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1.
建立了分离和测定荆花胃康原料药和胶丸中的主要成分对-异丙基甲苯(ρ-cymene)和α-萜品烯(α-Terpinene)的反相高效液相色谱梯度洗脱的方法.采用Spherisorb ODS1分析柱;甲醇-水梯度洗脱:0~15 min(V(甲醇):V(水)=75:25),15~22 min(V(甲醇):V(水)=85:15),22~28 min(V(甲醇):V(水)=75:25);紫外检测波长220 nm.对-异丙基甲苯在2.0~6.0 mg/mL,α-萜品烯在4.0~12.0 mg/mL范围内,峰面积与其质量浓度呈良好的线性关系;平均加样回收率对-异丙基甲苯为99.6%(RSD=1.3%),α-萜品烯为98.2%(RSD=1.1%).该方法灵敏度高,重现性好,结果稳定,可用于同时测定荆花胃康原料药及胶丸中的对-异丙基甲苯和α-萜品烯. 相似文献
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碱性拆分剂的选择不象酸性拆分剂的选择那么有限,但在众多合成的碱性拆分剂中,既廉价易得,而又有高拆分效果的物质很少。最常用的α-苯乙胺,由于其水溶性,有时会使拆分遇到困难。我们将光活性α-对氯苯基异戊酸[S(+)Ⅰ,R(-)Ⅰ]和它的降解产物α-异丙基对氯苄胺[S(-)Ⅱ,R(+)Ⅱ]分别用于拆分(±)1-苯基-2-对甲苯基乙胺(PTE)、(±)α-苯乙 相似文献
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以N-对甲苯磺酰基乙二胺、取代醛、芳酮及亚磷酸酯为原料,采用“一锅煮”合成了一系列新型的含磺酰基的α-氨基磷酸酯,其结构经1H NMR,13C NMR,31P NMR和元素分析表征. 相似文献
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Laurencin D Villanneau R Herson P Thouvenot R Jeannin Y Proust A 《Chemical communications (Cambridge, England)》2005,(44):5524-5526
The easy synthesis of [Sb2W20O70{Ru(p-cymene)}2](10-) by the reaction between the organometallic precursor [Ru(p-cymene)Cl2]2 and [Sb2W20O70]14-, formed in situ, confirms the importance of the organometallic route to well defined ruthenium(+II)-substituted heteropolytungstates. 相似文献
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G Xie N Chen LW Soromou F Liu Y Xiong Q Wu H Li H Feng G Liu 《Molecules (Basel, Switzerland)》2012,17(7):8159-8173
The objective of this study was to test the hypothesis that p-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6), lung water gain, inflammatory cell infiltration, lung tissue myeloperoxidase activity. In addition, p-cymene blocked the phosphorylation of IκBα protein and mitogen-activated protein kinases (MAPK) signaling pathway activation. Histopathologic examination of lung tissue indicated that p-cymene treatment markedly decreased focal thickening, congestion, pulmonary edema, and inflammatory cells infiltration. The results showed that p-cymene had a protective effect on LPS-induced ALI in mice. 相似文献
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以邻氨基苯甲醇为原料进行催化脱氢反应,经过对催化体系的一系列筛选,最终采用[RuCl2(p-cymene)]2/AgOTf共催化体系,使邻氨基苯甲醇发生催化脱氢和芳基端炔发生交叉偶联反应,并以39%~47%的收率获得合成一系列2-芳基喹啉衍类生物,发展了邻氨基苯甲醇与芳基末端炔烃合成喹啉衍类生物的新方法,是对喹啉类衍生物合成方法的一个重要补充。 相似文献
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Saur I Scopelliti R Severin K 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(4):1058-1066
The synthesis of water-soluble, organometallic macrocycles is described. They were obtained by self-assembly in reactions of the half-sandwich complexes [[Ru(C6H5Me)Cl2]2], [[Ru(p-cymene)Cl2]2], [[Rh(Cp)Cl2]2], and [[Ir(Cp*)Cl2]2] with the ligand 5-dimethylaminomethyl-3-hydroxy-2-methyl-4-(1H)-pyridone in buffered aqueous solution at pH 8. The structure of the Ru-(p-cymene) complex was determined by single-crystal X-ray crystallography. Upon mixing, these complexes undergo scrambling reactions to give dynamic combinatorial libraries. In combination with structurally related complexes based on amino-methylated 3-hydroxy-2-(1H)-pyridone ligands, an exchange of metal fragments but no mixing of ligands was observed. This self-sorting behavior was used to construct dynamic combinatorial libraries of macrocycles, in which two four-component sub-libraries are connected by two common building blocks. This type of network topology influences the adaptive behavior of the library as demonstrated in selection experiments with lithium ions as the target. 相似文献
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采用BT2.15型Calvet微量量热计常压下测定了α-蒎烯+对伞花烃和β-蒎烯+对伞花烃两个二元体系在298.15 K、308.15 K及318.15 K下的超额焓. 实验数据采用Redlich-Kister方程进行关联, 标准偏差较小. 该两个二元体系的超额焓在全浓度范围内均为正值, 其最大值在摩尔分数x1=0.5附近. 温度对超额焓有一定的影响, 超额焓随温度的升高而增大. 相同温度下, α-蒎烯+对伞花烃体系的超额焓比β-蒎烯+对伞花烃体系的大. 相似文献
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Philis JG 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2005,61(6):1239-1241
The spectrum of the first electronic transition of p-cymene cooled in a supersonic jet was measured by resonance-enhanced multiphoton ionisation (REMPI) in a time-of-flight (TOF) mass spectrometer. The band origin is strong and appears at 270.61nm (air value). This spectrum is useful for the detection of p-cymene in trace analysis. 相似文献
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Takezawa Y Böckmann P Sugi N Wang Z Abe S Murakami T Hikage T Erker G Watanabe Y Kitagawa S Ueno T 《Dalton transactions (Cambridge, England : 2003)》2011,40(10):2190-2195
Spherical protein cages such as an iron storage protein, ferritin, have great potential as nanometer-scale capsules to assemble and store metal ions and complexes. We report herein the synthesis of a composite of an apo-ferritin cage and Ru(p-cymene) complexes. Ru complexes were efficiently incorporated into the ferritin cavity without degradation of its cage structure. X-Ray crystallography revealed that the Ru complexes were immobilized on the interior surface of the cage mainly by the coordination of histidine residues. 相似文献
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Cokoja M Gemel C Steinke T Schroder F Fischer RA 《Dalton transactions (Cambridge, England : 2003)》2005,(1):44-54
The first carbonyl free ruthenium/low valent Group 13 organyl complexes are presented, obtained by insertion of ER (ER = GaCp*, InCp*, In[C(SiMe(3))(3)]) into the Ru-Cl bonds of [(p-cymene)RuCl2]2, [Cp*RuCl]4 and [Cp*RuCl2]2. The compound [(p-cymene)RuCl2]2 reacts with GaCp*, giving a variety of isolated products depending on the reaction conditions. The Ru-Ru dimers [{(p-cymene)Ru}2(GaCp*)4(mu3-Cl)2] and the intermediate [{(p-cymene)Ru}2(mu-Cl)2] were isolated, as well as monomeric complexes [(p-cymene)Ru(GaCp*)3Cl2], [(p-cymene)Ru(GaCp*)2GaCl3] and [(p-cymene)Ru(GaCp*)2Cl2(DMSO)]. The reaction of [Cp*RuCl]4 with ER gives "piano-stool" complexes of the type [Cp*Ru(ER)3Cl](ER = InCp*, In[C(SiMe3)3], GaCp*. The chloride ligand in complex can be removed by NaBPh4, yielding [Cp*Ru(GaCp*)3]+[BPh4]-. The reaction of [Cp*RuCl2]2 with GaCp* however, does not lead to an insertion product, but to the ionic Ru(II) complex [Cp*Ru(GaCp*)3]+[Cp*GaCl3]-. The ER ligands in complexes 3, 5, 6, 7 and 8 are equivalent on the NMR timescale in solution due to a chloride exchange between the three Group 13 atoms even at low temperatures. The solid state structures, however, exhibit a different structural pattern. The chloride ligands exhibit two coordination modes: either terminal or bridging. The new compounds are fully characterized including single crystal X-ray diffraction. These results point out the different reactivities of the two precursors and the nature of the neutral p-cymene and the anionic Cp* ligand when bonding to a Ru(II) centre. 相似文献
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Isotope ratio mass spectrometry online coupled with capillary gas chromatography (GC-Py-IRMS) on column INNOWAX is used in the origin specific analysis and the authenticity control of the phenolic essential oils (EOs). Isotopic data delta(2)H(V-SMOW) of thymol and carvacrol in natural essential oils were evidently more depleted than synthetic products (from -49 to 7 per thousand for thymol and -61 per thousand for carvacrol). delta(2)H(V-SMOW) values of p-cymene, gamma-terpinene and thymol in authentic thyme oils (Thymus vulgaris L. and Thymus zygis L.) were found from -300 to -270 per thousand, from -285 to -248 per thousand and from -259 to -234 per thousand, respectively. delta(2)H(V-SMOW) values of carvacrol and p-cymene in authentic oregano oils (Origanum heracleoticum L., Coridothymus capitatus L. and Origanum compactum L.) varied from -223 to -193 per thousand and from -284 to -259 per thousand, respectively. For authentic Satureja montana subsp. montana essential oils, the mean delta(2)H(V-SMOW) value for aromatic compounds were found to be the following: gamma-terpinene -273 per thousand (SD=4.6 per thousand) and p-cymene -283 per thousand (SD=3.0 per thousand), thymol -245 per thousand (SD=1.8 per thousand) and carvacrol -226 per thousand (SD=1.7 per thousand). In addition, p-cymene was previously found as a precursor of the biosynthesis of thymol and carvacrol in thyme oil, thus, we considered p-cymene as an endogenous reference compound (ERC) for D/H ratio analysis. The isotopic fractionation factors alpha(thymol/p-cymene)=1.05 and alpha(carvacrol/p-cymene)=1.08 were obtained and also used to control the authenticity of the phenolic EOs. 相似文献
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Remarkably favorable hydration of carbonyl substituents in dicationic bis(arene) ruthenium complexes
Velarde EL Stephen RA Mansour RN Hoang LT Burkey DJ 《Journal of the American Chemical Society》2003,125(5):1188-1189
The addition of water and methanol to the carbonyl substituents in the dicationic bis(arene)ruthenium complexes [(p-cymene)Ru(C6H5CHO)][OTf]2 (1) and [(p-cymene)Ru(C6H5C(O)CH3)][OTf]2 (2) is remarkably favorable-the equilibrium constants for these reactions are 1 million times greater than those for uncomplexed benzaldehyde and acetophenone. The addition of methanol to the carbonyl group in the o-anisaldehyde complex, [(p-cymene)Ru(C6H4{OCH3}CHO)][OTf]2 (6), occurs with a high degree of kinetic selectivity (94% de). 相似文献