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1.
Yu‐Jiao Zhong Qing‐Fa Wen Cong‐Ying Li Xue‐Hui Su Zhi‐Peng Yuan Yan‐Fang Li 《Helvetica chimica acta》2013,96(9):1750-1756
Two new naphthoquinones, (2R)‐6,8‐dihydroxy‐α‐dunnione ( 1 ), 6,8‐dihydroxy‐2,7‐dimethoxy‐3‐(1,1‐dimethylprop‐2‐enyl)‐1,4‐naphthoquinone ( 2 ), together with three known compounds, (2R)‐6,8‐dihydroxy‐7‐methoxy‐α‐dunnione ( 3 ), nevadensin ( 4 ), and lysioside C ( 5 ), were isolated from the whole plant of Lysionotus pauciflorus. Their structures were established by spectroscopic methods. Hydroxylated naphthoquinones are reported to occur in a Lysionotus species for the first time. The cytotoxic activities of compounds 1 – 3 were evaluated in vitro against a panel of tumor cell lines. 相似文献
2.
Shou‐Li Wang Zhong Chen Xiao‐Jing Tong Yan‐Li Liu Xia Li Qiong‐Ming Xu Xiao‐Ran Li Shi‐Lin Yang 《Helvetica chimica acta》2013,96(6):1126-1133
Three new triterpenoids, 21β,22α‐diangeloyloxy‐3β,15α,16α,28‐tetrahydroxyolean‐12‐en‐23‐al ( 1 ), 21β‐angeloyloxy‐3β,15α,16α,28‐tetrahydroxy‐22α‐(2‐methylbutanoyloxy)olean‐12‐en‐23‐al ( 2 ), and 21β‐angeloyloxy‐3β,16α,28‐trihydroxy‐22α‐(2‐methylbutanoyloxy)olean‐12‐en‐23‐al ( 3 ), along with six known triterpenoids, were isolated from the roots of Camellia oleifera C.Abel . The structures of compounds 1 – 3 were elucidated on the basis of spectroscopic analyses. Moreover, all compounds isolated were evaluated for their cytotoxic activities by MTT (=3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide) assay. 相似文献
3.
Yu‐Xi Liu Shuang‐Gang Ma Xiao‐Jing Wang Nan Zhao Jing Qu Shi‐Shan Yu Jun‐Gui Dai Ying‐Hong Wang Yi‐Kang Si 《Helvetica chimica acta》2012,95(8):1401-1408
Four new diketopiperazine alkaloids, rel‐(8R)‐9‐hydroxy‐8‐methoxy‐18‐epi‐fumitremorgin C ( 1 ), rel‐(8S)‐19,20‐dihydro‐9,20‐dihydroxy‐8‐methoxy‐9,18‐di‐epi‐fumitremorgin C ( 2 ), rel‐(8S,19S)‐19,20‐dihydro‐9,19,20‐trihydroxy‐8‐methoxy‐9‐epi‐fumitremorgin C ( 3 ), and (3S,8S,9S,18S)‐8,9‐dihydroxyspirotryprostatin A ( 4 ), together with the eight known compounds 5 – 12 , were isolated from the endophytic fungus Aspergillus fumigatus. The structures of the new compounds were determined by extensive spectroscopic methods including HR‐ESI‐MS, NMR, and CD experiments. Compound 12 showed weak inhibitory activity in vitro against the release of β‐glucuronidase in rat polymorphonuclear leukocytes induced by the platelet‐activating factor. None of the twelve compounds exhibited detectable cytotoxic activities toward five human tumor cell lines (HCT‐8, Bel‐7402, BGC‐823, A549, and A2780) in the MTT assay. 相似文献
4.
Su Yue Ze‐Zhao Jiao Hong‐Xiang Sun Tian‐Yun Jin Lan Xiang 《Helvetica chimica acta》2015,98(7):961-966
A new tricyclic alkaloid named portulacatone ( 1 ), i.e., 5,6‐dihydro‐8,9‐dihydroxy‐11H‐pyrrolo[2,1‐b] [3]benzazepin‐11‐one, together with eight known compounds, methyl 4‐hydroxyphenylacetate ( 2 ), p‐hydroxybenzaldehyde ( 3 ), vanillin ( 4 ), protocatechualdehyde ( 5 ), p‐hydroxybenzoic acid ( 6 ), iseluxine ( 7 ), oleracein E ( 8 ), and (+)‐(R)‐feruloyl malate ( 9 ) were isolated from aerial parts of Portulaca oleracea L. Their structures were elucidated based on spectroscopic analyses. Among them, compounds 1 – 7 and 9 were isolated from this medicinal plant for the first time. Compounds 1 and 7 showed dose‐dependent scavenging activities against DPPH (2,2‐diphenyl‐1‐picryl‐hydrazyl) free radical, with EC50 values of 14.36 μM and 9.98 μM , respectively, more potent than the natural antioxidant vitamin C (EC50 20.72 μM ). 相似文献
5.
Yasuhide Muroga Takeshi Yamada Atsushi Numata Reiko Tanaka 《Helvetica chimica acta》2010,93(3):542-549
11‐ and 4′‐epichaetomugilin A were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus. 11‐Epichaetomugilin A is the first compound to have an opposite absolute configuration at C(11) to that of other azaphilones isolated to date. Their absolute configurations were elucidated on the basis of spectroscopic analyses, including 1D‐ and 2D‐NMR techniques, and some chemical transformations. 11‐Epichaetomugilin A weakly inhibited the growth of cultured P388 cells and HL‐60 cells (IC50 88.9 and 66.7 μM , resp.). 相似文献
6.
Karsten Krohn Prof. Simeon F. Kouam Prof. Guy M. Kuigoua Hidayat Hussain Dr. Stephan Cludius‐Brandt Ulrich Flörke Dr. Tibor Kurtán Dr. Gennaro Pescitelli Dr. Lorenzo Di Bari Prof. Siegfried Draeger Dr. Barbara Schulz Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(44):12121-12132
Three new metabolites, microsphaeropsones A–C ( 1 – 3 ) with a unique oxepino[2,3‐b]chromen‐6‐one (ring‐enlarged xanthone) skeleton, were isolated from the endophytic fungus Microsphaeropsis species, co‐occurring with their putative biogenetic anthraquinoide precursors citreorosein ( 4 ) and emodin ( 5 ). From another Microsphaeropsis species, large amounts of fusidienol A ( 8 a ), smaller amounts of emodin ( 5 ), the known aromatic xanthones 9 a and 9 b , the new 3,4‐dihydrofusidienol A ( 8 b ), and the new aromatic xanthone 9 c were isolated. The endophyte Seimatosporium species produced a new aromatic xanthone, seimatoxanthone A ( 10 ), and 3,4‐dihydroglobosuxanthone A ( 12 ), closely related to α‐diversolonic ester ( 13 ) from Microdiplodia sp.. The structures were determined mainly by extensive 1D and 2D NMR experiments and supported by X‐ray single‐crystal analysis of 1 and the oxidation product 7 . The absolute configurations of the microsphaeropsones A–C ( 1 – 3 ) were established by comparison of the electronic and vibrational circular dichroism (ECD and VCD) spectra of 1 with time‐dependent DFT (TDDFT) and DFT calculations by using either the solid‐state structures or DFT‐optimized geometries as inputs. Preliminary studies indicated that 1 , 2 , and enone 7 showed antibacterial, fungicidal, and algicidal properties. 相似文献
7.
Li‐Li Wang Cheng‐Shi Jiang Yan Fu Fei‐Fei Chen Le‐Fu Lan Hai‐Yan Zhang Yue‐Wei Guo 《Helvetica chimica acta》2014,97(9):1301-1306
Two new limonoids, kihadanin C ( 1 ) and 23‐methoxydasylactone A ( 2 ), together with seven related known ones, 3 – 9 , were isolated from the root bark of the plant Dictamnus dasycarpus. The structures of the new compounds were elucidated on the basis of extensive analyses of their spectroscopic data (1D‐ and 2D‐NMR, MS) and by comparison of their NMR data with those reported in the literature. To the best of our knowledge, 1 presents the first example of A,D‐seco limonoid with an unusual 3,4‐dihydroxy‐2,5‐dimethoxytetrahydrofuran moiety as ring E. In the bioassay in vitro, 7 showed moderate antibacterial activity against Staphylococcus aureus, while 8 and 9 displayed neuroprotective activities against H2O2‐induced injury in SH‐SY5Y cells. 相似文献
8.
Bei‐Xi Jia Ao Jia Chao‐Jie Li Hui‐Qin Zhao Feng‐Xiao Ren Hong‐Min Liu Qiang Wang 《Helvetica chimica acta》2016,99(7):499-505
Baeckea frutescens is an aromatic shrub used as ornamentals and as food flavor spices in the southern part of P. R. China. Two novel C‐methylated biflavonoids named baeckeins J ( 1 ) and K ( 2 ) were isolated from the roots of B. frutescens, which possessed the unique carbon skeleton conjugated of a flavonol and one isoflavanonol molecule via the linkages of C(2)–C(8*) and C(3)–O–C(7*). The structures of compounds 1 and 2 were elucidated by analysis of 1D‐ and 2D‐NMR, and HR‐ESI‐MS spectral data, and the absolute configuration for chiral C‐atoms C(2) and C(3) were assigned by CD spectrometry combined with quantum chemical calculations. In the bioassay, baeckeins J and K exhibited strong cytoprotective effects on H2O2‐induced oxidative cell death in PC12 cells. 相似文献
9.
从人面果乙酸乙酯提取物中分离出5个新的口 山 酮 化合物garcinenone A (1), B (3), C (4), D (7) and E (8)和7个已知化合物,其结构经过波谱技术,特别是2D-NMR技术来鉴定。Jacareubin (2), 1,4,6-trihydroxy-5-methoxy-7-(3-methyl-2-buteny1)xanthone (6), subeliptenone B (11) 和symphoxanthone (12)为首次从该植物中分离出来。在DPPH自由基的清除活性实验中,所有的化合物都显示抗氧化活性,其IC50的值在 6.0-23.2 mM。结果表明人面果是潜在的有前景的天然抗氧化剂。 相似文献
10.
Sesquiterpenes from Rhizomes of Cyperus rotundus with Cytotoxic Activities on Human Cancer Cells in vitro
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Byeol Ryu Hye Mi Kim Jae‐Seung Lee Yoon Jin Cho Myung Sook Oh Jung‐Hye Choi Dae Sik Jang 《Helvetica chimica acta》2015,98(10):1372-1380
Two new sesquiterpenes, cyperusol A3 ( 1 ) and 3β‐hydroxycyperenoic acid ( 2 ), along with three known sesquiterpenes, britanlin E ( 3 ), 1β,4α‐dihydroxyeudesm‐11‐ene ( 4 ), and 11,12‐dihydroxyeudesm‐4‐en‐3‐one ( 5 ), were isolated from the AcOEt‐soluble fraction of rhizomes of Cyperus rotundus L. The structures of 1 and 2 were elucidated by physical and spectroscopic methods (1H‐ and 13C‐NMR, 2D‐NMR, and MS). All of the isolates, 1 – 5 , were evaluated for their cytotoxic activities against human ovarian cancer cells (A2780) and endometrial adenocarcinoma cells (Ishikawa) using MTT assays. 相似文献
11.
Lívia Soman de Medeiros Michael Murgu Antônia Q. L. de Souza Edson Rodrigues‐Fo. 《Helvetica chimica acta》2011,94(6):1077-1084
Four depsides, all of them new as natural products, were isolated from Cladosporium uredinicola solid‐media culture and identified as 3‐hydroxy‐2,5‐dimethylphenyl 2,4‐dihydroxy‐3,6‐dimethylbenzoate ( 1 ), 3‐hydroxy‐2,4,5‐trimethylphenyl 2,4‐dihydroxy‐3,6‐dimethylbenzoate ( 2 ), 3‐hydroxy‐2,5‐dimethylphenyl 3‐[(2,4‐dihydroxy‐3,6‐dimethylbenzoyl)oxy]‐6‐hydroxy‐2,4‐dimethylbenzoate ( 3 ), and 3‐hydroxy‐2,4,5‐trimethylphenyl 3‐[(2,4‐dihydroxy‐3,6‐dimethylbenzoyl)oxy]‐6‐hydroxy‐2,4‐dimethylbenzoate ( 4 ). The endophytic fungus was isolated from Psidium guajava fruits and cultivated over sterilized rice. The compounds 1 – 4 were purified by classical chromatographic procedures, and the chemical structures were identified by spectroscopic studies, mainly 1D‐ and 2D‐NMR and LC/ESI‐MS/MS. Three of the isolated depsides exhibited moderate bacteriostatic and/or bactericide effects on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtillis. 相似文献
12.
元胡多糖YhPS-1的理化性质、结构分析及抗肿瘤活性研究 总被引:2,自引:0,他引:2
A polysaccharide named YhPS- 1 was isolated from the root of Cordalis yanhusuo Wang and purified by means of gel-permeation chromatography and ionexchange chromatography. Its physicochemical properties, including monosaccharide composition, carbohydrate content, molecular weight and elemental composition, were determined. The structure of YhPS-1 was elucidated by chemical methods along with ^1H and ^13C NMR spectroscopy ways, such as including two-dimensional HMQC and HMBC experiments. These results show that YhPS-1 possesses a backbone consisting of terminal α-Glcp-(1→, a-Glcp-(1→6), a-Glcp-(1→4) and a-Glcp-(1→4,6). The bioactive assay showed that it could inhibit the growth of Sarcoma 180 and Lewis pulmonary carcinoma implanted in mice. 相似文献
13.
The three new 3‐O‐methylquercetin glucosides 1 – 3 , together with three known congeners and 3‐O‐methylquercetin, were isolated from the fern Ophioglossum pedunculosum (quercetin=2‐(3,4‐dihydroxyphenyl)‐3,5,7‐trihydroxy‐4H‐1‐benzopyran‐4‐one). The new compounds were identified on the basis of spectroscopic analysis as 5′‐isoprenyl‐3‐O‐methylquercetin 4′,7‐di‐β‐D ‐glucopyranoside ( 1 ), 3‐O‐methylquercetin 4′‐β‐D ‐glucopyranoside 7‐[O‐β‐D ‐glucopyranosyl‐(1→2)‐β‐D ‐glucopyranoside] ( 2 ), and 3‐O‐methylquercetin 7‐[O‐β‐D ‐glucopyranosyl‐(1→2)‐β‐D ‐glucopyranoside] ( 3 ). The effect of the isolated compounds on lipopolysaccharide (LPS)‐induced NO production was evaluated. The inhibitory activity of 3‐O‐methylquercetin derivatives decreased markedly with the increasing number of glucosyl groups in the structures. 相似文献
14.
Wen‐Shu Wang Xia Dai Li‐Ya Hong Peng Lu Jin‐Chao Feng Yu‐Guo Jiao 《Helvetica chimica acta》2008,91(6):1118-1123
From the whole plants of Ligularia duciformis, four new sesquiterpenoids, 3β‐acetoxy‐6β‐methoxyeremophila‐7(11),9(10)‐dien‐12,8β‐olide ( 1 ), 3β‐acetoxy‐8α‐hydroxy‐6β‐methoxyeremophila‐7(11),9(10)‐dien‐12,8β‐olide ( 2 ), 3β‐acetoxy‐10β‐hydroxy‐6β,8β‐dimethoxyeremophil‐7(11)‐en‐12,8α‐olide ( 3 ), and 3β‐acetoxy‐6β,8β,10β‐trihydroxyeremophil‐7(11)‐en‐12,8α‐olide ( 4 ) were isolated. Their structures were established by high‐field NMR techniques (1H,1H‐COSY, 13C‐APT, HMQC, HMBC, and NOESY) and HR‐ESI‐MS analysis, together with comparison of the spectroscopic data with those of structurally related compounds. In addition, the cytotoxicity of the new compounds against human hepatic cancer cells Bel‐7402, human pneumonic cancer cells A‐549, and human colonic cancer cells HCT‐8 were evaluated, the new compounds showed no cytotoxicity against the three tumor cells (all IC50 values >200 μM ). 相似文献
15.
Ndivhaleni A. Masevhe Maurice D. Awouafack Aroke S. Ahmed Lyndy J. McGaw Jacobus N. Eloff 《Helvetica chimica acta》2013,96(9):1693-1703
One new triterpenoid, (3β,11α,19β)‐3‐(butanoyloxy)‐11‐hydroxytaraxast‐20(30)‐ene‐23,28‐dioic acid (clerodendrumic acid; 1 ) was isolated from the hexane extract of the leaves of Clerodendrum glabrum var. glabrum along with heptadecanoic acid ( 2 ). The structure of the new compound was elucidated by interpretation of its NMR (1D and 2D), MS, and IR data. Combined fractions C and D from the column chromatography of the hexane extract exhibited significant antifungal activities (average MIC of 0.10 mg/ml) against Candida albicans and Cryptococcus neoformans. C. albicans was relatively resistant to clerodendrumic acid ( 1 ; MIC 125 μg/ml) and was resistant to heptadecanoic acid ( 2 ; MIC 188 μg/ml). Both compounds had low antibacterial activities against two Gram‐positive and two Gram‐negative bacteria with average MIC values of 157 and 172 μg/ml, respectively. Compounds 1 and 2 were relatively nontoxic against monkey kidney Vero cells in vitro with IC50 values of 202.6 and 108.4 μg/ml, respectively. 相似文献
16.
José G. Sena‐Filho Marcelo S. da Silva Josean F. Tavares Steno L. Oliveira Marco A. V. Romero Haroudo S. Xavier Jose M. Barbosa‐Filho Raimundo Braz‐Filho 《Helvetica chimica acta》2010,93(9):1742-1744
A new tropane alkaloid as well as a new substitution group, (3‐endo,8‐anti)‐8‐methyl‐8‐azabicyclo[3.2.1]oct‐3‐yl 4‐hydroxy‐3,5‐dimethoxybenzoate, called pungencine ( 1 ), was isolated from the roots of Erythroxylum pungens O. E. Schulz . The structure was elucidated by spectral analyses, including 1H‐ and 13C‐NMR and 2D‐NMR techniques (1H,1H‐COSY, NOESY, DEPT, HMQC, and HMBC) and HR‐ESI‐MS. Furthermore, compound 1 was tested for cytotoxicity against several cell lines (Jurkat, HL‐60, U937, K562, KG‐1, and U266) and was determined not to inhibit cell viability at 10 μM . 相似文献
17.
Xue‐Mei Gao Ming‐Zhu Cui Ting Yu Qiu‐Fen Hu Jian‐Xin Pu Xue Du Tian‐Cheng Liu Kathy Qian Luo 《Helvetica chimica acta》2013,96(3):494-498
One novel xanthone, oliganthone A ( 1 ), was isolated from the stems of the plant Garcinia oligantha. It features the O‐bearing C(3)‐atom and absence of C(4) compared with the structures of related known xanthones, which have never been reported before. The structure of this compound was elucidated by spectroscopic analysis. Compound 1 showed strong HeLa cell growth‐inhibiting effects with IC50 values below 10 μM . 相似文献
18.
Zwe‐Ling Kong Siauo Chi Yu Shu Ai Dai Cha‐Chung Tu Min‐Hsiung Pan Yeuk‐Chuen Liu 《Helvetica chimica acta》2011,94(5):892-896
Two new biologically active polyoxygenated sterols, 3,5,9‐trihydroxycholest‐7‐en‐6‐one ( 1 ) and cholest‐7‐ene‐3,6,9‐triol ( 3 ), together with one known sterone, topsentisterol D3 ( 2 ), were isolated from freshwater clam (Corbicula fluminea Muller ; an important cultured edible shellfish in Taiwan). The structure elucidation of sterols 1 – 3 were accomplished by 1H‐ and 13C‐NMR, HMQC, and HMBC, and MS analyses. The sterols 1 – 3 displayed cytotoxicities against the human hepatoma Hep G2 cells (IC50: 6.04±0.07, 40.78±4.28, and 10.57±0.51 μg/ml, resp.). 相似文献
19.
Xiaojun Zhou Riming Huang Jing Hao Huijuan Huang Manqin Fu Zhifang Xu Yongmei Zhou Xu‐E Li Samuel X. Qiu Bin Wang 《Helvetica chimica acta》2011,94(11):2092-2098
Two new prenylated xanthones (=9H‐xanthen‐9‐ones), garcimangosxanthones D ( 1 ) and E ( 2 ), together with the six known xanthones 3 – 8 , were isolated from the pericarp of Garcinia mangostana. Their structures were determined by analysis of their spectroscopic data. All of the isolated compounds were biologically evaluated for their in vitro cytotoxic activity against A549, Hep‐G2, and MCF‐7 human‐cancer cell lines and antioxidant activity. Compound 1 exhibited moderate cytotoxicity against Hep‐G2 (IC50=19.2 μM ) and weak cytotoxicity against MCF‐7 (IC50=62.8 μM ) cell lines, and compound 2 showed moderate cytotoxicity against A549, Hep‐G2, and MCF‐7 cell lines with IC50 values of 12.5–20.0 μM (Table 2). Both compounds 1 and 2 demonstrated a weak antioxidant activity with ferric reducing antioxidant power (FRAP) values of 41±7 and 130±4 μmol/g, respectively (Table 3). 相似文献
20.
Hua Zhou Hong‐Ping He Ning‐Chuan Kong Yue‐Hu Wang Xiang‐Dong Liu Xiao‐Jiang Hao 《Helvetica chimica acta》2006,89(3):515-519
Three new indole alkaloids, 11,12‐de(methylenedioxy)danuphylline ( 1 ), methyl (2β,11β,12β,19α)‐6,7‐didehydro‐8,21‐dioxo‐11,21‐cycloaspidospermidine‐2‐carboxylate ( 2 ), and (2β,5β)‐aspidofractinin‐16‐ol ( 3 ) were isolated from Kopsia officinalis, together with 16 known compounds. Their structures were determined by spectroscopic methods. The isolated known compound (?)‐12‐methoxykopsinaline displayed antimanic effects in Drosophila, with an IC50 value of 12.5 μg/ml. 相似文献