首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 31 毫秒
1.
The crystal structures of an unexpected carbon dioxide inserted carbamidiphenylthiophosphinic anhydride and l‐[(4‐nitrophenyl) sulfonyl]‐trans‐2, 5‐pyrrolidinedicarboxylic acid methyl ester were determined by X‐ray analysis. They crystallized in the space group P21(#4) with a =0.9550(2), b = 0.9401(4), c= 1.2880(2) nm, β= 107.74°, V= 1.1013 (5) nm3, Dcaled= 1.349 g/cm3, Z = 2 and P212121(# 19) with a = 1.4666(2), b = 0.7195(2), c = 1.6339(2) nm, V = 1.7240(7) nm3, Dcaled = 1.434 g/cm3, Z = 4, respectively. Through the investigation of these two crystal structures, the mechanistic insights into this unexpected carbon dioxide insertion in the reaction of trans‐2,5‐disubstituted pyrrolidine with diphenylthiophosphoryl chloride in the presence of potassium carbonate were disclosed.  相似文献   

2.
Two novel complexes [Cu L 2(MeOH)] ( 1 )and [Ag2 L (H L )2(MeOH)] ( 2 ) ( L = 5‐methyl‐1‐(4‐methylphenyl)‐1,2,3‐triazol‐4‐carboxylic acid) were synthesized and characterized by elemental analysis, IR and X‐ray diffraction. Complex 1 is a mononuclear structure; the molecules were assembled into an infinite 2–D supramolecular by the C–H···O weak interactions. Complex 2 is a centrosymmetric dinuclear structure with bis(unidentate) carboxylato co‐ordination mode, and the molecules were assembled into 2–D layers by C–H···O and O–H···O weak interactions.  相似文献   

3.
The condensation of 4‐amino‐5‐mercapto‐3‐(2‐phenylquinolin‐4‐yl)/3‐(1‐p‐chlorophenyl‐5‐methyl‐1,2,3‐triazol‐4‐yl)‐1,2,4‐triazoles 1a‐b with chloroacetaldehyde 2a‐b , ω‐bromo‐ω‐(1H‐1,2,4‐triazol‐1‐yl)acetophenone 3a‐b , chloranil 4a‐b , 2‐bromocyclohexanone 5a‐b , 2,4′‐dibromoacetophenone 6a‐b and 2‐bromo‐6′‐methoxy‐2′‐acetonaphthone 7a‐b are described. The structures of the compounds synthesized were confirmed by elemental analyses, IR, 1H NMR and mass spectra. The antibacterial activities were also evaluated.  相似文献   

4.
A simple and efficient one‐pot four‐component procedure has been developed for the synthesis of a wide range of compounds containing the (triazolyl)methyl oxo‐pyrimidine‐carboxylate system from propargyl β‐keto esters, various azides, aldehydes, and urea in the presence of catalytic amounts of (AcO)2Cu/sodium ascorbate in AcOH. The method worked well with different aryl and heteroaryl aldehydes, and for a variety of substituents in the triazolyl part of the molecule. The antimicrobial activities of the products were evaluated against two Gram‐positive and Gram‐negative bacteria, and one fungus. Compound 5j was active against Staphylococcus aureus and Candida albicans.  相似文献   

5.
The study on syntheses of some N‐substituted‐N′‐[5‐methyl‐1‐(4‐chlorophenyl)‐1,2,3‐triazol‐4‐yl]‐urea 6a‐e and N‐substituted‐[5‐methyl‐1‐(4‐chlorophenyl)‐1,2,3‐triazol‐4‐yl]carbonyl amide 6f‐l derivatives were reported in this paper. The yielded products 6a‐l were confirmed by elemental analyses, NMR, MS and IR spectra.  相似文献   

6.
The title compound 1 was prepared from L ‐leucine. The key steps include a Grignard addition to Bn2‐leucinal, a CO/CF2 replacement with Et2NSF3 (DAST) and use of a Ph group as synthetic equivalent of a COOH group. The difluoro‐δ‐amino acid 1 was incorporated into a peptide 8 ; tests with various proteases showed no inhibition by this particular peptide.  相似文献   

7.
The toxicity studies of free 5‐[(E)‐2‐(aryl)‐1‐diazenyl]‐2‐hydroxybenzoic acid and 2‐[(E)‐2‐(3‐formyl‐4‐hydroxyphenyl)‐1‐diazenyl]benzoic acid and their tri‐n‐butyltin(IV) complexes were evaluated by using sea urchin early developmental stages as recommended model organisms for toxicity tests. The novel complexes, as the parent tri‐n‐butyltin(IV) chloride (TBTCl), caused mitosis block and induced high embryonic mortality in sea urchin. Copyright © 2005 John Wiley & Sons, Ltd.  相似文献   

8.
Melamine trisulfunic acid is employed as a recyclable catalyst for the condensation reaction of aromatic aldehydes with 3‐methyl‐l‐phenyl‐2‐pyrazolin‐5‐one. This condensation reaction was performed in ethanol under refluxing conditions giving 4,4′‐(arylmethylene)‐bis‐(3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐ols) in 80‐96% yields.  相似文献   

9.
Nano‐Zn‐[2‐boromophenyl‐salicylaldimine‐methylpyranopyrazole]Cl2 (nano‐[Zn‐2BSMP]Cl2) as a nanoparticle Schiff base complex and a catalyst was introduced for the solvent‐free synthesis of 4‐((2‐hydroxynaphthalen‐1‐yl)(aryl)methyl)‐5‐methyl‐2‐phenyl‐1H‐pyrazol‐3(2H)‐ones by the multicomponent condensation reaction of various aromatic aldehydes, β‐naphthol, ethyl acetoacetate, and phenyl hydrazine at room temperature.  相似文献   

10.
A convenient method for one‐pot two‐step 1,3‐dipolar cycloadditon reaction of arylboronic acid, sodium azide followed with terminal alkynes in the presence of 2‐pyrrolecarbaldiminato‐Cu(II) complexes catalyst is reported. Various 1‐aryl‐1,2,3‐triazoles were prepared in 63%–97% yields in water at 30°C without any additives and avoiding the isolation of unstable aryl azides.  相似文献   

11.
A twofold interpenetrating three‐dimensional CdII coordination framework, [Cd(C8H3NO6)(C14H14N4)]n, has been prepared and characterized by IR spectroscopy, elemental analysis, thermal analysis and single‐crystal X‐ray diffraction. The asymmetric unit consists of a divalent CdII atom, one 1,3‐bis(2‐methyl‐1H‐imidazol‐1‐yl)benzene (1,3‐BMIB) ligand and one fully deprotonated 5‐nitrobenzene‐1,3‐dicarboxylate (NO2‐BDC2−) ligand. The coordination sphere of the CdII atom consists of five O‐donor atoms from three different NO2‐BDC2− ligands and two imidazole N‐donor atoms from two different 1,3‐BMIB ligands, forming a distorted {CdN2O5} pentagonal bipyramid. The NO2‐BDC ligand links three CdII atoms via a μ1‐η11 chelating mode and a μ2‐η21 bridging mode. The title compound is a twofold interpenetrating 3,5‐connected network with the {42.65.83}{42.6} topology. In addition, the compound exhibits fluorescence emissions in the solid state at room temperature.  相似文献   

12.
A novel two‐dimensional (2D) ZnII coordination framework, poly[[μ‐1,3‐bis(2‐methyl‐1H‐imidazol‐1‐yl)benzene](μ‐5‐nitrobenzene‐1,3‐dicarboxylato)zinc(II)], [Zn(C8H3NO6)(C14H14N4)]n or [Zn(NO2‐BDC)(1,3‐BMIB)]n [1,3‐BMIB is 1,3‐bis(2‐methyl‐1H‐imidazol‐1‐yl)benzene and NO2‐H2BDC is 5‐nitrobenzene‐1,3‐dicarboxylic acid], has been prepared and characterized by IR, elemental analysis, thermal analysis and single‐crystal X‐ray diffraction. Single‐crystal X‐ray diffraction analysis revealed that the compound is a new 2D polymer with a 63 topology parallel to the (10) crystal planes based on left‐handed helices, right‐handed helical NO2‐BDC–Zn chains and [Zn2(1,3‐BMIB)2]n clusters. In the crystal, adjacent layers are further connected by C—H…O hydrogen bonds, C—H…π interactions, C—O…π interactions and N—O…π interactions to form a three‐dimensional structure in the solid state. In addition, the compound exhibits strong fluorescence emissions in the solid state at room temperature.  相似文献   

13.
A series of novel 3‐((4‐(t‐butyl)‐2‐(2‐benzylidenehydrazinyl)thiazol‐5‐yl)methyl)quinolin‐2(1H)‐ones ( 7a – 7z ) were designed, synthesized and evaluated for their ability of inhibiting neuraminidase (NA) of in?uenza H1N1 virus. Some compounds displayed moderate influenza NA inhibitory activity. Compound 7l with the scaffold of 2‐(2‐(2‐methoxybenzylidene)hydrazinyl)thiazole was the best one, exhibiting moderate NA inhibitory activity with IC50 of 44.66 µmol/L. Structure‐activity relationship showed that compounds with methoxy or hydroxy groups at the ortho position, fluorine and nitro groups at the meta position and chlorine and bromine groups at the para position of phenyl ring were more active. Docking study indicated that compound 7l has important interactions with some key residues (including Asp151, Glu119, Arg292, Tyr406, and Asn347) and binds to 430‐cavity adjacent to NA active site.  相似文献   

14.
Nucleophilic trifluoromethylation of α‐imino ketones 2 , derived from arylglyoxal, with RuppertPrakash reagent (CF3SiMe3) offers a convenient access to the corresponding O‐silylated β‐imino‐α‐(trifluoromethyl) alcohols. In a ‘one‐pot’ procedure, by treatment with NaBH4, these products smoothly undergo reduction and desilylation yielding the expected β‐amino‐α‐(trifluoromethyl) alcohols 4 . The latter were used as starting materials for the synthesis of diverse trifluoromethylated heterocycles, including aziridines 5 , 1,3‐oxazolidines 8 , 1,3‐oxazolidin‐2‐ones 9 , 1,3,2‐oxazaphospholidine 2‐oxides 10 , 1,2,3‐oxathiazolidine 2‐oxides 11 , and morpholine‐2,3‐diones 12 . An optically active 5‐(trifluoromethyl)‐substituted 1,3‐oxazolidin‐2‐one 9g was also obtained.  相似文献   

15.
The (4E)‐N‐(4‐chlorophenyl)‐5‐(3‐chlorophenyl)‐2‐diazo‐3‐oxopent‐4‐enoic acid amides 5a˜j were synthesized with N‐(4‐chlorophenyl)‐2‐diazo‐3‐oxobutyramide 4 from p‐chloroaniline and various arylaldehydes. The yielded products 5a˜j were investigated with NMR, MS, IR, and X‐ray crystallographic techniques.  相似文献   

16.
An interesting flourophore, 4‐(2,5‐dimethoxyphenylmethelene)‐2‐phenyl‐5‐oxazolone (DMPO) was synthesized by mixing an equivalent molar quantity of hippuric acid and 2,5‐dimethoxybenzaldehyde in acetic anhydride in the presence of anhydrous sodium acetate. The absorption and fluorescence characteristics of 4‐(2,5‐dimethoxy‐phenylmethelene)‐2‐phenyl‐5‐oxazolone (DMPO) were investigated in different solvents. DMPO dye exhibits red shift in both absorption and emission spectra as solvent polarity increases, indicating change in the dipole moment of molecules upon excitation due to an intramolecular charge transfer interaction. The fluorescence quantum yield depends strongly on the properties of the solvents, which was attributed to positive and negative solvatokinetic effects. A crystalline solid of DMPO gave strong excimer like emission at 630 nm due to the excitation of molecular aggregates. This is expected from the idealized crystal structure of the dye that belongs to the B‐type class of Steven's Classification. DMPO displayed fluorescence quenching by triethylamine via nonemissive exciplex formation.  相似文献   

17.
A convenient diastereoselective synthesis of diisopropyl (2R,3R)‐3‐{{{(R/S)‐aryl[(diethoxyphosphinyl)amino]methyl}hydroxyphosphinyl}oxy}‐2‐hydroxybutanedioate through Mannich‐type reactions is reported. The reactions take place under mild conditions in good yields, and this makes it possible to introduce various substituents at the α‐position to the P‐atom of α‐aminophosphonates. The chiral diisopropyl (4R,5R)‐2‐chloro‐1,3,2‐dioxaphospholane‐4,5‐dicarboxylate ( 3 ) was found to be a good phosphonylating agent in this stereoselective reaction.  相似文献   

18.
A novel PVC‐based membrane sensor based on 2,6‐(p‐N,N‐dimethylaminophenyl)‐4‐phenylthiopyrylium perchlorate (DAPP) is described. The electrode exhibits a sub‐Nernstian response to 1‐(beta‐hydroxyethyl)‐2‐methyl‐5‐nitroimidazole (metronidazol) over a relatively wide concentration range (1.0 × 10?1 to 1.0 × 10?5 M) with a detection limit of 8.0 × 10?6 M. The best performance was obtained with the membrane containing 30% poly (vinyl chloride), 50% dibutyl phthalate, 7% DAPP and 13% oleic acid. It has a fast response time (< 30 s) and can be used for at least four weeks without any major deviation. The proposed sensor revealed very good selectivity for metronidazole over a wide variety of common cations, anions and amino acids and could be used in the pH range of 6.0–7.5. It was successfully used for direct determination of metronidazole in an oral synthetic antiprotozoal as an antibacterial agent, in metronidazole tablets, and metronidazole injections and metronidazole gels.  相似文献   

19.
On the line of a previous work on the spectral properties of some of heteroaryl chalcone, the effect of medium acidity and photoreactivity of 3‐(4‐dimethylamino‐phenyl)‐1‐(2,5‐dimethyl‐thiophen‐3‐yl)‐propenone (DDTP) has been investigated in dimethylformamide and in chloromethane solvents such as methylenechloride, chloroform and carbon tetrachloride. The dye solution (ca. 5×10−4 mol·L−1 in DMF) gives a good laser emission in the range 470–560 nm with emission maximum at 515 nm upon pumping by nitrogen laser (λex=337.1 nm). The laser parameters such as gain coefficient (α), emission cross section (δe) and half life energy (E1/2) at maximum laser emission are also determined.  相似文献   

20.
New 4‐aryl‐5‐(1‐phenyl‐5‐methyl‐1,2,3‐triazol‐4‐yl)‐1,2,4‐triazol‐3‐thiones 3 have been synthesized by the intramolecular cyclization of 4‐aryl‐1‐(1‐phenyl‐5‐methyl‐1,2,4‐triazol‐4‐formyl)thiosemicarbazides 2 with an 8% NaOH solution, and then 3 reacted with ω‐bromo‐ω‐(1H‐1,2,4‐triazol‐1‐yl)acetophenone to afford ω‐[4‐aryl‐5‐(1‐phenyl‐5‐methyl‐1,2,3‐triazol‐4‐yl)‐1,2,4‐triazol‐3‐thio]‐ω‐(1H‐1,2,4‐triazol‐1‐yl)‐acetophenones 4 . The preliminary biological test showed that the representative compounds possess some anti fungal activities.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号