共查询到20条相似文献,搜索用时 15 毫秒
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Haiyin Li Xiqi Zhang Xiaoyong Zhang Bin Yang Yang Yang Yen Wei 《Macromolecular rapid communications》2014,35(19):1661-1667
Aggregation‐induced emission (AIE) dye‐based cross‐linked fluorescent polymeric nanoparticles (FPNs) are facilely prepared via a two‐step polymerization process including emulsion polymerization and subsequent anhydride cross‐linking. Then, a variety of characterization methods are carried out to determine the performance of the FPNs, which show high dispersibility and strong fluorescence in an aqueous solution due to the hydrophilic carboxyl groups on the surfaces and the AIE components as the cores. Biocompatibility evaluation and cell imaging results suggest that these FPNs are biocompatible for cell imaging. More importantly, this cross‐linking strategy is proven to overcome the issue of critical micelle concentration and opens the opportunity to develop more robust fluorescent bioprobes.
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Tianxiang Wang Yunbo Cai Zhipeng Wang Erjia Guan Dahai Yu Anjun Qin Jingzhi Sun Ben Zhong Tang Changyou Gao 《Macromolecular rapid communications》2012,33(18):1584-1589
Tetraphenylethylene (TPE)‐substituted poly(allylamine hydrochloride) (PAH‐g‐TPE) is synthesized by a Schiff base reaction between PAH and TPE‐CHO. The PAH‐g‐TPE forms micelles in water at pH 6, which are further transformed into pure TPE‐CHO nanoparticles (NPs) with a diameter of ≈300 nm after incubation in a solution of low pH value. In contrast, only amorphous precipitates are obtained when TPE‐CHO methanol solution is incubated in water. The aggregation‐induced emission feature of the TPE molecule is completely retained in the TPE NPs, which can be internalized into cells and show blue fluorescence. Formation mechanism of the TPE NPs is proposed by taking into account the guidance effect of linear and charged PAH molecules, and the propeller‐stacking manner between the TPE‐CHO molecules. 相似文献
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Photoactivatable Aggregation‐Induced Emission Fluorophores with Multiple‐Color Fluorescence and Wavelength‐Selective Activation 下载免费PDF全文
Lu Peng Yue Zheng Xiaoyan Wang Prof. Aijun Tong Prof. Yu Xiang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(11):4326-4332
Photoactivatable (caged) fluorophores are widely used in chemistry, materials, and biology. However, the development of such molecules exhibiting photoactivable solid‐state fluorescence is still challenging due to the aggregation‐caused quenching (ACQ) effect of most fluorophores in their aggregate or solid states. In this work, we developed caged salicylaldehyde hydrazone derivatives, which are of aggregation‐induced emission (AIE) characteristics upon light irradiation, as efficient photoactivatable solid‐state fluorophores. These compounds displayed multiple‐color emissions and ratiometric (photochromic) fluorescence switches upon wavelength‐selective photoactivation, and were successfully applied for photopatterning and photoactivatable cell imaging in a multiple‐color and stepwise manner. 相似文献
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Yahui Zhang Lingwei Kong Jianbing Shi Bin Tong Junge Zhi Xiao Feng Yuping Dong 《中国化学》2015,33(7):701-704
A new type of AIE molecules based on hexaphenyl‐1,3‐butadienes was reported with respect to the synthesis and characterization. This material exhibited different maximum emission wavelength and enhanced emission intensity at different aggregate state (amorphous and crystalline state). 相似文献
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A new type of fluorescent polymeric micelles is developed by self‐assembly from a series of amphiphilic block copolymers, poly(ethylene glycol)‐b‐poly[styrene‐co‐(2‐(1,2,3,4,5‐pentaphenyl‐1H‐silol‐1‐yloxy)ethyl methacrylate)] [PEG‐b‐P(S‐co‐PPSEMA)]. Their capability of loading doxorubicin (DOX) is investigated by monitoring the loading content, encapsulation efficiency, and photophysical properties of micelles. Förster resonance energy transfer from PPSEMA to DOX is observed in DOX‐loaded micelles, which can serve as an indication of successful encapsulation of DOX in these micelles. The application of this new type of fluorescent polymeric micelles as a fluorescent probe and an anticancer drug carrier simultaneously is explored by studying the intracellular uptake of DOX‐loaded micelles.
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White‐Light Emission Strategy of a Single Organic Compound with Aggregation‐Induced Emission and Delayed Fluorescence Properties 下载免费PDF全文
Dr. Zongliang Xie Dr. Chengjian Chen Shidang Xu Jun Li Prof. Yi Zhang Prof. Siwei Liu Prof. Jiarui Xu Prof. Zhenguo Chi 《Angewandte Chemie (International ed. in English)》2015,54(24):7181-7184
A novel white‐light‐emitting organic molecule, which consists of carbazolyl‐ and phenothiazinyl‐substituted benzophenone (OPC) and exhibits aggregation‐induced emission‐delayed fluorescence (AIE‐DF) and mechanofluorochromic properties was synthesized. The CIE color coordinates of OPC were directly measured with a non‐doped powder, which presented white‐emission coordinates (0.33, 0.33) at 244 K to 252 K and (0.35, 0.35) at 298 K. The asymmetric donor–acceptor–donor′ (D‐A‐D′) type of OPC exhibits an accurate inherited relationship from dicarbazolyl‐substituted benzophenone (O2C, D‐A‐D) and diphenothiazinyl‐substituted benzophenone (O2P, D′‐A‐D′). By purposefully selecting the two parent molecules, that is, O2C (blue) and O2P (yellow), the white‐light emission of OPC can be achieved in a single molecule. This finding provides a feasible molecular strategy to design new AIE‐DF white‐light‐emitting organic molecules. 相似文献
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Boron Diiminate with Aggregation‐Induced Emission and Crystallization‐Induced Emission‐Enhancement Characteristics 下载免费PDF全文
Ryousuke Yoshii Amane Hirose Kazuo Tanaka Prof. Yoshiki Chujo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(27):8320-8324
Organoboron complexes having aggregation‐ and crystalization‐induced emission properties are presented. The series of boron diiminates were synthesized and the emission behaviors of the synthesized compounds were investigated. Finally, it was found that significant enhancement of the emission depended on the crystallinity in the solid states. 相似文献
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Structure‐Dependent cis/trans Isomerization of Tetraphenylethene Derivatives: Consequences for Aggregation‐Induced Emission 下载免费PDF全文
Dr. Chong‐Jing Zhang Dr. Guangxue Feng Shidang Xu Dr. Zhenshu Zhu Prof. Dr. Xianmao Lu Dr. Jien Wu Prof. Dr. Bin Liu 《Angewandte Chemie (International ed. in English)》2016,55(21):6192-6196
The isomerization and optical properties of the cis and trans isomers of tetraphenylethene (TPE) derivatives with aggregation‐induced emission (AIEgens) have been sparsely explored. We have now observed the tautomerization‐induced isomerization of a hydroxy‐substituted derivative, TPETH‐OH, under acidic but not under basic conditions. Replacing the proton of the hydroxy group in TPETH‐OH with an alkyl group leads to the formation of TPETH‐MAL, for which the pure cis and trans isomers were obtained and characterized by HPLC analysis and NMR spectroscopy. Importantly, cis‐TPETH‐MAL emits yellow fluorescence in DMSO at ?20 °C whereas trans‐TPETH‐MAL shows red fluorescence under the same conditions. Moreover, the geometry of cis‐ and trans‐TPETH‐MAL remains unchanged when they undergo thiol–ene reactions to form cis‐ and trans‐TPETH‐cRGD, respectively. Collectively, our findings improve our fundamental understanding of the cis/trans isomerization and photophysical properties of TPE derivatives, which will guide further AIEgen design for various applications. 相似文献
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Aggregation‐Induced Emission and Aggregation‐Promoted Photo‐oxidation in Thiophene‐Substituted Tetraphenylethylene Derivative 下载免费PDF全文
Dr. Linna Zhu Rui Wang Dr. Luxi Tan Xianfeng Liang Dr. Cheng Zhong Dr. Fei Wu 《化学:亚洲杂志》2016,11(20):2932-2937
Aggregation‐induced emission combined with aggregation‐promoted photo‐oxidation has been reported only in two works quite recently. In fact, this phenomenon is not commonly observed for AIE‐active molecules. In this work, a new tetraphenylethylene derivative (TPE‐4T) with aggregation‐induced emission (AIE) and aggregation‐promoted photo‐oxidation was synthesized and investigated. The pristine TPE‐4T film exhibits strong bluish‐green emission, which turns to quite weak yellow emission after UV irradiation. Interestingly, after solvent treatment, the weakly fluorescent intermediate will become bright‐yellow emitting. Moreover, the morphology of the TPE‐4T film could be regulated by UV irradiation. The wettability of the TPE‐4T microcrystalline surface is drastically changed from hydrophobic to hydrophilic. This work contributes a new member to the aggregation induced photo‐oxidation family and enriches the photo‐oxidation study of tetraphenylethylene derivatives. 相似文献
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Alkaline phosphatase (ALP) is associated with many diseases, and its accurate detection is of great significance. Fluorescent compounds with aggregation‐induced emission (AIE) feature show beneficial advantages for serving as fluorescent probes. Herein, an AIE‐active “turn on” probe for ALP detection was synthesized through incorporating a strong electron‐withdrawing group (cyano) in the middle and the recognition moiety phosphate group at the end, thereby rendering a D–A–D structure with a relatively high conjugation degree and good water solubility. It was found that the probe TPE‐CN‐pho is highly sensitive to ALP in aqueous solution. In the presence of ALP, the hydrophilic phosphate group on the probe is rapidly removed, resulting in a decrease in water solubility and subsequent formation of aggregates, thereby achieving aggregation‐induced emission. Moreover, the probe TPE‐CN‐pho has also been successfully applied to imaging ALP in living cells. 相似文献
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Zhe Peng Zhi Wang Bin Tong Yingchun Ji Jianbing Shi Junge Zhi Yuping Dong 《中国化学》2016,34(11):1071-1075
In order to get an easy way to achieve the transformation from aggregation‐caused quenching luminophores (ACQphores) to aggregation‐induced emission luminogens (AIEgens), we took aldehyde groups as the modifying group to decorate anthracene. The fluorescence performances of 9‐anthraldehyde (AnA) and 9,10‐anthracenedicarboxaldehyde (AnDA) in solution and aggregated state were studied. We found out that the aldehyde group can transform anthracene with aggregation‐caused quenching properties to AIEgen. The single‐crystal structures analysis of AnA and AnDA showed that their structure characteristics are responsible for the AIE properties of AnA and AnDA. On one hand, the aldehyde group can cause steric effects to lower intermolecular π‐π packing style in aggregated state. On the other hand, intermolecular H‐bonding interactions can restrict the intramolecular rotation and suppress internal charge transfer. These results may supply a new simple method for the transformation from ACQphores to AIEgens on the point of the molecular design. 相似文献
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《Macromolecular rapid communications》2017,38(10)
Aggregation‐induced emission (AIE) is an abnormal phenomenon that has sparked great attention for diverse applications in different fields. In particular, the fabrication and biological imaging applications of AIE‐active fluorescent organic nanoparticles (FONs) have become a focus in the emerging and promising fields. A large number of AIE‐active polymeric nanoprobes have recently been fabricated through different strategies. The advances and progress in this direction have also recently been summarized by some groups. However, the fabrication and biomedical applications of AIE‐active FONs based on carbohydrate polymers and AIE‐active dyes are quite rare and limited. In this feature article, the recently reported AIE‐active FONs with different structures and applications based on AIE‐active dyes and carbohydrate polymers are highlighted, and the major current limitations and development tendencies are also discussed.
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《Macromolecular rapid communications》2017,38(8)
Fluorescent polymeric nanoparticles (FPNs) with aggregation‐induced emission (AIE) property have received increasing attention and possess promising biomedical application potential in the recent years. Many efforts have been devoted to the fabrication methodologies of FPNs and significant advance has been achieved. In this contribution, a novel strategy for the fabrication of AIE‐active amphiphilic copolymers is reported for the first time based on the Ce(IV) redox polymerization. As an example, ene group containing AIE‐active dye (named as Phe‐alc) is directly grafted onto a water soluble polymer polyethylene glycol (PEG) in H2O/THF system under low temperature. Thus‐obtained amphiphilic fluorescent polymers will self‐assemble into FPNs with ultra‐low critical micelle concentration, ultra‐brightness, and great water dispersibility. Biological evaluation results suggest that the PEG‐poly(Phe‐alc) possess excellent biocompatibility and can be used for tracing their behavior in cells using confocal laser scanning microscope. These features make PEG‐poly(Phe‐alc) FPNs promising candidates for many biomedical applications, such as cell imaging, drug delivery vehicles, and targeted tracing. More importantly, many other functional groups can also be incorporated into these AIE‐active FPNs through the redox polymerization. Therefore, the redox polymerization should be a facile and effective strategy for fabrication of AIE‐active FPNs.
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Jan Freudenberg Dr. Frank Rominger Prof. Uwe H. F. Bunz 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(47):16749-16753
The synthesis of five novel distyrylbenzene (DSB) derivatives, featuring a central tetraphenylbenzene core, is reported. The targets show aggregation‐induced emission (AIE), which, however, is substituent‐dependent. For the pure hydrocarbon and derivatives that do not carry (+M) or (?M) substituents, classic AIE behavior is observed, that is, the DSBs are non‐fluorescent in solution, but are highly fluorescent in cold matrices, upon aggregate formation in poor solvents and in the solid, crystalline state. If aldehyde or dibutylamino groups are attached in the para‐position of the DSB unit, non‐classic AIE‐phores result. These are fluorescent both in dilute solution as well as in the solid state. Prolonged irradiation of the targets leads to benzotetraphene derivatives by a double cyclization. 相似文献
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Coordination‐Driven Self‐Assembly of Carbazole‐Based Metallodendrimers with Generation‐Dependent Aggregation‐Induced Emission Behavior 下载免费PDF全文
Wen‐Jia Fan Bin Sun Jianqiu Ma Prof. Dr. Xiaopeng Li Prof. Dr. Hongwei Tan Prof. Dr. Lin Xu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(37):12947-12959
A new family of 120° carbazole‐based dendritic donors D1 – D3 have been successfully designed and synthesized, from which a series of novel supramolecular carbazole‐based metallodendrimers with well‐defined shapes and sizes were successfully prepared by [2+2] and [3+3] coordination‐driven self‐assembly. The structures of newly designed rhomboidal and hexagonal metallodendrimers were characterized by multinuclear NMR (1H and 31P) spectroscopy, ESI‐TOF mass spectrometry, FTIR spectroscopy, and the PM6 semiempirical molecular orbital method. The fluorescence emission behavior of ligands D1 – D3 , rhomboidal metallodendrimers R1 – R3 , and hexagonal metallodendrimers H1 – H3 in mixtures of dichloromethane and n‐hexane with different n‐hexane fractions were investigated. The results indicated that D1 – D3 featured typical aggregation‐induced emission (AIE) properties. However, different from ligands D1 – D3 , metallodendrimers R1 – R3 and H1 – H3 presented interesting generation‐dependent AIE properties. Furthermore, evidence for the aggregation of these metallodendrimers was confirmed by a detailed investigation of dynamic light‐scattering, Tyndall effect, and SEM. This research not only provides a highly efficient strategy for constructing carbazole‐based dendrimers with well‐defined shapes and sizes, but also presents a new family of carbazole‐based dendritic ligands and rhomboidal and hexagonal metallodendrimers with interesting AIE properties. 相似文献
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A Fluorogenic Probe with Aggregation‐Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers 下载免费PDF全文
Xiaojing Wang Huan Liu Jingwen Li Kaiguo Ding Zhonglin Lv Prof. Yonggang Yang Prof. Hong Chen Prof. Xinming Li 《化学:亚洲杂志》2014,9(3):784-789
Herein, we report a novel fluorescent “light‐up” probe useful for carboxylesterase assay that is based on a tetraphenylethylene derivative containing carboxylic ester groups. The specific cleavage of the carboxylic ester bonds by carboxylesterase results in the generation of a relatively hydrophobic moiety that self‐assembles into supramolecular microfibers, thus giving rise to “turn‐on” fluorescent signals. A high sensitivity towards carboxylesterase was achieved with a detection limit as low as 29 pM , which is much lower than the corresponding assays based on other fluorescent approaches. 相似文献