共查询到20条相似文献,搜索用时 31 毫秒
1.
I. V. Ukrainets A. A. Tkach L. V. Sidorenko O. V. Gorokhova 《Chemistry of Heterocyclic Compounds》2006,42(10):1301-1307
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides have been prepared. It has been shown experimentally that
these compounds are brominated by molecular bromine in glacial acetic acid at position 4 of the anilide fragment. The antitubercular
properties of the compounds synthesized are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1508–1516, October, 2006. 相似文献
2.
I. V. Ukrainets N. L. Bereznyakova V. A. Parshikov 《Chemistry of Heterocyclic Compounds》2009,45(3):345-350
4-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hetarylamides can be prepared by two fundamentally different routes
with allowance made for the thermal stability of the starting hetarylamines.
* For Communication 152 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 426–432, March, 2009. 相似文献
3.
I. V. Ukrainets N. Yu. Golik O. V. Bevz O. V. Gorokhova 《Chemistry of Heterocyclic Compounds》2011,47(7):833-837
A novel method has been developed for the synthesis of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids esters based
on the use of monoethyl malonate as an acylating agent in the presence of N,N'-dicyclohexylcarbodiimide and characterized by high yields and purity for the final products. Practical recommendations are
given for the removal of specific admixtures. 相似文献
4.
5.
I. V. Ukrainets I. A. Tugaibei N. L. Bereznyakova V. N. Kravchenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2008,44(5):565-575
Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid were prepared with a view
to establishing a structure-biological activity relationship. A comparative analysis has been made of their diuretic properties
and those of the structurally similar 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 718–729, May, 2008. 相似文献
6.
I. V. Ukrainets O. V. Bevz E. V. Mospanova L. V. Savchenkova S. I. Yankovich 《Chemistry of Heterocyclic Compounds》2012,48(2):320-326
In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried
out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides.
It has been shown that bromination of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid allylamide using
an equivalent of molecular bromine occurs with a conventional addition of the halogen to the allyl double bond and not with
halocyclization. The results of the study of the analgesic properties of the compounds prepared are presented. 相似文献
7.
I. V. Ukrainets A. A. Davidenko E. V. Mospanova L. V. Sidorenko E. N. Svechnikova 《Chemistry of Heterocyclic Compounds》2010,46(5):559-568
We have carried out the synthesis and a comparative analysis of the acidic properties of a large group of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic
acids. Features of the recorded NMR spectra of these compounds are discussed together with their analgesic properties. 相似文献
8.
I. V. Ukrainets N. L. Bereznyakova I. A. Turaibei 《Chemistry of Heterocyclic Compounds》2008,44(1):50-63
Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral
agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results
are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 61–77, January, 2008. 相似文献
9.
А. Yu. Ershov I. V. Lagoda D. G. Nasledov M. Yu. Vasil’eva L. Yu. Kuleshova L. V. Pavlova A. V. Yakimanskii 《Russian Journal of Organic Chemistry》2017,53(11):1682-1686
Basing on natural amino acid L-cysteine, commercially available aliphatic aldehydes, 2-acetylsulfanylbenzoyl chloride and 2,2′-disulfandiyldibenzoyl dichloride a synthesis was developed of (2R,4R)-2-alkyl-3-(2-mercaptobenzoyl)thiazolidine-4-carboxylic acids, potential antihypertensive compounds, inhibitors of angiotensin transforming enzyme. 相似文献
10.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova S. V. Shishkina 《Chemistry of Heterocyclic Compounds》2006,42(6):776-781
Alkaline hydrolysis of the ethyl ester of 4-(cyanoethoxycarbonylmethyl)-2-oxo-1,2-dihydroquinoline-3-carboxylic acid is accompanied
by decarboxylation with loss of two molecules of CO2 and leads to 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 887–893, June, 2006. 相似文献
11.
Two novel methods have been developed for the preparation of 2-[(4R)-2-oxo-4-phenylpyrrolidin-1-yl]acetamide ((R)-Phenotropil). In the first, n-butyl (3R)-4-amino-3-phenylbutyrate is alkylated with haloacetamide in DMF in the presence of potassium phosphate monohydrate, and the intermediate 4-carbamoylmethylamino-3-phenylbutyrate is subsequently cyclized by refluxing in toluene in the presence of potassium phosphate monohydrate and tetrabutylammonium bromide. In the second, chloroacetonitrile is used under similar conditions in place of the haloacetamide. Both methods lead to (R)-Phenotropil in 40-60% yields calculated on the starting n-butyl (3R)-4-amino-3-phenylbutyrate. 相似文献
12.
G. V. Mokrov A. M. Likhosherstov V. S. Troitskaya T. A. Gudasheva 《Russian Journal of Organic Chemistry》2009,45(12):1829-1833
New procedures have been developed for the synthesis of α-(2-formyl-1H-pyrrol-1-yl)-substituted carboxylic acids, α-(2-R-aminomethyl-1H-pyrrol-1-yl)-substituted carboxylic acids, and 1,2-dihydropyrrolo-[1,2-a]pyrazin-3(4H)-ones on the basis of furfurol and α-amino acids. 相似文献
13.
14.
I. V. Ukrainets I. A. Tugaibei A. A. Tkach V. B. Rybakov A. V. Turov 《Chemistry of Heterocyclic Compounds》2008,44(3):316-323
Condensation of aminopyrazine with triethyl methanetricarboxylate gave ethyl 2-hydroxy-4-oxo-4H-pyrazino[1,2-a]pyrimidine-3-carboxylate.
According to X-ray analytical data the compound exists in the 2-hydroxy-4-oxo form in the crystal.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 411–419, March, 2008. 相似文献
15.
I. V. Ukrainets L. A. Grinevich A. A. Tkach O. V. Bevz S. V. Slobodzian 《Chemistry of Heterocyclic Compounds》2009,45(9):1058-1068
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyrazin-2-ylamides have been synthesized as potential antitubercular
agents. In contrast to pyrimidin-2-ylamides the compounds prepared are brominated by molecular bromine in glacial acetic acid
at position 6 of the quinolone ring rather than in the amide part of the molecule. The 1-N-allyl derivative behaves similarly
but undergoes halocyclization to give 2-bromomethyl-5-oxo-1,2-dihydro-5H-oxazolo[3,2-a]quinoline-4-carboxylic acid pyrazin-2-ylamide. A comparative analysis of the antimycobacterial properties of the synthesized
compounds and their isomeric pyrimidin-2-ylamides has been carried out. 相似文献
16.
Summary. Treatment of meso-tetra(tert-butyl)porphyrin with sulfuric acid/n-butanol affords a mixture of porphyrin and mono-tert-butylporphyrin in relatively high yield. 相似文献
17.
L. M. Potikha A. R. Turelyk V. A. Kovtunenko 《Chemistry of Heterocyclic Compounds》2011,47(6):745-754
Fusion of 4-bromo-1,3-diphenyl-2-buten-1-ones (γ-bromodypnones) with 1,2-dimethyl-1H-benzimidazole and further treatment of
the reaction product with a base (morpholine) gives 7,9-diaryl-5-methyl5,10-dihydroazepino[1,2-a]benzimidazol-11-ium bromides. The reaction of γ-bromodypnone with 1-alkyl-2-methyl-1H-imidazoles in benzene at 25 °C gives
quaternary azolium salts. Upon heating their solutions in alcohol in the presence of K2CO3 the latter cyclize to 1-R-6,8-diaryl-1,5-dihydroimidazo[1,2-a]azepin-4-ium bromides or 1-R-6,8-diaryl-1H-imidazo[1,2-a]azepines
depending on the nature of the substituent in the benzene rings and the substituent at the N(1) atom of the imidazole. 相似文献
18.
An improved method for the preparation of ethyl 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylate
has been proposed and a series of hetarylamides has been synthesized from it. A comparative analysis has been carried out
of the antitubercular activities of the synthesized compounds with the active structural analogs 4-hydroxy-2-oxo-1,2-dihydroquinoline-3
and 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]quinoline-2-carboxamides studied before.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1189–1202, August, 2008. 相似文献
19.
20.
O. V. Ardashov A. M. Genaev I. V. Il’ina D. V. Korchagina K. P. Volcho N. F. Salakhutdinov 《Russian Journal of Organic Chemistry》2010,46(12):1786-1789
Hydrogenation of (1R,2R,6S)-3-methyl-6-(1-methylethenyl)cyclohex-3-ene-1,2-diol was studied. Nickel chloride-sodium tetrahydridoborate system turned
out to selectively reduce the double bond in the isopropenyl group. The results of conformational analysis of (1R,2R,6S)-3-methyl-6-(1-methylethenyl)cyclohex-3-ene-1,2-diol and its partly and completely hydrogenated derivatives were in a good
agreement with the NMR data. 相似文献