Friedlnder法合成茚并喹啉类衍生物

胡椒醛 ( 1)经硝化和还原得到中间体 6 氨基胡椒醛 ( 3 ) ,再分别与 5种茚酮衍生物 4a～ 4e发生Friedl nder缩合反应 ,得到 5种新的茚并喹啉类衍生物 5a～ 5e .所合成的新化合物的化学结构 5a～ 5e分别经IR ,1HNMR ,MS ,元素分析予以证实     

Friedl(a)nder法合成茚并喹啉类衍生物

胡椒醛(1)经硝化和还原得到中间体6-氨基胡椒醛(3),再分别与5种茚酮衍生物4a～4e发生Friedl(a)nder缩合反应,得到5种新的茚并喹啉类衍生物5a～5e.所合成的新化合物的化学结构5a～5e分别经IR,1H NMR,MS,元素分析予以证实.     

4＇，4＂（5＂）-{二-[1，3]二氧[4，5-g]喹啉}-二苯并-18-冠-6的合成

6-氨基胡椒醛与4＇，4＂（5＂）-二乙酰基二苯并-18-冠-6进行Friedlander缩合得到新的冠醚衍生物——4＇，4＂（5＂）-{二-[1，3]二氧[4，5-g]喹啉}-二苯并-18-冠-6（3），产率62％。3的结构经UV，^1H NMR，^13C NMR，IR和MS表征。     

喹啉衍生物的合成

以6-氨基胡椒醛为原料,与α-位有活泼亚甲基羰基的化合物发生Friedlander缩合,得到喹啉衍生物3a-3d。其结构经IR,^1H NMR和MS予以证实。3c为未见文献报道的新化合物。     

Friedlnder反应合成2-(2-羟基苯基)-6,7-亚甲二氧基喹啉及其衍生物

以 6 氨基胡椒醛为原料 ,与邻羟基苯乙酮 (2a) ,4 氯 2 羟基苯乙酮 (2b)发生Friedl nder缩合反应 ,得到新的喹啉衍生物 2 (2 羟基苯基 ) 6 ,7 亚甲二氧基喹啉 (3a)和 2 (5 氯 2 羟基苯基 ) 6 ,7 亚甲二氧基喹啉 (3b) .新的喹啉衍生物 3a～ 3b分别经IR红外光谱 ,1 HNMR核磁共振谱 ,MS质谱 ,元素分析予以证实     

Friedlander反应合成2-(2-羟基苯基)-6,7-亚甲二氧基喹啉及其衍生物

以6-氨基胡椒醛为原料,与邻羟基苯乙酮(2a),4-氯-2-羟基苯乙酮(2b)发生Friedlander缩合反应,得到新的喹啉衍生物2-(2-羟基苯基)-6,7-亚甲二氧基喹啉(3a)和2-(5-氯-2-羟基苯基)-6,7-亚甲二氧基喹啉(3b),新的喹啉衍生物3a～3b分别经IR红外光谱,1H NMR核磁共振谱,MS质谱,元素分析予以证实.     

4′,4″(5″)-{二-[1,3]二氧[4,5-g]喹啉}-二苯并-18-冠-6的合成

6-氨基胡椒醛与4′,4″(5″)-二乙酰基二苯并-18-冠-6进行Friedlander缩合得到新的冠醚衍生物——4′,4″(5″)-{二-[1,3]二氧[4,5-g]喹啉}-二苯并-18-冠-6(3),产率62%。3的结构经UV,1HNMR,13CNMR,IR和MS表征。     

4'',4″(5″)-{二-[1,3]二氧[4,5-g]喹啉}-二苯并-18-冠-6的合成

6-氨基胡椒醛与4',4″(5″)-二乙酰基二苯并-18-冠-6进行Friedlnder缩合得到新的冠醚衍生物--4',4″(5″)-{二-[1,3]二氧[4,5-g]喹啉}-二苯并-18-冠-6(3),产率62%.3的结构经UV, 1H NMR, 13C NMR, IR和MS表征.     

Friedlaender反应合成2－（2－羟基苯基）－6，7－亚甲二氧基喹啉及其衍生物

以6－氨基胡椒醛为原料，与邻羟基苯乙酮（2a），4－氯－2－羟基苯乙酮（ 2b）发生Friedlaender综合反应，得到新的喹啉衍生物2－（2－羟基苯基）－6， 7－亚甲二氧基喹啉（3a）和2－（5－氯－2－羟基苯基）－6，7－亚甲二氧基喹啉 (3b），新的喹啉衍生物3a－3b分别经IR红外光谱，^1H NMR核磁共振谱，MS质谱， 元素分析予以证实。     

6-硝基胡椒酸的合成

胡椒醛经硝化,氧化,合成了6-硝基胡椒酸。其结构经UV,IR和MS确认,总收率44％。     

Solvent-free synthesis of 4-chalcogenophosphorylpyridines viaSNHAr reaction of pyridines with secondary phosphine chalcogenides

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In memoriamMichell J. Sienko

Calcium urate hexahydrate, Ca(C₅H₃O₃N₄)₂ · 6H₂O, has been synthesized for the first time. A tentative assignment of some infrared and Raman bands is given by referring to the isotopic frequency shifts, group frequency considerations, Raman intensities as well as to the spectrum of potassium salt. The spectroscopic data suggest that there are, at least, two types of water molecules in the unit cell. Centrosymmetric unit cell is proposed to explain the spectral features of this compound. X-Ray powder diffraction data are also given.     

From d-xylose to a d-glycero-l-altrose derivative

A key intermediate corresponding to a rare sugar framework has been synthesized, starting from d-xylose, an inexpensive carbohydrate. This approach gave access to new elaborated sugar moieties for structure–activity relationships in the KRN research.     

Stereodivergent synthesis of the 2,3,5,6-tetrasubstituted piperidine ring system: an application to the synthesis of alkaloids 223A and 205B from poison frogs

Stereodivergent synthesis of the 2,3,5,6-tetrasubstituted piperidine ring system has been achieved by sequential stereocontrolled Michael-type conjugate addition reaction of appropriate enaminoesters. This methodology has been applied to the total syntheses of the poison frog alkaloids 223A and 205B. The relative stereochemistry of natural 223A at the 6-position was revised, and the absolute stereochemistry of natural 205B was determined by the present synthesis.     

Polarized light microscopy : By

In capillary systems with narrow pores the Helmholtz electrochemical double layer located at the pore wall extends over the entire cross section of the pores. It loses its character as the “charge on the wall”. It will be shown that not only the electrokinetic phenomena but also the electrical conductivity and the dialysis potential of membranes with narrow pores can be understood from the same point of view, namely: the electrolyte solution in the pores of a membrane with narrow pores is considered to be an approximately homogeneous solution in contact with immobilised charges located at the pore wall. In this case the electrochemical equations contain the fixed ion concentration as a parameter instead of the ζ potential. This makes it possible to describe quantitatively to a good approximation data on the electroosmosis, the electrical conductivity, the streaming potential and the dialysis potential taken from the literature, as well as results of our own measurements, by using a single membrane constant.     

Electrochemistry of capillary systems with narrow pores. I. Overview

In capillary systems with narrow pores the Helmholtz electrochemical double layer located at the pore wall extends over the entire cross section of the pores. It loses its character as the “charge on the wall”. It will be shown that not only the electrokinetic phenomena but also the electrical conductivity and the dialysis potential of membranes with narrow pores can be understood from the same point of view, namely: the electrolyte solution in the pores of a membrane with narrow pores is considered to be an approximately homogeneous solution in contact with immobilised charges located at the pore wall. In this case the electrochemical equations contain the fixed ion concentration as a parameter instead of the ζ potential. This makes it possible to describe quantitatively to a good approximation data on the electroosmosis, the electrical conductivity, the streaming potential and the dialysis potential taken from the literature, as well as results of our own measurements, by using a single membrane constant.     

,-Difluoroketone inhibitors of HMG CoA reductase

The rationale for a new class of HMG CoA reductase inhibitors, represented by ,ga-difluoroketones 3 and 4, is described. The syntheses of 3, 4, and their nonfluorinated analogue 5 are presented.