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1.
The reaction of 2-mercapto-3-ureido- and 2-mercapto-3-aminopyridines with -halo derivatives of carbonyl compounds (ketones, acids, and aldehydes) and with acrylonitrile proceeds not only via the mercapto group but also via the amino group, as a result of which S--keto (carboxy, cyano) alkyl, N,S-bis(-ketoalkyl), and N,S-diacyl derivatives of pyridine are formed. The action of acids, alkalis, and dehydrating agents on 2-S--keto (carboxy, cyano) ethyl-3-aminoureidopyridines was studied. A method for the preparation of derivatives of a new heterocyclic system, viz., 6-oxopyrido [2,3-b] [1,5] thiazepine, by the reaction of 2-mercapto-3-aminopyridines with -bromopropionic acid and subsequent treatment of 2-(-car-boxyethyl) thio-8-aminopyridines with dicyclohexylcarbodiimide was developed.See [5] for Communication 38.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 634–639, May, 1981. 相似文献
2.
L. P. Rasteikene T. A. Pranskene V. A. Zabelaite Z. A. Stumrevichute M. G. Lin'kova I. L. Knunyants 《Russian Chemical Bulletin》1972,21(10):2181-2183
Conclusions
-Chloro--alkthiobutyric acid derivatives were obtained by the addition of methylsulfenyl chloride and-chloroethylsulfenyl chloride to crotonie acid and its derivatives, which isomerize quite rapidly to-alkthio--chlorobutyric acid derivatives. An exception are the acid chlorides of the-chloro--alkthio-butyric acids, which do not isomerize spontaneously.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2247–2249, October, 1972. 相似文献
3.
T. N. Makar'eva I. A. Gorshkova B. A. Gorshkov A. I. Kalinovskii V. A. Stonik 《Chemistry of Natural Compounds》1987,22(4):411-415
Five new sulfated derivatives of sokotrasterol and halistanol have been obtained: 24-nor-5-cholane-2,3,6,23-tetraol 2,3,6-tri(sodium sulfate); 24-nor-5-cholane-2,3,6,23-tetraol 2,3,6-tri(sodium sulfate) 23-palmitate; 24,25-dimethyl-5-cholestane-2,3,6-triol 3-(sodium sulfate); 24,25-dimethyl-5-cholestane-2,3,6-triol 6-(sodium sulfate); and 24,25-dimethyl-5-cholestane-2,3,6-triol 2,6-di(sodium sulfate). The inhibiting and membranolytic properties of the polysulfated steroids from sponges and their derivatives have been studied. It has been shown that physiological activity in this series of compounds depends on biphilicity.Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 441–445, July–August, 1986. 相似文献
4.
Another new cardenolide glycoside has been isolated from the plantCheiranthus allioni Hort., and has been named glucocheiranthoside. Its chemical structure has been established as 3-(4-O--D-glucopyranosyl--D-gulmoethylpyranosyloxy)-14-hydroxy-19-oxo-5,14-card-20(22)-enolide.State Scientific Center for Drugs, Ukraine, 310085, Kharkov, USSR. ul. Astronomicheskaya, 33. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 269–271, March–April, 1994. 相似文献
5.
Teruko Imai Tetsumi Irie Masaki Otagiri Kaneto Uekama Masaki Yamasaki 《Journal of inclusion phenomena and macrocyclic chemistry》1984,2(3-4):597-604
Abstruct Some physicochemical properties of methylated -cyclodextrins, i.e., heptakis(2,6-di-O-methyl)--cyclodextrin (DM--CyD) and heptakis(2,3,6-tri-O-methyl)--cyclodextrin (TM--CyD) were compared with those of natural -cyclodextrin (-CyD). Inclusion behaviors of -CyD and methylated -CyDs in water and in solid state were studied by solubility analysis, spectroscopies (UV, CD,13C-NMR and IR), X-ray diffractometry and thermal analysis, using an antiinflammatory drug flurbiprofen (FP) as a guest molecule. The spectral data suggest that the inclusion mode of FP-TM--CyD is somewhat different from those of FP--CyD and FP-DM--CyD. The solid complexes of FP with - and methylated -CyDs were obtained in molar ratio of 11, and their dissolution behavior and release from suppository base were examined. The data are presented suggesting that DM--CyD is particularly useful for improving the pharmaceutical properties of FP in various dosage forms. 相似文献
6.
Chlorolysis of -functionalized alkyl polyfluoroalkenyl sulfides giving rise to -functionalized polyfluoroalkenesulfenyl chlorides was examined. -Cyano-containing sulfenyl chlorides underwent intramolecular cyclization at the nitrile group to form substituted isothiazoles. 相似文献
7.
The reactions of -aroylacrylic acids and their methyl esters with 1-methyl- and 1-benzyl-3,4-dihydroisoquinolines lead to the formation of -substituted -aroylpropionic acids and their esters, which undergo cyclization to benzopyrrocolinone derivatives.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 943–945, July, 1979. 相似文献
8.
T. P. Vasil'eva V. M. Bystrova M. G. Lin'kova O. V. Kil'disheva I. L. Knunyants 《Russian Chemical Bulletin》1983,32(3):556-560
Conclusions Amides of -mercapto- or -(acetylthio)alkanoic acids were obtained by the reaction of -thiolactones or -(acetylthio)alkanoic acid chlorides with amines.For Communication 2, see [1].Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 616–621, March, 1983. 相似文献
9.
New triterpene glycosides have been isolated from the epigeal part ofClimacoptera transoxana (Iljin) Botsch. — copterosides E and F. According to chemical transformations and physicochemical characteristics, copteroside E has the structure of oleanolic acid 28-O--D-glucopyranoside 3-O-{[O--D-xylopyranosyl-(12)]-[O--D-xylopyranosyl-(14)]--D-glucuronopyranoside} and copteroside F that that of hederagenin 28-O--D-glucopyranoside 3-O-{[O--D-xylopyranosyl-(12)]-[O--D-xylopyranosyl-(14)]--D-glucopyranoside}.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 596–601, September–October, 1983. 相似文献
10.
N. D. Abdullaev O. E. Vasina V. A. Maslennikova N. K. Abubakirov 《Chemistry of Natural Compounds》1986,21(5):616-622
The PMR and13C NMR spectra of new withasteroids — visconolide and 28-hydroxywithaperuvin C, isolated fromPhysalis viscosa L. — have been investigated. A detailed analysis of the spectral characteristics obtained is given. For visconolide is proposed the structure of 4,12,17,28-pentahydroxy-1-oxo-5, 6-epoxy-22R-witha-2,24-dienolide, and for 28-hydroxywithaperuvin C that of 6,14,17,20R, 28-pentahydroxy-l-oxo-22R-witha-2, 4, 24-trienolide.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 657–663, September–October, 1985. 相似文献
11.
Conclusions Trichlorogermyl derivatives of -furylpropionic acids were obtained regiospecifically by the addition of HGeCl3 to esters of -furylacrylic acids.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 717–719, March, 1986. 相似文献
12.
R. G. Aflyatunova N. A. Aliev Ch. Sh. Kadyrov M. R. Yagudaev 《Chemistry of Natural Compounds》1984,19(4):478-482
The reactions of benzoxazolinone and benzoxazolinethione with alkyl -chlorovinyl ketones have been studied. The reaction products are N-(-acylvinyl)benzoxazolinones and N-(-acylvinyl)benzoxazolinethiones. The reaction of alkali-metal salts of benzoxazolinone with alkyl -chlorovinyl ketones leads to the opening of the oxazolinone ring. The structures of the compounds synthesized have been studied by IR, mass, and PMR spectroscopy.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 507–511, July–August, 1983. 相似文献
13.
The cyclization of secondary and tertiary aryl(-halogenoallyl)amines into 2-methylindoles on heating in orthophosphoric or polyphosphoric acid has been studied. Cyclization of N,N-di(-bromoallyl)-p-toluidines in polyphosphoric acid forms 1-(-bromoallyl)-2, 5-dimethyl-indole and 2, 5-dimethylindole. The probable mechanism of the rearrangement in the formation of the indole ring is put forward. 相似文献
14.
Conclusions Syntheses are reported for ,-dithioalkyldivinyl ketones, which react with ammonia to give -amino--thioalkyldivinyl ketones.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2414–2415, October, 1988.The authors thank A. M. Kachurin for assistance in taking the spectra. 相似文献
15.
Al'fonsov V. A. Bakaleinik G. A. Gubaidullin A. T. Kataev V. E. Kovylyaeva G. I. Konovalov A. I. Litvinov I. A. Strobykina I. Yu. Andreeva O. V. Korochkina M. G. 《Russian Journal of General Chemistry》2001,71(7):1144-1148
Acetylation with acetic anhydride of (4,8,13)-16-hydroxy-13-methyl-17-norkaurane-18-carboxylic acid and its methyl ester, obtained by reduction of isosteviol and (4,8,13)-18-methoxycarbonyl-13-methyl-16-oxo-17-norkaurane, respectively, gives rise to (4,8,13)-16-acetoxy-13-methyl-17-norkaurane-18-carboxylic acid and (4,8,13)-16-acetoxy-18-methoxycarbonyl-13-methyl-17-norkaurane. The molecular and crystal structures of the compounds were established by X-ray diffraction. 相似文献
16.
M. Yu. Lidak I. V. Dipan R. A. Paégle Ya. P. Stradyn 《Chemistry of Heterocyclic Compounds》1972,8(5):644-648
The protolysis constants of -(1-uracilyl)propionitriles and -(1-uracilyl)propionic -amino--(1-pyrimidyl)propionic, and -amino--(1-pyrimidyl)butyric acids (willardiine analogs) were determined. The electronic effect of substituents and of transannular interaction of the groups on the deprotonation constants is discussed.
-(1-Uracilyl)--alanine (willardiine) was isolated by Gmelin from the seeds of Acacia willardiana.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 708–712, May, 1972. 相似文献
17.
Zh. A. Krasnaya Yu. V. Smirnova V. S. Bogdanov 《Chemistry of Heterocyclic Compounds》1996,32(5):560-567
Condensation of the bis-N,O-acetal of amethylarrtinomethylenerrzalonaldehyde with ketones, -dimethylaminovinylketones, and -dimethylaminodienones is accompanied by an unusual intramolecular cyclization to give cross conjugated cyclic or acylic ketones containing an N-methyl pyrrole ring in the - or - and'-positions. This is a novel route to substituted pyrroles. Treatment of the bis-N,O-acetal of dimethylaminomethylenemalonaldehyde with 2-(3'-dimethylaminopropen-2'-ylidene)cyclopentanone gave a polyenyl tris-dimethylaminodiketone.N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 117913. Translated from Khimiya Geterotsiklicheskikh Soednenii, No.5, pp. 654–662, May, 1996. Original article submitted February 14, 1996. 相似文献
18.
K. Nakanishi T. Masukawa T. Nadai K. Yoshii S. Okada K. Miyajima 《Journal of inclusion phenomena and macrocyclic chemistry》1996,25(1-3):181-184
Triacetyl--cyclodextrin (TA--CyD), a hydrophobic cyclodextrin derivative, that is insoluble in water, was used to form a complex with flufenamic acid (FA). FA-TA--CyD complex formation was demonstrated by differential scanning calorimetry and powder X-ray diffractometry. The release rate of FA from the FA-TA--CyD complexes in phosphate buffer pH 6.8 was significantly retarded compared to that of FA from the FA and glucose mixture. When the FA-TA--CyD complexes were administered directly into the intraduodenal lumen, the plasma concentration of FA remained at a plateau level (10-18 g/ml) for 6–8 h. An increased mean residence time of FA following FA-TA--CyD complexes administration was observed. These results indicate that TA--CyD may serve as a hydrophobic carrier in prolonged-release preparations of FA. 相似文献
19.
E. Ziegler F. Hradetzky K. Belegratis 《Monatshefte für Chemie / Chemical Monthly》1965,96(4):1347-1351
Zusammenfassung Primäre und sekundäre Enaminderivate, die aus -Ketoestern und -Diketonen darstellbar sind, reagieren mit Malonylchloriden bzw. Malonsäuren in Acetanhydrid zu 4-Hydroxypyridonen.
Primary and secondary enamines readily obtained from -ketoesters and -diketones react with malonyl chlorides or malonic acids in acetic anhydride to yield derivatives of 4-hydroxy-2-pyridone.相似文献
20.
Conclusions The reactions of the-chloroethyl derivatives of trivalent phosphorus acids proceed via an ionic intermediate, which, depending on the experimental conditions, is stabilized in the direction of ring closure to give an adduct with a pentacovalent phosphorus atom and the formation of the corresponding unsaturated and (-methyl--nitroethyl)phosphoryl compounds. The liberated-chloroethyl nitrite functions as an oxidizing agent of the starting-chloroethyl derivatives of trivalent phosphorus acids.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 6, pp. 1398–1401, June, 1978.The authors thank É. I. Gol'dfarb for taking the31P–{1H} NMDR spectra. 相似文献