Stoffwechselprodukte von Mikroorganismen 217. Mitteilung Röntgenstrukturanalyse von O-Acetyldihydrostreptazolin

The X-ray crystal structure analysis of the O-acetyl dihydro derivative of the antibiotic streptazolin (orthorhombic, a = 8.628, b = 9.814, c = 14.932 Å, space group P2₁2₁2₁) established the constitution of the latter as 1.     

Stoffwechselprodukte von Mikroorganismen 215. Mitteilung Röntgenstrukturanalyse von Di-O-acetyl-aspochalasin C

The X-ray crystal structure analysis of the 17,18-di-O-acetyl derivative of the antibiotic aspochalasin C (monoclinic, a = 26.377, b = 10.840, c = 11.937 Å, β = 102.08°, space group C 2) confirms the constitution elucidated by spectroscopic methods and chemical degradation, and establishes the relative configuration.     

Antimykotisch wirksame Imidazolyl-alkene: Synthese und Röntgenstrukturanalyse von Omoconazol

Antimycotic Imidazolyl-alkenes: Synthesis and X-Ray Crystal Structure of Omoconazol The synthesis of omoconazol 4 from 2′,4′-dichloro-α-(1H-imidazol-1-yl)propiophenon ( 5 ) and 1-bromo-2-(4-chlorophenoxy)ethane ( 6 ) is described. Omoconazol, C₂₀H₁₇Cl₃N₂O₂, crystallises in the monoclinic space group P2₁/n, a = 14.329, b = 8.703, c = 16.791 Å, β = 105.75°. The crystal structure showed that omoconazol has the (Z)-configuration, in accordance with previous NMR results.     

Stoffwechselprodukte von Mikroorganismen. 211. Milteilung. Röntgenstrukturanalyse von Elaiophylin

The X-ray crystal structure analysis of the antibiotic elaiophylin ( 1 ), monoclinic, a = 9.927, b = 10.105, c = 31.183 Å, β = 93.20°, space group P2₁, confirms the constitution elucidated by spectroscopic methods and chemical degradation. In the crystal the two chemically equivalent halves of the molecule are related by an approximate twofold rotation axis.     

Röntgenstrukturanalyse großer Biomoleküle

Crystallography is a powerful tool for the determination of three-dimensional structures of large biomolecules. In recent years, the number of published crystal structures has dramatically increased. this is due in part to the knowledge on the three-dimensional structure to the general understanding of biochemical processes is demonstrated for three selected examples. Crystal structures of human growth hormone bound to receptor peptides strongly suggests a general principle of receptor-mediated signal transduction. A self-splicing RNA nitron, seen in three dimensions, reveals general folding patterns in nucleic acids. Finally, HIV protease is discussed as a paradigm for structure-based drug design.