朱砂莲化学成分的研究 Ⅰ.朱砂莲素和朱砂莲苷的结构

从朱砂莲根中分得两种新的阿朴啡生物碱,命名为朱砂莲素和朱砂莲苷,经光谱和化学方法确证,它们的结构分别为3和4。     

款冬花化学成份的研究I.款冬酮的结构

本文报道从中药款冬花(Tussilago farfara L.)中分得一个升高血压有效成份--款冬酮(tussilagone 1),根据13C NMR, 400MHz1H NMR,UV, IR, HRMS, 2D 1H-1HCOSY, 2D13C-1H COSY, 2D NOE以及生物2,3和4的各种数,推定了1的化学结构,根据1及6的DCD确定其绝对构型为3S, 4S, 5S, 7R, 9R及14R.     

蒙古蒿精油化学成份的研究I.

The chemical constituents of the essential oil from the leaves of artemisia mongolica Fisch. were separated by gas chromatography employing glass capillary eolumns and identified by GC-MS-COM. 30 components have been separated and identified, i.e. 2-methyl-2-butene, methylene cyclopentane, 7,7-dimethyl-3-methylen-bicyclo-(3, 1, 1) heptane, α-thujene, α-pinene, camphene, 1-octen-3-o1, β-thujene, β-pinene, α-phellandrene, bornylene, p-cymene, terpinen-1-o1, artemisia ketone, γ-terpinene, β-terpineol, 3,7,7-trimethyl-bicyclo-(3, 1,1)-2-heptanol, α-terpinolene, verbenone, linalool iso-thujone, thujone, camphor, isopulegone, isoborneol, terpinen-4-o1, α-terpineol, myrtenol, trans- carveol, cis-carveol.     

北柴胡挥发油的成份研究I.

The chemical constituents of essential oil from the roots of Bupleurum chinense DC. were examined by means of GC-MS technique combined with preparative GC TLC and IR. As a result of the analyses, twenty components were identified namely: pentanoic acid, caproic acid, heptanoic acid, 2-heptenoci acid, caprylic acid, 2-octenoic acid, pelargonic acid, 2-nonenoic acid, phenol, cresol, ethylphenol, thymol, eugenol, 0-methoxyphenol, γ-heptalactone, γ-octalactone, γ-decalactone, γ-undecalactone, messoialactone and vanillin acetate.     

鸦胆子化学成份的研究 II.鸦胆子苦素E-葡萄糖苷

A new quassinoid glucoside, yadanzigan (1a), has been isolated from Brucea javanica (L) Merr. 1a has formula C26H38O14(M+574), m.p. 243-245C, (α)D^2^3 60.0 (c. 1.70, H2O). The structure has been established as brucein E-2-β-D-glucopyranoside by enzymatic hydrolysis of 1a and elemental analyses, ^1H NMR, ^1^3C NMR and mass spectral analyses of 1a and its aglycone 2a.     

龙头乌头生物碱成份的研究

毛茛科乌头属植物龙头乌头(Aconitum Longtounense T.L.Ming)主要产于云南西部.民间用于止血、接骨.我们从干燥的植物根部总碱中经氧化铝柱层析分离到四个19-C 二萜生物碱.其中碱1经鉴定为查斯马宁(chasmanine),碱2为滇乌碱(yunaconitine),碱3和碱4经红外光谱、~1HNMR 和~(13)CNMR 谱、质谱以及 X 衍射证明系首次发现的19-C 二萜生物     

线叶旋复花化学成份的研究

Xian-Ye-Xuan-Fu-Hua, the flowers of Inula linariaefolia Turcz (Compositae), is a commonly known Chinese medicinal herb and used as expectorant as well as for the treatment of some malignant tumors. The chemical investigation of its active principles by our early work in 1964 resulted in the isolation of a new sesquiterpene lactone (m.p. 190-192`C, (α)D-24 in CHCl3), which possesses significant inhibitory action against Hela cells and fungi in vitro. Besides, it also shows some expectorant activity in preliminary pharmacological tests. Analyses of the spectral data (IR, UV, ^1H NMR, 13C NMR, MS) and our early results of chemical reactions suggested that the compound is the same as britanin 1 (m.p. 192-194`C, (α)D-26 in CHCl3) studied Chugunov in 1971. However its stereochemistry remained unsolved. On careful examination of the 360 MHZ 1H NMR data (in CDCl3 and in C6D6) and the Cotton effects of ORD spectra of its saturated lactone and cyclopentanone derivatives, we considered that britanin must be ambros-11(13)-en-2β, 4β, 6α, 8α-tetraol-12-oic-(12,8)- lactone, 2, 6-diacetate (7). Since the large values for J6,7, J7,8, J8,9, J9,10 and J1,10 indicate the existence of successive a-a trans coupling in all vicinal protons form C6 to C1, the cofnformation of the cycloheptane ring must be in chair from. The other constitutent isolated from the same plant has been identified as taraxasteryl palmitate.     

尖山橙生物碱的研究

从尖山橙(Melodinus fusiformis)全植物中分得15个生物碱, 其中三个为新生物碱,采用波谱分析和化学方法,它们的结构分别鉴定为: 11,19(R)-dihydroxy tabersonine,11-hydroxy-14,15a-epoxy tabersonine 和 scandine N~b-oxide。其余12个为已知生物碱: scandine, moloscandonine, 10-hydroxysoandine, Kopsinine,15α-hydroxydopsinine, venalstonine, tabersonine,11-methoxytabersonine, 11-hydroxytabersonine, tubotaiwine(13), vindolinine (14)和deacetylpicraline。新生物碱1和2分别显示有明显的抗生育和抗肿瘤的作用。     

贡甲根中生物碱的化学研究

从芸香科植物贡甲(Acronychia oligophylebia Merr.)的根中分得了九个生物碱1～9和β-谷甾醇(10),其中吴茱萸春(1)、香草木宁(3)、原茵芋碱(4)、茵芋碱(5)和斑点弗林定(6)是已知生物碱,1,4,6三个生物碱是第一次从山油柑属植物中分得.贡甲定碱(2)和贡甲辛定碱(9)是两个新化合物.贡甲辛碱(7)和贡甲碱(8)是首次从植物中分得.用光谱方法推断了2,7,8,9的结构,由合成证明7,9的结构. 7和8具广谱抗真菌作用,但作用较弱.     

华马钱生物碱的研究

华马钱(Strychnos cathayansis Merr)产于我国广西、海南岛等地,民间用以镇痛。本文报道其有效成分的提取和结构鉴定。从广西华马钱粗提物中得到的总生物碱,经硅胶离心层析,分得三个主要组分。组分A:高分辨质谱测得分子量352.1704,分子式为C_(21)H_(24)N_2O_3。λ_(max):250nm示有N-乙酰基-二氢吲哚核的特征吸收;ν_(max):1640cm~(-1)和720cm~(-1),说明含有酰胺基及苯环上有四个相邻的芳氢,~1H NMR除证实有四个芳氢外,还显示δ2.27ppm酰胺的甲基信号,说明吲哚核上的氮原子已被乙酰化;质谱m/z352(M~ ,100％),180(碎片c,81),144(碎片b-C_2H_2O,84),130(碎片a-C_2H_2O,36),显示具有Wieland Gumlich醛的骨架,其断裂机理如下所示:     

中国乌头之研究: 一枝蒿戊素和己素的结构

作者曾从雪上一枝蒿中分离出二个生物: 一枝蒿戊素和一支蒿己素. 本文报导了用质子核磁共振, 碳十三核磁共振, 质谱, X-射线衍射研究和化学转化等方法鉴定了它们的结构. 证明一枝蒿己素为15β-羟基尼奥灵. 一枝蒿戊素实为丙酮与15β-羟基尼奥灵的8-OH和15-OH的缩合物.     

大渡乌碱的结构

从大渡乌头的根中分得一新的微量生物碱——大渡乌碱,其结构经化学方法及IR、~1HNMR、~13C NMR和MS推定为1.     

百部生物碱的化学研究 II. 细花百部中微量生物碱的结构研究

从海南岛产野生百部(Stemona parviflora Wright C.H.)的根部又分得三个微量生物碱成份, 其中羟基百部叶碱(oxystemofoline)(1)和甲氧代百部叶碱(methyloxystemofoline)(2)为新生物碱成份。经IR, MS, ^1H和^1^3C NMR, NOE, 2D-同核及异核相关谱以及远程偶合相关谱推定了它们的结构, 并首次归属了它们的^1^3CNMR信号。     

加州假鹤虱中的生物碱

紫草科植物加州假鹤虱,是美国加州一种常见蛾的幼毛虫的寄主植物, 该科植物中不少都含有吡咯里西啶类生物碱, 本文报道其中两种新生物碱的分离及其结构。     

生长于台湾及中国大陆的数种苔植物化学精报

本篇论文报道数则近年分离自台湾苔植物的新化合物结构, 同时并将采自台湾及中国大陆各地的苔植物化学成分作一化学分类上的比较。     

三尖彬属植物中生物碱的研究:VI.三尖杉中两种高刺桐类型的新生物碱的结构

本文报导从安徽产三尖杉弱碱部份分得五种高刺桐类型生物碱, 其中两种新生物碱经UV, IR光谱分析分鉴定为:2-O-乙基表福建三尖杉碱(2-O-ethglepicephalofortuneine)和2-O-乙基福建三尖杉碱(2-O-ethylcephalofortuneine)。