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采用涂布手性固定相的毛细管柱在气相色谱上进行手性化合物对映体的分离是近年发展起来的一种简便、快速分析的新方法。本文就分离机理,手性化合物的衍生化,构型分析和光学活性固定相等四个方面的新进展进行综述和讨论。 相似文献
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自从Gil-Av等人首次成功地用气相色谱法分离对映体以来,手性固定相的发展非常迅速,国外已出现了多种性能优良的手性固定相。我们从1984年开始从事“用气相色谱法分离对映体”的研究,已研制出几种性能优良的二酰胺类手性固定相。 交联毛细管柱具有耐温性好和耐溶剂冲洗的特点,并且能用于超临界流体色谱中,因此,手性交联毛细管柱的研制引起了人们的极大兴趣。 手性固定相不同于一般固定相,若交联条件不当会引起固定相的外消旋化而失去拆分对映体的能力。因此,具有较好对映体选择性的手性交联毛细管柱的 相似文献
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《Journal of separation science》2017,40(8):1710-1717
Natural and regenerated chitins were derivatized with 3,5‐dimethyphenyl isocyanate. The corresponding chiral stationary phases were prepared by coating the resulting chitin derivatives on 3‐aminopropyl silica gel. The swelling capacity of the chitin derivatives, enantioseparation capability, as well as eluents tolerance of the chiral stationary phases were evaluated. The results demonstrated no remarkable difference in enantioseparation capability between natural and regenerated chitins based chiral stationary phases. The similar enantioseparation characteristics of two chiral stationary phases could be understood by comparing the IR spectra of related chitin derivatives. The one of the two chiral stationary phases prepared by coating the chitin derivative with a lower molecular weight generally provided better enantioseparations. All chiral stationary phases can work in 100% chloroform, 100% ethyl acetate, 100% acetone, and the mobile phases containing a certain amount of tetrahydrofuran. The chiral stationary phase prepared from the chitin derivative with the highest swelling capacity exhibited better enantioseparations than others. This chiral stationary phase was damaged by flushing with 100% tetrahydrofuran, however, the enantioseparation capability was recovered again after the column was allowed to stand for 1 month. Furthermore, the recovered chiral stationary phase provided better enantioseparations for some chiral analytes than before. 相似文献