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Jaspreet S. Dhau Amritpal Singh Rupy Dhir 《Journal of organometallic chemistry》2011,696(10):2008-2013
The synthesis of 3,5-lutidinyl chalcogen and -dichalcogen compounds has been described by a method involving selective mono- and dilithiation of 3,5-lutidine (1) ring. The selective mono- and dilithiation of 1 has been achieved by reacting BF3-complexed 3,5-lutidine (2) with 1 and 2 equiv of LTMP/LDA respectively. The subsequent insertion of elemental selenium followed by aerial oxidation or quenching with iodomethane leads to the formation of bis(3,5-dimethyl-2-pyridyl) diselenide (5) and 2,6-bis(selenomethyl)-3,5-lutidine (7) respectively. In addition, sequential incorporation of sulfur and selenium atom in the same lutidine ring has been reported for the first time. Single-crystal X-ray studies of (5), having a rare C-Se-Se-C torsion angle of 180°(4), and (7) have also been reported. 相似文献
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O. S. Attaryan V. I. Rstakyan A. G. Hasratyan 《Russian Journal of General Chemistry》2012,82(10):1724-1727
Reactions of 3,5-dimethyl-1-phenyl-1H-pyrazole with various electrophilic reagents were studied. Electrophilic attack occurred regioselectively at the C4 atom in the pyrazole ring. 相似文献
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É. É. Liepin'sh I. P. Skrastin'sh V. V. Kastron G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1989,25(11):1316-1317
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1568–1569, November, 1989. 相似文献
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I. P. Skarstin'sh V. V. Kastron G. Ya. Dubur I. B. Mazheika É. É. Liepin'sh 《Chemistry of Heterocyclic Compounds》1989,25(7):791-795
The action of mild brominating agents (pyridinium bromide-perbromide, dioxan dibromide N-bromosuccinimide, and N-bromoacetamide) on 2,6-dimethyl-3,5-dimethoxy-carbonyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine (Foridone) has been studied. Depending on reaction conditions, furo-, difuro-, and dibromomethyl-1,4-dihydropyridines are obtained together with certain oxidized forms.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 948–952, July, 1989. 相似文献
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G. D. Tirzit I. É. Kirule L. Kh. Baumane R. A. Gavar Ya. P. Stradyn' G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1984,20(8):915-918
A comparison of data on the kinetics of the accumulation of peroxides and the ESR spectra in the case of inhibition of the autooxidation of methyl oleate by 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(2-nitrophenyl)1,4-dihydropyridine (I) established that the antioxidant action of the latter is exerted by the formation of a nitroxyl radical. This radical is produced analogously to the well-known scheme from 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(2-nitrosophenyl)pyridine, which is generated in the reaction medium from I and methyl oleate.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1120–1122, August, 1984. 相似文献
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I. P. Skrastin'sh V. V. Kastron É. É. Liepin'sh I. B. Mazheika R. O. Vitolinya G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1990,26(3):323-325
Chlorination of 2,6-dimethyl-3,5-dicarbomethoxy-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine gives 2,3,4,5-tetrahydropyridines with different degrees of chlorination dependent upon the quantitative ratio of reagents. The reaction proceeds without oxidation of the dihydropyridine ring.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 376–379, March, 1990. 相似文献
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Dong H. Kim 《Journal of heterocyclic chemistry》1986,23(5):1471-1474
The treatment of 4-(2-aminophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid diethyl ester (III) with refluxing toluene or pyridine afforded 1,2,3,6-tetrahydro-2,4-dimethyl-2,6-methano-1,3-benzodiazocine-5,11-dicarboxylic acid diethyl ester (IV) as the major product. In addition, the following minor products were isolated: 2-methyl-3-quinolinecarboxylic acid ethyl ester (V), 3-(2-aminophenyl)-5-methyl-6-azabicyclo[3,3,1]-hept-1-ene-2,4-dicarboxylic acid diethyl ester (VI), and 5,6-dihydro-2,4-dimethyl-5-oxobenzo[c][2,7]naphthyridine-1-carboxylic acid ethyl ester (VII). In contrast, acidic conditions caused the conversion of III into V in a 95% yield. The formation of the latter appears to involve IV as an intermediate, since IV degraded rapidly in acid to give V in a quantitative yield. 相似文献
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2,6-二甲基-3,5-二氯-4-吡啶酚糖苷的合成 总被引:4,自引:0,他引:4
在相转移催化条件下, 使 a-D-乙酰基化溴代的葡萄糖、半乳糖、葡萄糖醛酸甲酯1a, 1b, 1c分别与2,6-二甲基-3,5-二氯-4-吡啶酚(俗称氯吡醇, 氯羟吡啶)作用, 合成了氯吡醇的糖苷: 1-O-(2',6'-二甲基-3',5'-二氯-4'-吡啶基)-2,3,4,6-四-O-乙酰基-β-D-葡萄吡喃糖苷(2a), 1-O-(2',6'-二甲基-3',5'-二氯-4'-吡啶基)-2,3,4,6-四-O-乙酰基β-D-半乳吡喃糖苷(2b), 1-O-(2'6'-二甲基-3',5'-二氯-4'-吡啶基)-2,3,4-三-O-乙酰基-β-D-葡萄吡喃糖醛酸甲酯(2c)。2a, 2b, 2c分别在甲醇中氨解, 相应得到: 1-O-(2', 6'-二甲基-3',5'-二氯-4'-吡啶基)-β-D-葡萄吡喃糖苷(3a), 1-O(2',6'-二甲基-3',5'-二氯-4'-吡啶基)-β-D-半乳吡喃糖苷(3b),1-O-(2', 6'-二甲基-3',5'-二氯-(4'-吡啶基)-β-D-葡萄吡喃糖醛酸酰胺(3c)。2c用CH~3ONa/CH~3OH处理, 得到1-O-(2',6'-二甲基-3',5'-二氯-4'-吡啶基)-β-D-葡萄吡喃糖醛酸甲酯(3d)。 相似文献
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QIAN Quna ZHANG Mina②LI Zhi-Fena CAO Wei-Guoa ZHANG Juna SHAO Minb XIA Yi-Benca 《结构化学》2008,27(10):1163-1166
The reaction of hydrazine hydrate with a new α,γ-diketone ester 3, derived from the reaction of 2,6-dimethyl-3,5-diacetyl-pyridine 2 with diethyl oxalate in the presence of sodium ethoxide, afforded the pyrazole derivative 4. Treatment of 4 with 2-chlorobenzoyl chloride gave diethyl 2,6-dimethyl-3,5-diyl-(1-2(chlorobenzoyl)-1H-pyrazole-3-diethyl-carboxylate) pyridine 5. Fine crystal of 5 suitable for XRD analysis was obtained form recrystalization in ethyl acetate. The crystal belongs to the triclinic system, space group P1^-, with a = 1.0342(11), b = 1.2211(12), c = 1.5013(15) nm, α = 82.5190(10),β = 85.7960(10),γ = 85.3150(10)°, V= 1.8697(3) nm^3, Dc= 1.173 g/cm^3, μ = 0.219 mm^-1, F(000) = 684, Z = 2, the final R = 0.0720 and wR = 0.2211. 相似文献
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G. L. Rusinov R. I. Ishmetova N. I. Latosh I. N. Ganebnych O. N. Chupakhin V. A. Potemkin 《Russian Chemical Bulletin》2000,49(2):355-362
A number of 1,4-dihydropyridazines and pyridazines were prepared by the Diels-Alder reaction with an inverse electron demand
from cyclic heterodiene systems, 3,6-bis(3,5-dimethyl-4-R-pyrazol-1-yl)-1,2,4,5-tetrazines, and some enamines as well as from
4-vinylpyridine, butyl vinyl ether, phenylacetylene, and acrylamide. The reaction of 3,6-bis(3,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazine
with styrene afforded 4,5-dihydropyridazine, which was readily oxidized by atmospheric oxygen to form the corresponding pyridazine.
Electron-withdrawing substituents (Br or Cl) in the pyrazole rings accelerate [4+2]-cycloaddition. When heated, 1,4-dihydropyridazines,
which were synthesized from tetrazines and enamines, eliminated amine to give pyridazines. The reactivities of tetrazines
were evaluated by quantum-chemical methods.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 354–360, February, 2000. 相似文献