α-羰基一硫代半缩醛与二胺的反应研究

利用α－羰基一硫半缩醛与二胺反应，合成了4种未见文献报道的对称结构的化合物，其结构经红外，核磁、质谱和元素分析得到了证实。     

Ultrasound promoted facile synthesis of arylhydrazones at ambient conditions

Arylhydrazones have been synthesized in excellent yields in short reaction times at ambient temperature conditions in the absence of any added catalyst by the reaction of phenylhydrazines with carbonyl compounds under ultrasonic irradiation.     

Study on Photophysical Properties of Novel Fluorescent Phenanthroimidazole-Thiadiazole Hybrid Derivatives

Journal of Fluorescence - Phenanthroimidazole-thiadiazole hybrid derivatives, which are new heterocyclic compounds with fluorescence properties, were synthesized by designing a two-step reaction...     

Antibacterial evaluation and molecular docking studies of pyrazole–thiosemicarbazones and their pyrazole–thiazolidinone conjugates

Molecular Diversity - A library of pyrazole–thiazolidinone conjugates was synthesized using a molecular hybridization approach through a Vilsmeier–Haack reaction. The compounds were...     

Synthesis of spirooxindolocarbamates based on Betti reaction: antibacterial,antifungal and antioxidant activities

Molecular Diversity - A series of new spirooxindolocarbamates 4a–l and 6a–d were synthesized by using the Betti reaction. All the target compounds were well characterized by IR, NMR and...     

正交实验法研究MAH-β-CD衍生物的制备工艺

用顺丁烯二酸酐（MAH）对β-环糊精（β-CD）进行化学改性,合成出了顺丁烯二酸酐-β-环糊精衍生物（MAH-β-CD）。针对影响衍生物制备的因素,采用正交实验法,以产物产率为评价指标,优选顺丁烯二酸酐-β-环糊精衍生物制备的最佳工艺条件为：投料比1∶10,反应温度80℃,反应时间9h。     

Spectrophotometric Studies on the Complexes of 25,26,27,28-Tetraepoxypropoxy-p-tert-butylcalix[4]arene and 25,26,27,28-Tetrahydroxypropilaminoxy-p-tert-butylcalix[4]arene with Iodine

Two p-tert-butylcalix[4]arene derivatives were synthesized from the reaction of calixarene with epichlorohydrine and then its reaction of ammonia. These donor macromolecular compounds were interacted with iodine in chloroform and interaction was investigated by using a UV-visible spectrophotometer. The chargetransfer spectra of n-[sgrave] type interactions were observed at 362 nm and 369 nm. The stability constants and some thermodynamic parameters were found.     

Ultrasonics in isocyanide-based multicomponent reactions: A new,efficient and fast method for the synthesis of fully substituted 1,3,4-oxadiazole derivatives under ultrasound irradiation

A fast and convenient approach to the synthesis of fully substituted 1,3,4-oxadiazoles via three-component reaction of aromatic carboxylic acids, acenaphthoquinone, and (N-isocyanimino)triphenylphosphorane under ultrasound irradiation is described. Furthermore, a series of compounds were synthesized and characterized by melting point, IR, NMR and MS. Utilization of easy reaction conditions, very high to excellent yields, and short reaction times makes this manipulation potentially very useful.     

壳聚糖与Cd(Ⅱ),Pb(Ⅱ),Ce(Ⅲ),Zr(Ⅳ)配合物的制备及光谱分析

用壳聚糖(CTS)分别与硝酸亚铈,硝酸锆,硫酸镉和硝酸铅在酸性介质中反应,制备了壳聚糖-Ce(Ⅲ)、壳聚糖-Zr(Ⅳ)、壳聚糖-CA(Ⅱ)、壳聚糖-Pb(Ⅱ)四种壳聚糖-重金属离子配合物(用通式M-CTS表示).用红外光谱(IR)、X-ray衍射(XRD)和X射线光电子能谱(XPS)等光谱分析手段对M-CTS进行了结构表征.结果表明:在壳聚糖-Cd(Ⅱ)配合物中的配位原子是壳聚糖-NH2上的N原子,而在壳聚糖-Ce(Ⅲ)、壳聚糖-Zr(Ⅳ)、壳聚糖-Pb(Ⅱ)配合物中不仅壳聚糖-NH2上的N原子参与了配位,同时OH上的O原子也参与了配位.说明不同的重金属离子与壳聚糖之间形成配位键的配位原子是不完全相同的.     

An infrared spectroscopic study of the reactions of silicic acid with heavy metal ions

This paper deals with the results of an infrared spectroscopic study of the reactions of low polymeric silicic acid with heavy metal ions. The individuality of the compounds obtained is established. It is also found that the shift in the IR absorption band of the Sio ₄ ^4– tetahedra depends on the number and kinds of cations taking part in the reaction. Conclusions are drawn concerning the reaction mechanism. The thermal transitions of the compounds synthesized have been studied.     

Ultrasound-assisted synthesis of aromatic 1,2-diketones from oximinoketones under neutral conditions in aqueous media

We report a convenient, neutral, and facile methodology for the synthesis of aromatic 1,2-diketones from the corresponding oximinoketones in the presence of I₂/SDS/water system under ultrasound-assisted conditions. Furthermore, a series of compounds were synthesized and characterized by melting point, IR, NMR, MS, and elemental analysis. Utilization of easy reaction conditions, very high to excellent yields, and short reaction times makes this manipulation potentially very useful.     

Ultrasound-assisted dehydrogenation of 5-acetyl-3,4-dihydropyrimidin-2(1H)-ones

In this study, various 5-acetyl-3,4-dihydropyrimidin-2(1H)-ones were synthesized and the dehydrogenation of these compounds by potassium peroxydisulfate in aqueous acetonitrile under thermal and sono-thermal conditions were investigated. Whereas the effect of the nature of 4-substituent influences the rate of reaction, the application of sonic waves decreases drastically the time of thermal reaction.     

Synthesis of 1,5-benzothiazepine derivatives bearing 2-phenoxy-quinoline moiety via 1,3-diplolar cycloaddition reaction

A series of 1,5-benzothiazepine derivatives were synthesized by the reaction of 1,5-benzothiazepine containing 2-phenoxy-quinoline with benzohydroximinoyl chlorides and hydrazonoyl chlorides at room temperature. The structures of these novel compounds were confirmed by spectrum, elemental, and X-ray crystallographic analysis.     

Expanding cyclitol structural diversity by biocatalysis and metalocatalysis. A click chemistry approach

The palladium catalyzed cross-coupling reaction of phenyltrifluoroborate with a chemoenzymatically derived bromoazidoconduritol, combined with 1,3-dipolar cycloaddition, with a variety of alkynes is described. Fourteen new compounds were synthesized in moderate to good yields. The click chemistry reaction can be effected by using sodium ascorbate and CuSO₄ · 5H₂O as catalyst in toluene–H₂O at room temperature.     

Novel Multicolor Schiff Base Polymers Prepared via Oxidative Polycondensation

A series of diimine Schiff bases and their polymers were synthesized via the oxidative polycondensation reaction. The structures of the compounds were confirmed by ¹H-NMR, ¹³C-NMR, FT-IR and UV–vis spectral measurements. Electrochemical and optical band gap values of synthesized compounds were determined by cyclic voltammetry (CV) and UV–vis measurements, respectively. Fluorescence measurements of the compounds were conducted in various solvents. The effects of solution concentration on the fluorescence spectra were investigated and quantum yield was calculated for the polymer of 5-(diethylamino)-2-(biphenylmethylene) hydrazonomethylphenol (PDEAHP). According to fluorescence measurements, the quantum yield of PDEAHP was found as 16 % in DMF solution. Thermal characteristics of polymers were studied by TG-DTA and DSC analyses.     

Multiple simultaneous synthesis of phenolic libraries

Summary A series of analogous arrays of small, non-peptidyl, non-oligomeric compounds were synthesized on polystyrene resin. With the aid of a functionally differentiated phenolic scaffold, the batch preparation of unique benzamide and urea resins was accomplished, which were further derivatized in modified 96-well plates. An efficient cleavage reaction of the phenyl benzoate link enabled the isolation of more than 600 phenolic compounds in milligram quantities that were suitable for direct biological screening. The technology described herein represents a facile, economical approach to non-peptidyl chemical diversity.     

[Hmim]TFA catalyzed multicomponent reaction: direct,mild, and efficient procedure for the synthesis of 1,2-dihydroquinazoline derivatives

4-Substituted-spiro-1,2-dihydroquinazolines and related compounds were synthesized by direct reaction of 2-aminobenzophenones, isatin, or 1,2-diketone derivatives and ammonium acetate in the presence of dual role catalyst-solvent ionic liquid, [Hmim]TFA. Excellent conversion of starting materials was achieved to the desired 1,2-dihydroquinazoline products.     

锗丙酰氨基酸酯系列倍半氧化物的合成及其NMR研究

锗丙酰和取代锗丙酰氯分别与氨基酸缩合,继而水解,用三乙胺作缚酸剂,得到13个倍半氧化物.根据对以上系列化合物¹H NMR、¹³C NMR和¹H-¹³C COSY的分析,讨论了其核磁共振谱构关系规律,并观察到了取代氨基酸中2×CH₃和乙酯的CH₃在¹H和¹³C NMR中出现反常现象,应用重核NMR屏蔽效应新原理对其产生的原因进行了合理阐明.     

A simple and efficient synthesis of fused morpholine pyrrolidines/piperdines with potential insecticidal activities

A simple and efficient synthesis of fused morpholine pyrrolidine/piperdine core structures was accomplished via a Petasis-borono Mannich reaction of cyclic amino alcohols, glyoxal and arylboronic acids with moderate to good yields. The bioassay data showed that the synthesized compounds displayed selective insecticidal activities against armyworm and root-knot nematode.     

Synthesis of Benzimidazoles Containing Pyrazole Group and Quantum Chemistry Calculation of Their Spectroscopic Properties and Electronic Structure

Five benzimidazole compounds containing pyrazole group were synthesized via one-step reaction of o-phenylenediamine and 1-arylpyrazole-4-carbaldehyde in ethanol under mild conditions. The composition and structure of resultant benzimidazole compounds were analyzed by means of elemental analysis, mass spectrometry, ¹H-nuclear magnetic resonance spectroscopy and X-ray single crystal diffraction. The ultraviolet–visible light spectra and fluorescent spectra of the products were measured. Their ground-state (S ₀) equilibrium geometries and vibrational frequencies were determined based on B3LYP method, and their first excited-state (S ₁) geometries were fully optimized based on 6–31G (d, p) basis set of TD-B3LYP method. Besides, the spectroscopic properties of the products were computed based on cc-pVTZ basis set of TD-B3LYP method and compared with corresponding experimental data. It has been found that benzimidazole compounds containing pyrazole group can be readily synthesized in a high yield via one-step reaction of o-phenylenediamine and 1-arylpyrazole-4-carbaldehyde in ethanol solvent. The fluorescence properties of the five synthesized compounds are closely related to their molecular structure; and their computed fluorescence spectra well correspond to their experimental values. Moreover, they have stable structure and strong fluorescence, showing potential application in time-resolved fluoroimmunoassay and DNA probe.