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PVC膜培氟沙星选择电极的研制与应用 总被引:2,自引:0,他引:2
钟爱国 《理化检验(化学分册)》2003,39(5):305-306
培氟沙星(pefloxacin)是第三代氟喹诺酮类抗生素,临床上用于消化系统、泌尿系统疾病的治疗。测定方法有高效液相色谱法、二阶导数光谱法和紫外分光光度法等。对该药含量测定方法各国药典未见收载。本文首次以培氟沙星和碘铋酸盐形成的分子缔合物为电活性物质,制备了PVC膜培氟沙星选择电极,并用该电极对市售培氟沙星药片的 相似文献
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新型PVC膜涂丝诺氟沙星选择电极的研制与应用 总被引:2,自引:0,他引:2
制备了一种稳定性和重现性均良好的新型PVC膜涂丝诺氟沙星选择电极 ,该电极是以Ag/AgCl丝为基体 ,在其表面先涂一层含Cl-的脲醛树脂 ,然后再涂一层含硅钨酸 -诺氟沙星离子缔合物的PVC膜。采用正交设计法 ,研究了离子缔合物的种类、活性物在膜中的含量及增塑剂3因素对电极的影响。电极的线性范围为7.9×10 -5~1.0×10 -2mol·L -1 ,检出限为2.5×10 -5mol·L -1,斜率为35.7mV/decade(30℃) ,可直接用于诺氟沙星胶囊的含量测定 ,回收率为99 %~102 % ,结果与中国药典法基本一致。 相似文献
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新型涂碳式双嘧达莫选择电极的研制与应用 总被引:4,自引:0,他引:4
报道了一种以双嘧达莫与碘化铋形成的缔合物为电活性物的新型涂碳式PVC膜双嘧达莫选择电极,测定了双嘧达莫片的含量。电极线性响应范围为1.0×10-2~2.2×10-5mol/L,级差电位为48 mV/pc,检出限为1.8×10-5mol/L。该电极响应迅速,重现性好,分析结果与药典法相符。 相似文献
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涂碳型PVC膜氧氟沙星选择电极的研制与应用 总被引:2,自引:0,他引:2
报道了一种以氧氟沙星碘化物与碘化铋的分子缔合物为电活性物的新型涂碳PVC膜氧氟沙星选择电极.电极的能斯特响应范围为1.0×10-5~3.2×10-2mol/L,斜率为31mV/pC,电极响应迅速,重现性好.用此电极对药片中的氧氟沙星进行测定,结果与紫外分光光度法相符. 相似文献
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双臂套索冠醚PVC膜碘离子选择电极 总被引:2,自引:2,他引:2
研究了两种新型双臂套索冠醚1,10-二(5-氯-8-羟基喹啉-7-亚甲基)-1,10-二氮杂-4,7,16-三氧杂-13,19-二硫杂环二十一烷(Ⅰ)和1,13-二(5-甲基-8-羟基喹啉-7-亚甲基)-1,13-二氮杂-4,7,10-三氧杂-16,19-二硫杂环二十一烷(Ⅱ)为载体的PVC膜电极的响应行为;实验结果表明,两电极均显示阴离子响 应,其中对碘离子具有优良的能斯特电位响应性能,线性范围为10^-5-10^-1mol/L,斜率分别为-59.1mV/pcI-和-57.6mV/pcI-;电极具有读数稳定,重复性好,PH值范围宽等优点;将该电极用于药品中碘含量的测定,其结果与药典法一致。 相似文献
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报导了以三苄基锡酸酯为中性载体的一种溶剂聚合膜阴离子敏感电极的研制。该电极对水杨酸根离子的电位响具有优良的选择和灵敏度。 相似文献
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A novel coated wire electrode (CWE) for Al(III) ions is described based on 2-(1H-benzo[d]imidazole-1-yl)-1-phenylethanoneoxime as a new ionophore in carbon-PVC composite. The sensor exhibits significantly enhanced selectivity toward Al3+ ions over the concentration range 4.3 × 10−7 to 5.0 × 10−2 M with a lower detection limit of 2.5 × 10−7 M and a Nernstian slope of 19.41 ± 0.52 mV decade−1 of aluminium activity. This sensor has a short response time of about 10 s and is reproducible and stable for at least forty-five days. This proposed CWE which is designed for the first time revealed good selectivity for Al(III) over a wide variety of other cations. The performance of the sensor is best in the pH range of 3.1-5.5 and it also works well in partially non-aqueous medium. Moreover, the assembly has been successfully used as an indicator electrode in the potentiometric titration of aluminium (III) against EDTA and also in determining Al(III) quantitatively in pharmaceutical and mineral water samples. 相似文献
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以有序介孔碳(OMC)球为离子-电子转换层,制备了固态氯离子选择性电极,构建了基于离子敏感的场效应晶体管(ISFET)的手持式传感系统,用于检测人体血清中的氯离子。优化了OMC前驱体的碳化温度,探究了OMC形貌结构对电极传感性能的影响;电极柔性化制备后考察了其在手持系统中对氯离子的检测效果。结果表明,最优条件下,电极在5.12×10^-4~1.02 mol/L的浓度范围呈现线性响应,响应斜率为60 mV/decade。该柔性电极在手持传感系统中展现出高灵敏度和重现性,可用于人体血清样品中氯离子的检测,其回收率为96.3%~104.9%。 相似文献
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Poly(vinylchloride) (PVC) based membranes of macrocycles 2,3,4:9,10,11-dipyridine-1,3,5,8,10,12-hexaazacyclotetradeca-2,9-diene (L1) and 2,3,4:9,10,11-dipyridine-1,5,8,12-tetramethylacrylate-1,3,5,8,10,12-hexaazacyclotetradeca-2,9-diene (L2) with NaTPB and KTpClPB as anion excluders and dibutylphthalate (DBP), benzyl acetate (BA), dioctylphthalate (DOP), o-nitrophenyloctyl ether (o-NPOE) and tri-n-butylphosphate (TBP) as plasticizing solvent mediators were prepared and investigated as Co2+ selective electrodes. The best performance was observed with the membranes having the composition L2:PVC:TBP:NaTPB in the ratio of 6:39:53:2 (w/w; mg). The performance of the membrane based on L2 was compared with polymeric membrane electrode (PME) and coated graphite electrode (CGE). The PME exhibits detection limit of 4.7 × 10−8 M with a Nernstian slope of 29.7 mV decade−1 of activity between pH 2.5 and 8.5 whereas CGE exhibits the detection limit of 6.8 × 10−9 M with a Nernstian slope of 29.5 mV decade−1 of activity between pH 2.0 and 9.0. The response time for PME and CGE was found to be 11 and 8 s, respectively. The CGE has been found to work satisfactorily in partially non-aqueous media up to 35% (v/v) content of methanol, ethanol and 25% (v/v) content of acetonitrile and could be used for a period of 4 months. The CGE was successfully applied for the determination of Co2+ in real and pharmaceutical samples and as an indicator electrode in potentiometric titration of cobalt ion. 相似文献
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Plasticized membranes using 2,3,4:12,13,14-dipyridine-1,3,5,8,11,13,15,18-octaazacycloicosa-2,12-diene (L1) and 2,3,4:12,13,14-dipyridine-1,5,8,11,15,18-hexamethylacrylate-1,3,5,8,11,13,15,18-octaazacycloicosa-2,12-diene (L2) have been prepared and explored as Ce(III) selective sensors. Effect of various plasticizers viz. dibutylphthalate (DBP), tri-n-butylphthalate (TBP), o-nitrophenyloctylether (o-NPOE), dioctylphthalate (DOP), benzylacetate (BA) and anion excluders, sodium tetraphenylborate (NaTPB) and potassium tetrakis p-(chlorophenyl) borate was studied in detail and improved performance was observed. Optimum performance was observed for the membrane sensor having a composition of L2:PVC:o-NPOE:KTpClPB in the ratio of 6:34:58:2 (w/w, mg). The performance of the membrane based on L2 was compared with polymeric membrane electrode (PME) as well as with coated graphite electrode (CGE). The electrodes exhibit Nernstian slope for Ce(III) ions with limits of detection of 8.3 × 10−8 mol L−1 for PME and 7.7 × 10−9 mol L−1 for CGE. The response time for PME and CGE was found to be 12 s and 10 s respectively. The potentiometric responses are independent of the pH of the test solution in the pH range 3.5-7.5 for PME and 2.5-8.5 for CGE. The CGE could be used for a period of 5 months. The practical utility of the CGE has been demonstrated by its usage as an indicator electrode in potentiometric titration of oxalate and fluoride ions with Ce(III) solution. The proposed electrode was also successfully applied to the determination of fluoride ions in mouthwash solution and oxalate ions in real samples. 相似文献
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以Ag/AgCl丝为基体依次外涂含0.1 mol/L KCl的琼脂凝胶膜及含四苯硼-司帕沙星缔合物的PVC膜,制备了一种双涂膜司帕沙星选择电极。采用正交设计法,研究了离子缔合物的种类、活性物在膜中的浓度及增塑剂三因素对电极的影响。电极的线性范围为1.0×10-5~1.0×10-3mol/L,检出限为2.4×10-6mol/L,斜率为28.8 mV/decade(16℃),可直接用于司帕沙星片剂的含量测定,回收率为99.6%~101.1%,结果与文献法一致。 相似文献