124例缺锌儿童补锌疗效观察

对１２４例１￣５岁缺锌儿童进行补锌疗效观察，结果表明，患儿身高、体重及症状体征均有明显改善，治疗总有效率达７８．１％，提示补锌４￣６周并配合饮食治疗，即可对缺锌引起的一系列病变有非常明显的疗效。     

700例儿童发中锌钙镁铁铜的测定结果及统计分析

用原子吸收分光光度法测定了７００例学龄儿童中发锌，钙，铜，镁，铁等五种元素，对缺锌情况以及互相间的相关关系进行统计分析，结果表明我国儿童缺锌比例较大，尤其在４周岁以下的儿童缺锌比例大约占６５％～８６％，Ｚｎ与钙，镁有很好相关，这提示单纯对缺锌儿童补锌的方法并不有利。     

2283例儿童发锌测定结果分析

于1995年5至6月，对本地区城乡部分幼儿园儿童进行发锌测定，共测定2283人。缺锌率57．8％，与1992年对比，有着显著性差异，结果表明，儿童缺锌与城乡差别无关。与年龄有一定的关系。但男女之间有显著性的差异，并有上升的趋向。     

644例儿童头发微量元素检测结果分析

对肇庆市城区６４４例五岁以下儿童头发锌、铁、铜、钙进行了检测，结果显示：缺锌、缺铜是该区儿童生长发育阶段普遍存在的营养缺乏症，患病率与性别无关，但与年龄有关，３￣４岁组为高发年龄段，与其它年龄组比较，Ｐ〈０．０５，有显著性差异。认为本区儿童微量元素缺乏症患病率偏高，值得儿保工作者和家长关注。     

高明市2389名0—6岁儿童锌,铁,铜,钙缺乏状况调查

调查了高明市２３８９名０￣６岁儿童锌、铁、铜、钙缺乏状况。结果表明，本市儿童缺锌、铜、铁和钙各为４５．９２％，６０．２０％，１３．４４％和４．６０％。讨论了缺锌、铜、铁的原因。     

小儿血清锌的检测

1988～990年测定了肇庆市9个县10岁以下健康儿童血清微量元素锌的含量，并探讨了缺锌与健康的关系，5930例中，其正常范围在11．6～15．4μmol/L；低于正常值低限者2365例，占39．73%，缺锌与男女性别无关，缺锌与生长发育、贫血都有非常密切关系。     

两次双波长分光光度法测定铅和汞

基于卟啉试剂ＴＡＰＰ与Ｐｂ￣（２＋）、Ｈｇ￣（２＋）在碱性介质中有灵敏的显色反应，建立了两次双波长分光光度法同时测定Ｐｂ、Ｈｇ的新方法，摩尔吸光系数分别为４．５９×１０￣５和４．３２×１０￣５ｍｏｌ￣（－１）·ｃｍ￣（－１）·Ｌ；可同时测定１：５～１０：１范围内的Ｐｂ和Ｈｇ，用于水中Ｐｂ和Ｈｇ的同时测定，结果满意。     

发锌与儿童生长发育关系分析

对134例3岁以内疑有缺锌临床症状的小儿测定发锌，其中97例发锌低于正常值．结果显示缺锌年龄组1～3岁最多，其次为6月～1岁，0～6月最少，体重低于均值的小儿缺锌率占68％，身长低于均值的小儿缺锌率占57．7%，摄锌后体重、身长可相应改善．     

佝偻病与微量元素营养关系临床研究

通过５０例佝偻病儿头发中微量元素锌、铜、铁的检测，并与健康儿童对照研究，发现患儿有明显的缺锌（Ｐ〈０．００１），结果提示，缺锌对佝偻病的发生，发展起重要作用，佝偻病与缺锌密切相关。     

厌食症儿童发锌铜含量测定

用原子吸收分光光度法测定了５２例厌食症儿童头发中锌、铜的含量,结果表明,厌食症儿童发一明显地对照组。发铜与对照这间无差异。提示厌食症与缺锌有密切关系。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.