Facile Synthesis of 5-Hydroxy-2-（2-phenylethyl）chromone

5-Hydroxy-2-(2-phenylethyl)chromone(1) was synthesized from 2,6-dihydroxyacetophenone(7) obtained via four-steps resorcinol-reacting with phenylpropionic acid,the procedures involved are Baker-Venkataraman rearrangement and cyclization which are easy to conduct,the overall yield is 32%.     

A Facile Method for Asymmetric Synthesis of β-Hydroxy-α-amino Acids

β-Hydroxy-a-amino acids are an important class of amino acids due to their inherent biological investigations[1] and as structural components of more complex biomolecules.[2] β-Hydroxy-a-amino acids have been used as intermediates in the asymmetric synthesis of other compounds.[3] An efficient and convenient concise method for the preparation of optically pure enantiomers of β-hydroxy-α-amino acids would be of general interest.     

A Facile Synthesis of Pure O2PtF6

A new and facile synthesis of O₂PtF₆ is reported without the demanding synthesis of PtF₆ or the use of high pressure fluorination in the presence of oxygen. The O₂PtF₆ is obtained in form of single crystals by direct Klemm‐type fluorination of commercially available PtO₂ · xH₂O in a stream of diluted F₂ of atmospheric pressure at a temperature of 275 °C. Its identity and purity was evidenced by powder X‐ray diffraction, Raman and infrared spectroscopy. The synthesis allows the preparation of pure dioxygenyl hexafluoridoplatinate(V). The new synthesis of O₂PtF₆ is deemed more convenient than those that require the extremely reactive PtF₆.     

Synthesis and Transformations of 4-Hydroxy-2-methylquinoline-6-carbohydrazide

Russian Journal of Organic Chemistry - A substituted quinoline-6-carbohydrazide was synthesized by the reaction of ethyl 4-hydroxy-2-methylquinoline-6-carboxylate with hydrazine hydrate. The...     

A Facile and Practical Procedure for the Synthesis of 8-Hydroxy-4-oxochroman Derivatives

Abstract: Novel 8-hydroxy-4-oxochroman derivatives were prepared from appropriate 4-chromanones via the Baeyer-Villiger oxidation followed by an intramolecular Fries rearrangement.     

A Facile Synthesis of 2-Aminonicotinaldehyde

A synthesis of 2-aminonicotinaldehyde (1) which does not require chromatography and is easily scaled up has been developed. Bromination of 2-amino-3-picoline, protected as a phthalimide (4), produced the gem-dibromide (5), which was reacted with Nh₄OH. The imine intermediate (7) was hydrolyzed with acid, producing (1) in a 56% conversion from 4.     

3-(4-羟基-2-酮基喹啉)吡唑啉的合成及其荧光性质研究

3-a,β-不饱和酮取代-4-羟基喹啉-2-酮与苯肼反应,直接成环得到一系列新型1,3,5-莞取代吡唑啉.液相和固相荧光测试结果表明该类产物是一类具有较大Stokes位移的小分子有机光学材料.吡唑啉3,5位上的取代基性质对其液相和固态荧光发射波长与发射强度有不同的影响.     

二苯基羟乙酮的合成

本文研究了维生素B1（VB1）催化下二苯羟乙酮的合成，找出了最佳反应条件，提高了产物的收率且重现性好。     

二苯基羟乙酮的合成

本文对由苯甲醛通过辅酶催化合成二苯基羟乙酮的反应条件进行了全面的研究 ,找出了最佳反应条件 ,提高了产物的收率且重现性好     

A Convenient One-Step Synthesis of 2-Hydroxy-1,3,5-Benzenetricarbaldehyde

The hexamethylenetetramine/trifluoroacetic acid system was demonstrated to be capable of introducing three aldehyde groups into the phenol molecule. Facile, one-step procedures were developed for the preparation of hitherto difficult to synthesize 2-hydroxy-1,3,5-benzenetricarbaldehyde starting from either phenol or 4-hydroxybenzaldehyde. New pKa measurements showed 2-hydroxy-1,3,5-benzenetricarbaldehyde to be an acid stronger than previously reported.     

Synthesis of 6-Hydroxy-2-methyl-3-thioxo-2H-1,2,4-triazin-5-one

The title compound has been prepared in three steps from 2-methylthiosemicarbazide following acylation, cyclisation and cation exchange chromatography. It was fully characterised by the usual spectroscopic means as well as by ¹⁵N nmr spectroscopy and X-ray crystallographic analysis.     

A Facile Synthesis of 2-Benzoyl-6-Hydroxy-3-Methyl-5-(2-Substituted-2,3-Dihydro-1H-1,5-Benzodiazepin-4-YL) Benzo[b]Furans

The synthesis and characterisation of some new 1,5-benzodiazepines prepared from 4,6-diacetylresorcinol is reported.     

A Facile One-Pot Synthesis of 4-Hydroxy-3-methoxycarbonyl-2-methyl-2H-1,2-benzothiazine 1,1-Dioxide,A Key Intermediate in the Synthesis of Oxicam Anti-Inflammatory Agents

4-Hydroxy-3-methoxycarbonyl-2-methyl-2H-1,2-benzothiazine 1,1-dioxide (8) was synthesized by a one-pot procedure, starting from the readily available saccharine. The synthesis involves 4 transformations with an overall yield equivalent to that from the stepwise process.     

6-羟基-3,4-二氢-2(1H)喹啉酮合成新方法

提出了一种以苯胺和3-氯丙酰氯为原料，经环合、硝化、还原、重氮化水解合成目标产物6-羟基-3，4二氢-2(1H)喹琳酮的新方法。此法合成的目标产物产率高，总产率达67％以上。单步产率均在86．5—99．6％之间，反应条件温和。各步产品经MS，1HNMR进行定性及结构表征。     

A New Facile Synthesis of 2-Alkylcyclopent-2-Enones

A new, simple and short route to 2-alkylcyclopent-2-enones starting from inxpensive terminal epoxides is described.     

4-羟基-2-吡啶酮的合成

以氰乙酸乙酯和原乙酸三甲酯为原料,经缩合反应制得2-氰基-3-甲氧基丁烯-2-羧酸乙酯(1);1与二甲基甲酰胺缩二甲醇缩合得2-氰基-5-(二甲氨基)-3-甲氧基-2,4-戊二烯酸乙酯(2);2在80%醋酸中环合得4-甲氧基-2-吡啶酮-3-甲酸乙酯(3);3在HBr中脱甲基和脱羧合成了4-羟基-2-吡啶酮,总收率31%,其结构经1H NMR,IR和MS确证。     

2-羟基-3,4,6-三甲氧基查尔酮的合成

本文开发了一种天然产物2-羟基-3,4,6-三甲氧基查尔酮(1)的十克级规模快速合成方法.通过改良合成2-羟基-3,4,6-三甲氧基苯甲醛(7)的甲基化和甲酰化条件,将7的合成总收率从文献报道的22％提高至68％.并以7为原料在乙腈为溶剂、80℃加热的条件下通过Wittig反应在50mmol规模以85％的收率合成了产物...