. We have reported that the metal complex can considerably modulate both the a…     

The furan approach to thiacyclic compounds. Stereoselective synthesis of 2,3-disubstituted tetrahydrothiopyrans

We describe an efficient new approach to the synthesis of thiacyclic compounds that extends the methodology we previously developed for oxacycles: oxidation of a furan ring with singlet oxygen, followed by intramolecular hetero Michael addition. The new approach provides a new entry to nucleoside analogues and α-glucosidase inhibitors.     

Stereoselective synthesis of 2'-purine and pyrimidine derivatives of 1',4'-anhydro-2'-deoxy D-arabitol and D-altritol

A series of 2'-purine and pyrimidine derivatives of 1' ,4'-anhy-dro-2'-deoxy-D-arabitol (1) and 1', 4'-anhydro-2'-deoxy-D-altritol (2) were synthesized regio- and stereo-selectively from D-sorbitol through some conversion in high yields.     

Stereoselective synthesis of 3-butylphtalide via CBS catalytic reduction

Optically active 3-butylphtalide of high enantiomeric excesses (up to 93% e.e.) was synthesized from the reduction of o-pentanoylbenzoic ester with borane using B-methyloxyoxazaborolidine (1b) as the chiral catalyst.     

Stereoselective synthesis of the right-hand cores of 16-methylated oxazolomycins

The right-hand heterocyclic cores of oxazolomycins having either 16R or 16S-methyl group configurations on the β-lactones were stereoselectively synthesized from the common intermediate utilized for our previous syntheses of neooxazolomycin and oxazolomycin A. In addition, the right-hand segment required for the synthesis of KSM-2690 and lajollamycin members was also synthesized in a stereoselective manner.