The bounded solution of a class of differential-difference equation of advanced type and its asymptotic behavior

In this paper, we consider the differential-difference equation of advanced type with perturbation term. It is shown that if the bounded solution of the reduced equation has negative exponential order and the perturbation term f satisfies certain condition, then the bounded solution of the perturbation equation has negative exponential order.     

微针设计与刺入过程力学问题研究进展

近年来, 一种可实现无痛和微创给药以及生物微量采样分析的新技术—— 微针逐渐引起了人们的广泛关注. 本文首先简要介绍了微针技术的发展历史和现状, 随后结合人类皮肤的力学特点, 重点分析了微针设计和应用中面临的主要力学问题, 特别是微针刺入力、结构强度、刚度以及药物输送技术等方面的研究进展.最后介绍了有关生物微针及仿生微针方面的最新研究进展, 阐述了生物微针的特殊微纳结构和超级省力的力学原理, 并分析了其对改进人造微针设计带来的重要启示.     

Numerical study of opposed zero-net-mass-flow jet-induced erythrocyte mechanoporation

With the advantages of biosafety and efficiency, increasing attention has been paid to the devices for gene and macromolecular drug delivery based on mechanoporation. The transient pore formation on the cell membrane allows cargo transportation when the membrane areal strain is beyond the critical pore value and below the lysis tension threshold. Based on this principle, we propose a method to apply the proper fluid stress on cells moving in a microchannel under the action of zero-net-mass-flux (ZNMF) jets. In this study, an immersed finite element method (IFEM) is adopted to simulate the interaction between the cells and the fluid fields so as to investigate the cell movement and deformation in this mechanoporation system. To evaluate the efficiency of the cargo delivery, a pore integral is defined as the mean pore rate when the cell passes through the jet region. By analyzing the effects of the parameters, including the pressure gradient along the microchannel, the jet amplitude, and the jet frequency, on the pore integrals, a group of optimized parameters for cargo delivery efficiency are obtained. Additionally, the stability and safety of this system are analyzed in detail. These results are helpful in designing the mechanoporation devices and improving their efficiency of drug delivery.     

MASS TRANSPORT IN SOLID TUMORS(Ⅱ)──DRUG DELIVERY

Based on the flow field solution of the three-porous-medium model for tumor microcirculation, the diffusion-convection equations are solved with various initial and boundary conditions using finite element method. The concentration profile of two therapeutic agents: immunoglobulin G (IgG) and its antigen-binding fragment (Fab) in blood, lymph and interstitial fluid are obtained for normal-tissue-surrounded tumor. The effect of tumor microvasculature, lymph function, drug injection mode, the molecular weight and binding kinetics of the drug on the distribution in tumors are also considered.     

A highly-efficient method for stationary response of multi-degree-of-freedom nonlinear stochastic systems

Analytical and numerical studies of multi-degree-of-freedom(MDOF) nonlinear stochastic or deterministic dynamic systems have long been a technical challenge.This paper presents a highly-efficient method for determining the stationary probability density functions(PDFs) of MDOF nonlinear systems subjected to both additive and multiplicative Gaussian white noises. The proposed method takes advantages of the sufficient conditions of the reduced Fokker-Planck-Kolmogorov(FPK) equation when constructi...     

Research on linear/nonlinear viscous damping and hysteretic damping in nonlinear vibration isolation systems

A nonlinear vibration isolation system is promising to provide a high-efficient broadband isolation performance. In this paper, a generalized vibration isolation system is established with nonlinear stiffness, nonlinear viscous damping, and Bouc-Wen(BW)hysteretic damping. An approximate analytical analysis is performed based on a harmonic balance method(HBM) and an alternating frequency/time(AFT) domain technique.To evaluate the damping effect, a generalized equivalent damping ratio is defined w...     

储罐用波纹管的几何非线性分析

根据现场实际,对储罐连接波纹管进行了几何非线性有限元分析。将波纹管视为旋转薄壳,基于Sanders小应变,中等转动薄壳理论,通过引入“伪载荷”而建立起一个形式简单,易于实施的迭代格式,并进行了数值求解。文末以50000m^3储罐－波纹管－管道系统为例,研究了波纹管危险点的等效应力随长度的变化规律,并由此给出一种波纹管安全运行长度的设计方法。     

An engineering formula on the calculation of oblique penetration by long-rod projectile

Based on the concept supposed in this paper that damage of a target is determined by momentum rather than by stress, an engineering .formula on the calculation of oblique penetration by long-rod projectile is established. The results calculated from this formula show good agreements with experimental data.     

结构模型缩聚的改进IRS方法1)

模型缩聚法在结构的静力和动力特性分析中有着广泛的应用。应用模型缩聚法,可以有效降低结构的有限元计算规模,节省计算时间和成本,并能获得和实验测量自由度相匹配的有限元模型。本文在改进模型缩聚方法(improved reduced system, IRS)的基础上,提出一种考虑二阶惯性量的改进IRS方法,有效改进了IRS方法的计算精度,和模型缩聚迭代法(iterated IRS, IIRS)相比,此方法计算量更小且计算精度更高。以桁架结构和框架结构为例对所提二阶IRS方法进行了验证,并将计算结果与精确值、Guyan缩聚解、IRS缩聚解和IIRS缩聚解进行了比较,结果表明了所提方法计算精度最好,具有良好的工程应用前景。