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1.
Kozlov N. G. Pashkovskii F. S. Gusak K. N. Koroleva E. V. Tereshko A. B. Lokot’ I. P. 《Russian Journal of Organic Chemistry》2004,40(4):555-559
Three-component condensation of 6,6-heptamethylenetetrahydropyran-2,4-dione with 2-amino-naphthalene or 6-aminoquinoline and aromatic aldehydes in an aliphatic alcohol afforded 12-aryl-9,9-hepta-methylene-8,9,10,12-tetrahydro-7H-benzo[f]pyrano[3,4-b]quinolin-11-ones and 12-aryl-9,9-heptamethylene-8,9,10,12-tetrahydro-7H-pyrano[4,3-b][4,7]phenanthrolin-11-ones, new N,O-heterocycles which include azaor diazaphenanthrene system fused to -pyrone ring and aromatic and spiro substituents. 相似文献
2.
V. N. Britsun A. N. Esipenko M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2005,41(6):782-786
The products of the reaction of 2-aryl-5-R-5,6-dihydro-7H-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-ones with aryl bromomethyl ketones are 2-aryl-7H-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-ones and aryl methyl ketones or 2,5-diaryl[1,3]thiazolo[3,2-b][1,2,4]triazoles and 3-phenyl-2-propenoic acid, depending on the structure of R. The reaction of 2-aryl-5-R-5,6-dihydro-7H-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-ones with benzyl bromide yields 5-aryl-3-benzylthio-4H-1,2,4-triazoles and 3-aryl-2-propenoyl bromide.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 905–909, June, 2005. 相似文献
3.
N. G. Kozlov E. V. Koroleva Zh. V. Ignatovich K. N. Gusak A. P. Kadutskii 《Russian Journal of Organic Chemistry》2007,43(6):901-906
New 12-aryl-9-(p-methoxyphenyl)-8,9,10,12-tetrahydro-7H-benzo[b][4,7]phenanthrolin-11-ones having two asymmetric carbon atoms (C9 and C12) were synthesized by three-component condensation of quinolin-6-amine with 5-(p-methoxyphenyl)cyclohexane-1,3-dione and substituted benzaldehydes. According to the 1H NMR data, the products are mixtures of diastereoisomers. 相似文献
4.
Liqiang Wu Yanfang Wu Fulin Yan Lizhen Fang 《Monatshefte für Chemie / Chemical Monthly》2010,14(4):871-875
Abstract
Three-component one-pot synthesis of some novel 12-aryl-12H-benzo[i][1,3]dioxolo[4,5-b]xanthene-6,11-diones involving treatment of 3,4-methylenedioxyphenol, aldehydes, and 2-hydroxy-1,4-naphthoquinone in presence of HClO4–SiO2 was achieved, and this reaction was extended to preparation of 10-aryl-6,7,8,10-tetrahydro-7,7-dimethyl-9H-[1,3]dioxolo[4,5-b]xanthen-9-ones by three-component reaction of 3,4-methylenedioxyphenol, aldehydes, and dimedone. 相似文献5.
By condensation of 5-phenyl-1,3-cyclohexanedione with 6-quinolylamine and aldehydes of aromatic, heterocyclic, and cyclohexene series new 12-aryl(heteryl, cyclohexenyl)-9-phenyl-8,9,10,12-tetrahydro-7H-benzo[b][4,7]phenanthrolin-11-ones were prepared. The presence of diastereomers in the target reaction products was determined by 1H NMR spectroscopy.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 5, 2005, pp. 742–748.Original Russian Text Copyright © 2005 by Gusak, Tereshko, Kozlov. 相似文献
6.
Kozlov N. G. Pashkovskii F. S. Tereshko A. B. Lokot' I. P. Gusak K. N. Lakhvich F. A. 《Russian Journal of Organic Chemistry》2003,39(1):115-119
Condensation of 6-methyl(or phenyl)-tetrahydropyran-2,4-diones with 2-aminonaphthalene or 6-aminoquinoline and aromatic aldehydes in an aliphatic alcohol gave 5-aryl-2,2-dimethyl(or 2-phenyl)-1,2,5,6-tetrahydro-4H-benzo[f]pyrano[3,4-c]quinolin-4-ones and 5-aryl-2-methyl-1,2,5,6-tetrahydro-4H-pyrano[4,3-a][4,7]phenanthrolin-4-ones which are new N,O-heterocyclic systems containing fused aza- and diazaphenanthrene moieties and a 2-pyranone ring. 相似文献
7.
Piergiorgio Pecorari Marcella Rinaldi M. Paola Costi Luciano Antolini 《Journal of heterocyclic chemistry》1992,29(6):1449-1455
Derivatives of two new molecular structures, namely, 7,8-dihydro-6H,10H-[1,2,5]thiadiazolo[3′,4′:4,5]pyrimido[2,1-b][1,3]thiazin-10-one and 6,7-dihydro-9H-thiazolo[3,2-a][1,2,5]thiadiazolo[3,4-d][pyrimidin-9-one, and derivatives of N-substituted sulfamic acid, namely, (8-amino-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-on-7-yl)sulfamic acid and (7-amino-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-on-6-yl)sulfamic acid, were separated out as by-products in the reduction reaction of 8-amino-3,4-dihydro-7-nitroso-2H,6H-pyrimido[2,1- b][1,3]thiazin-6-one and 7-amino-2,3-dihydro-6-nitroso-5H-thiazolo[3,2-a]pyrimidin-5-one derivatives, respectively, with sodium hydrosulfite. A mechanism of reaction, which hypothesizes the action of sodium hydrosulfite in an asymmetic form, is proposed. The results of single-crystal X-ray investigation on 7,8-dihydro-6H,10H-[1,2,5]thiadiazolo[3′,4′:4,5]pyrimido[2,1-b][1,3]thiazin-10-one (R = 0.032 for 863 reflections) and (8-amino-3,4-dihydro-2H,6H-pyrimido[2,1-b]- [1,3]thiazin-6-on-7-yl)sulfamic acid, sodium salt (R = 0.028 for 3507 reflections) are reported. 相似文献
8.
The synthesis of 11-acyl-11,12-dihydrodibenz[bf][1,5]oxazocin-6-ones 9-13 is reported by reaction of N-(2-hydroxybenzyl)anthranilic acids 1 with acetic, isobutyric, 2-ethylbutyric anhydrides. The structures of the obtained 6,8,6 products are proved with the use of ir, mass spectrometry, 1H and 13C nmr spectra, homo-and heteronuclear two-dimensional nmr experiments. The formation of 9-13 is discussed in relation to the obtainment of 12H-quino[2,1-b][1,3]benzoxazin-5-ones 2-8 and 6a,12-dihydro[3,1]benzoxazino[2,1-b][1,3]-benzoxazin-5-ones 14-19 from the same starting products 1 with suitable anhydrides under controlled reaction conditions. 相似文献
9.
6-Aminoquinaldine condensation with aromatic aldehydes and cyclic -diketones (1,3-cyclohexanedione or dimedone) in butanol afforded new 12-aryl-3-methyl-8,9,10,12-tetrahydro-7H-benzo[b][4,7]phenanthrolin-11-ones and their 9,9-dimethyl derivatives.Translated from Zhurnal Organicheskoi Khimii, Vol. 40, No. 11, 2004, pp. 1709–1714.Original Russian Text Copyright © 2004 by Gusak, Tereshko, Kozlov. 相似文献
10.
N. G. Kozlov K. N. Gusak A. B. Tereshko S. I. Firgang A.S. Shashkov 《Russian Journal of Organic Chemistry》2004,40(8):1181-1186
12-Aryl(heteryl,cyclohexenyl)-8,9,10,12-tetrahydro-7H-benzo[b][4,7]phenanthrolin-11-ones were synthesized by condensation of 1,3-cyclohexanedione with 6-quinolylamine and aldehydes of aromatic, heterocyclic, and cyclohexene series. 相似文献
11.
Vovk M. V. Lebed' P. S. Sukach V. A. Kornilov M. Yu. 《Russian Journal of Organic Chemistry》2003,39(12):1781-1788
1-Chloroalkyl isocyanates react with 2-R-methylbenzothiazoles [R = CN, C(O)OAlk, 2-benzothiazolyl] in the presence of triethylamine to give 4-R-2,3-dihydro-1H-pyrimido[6,1-b][1,3]benzothiazol-1-ones. The same reaction at elevated temperature in the absence of a base yields isomeric 4-R-2,3-dihydro-1H-pyrimido[6,1-b][1,3]benzothiazol-3-ones. 4-R-1H-Pyrimido[6,1-b][1,3]benzothiazol-1-ones are formed in the reaction of 1,1-dichloroalkyl isocyanates or methyl 1-chloroalkylidenecarbamates with 2-benzothiazolylacetonitrile or bis(2-benzothiazolyl)methane. 相似文献
12.
Istvn Hermecz Benjaminnyi Pod Zoltn Mszros Gyrgy Szsz Jzsef Kksi 《Journal of heterocyclic chemistry》1985,22(5):1373-1375
Fischer indolization of 6-arylhydrazono-6,7,8,9-tetahydro-11H-pyrido[2,1-b]quinazolin-11-ones 1 afforded substituted 7,8-dihydro-5H,13H-indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5-ones 3-12 in high yields. 相似文献
13.
Previously unknown 7-aryl(hetaryl)-3-methyl-7,10,11,12-tetrahydro-9H-benzo[b][1,7]phenanthrolin-8-ones and their 10,10-dimethyl-substituted analogs were synthesized by three-component condensation of
2-methylquinolin-5-amine with aromatic aldehydes and cyclic β-diketones (cyclohexane-1,3-dione and dimedone) in butyl alcohol. 相似文献
14.
The reaction of 2-mercaptobenzimidazole, 5-ethoxy-2-mercaptobenzimidazole, and 2-mercaptoimidazoline with cinnamoyl chloride, its derivatives, and heteroanalogs was studied. Convenient methods were found for the synthesis of 2-aryl-2,3-dihydro-4H-[1,3]thiazino[3,2-a]benzimidazol-4-ones and 7-aryl-2,3,6,7-tetrahydro-5H-imidazo[2,1-b]-1,3-thiazin-5-ones. 相似文献
15.
V. N. Britsun A. N. Esipenko A. N. Chernega M. O. Lozinskii 《Russian Journal of Organic Chemistry》2005,41(1):108-113
3-Aryl-1,2,4-triazole-5-thiones react with dimethyl acetylenedicarboxylate and methyl 3-phenyl-propynoate to afford the corresponding 5-substituted 2-aryl-7H-[1,2,4]triazolo[3,2-b][1,3]thiazin-7-ones. Treatment of 2-aryl-2,3-dihydro-4H-[1,3]thiazino[3,2-a]benzimidazol-4-ones with alkalies leads to formation of 3-(benzimidazol-2-ylsulfanyl)-3-arylpropionic acids, their reaction with methyl p-toluenesulfonate yields 1-(3-methyl-2-thioxo-2,3-dihydro-1N-benzimidazol-1-yl)-3-phenyl-2-propen-1-one, and oxidation with hydrogen peroxide gives benzimidazole-2-sulfonic acid and 3-aryl-2-propenoic acids.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 109–114.Original Russian Text Copyright © 2005 by Britsun, Esipenko, Chernega, Lozinskii. 相似文献
16.
Britsun V. N. Esipenko A. N. Kudryavtsev A. A. Lozinskii M. O. 《Russian Journal of Organic Chemistry》2004,40(2):232-238
A new procedure for preparation of 2-R-5-aryl-5,6-dihydro-7H-[1,2,4]triazolo[5,1-b][1,3]thiazin-7-ones by condensation of 5-R-1,2,4-triazole-3-thiones with 3-arylacryloyl chlorides was developed. The thiazine ring of the [1,2,4]triazolo[5,1-b][1,3]thiazin-7-ones is easily cleaved by treating with ammonia and hydrazine affording amides and hydrazides of 3-aryl-3-(1H-1,2,4-triazol-5-ylsulfanyl)propanoic acids. The latter react with isothiocyanates furnishing carbamoyl thiohydrazides of 3-aryl-3-(1H-1,2,4-triazol-5-ylsulfanyl)propanoic acids that in alkaline media undergo cyclization into 4-aryl-5-[2-(4H-1,2,4-triazol-5-ylsulfanyl)-2-phenylethyl]-2,4-dihydro-3H-1,2,4-triazole-5-thiones. 相似文献
17.
A synthesis of 4-N-oxides and of 3-hydroxy derivatives of 1,3-dihydro-2H-benzofuro[3,2-e][1,4]diazepin-2-ones and of 2,3-dihydro-1H-benzofuro[3,2-e][1,4]diazepines is described. Condensation of 2-acetyl- and 2-benzoyl-3-ethoxycarbonylaminobenzofurans with acrylonitrile gave derivatives of 1,2-dihydro- and of 1,2,3,4-tetrahydrobenzofuro[3,2-b]pyridine. 相似文献
18.
I. V. Dyachenko R. I. Vas’kevich M. V. Vovk 《Russian Journal of Organic Chemistry》2014,50(2):263-270
2-[Allyl(propargyl)sulfanyl]pyrido[3,4-d]pyrimidin-4-ones at heating in polyphosphoric acid undergo an intramolecular cyclization with the formation of pyrido[4,3-e]thiazolo-[3,2-a]pyrimidin-5-ones of angular structure. Under similar conditions the cyclization of 2-(cinnamylsulfanyl)pyrido[3,4-d]-pyrimidin-4-one results in a linear pyrido[3′,4′:4,5]pyrimido-[2,1-b][1,3]thiazin-6-one. The iodocyclization of the same substrates affords the corresponding 9-(iodomethyl)(iodomethylidene)pyrido[4,3-e][1,3]thiazolo-[3,2-a]pyrimidin-5-ones and 3-iodopyrido[3′,4′:4,5]pyrimido[2,1-b][1,3]thiazin-6-one of angular structure. 9-(Iodomethyl)-8,9-dihydro-5H-pyrido[4,3-e][1,3]thiazolo[3,2-a]pyrimidin-5-one treated with sodium azide gave 9-(azidomethyl) derivative whose cyclization with substituted alkynes in the presence of copper compounds provided pyrido [4,3-e][1,3]thiazolo[3,2-a]pyrimidinylmethyltriazoles. 相似文献
19.
Piergiorgio Pecorari Marcella Rinaldi Maria Paola Costi Luciano Antolini 《Journal of heterocyclic chemistry》1991,28(4):891-898
The cyclization reactions, carried out in strongly- or weakly-basic media, are described. Sometimes, 7-amino-2,3-dihydro-3-hydroxymethyl-5H-thiazolo[3,2-a]pyrimidin-5-one is separated out, together with 8-amino-3,4-dihydro-3-hydroxy-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-one, as the principal product. A mechanism of reaction, during which the cyclizating agents are changed into oxirane derivatives, is proposed. The results of single-crystal X-ray investigations on 8-amino-3,4-dihydro-3-hydroxy-7-nitroso-2H,6H-pyrimido[2,1-b][1,3]thiazin-6-one (R = 0.035 for 1013 reflections), and on 7-hydroxymethyl-6,7-dihydrothiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidin-9(1H)-one (R = 0.027 for 1607 reflections) are reported. 相似文献
20.
Issa Yavari Zinatossadat Hossaini Maryam Sabbaghan Majid Ghazanfarpour-Darjani 《Monatshefte für Chemie / Chemical Monthly》2007,138(7):677-681
Summary. The 1,3-dipolar intermediates generated by addition of isoquinoline, to dialkyl acetylenedicaboxylates are trapped by N-alkylisatins to produce dialkyl 1,2-dihydro-2-oxo-1-alkylspiro[3H-indol-3,2′-[2H,11bH][1,3]oxazino[2,3-a]isoquinoline]-3′,4′-dicarboxylates in excellent yields. The reaction of isoquinoline, quinoline, or pyridine with dimethyl
acetylenedicarboxylate in the presence of ninhydrin led to dimethyl 1,2-dihydro-1,3-dioxospiro[3H-indene-3,2′-[2H,11bH][1,3]oxazino[2,3-a]isoquinoline]-3′,4′-dicarboxylate, dimethyl 1,2-dihydro-1,3-dioxospiro[3H-indene-3,3′[3H,4aH][1,3]oxazino[3,2-a]quinoline]-1,2-dicarboxylate, or dimethyl 1,2-dihydro-1,3-dioxospiro[3H-indene-3,2′-[2H,9aH]pyrido[2,1-b][1,3]oxazino]-3,4-dicarboxylate. 相似文献