共查询到20条相似文献,搜索用时 15 毫秒
1.
Hydrosilation of methylenecyclohexane and hex-1-ene by octa(hydridosilsesquioxane) catalysed by hexachloroplatinic acid is a new route to polyhedral organylsilsesquioxanes. Quantitative yield of octa(cyclohexylmethylsilsesquioxane) is reached. This reaction opens a vast field of yet unknown polyhedral silsesquioxanes. 相似文献
2.
5-Isoxaz0lamineshavebeenusedasintermediatesforthesynthesis0fderivatives0fantihistaminic,analgetic,antibacterial,insecticidal,herbicidalandfungicidalactivity'.Usuallytheyaresynthesizedbytheintramolecularcondensation0fhydr0xylamineand0-nitrilegr0up'.Otherapproaches,suchasreductivecyclizati0nofZ-a-cyano-6-nitroethylenesandIithiumaIuminumhydridereduction0f3-cyanooxazoleshaveals0beenrepoFted'-'.HerewerepoFtanewsyntheticrouteofthesecompounds.Ohn0andNaruse7havereportedthatthereactionof2-chlorocycl… 相似文献
3.
4.
5.
6.
Indenones are useful intermediates in the synthesis of several natural products, e.g. gibberellins (1) and steroid hormones with a C-nor-D-home system (2). Despite the nernerous methods for indenone synthesized, or the yields was much lower as mentioned in earlier reports (1)(4). One of the difficulties of the usual methods is the required electrophilic cyclization meta to a methoxyl substiruent. House (5) deals with these difficulties in more detail. In our method the synthesis of 6-methoxyinde-nones is effected by substitution dara to methoxyl function. 相似文献
7.
8.
9.
10.
Russian Journal of Organic Chemistry - New cinnoline derivatives have been synthesized by reductive cyclization of hydrazones obtained by condensation of various 2-nitrophenylhydrazine derivatives... 相似文献
11.
12.
13.
14.
15.
Istvn Moldvai Eszter Temesvri‐Major Mria Incze Gbor Drnyei va Szentirmay Csaba Szntay 《Helvetica chimica acta》2005,88(6):1344-1356
Rye is sometimes infected by a fungus called Claviceps purpurea. The term ergot designates the dark, brown, tuberous bodies which can be collected before or during harvesting and represent one of the most remarkable drugs of our therapeutic arsenal. Actually, the most significant alkaloids are metabolic products of these fungi. We elaborated three alternative total synthetic pathways to construct the ergoline skeleton, one of which – suitable for scaling up – finally resulted in (+)‐lysergic acid ( 32a ) and α‐ergocryptine ( 1 ) (Schemes 5 and 6). 相似文献
16.
Matthias Schulze 《合成通讯》2013,43(22):3415-3422
Racemic fluoxetine was synthesized from 3-benzoylpropionic acid in five steps in 54% overall yield. 相似文献
17.
A revised synthetic route to Emivirine (MKC‐442) via properly substituted β‐keto ester converted from Meldrum's Acid was developed. This method could be applied to the synthesis of a variety of MKC‐442 analogues and open the way for their systematic biological evaluation. 相似文献
18.
A New Synthetic Route to 12-Oxo-1, 15-pentadecanlactam 总被引:1,自引:0,他引:1
JiaXingHUANG XiaoMeiLIANG DaoQuanWANG 《中国化学快报》2004,15(2):169-170
12-Oxo-1,15-pentadecanlactam 7 was synthesized from cyclododecanone with a totalyield of 36% in a seven-step reaction. The azide 5 to 12-nitro-1,15-pentadecanlactam 6 is the key step featured by direct ring expansion. 相似文献
19.
Starting from ethyl 2-cyclohexen-1-carboxylate ( 3 ) the total synthesis of the perhydrohistrionicotoxin intermediate 23 was achieved in 25% overall-yield. The two key steps involve a positionally specific addition of HOBr to the oxime-olefin 7 and the alkylation of bromooxime 17 with 1-lithio-1-butyne. The latter represents a novel method for stereospecific and position-specific introduction of a nucleophilic butyl equivalent in α-position to a ketonic carbonyl group. 相似文献
20.
Three naturally occurring furan–lignans and two analogs have been synthesized by a short and efficient route starting from the corresponding aryl acid. The selective reductive removal of allylic hydroxy by palladium oxide in a mixed solvent of THF–CHCl3 was employed as the key step. 相似文献