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1.
Afshar N. Hatamjafari F. Shiroudi A. Pourshamsian K. Oliaey A. R. 《Russian Journal of Organic Chemistry》2020,56(12):2153-2158
Russian Journal of Organic Chemistry - Three-component reaction of substituted benzoyl chlorides, ammonium thiocyanate, and isatin in anhydrous acetone gave a series of novel... 相似文献
2.
Synthesis and Antibacterial Activity of Some New Derivatives of Thiosemicarbazide and 1,2,4-Triazole
Monika Wujec Anna Pachuta-Stec Joanna Stefańska Edyta Kuśmierz Agata Siwek 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):1661-1669
Abstract In a reaction of hydrazides of cyclohexylacetic acid 1 and phenylacetic acid 2 with isothiocyanates, respective thiosemicarbazide derivatives 3–18 were obtained. Further cyclization with 2% NaOH led to the formation of 5-(cyclohexylmethyl/benzyl)-4-substituted-2,4-dihydro-3H-1,2,4-triazole-3-thiones 19–34. Structures of all new products were confirmed by analytical and spectroscopic methods. All compounds were screened for their in vitro activity against some species of bacteria and fungi. [Supplementary materials are available for this article. Go to the publisher's online edition ofPhosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional figures and tables.] 相似文献
3.
Wafaa S. Hamama Ghada G. El‐Bana Mohamed El‐H. Mostafa Hanafi H. Zoorob 《Journal of heterocyclic chemistry》2019,56(1):239-250
A new series of 1,2,4‐triazine derivatives were designed, synthesized, and identified on the basis of IR, 1H‐NMR, 13C‐NMR, and EI‐MS spectral data. The potent acaricidal activity of 1,2,4‐triazine derivatives against eggs and adult female of Tetranychus urticae (Koch) was assessed compared with pyridaben under laboratory conditions. Structure acaricidal activity relationships of the promising 1,2,4‐triazine derivatives were analyzed for eggs and adult female; the nature and position of the substituents were important in demonstration of the activities. 相似文献
4.
Abdolali Alizadeh 《Helvetica chimica acta》2005,88(10):2777-2780
The reactive 1 : 1 intermediate produced in the reaction between triphenylphosphine and diisopropyl azodicarboxylate has been trapped by isocyanates or isothiocyanates to yield 1,2,4‐triazole derivatives 2 (Scheme 1). The structures of the highly functionalized compounds 2 were corroborated spectroscopically (IR, 1H‐ and 13C‐NMR, EI‐MS) and by elemental analyses. A mechanism for this type of cyclization is proposed (Scheme 2). 相似文献
5.
Yaşar Dürüst 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):2923-2935
Synthesis and spectral characterization of novel 1,3,4-thiadiazole derivatives including one organo-mercury compound are described. Their structure elucidation was performed by means of spectroscopic and physical methods (IR, 1H NMR, 13C NMR, MS, X-ray). 相似文献
6.
Sirakanyan S. N. Hakobyan E. K. Hovakimyan A. A. 《Russian Journal of Organic Chemistry》2019,55(3):308-313
Russian Journal of Organic Chemistry - Pentacyclic heterocyclic compounds containing a 1,2,4-triazole ring have been synthesized from... 相似文献
7.
Synthesis of nine new benzimidazole derivatives was reported. The products were identified by 1H NMR, mass spectroscopy, and infrared spectroscopy. 相似文献
8.
含均三唑环的新型联苯四唑衍生物的合成及抗菌活性 总被引:6,自引:0,他引:6
通过4-芳基-5-(4-吡啶基)-1,2,4-三唑-3-硫醇(1)和2-三苯基甲基-5-(4′-溴甲基联苯-2-基)-四唑(5)反应, 制得一系列新的S-烷基化产物(6), S-烷基化产物在酸性条件下脱保护, 得到了14个未见文献报道的含1,2,4-三唑类联苯四唑(7a~7n)衍生物. 结构经元素分析, IR, NMR及FAB-MS确认. 对大肠杆菌、链球菌、枯草杆菌、金黄色葡萄球菌初步抑菌试验证明, 多数化合物表现了较好的抑菌活性. 相似文献
9.
Henryk Foks Mieczyslaw Janowiec Zofia Zwolska Ewa Augustynowicz-Kopeć 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):537-543
Abstract The Mannich reaction's products of 1,2,4-triazole-3-thiones, substituted in position 4 (with ethyl, allyl, phenyl, Ph-4-Br) or 5 (with phenyl, Ph-4-OH, Ph-3,4,5-(OMe)3, 2-phenyl) were obtained. Their amino-components were 1-phenylpiperazine, 1-(4-fluorophenyl)-piperazine, 1-benzylpiperazine, 1-(2-pyridyl)-piperazine and 1-piperonyl-piperazine. Tuberculostatic activity of the compounds obtained was tested and their MIC values within 25–100 mcg/mL. 相似文献
10.
Moustafa A. Gouda 《Journal of heterocyclic chemistry》2015,52(4):990-998
Diazodization of pyrazolo[3,4‐b]pyridine 1 afforded diazonium salt 2 that coupled with active methylene compounds such as 3a , 3b , 6 , 7 , 8 , 15a , 15b , 16a , 16b , 17 , and 24 in pyridine to give aryl hydrazone derivatives 4a , 4b , 9 , 10 , 11 , 18a , 18b , 19a , 19b , 20 , and 25 , respectively. The previous synthesized compounds underwent cyclization in acetic acid to give the corresponding pyridopyrazolotriazines 5a , 5b , 12 , 13 , 14 , 21a , 21b , 22a , 22b , 22c , 23 , and 26 , respectively. The newly synthesized compounds were characterized by elemental analysis and spectral data and screened for their antioxidant activities. The results of ABTS method showed clearly that compounds 1 , 4b , 5b , 11 , 20 , 25 , and 26 displayed promising in vitro antioxidant activities. Compounds 1 and 4a exhibited high protection against DNA damage induced by the bleomycine iron complex. 相似文献
11.
Abd El-Badih A. G. Ghattas Hassan M. Moustafa Elsayed A. A. Hassanein Bahgat R. M. Hussein 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):1469-1481
Abstract Alkylation of 4-anilino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) with some halo compounds yielded the corresponding sulfides 2a–f. Some sulfides 2e,f were cyclized to give triazolothiadiazines 3 and 4. Triazolothiadiazoles 5 and 6 were prepared through the reaction of compound 1 with carbon disulfide or ethyl orthoformate, respectively. Treatment of compound 1 with ethyl chloroformate or phenyl isothiocyanate yielded triazolo-thiadiazole and triazole 9 and 10, respectively. Reaction of compound 1 with Lawesson's reagent gave triazolothiadiazaphosphole derivative 11. Also, compound 1 underwent cyclocondensation reactions with some bidentate reagents to give triazolothiazines 4, 12, and 13. Triazolo-thiazepines and triaziepine 14–16 were synthesized via the reaction of compound 1 with β-ketoesters or ethyl cyanoacetate. Tricyclic systems 19 and 20 were prepared through the reaction of compound 4 with the appropriate reagent. Some synthesized compounds were tested for antibacterial activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
12.
Fayed A. A. Alahmadi Y. M. Yousif M. N. M. Yousif N. M. Amer A. A. El-Farargy A. F. Ouf N. H. Gad F. A. 《Russian Journal of General Chemistry》2019,89(9):1887-1895
Russian Journal of General Chemistry - Synthesis of a new series of pyrimidinothienocinnoline derivatives involves the reaction of 9-aminodibenzo[f,... 相似文献
13.
Mihaiela Stuparu Ion Grosu Luminita Muntean Gérard Plé Crina Cismas Anamaria Terec Alexandrina Nan Sorin Mager 《Monatshefte für Chemie / Chemical Monthly》2004,16(4):89-96
The synthesis and stereochemistry of some new 2,5-substituted 1,3-oxathiane derivatives are reported. The anancomeric or flexible structure of the derivatives and some peculiar cases of prochirality are revealed by NMR investigations. 相似文献
14.
Summary. The synthesis and stereochemistry of some new 2,5-substituted 1,3-oxathiane derivatives are reported. The anancomeric or flexible structure of the derivatives and some peculiar cases of prochirality are revealed by NMR investigations. 相似文献
15.
2-(2-Cyano-acetylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide(3) was used as starting material for synthesis of 4-thiazolidinone, thiazolidine, and thiophene derivatives 6, 7a, b, and 8a, b, respectively. Thiocarbomyl derivative 5, 4-thizolidinone 9, and thioxothiazolidine 10 were obtained from reaction of 3 with thioglycolic acid and phenyl isothiocyanate/sulfur, respectively. Condensation of 3 with selected cyclic ketones and aromatic aldehydes yielded the arylidine derivatives 11a, b and 13, respectively. Refluxing of 11a, b with sulfur and morpholine yielded the thiophene derivatives 12a, b, respectively. Diazocoupling of compound 3 withp-tolyl diazonium chloride yielded the hydrazone derivative 14. The newly synthesized compounds were characterized by infrared, 1H NMR, and mass spectral studies. Representative compounds of the synthesized product were tested and evaluated as antimicrobial agents. Compound 12b gives very high antimicrobial activity against Ampicillin. 相似文献
16.
Hala M. Refat 《Journal of heterocyclic chemistry》2015,52(5):1488-1495
In an attempt to find a new class of antimicrobial agents, a series of spiroindolinone compounds containing pyridine, pyrimidine, benzopyrans, pyrido, naphtodiazepines, pyrazole, and isoxazole ring systems were prepared via the reaction of 3‐(2‐oxo‐2‐(3‐oxo‐3H‐benzo[f]chromen‐2‐yl)ethylidene)indolin‐2‐one ( 4 ) with an appropriate nucleophilic reagent. Newly synthesized compounds were characterized by elemental analysis and spectral data (IR, 1H‐NMR, 13C‐NMR, and mass spectra). Representative compounds were tested and evaluated as antimicrobial agents. 相似文献
17.
Ru-Yu Chen Hua-Zheng Yang Shu-Hua Cui Jin-Shu Shao Zheng-Pu Zhang Hui-Lin Wang 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3-4)
Abstract A series of new 1,3,2-oxazaphospholane derivatives(I) have been synthesized by the reaction of P(NEt2)3 with RNHCH2O2OH at 80°C. When they were refluxed with sulfur in benzene, compounds II were obtained conveniently. 相似文献
18.
The reactions of 4-carboxyhydrazide-5,6-diphenyl-3(2H)-pyridazinone (I) with aromatic aldehydes, phenyl isothiocyanate, β dicarbonyl compounds, ethyl ethoxymethylenecyanoacetate, ethyl cyanoacetate and acylating agents have been investigated. Oxadiazolines (III) and thiazolidinones (IV) were synthesized from arylidenehydrazides (II) through appropriate routes. The thiosemicarbazide derivative (V) on reaction with malonic acid and acetyl chloride gave VII , and on treatment with monochloroacetic acid and sodium acetate afforded IX . Some reactions with 3-amino-4,5-diphenylpyrazolo [3,4-b] pyridazine ( XIVa ) were also reported. 相似文献
19.
Eatedal H. Abdel Aal Osama I. El-Sabbagh Shaker Youssif Sameh M. El-Nabtity 《Monatshefte für Chemie / Chemical Monthly》2002,133(3):255-266
Summary. New benzenesulfonamide derivatives containing pyrazole and oxadiazole moieties were prepared starting from sodium saccharin.
The structures of the novel compounds were characterized by elemental analyses and spectroscopic methods. The new compounds
are structurally related to the COX-2 inhibitor celecoxib (Celebrex?). A pharmacological study of the pyrazoles revealed that several compounds possess higher analgesic and antiinflammatory
activities than celecoxib, particularly 11 and 17. Most of the pyrazoles showed a significant increase in the sleeping time of thiopentone anaesthesized mice and also protected
mice against the convulsive and lethal effects of pentylenetetrazole. Moreover, the ulcerogenic activity of those compounds
showing a pronounced antiinflammatory effect was also studied.
Received August 20, 2001. Accepted (revised) November 19, 2001 相似文献
20.
I. M. El-Deen H. K. Ibrahim 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):733-740
Reaction of 2-mercapto-4-hydroxy-5H-[1]-benzopyrano-[4,3- d ]-pyrimidin-5-one ( 3 ) with phenyl isothiocyanate and methyl acrylate yielded the corresponding 2-(substituted)thio-4-hydroxy-5H-[1]-benzopyrano-[4,3- d ]-pyrimidin-5-ones ( 4 , 5 ). Hydrolysis and hydrazinolysis of 5 gave acid derivative 6 , and hydrazone 7 . Treatment of hydrazone 7 with ethyl acetoacetate, diethyl malonate, and phenyl isothiocyanate yielded the corresponding 2-(substituted)thio-4-hydroxy-5H-[1]-benzopyrano- [4,3- d ]-pyrimidin-5-ones ( 8 , 9 , and 11 ). Cyclization of 11 with 2 N NaOH led to 12 . 相似文献