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1.
Deoxygenation of the cyclic thionocarbonates of 2,3-dihydroxy esters was mediated with magnesium in methanol, which provided a facile method for the synthesis of α-hydroxy esters 相似文献
2.
Enantioselective conjugate radical addition to 2‐acyloxymethyl cycloalkenones proceeds in high yield with outstanding diastereoselectivity and excellent enantioselectivity using chiral salen Lewis acids. The process provides access to 2,3‐disubstituted cycloalkanones, a structural motif present in natural products. 相似文献
3.
Carl A. Elliger 《合成通讯》2013,43(14):1315-1324
Treatment of hydroxy-substituted aromatic aldehydes and ketones with sodium cyanoborohydride yields the corresponding methylene compounds under conditions which favor intermediate carbonium ion formation. 相似文献
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Cyclopropanesareveryusefillintermediatesinorganicsynthesis'.OurpreviousstUdiesshowedthatthereactionsof2,4,6-triphenyIcycIoheptatrienonewithhaIcoarbenesgavealmostnocyclopropaneproduct'.Ontheotherhand.whenanotherpre-aromaticketoneIwasusedassubstrate,theonlyisolatedproductwasfoundtocontaincyclopropane(eq.I).Furthermore,whenthesubstratewastetraphenylcyclone(TPCP,2),bothcyclopropanationanddeoxygenationproductswereobtained(eq.2).Nowwewishtoreporttheserecentfindingsandelucidatethepossiblefactorsw… 相似文献
6.
XU Wei-liang * FU Cheng-lingOrganic Chemistry Group Huajiachi Section Zhejiang University Hangzhou P. R. China 《高等学校化学研究》2002,18(4):412-413
IntroductionThe thermal and photochemical decompositionof the diperoxides of cyclic ketones has been foundto provide a general method for the facile synthesisof macrocyclic compounds[1,2 ] .In addition,the useof diperoxides as initiators in polymerization hasbeen studied[3] .Forthose reasons,a better methodfor the synthesis of the requisite diperoxides isrequired.There are two different methods for thepreparation of the diperoxides. Griesbaum[4 ]obtained cyclopentanone diperoxide(yield 1 3 % … 相似文献
7.
Asymmetric reduction of prochiral ketones to optically active chiral secondary alcohols was achieved using a reagent prepared by modifying lithium aluminium hydride with a chiral auxiliary, (+)threo-1,16-dibenzyloxy,7,8-dihydroxy hexadecane and various additive alcohols. (+)threo-1,16-dibenzyloxy,7(R),8(R)-dihydroxy hexadecane was prepared from (+)threo-9(R),10(R),16-trihydroxy hexadecanoic acid. Alcohols such as CH3(CH2)n-OH of different chain length (n = 0–11) and (R)-hydnocarpic alcohol were used. Complex prepared from (+)threo-1,16-dibenzyloxy,7(R),8(R)-dihydroxy hexadecane, LAH and (R)-hydnocarpic alcohol reduced acetophenone in moderate enantioselectivity (maximum of 70% ee). Various arylalkylketones were reduced with the same complex. 相似文献
8.
Laura L. Adduci Dr. Matthew P. McLaughlin Trandon A. Bender Dr. Jennifer J. Becker Prof. Dr. Michel R. Gagné 《Angewandte Chemie (International ed. in English)》2014,53(6):1646-1649
The conversion of readily available cellulosic biomass to valuable feedstocks and fuels is an attrative goal but a challenging transformation that requires the cleavage of multiple nonactivated C? O bonds. Herein, the Lewis acid trispentafluorophenylborane (B(C6F5)3) is shown to catalyze the metal‐free hydrosilylative reduction of monosaccharides and polysaccharides to give hydrocarbons with reduced oxygen content. The choice of the silane reductant influences the degree of deoxygenation, with diethylsilane effecting the complete reduction to produce hexanes while tertiary silanes give partially deoxygenated tetraol and triol products. 相似文献
9.
Dr. Bao‐Hua Xu Raul Alfonso Adler Yanez Hiroshi Nakatsuka Prof. Dr. Masato Kitamura Dr. Gerald Kehr Prof. Dr. Gerhard Erker 《化学:亚洲杂志》2012,7(6):1347-1356
The frustrated Lewis pair (FLP) Mes2PCH2CH2B(C6F5)2 ( 1 ) reacts with an enolizable conjugated ynone by 1,4‐addition involving enolate tautomerization to give an eight‐membered zwitterionic heterocycle. The conjugated endione PhCO‐CH?CH‐COPh reacts with the intermolecular FLP tBu3P/B(C6F5)3 by a simple 1,4‐addition to an enone subunit. The same substrate undergoes a more complex reaction with the FLP 1 that involves internal acetal formation to give a heterobicyclic zwitterionic product. FLP 1 reacts with dimethyl maleate by selective overall addition to the C?C double bond to give a six‐membered heterocycle. It adds analogously to the triple bond of an acetylenic ester to give a similarly structured six‐membered heterocycle. The intermolecular FLP P(o‐tolyl)3/B(C6F5)3 reacts analogously with acetylenic ester by trans‐addition to the carbon–carbon triple bond. An excess of the intermolecular FLP tBu3P/B(C6F5)3, which contains a more nucleophilic phosphane, reacts differently with acetylenic ester examples, namely by O? C(alkyl) bond cleavage to give the {R‐CO2[B(C6F5)3]2?}[alkyl‐PtBu3+] salts. Simple aryl or alkyl esters react analogously by using the borane‐stabilized carboxylates as good leaving groups. All essential products were characterized by X‐ray diffraction. 相似文献
10.
Abstract A novel and effective catalytic system, silica-supported chitosan Schiff base palladium complex (SiO2–CS–Schiff base–Pd) was described for catalytic hydrogenation of aromatic ketones to corresponding hydrocarbons at ambient temperature and normal pressure of H2. 相似文献
11.
Tse-Lok Ho 《合成通讯》2013,43(7):665-668
Iodotrimethylsilane has rapidly become a valuable reagent for organic synthesis since its use in the cleavage of alkyl esters and ethers1,2,3 under essentially neutral conditions was introduced. For example, the conversion of ketals to ketones4, alcohols to iodides5, alkyl carbamates to amines, and sulfoxides to sulfides7 can now be readily promoted by iodotrimethylsilane. 相似文献
12.
Andrzej Duda Adam Kowalski Jan Libiszowski Stanislaw Penczek 《Macromolecular Symposia》2005,224(1):71-84
Recent advances in the controlled ring-opening polymerization (ROP) of cyclic aliphatic esters are reviewed with a particular attention to thermodynamics and kinetics of the polymerization of industrially important monomers, namely: lactide (LA), 1,4-dioxan-2-one (DX), and ϵ-caprolactone (CL). For comparison, polymerization of β-lactones is discussed. Progress in stereocontrolled polymerization of monomers bearing centers of chirality [LA and β-butyrolactone (BL)] is also briefly reviewed. 相似文献
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treatment of the title compounds with acyl halide and Lewis acid affords unsaturated ketones (mainly α-β with aluminium chloride, selectively β-γ with silver tetrafluoroborate). Reduction of the alkenyl group gives polyfunctional ketones. 相似文献
15.
Daniel R. Zuidema Sarah L. Williams Katherine J. Wert Karin J. Bosma Abigail L. Smith Robert C. Mebane 《合成通讯》2013,43(19):2927-2931
Aryl ketones are readily deoxygenated to their corresponding aryl alkanes upon treatment with Raney nickel catalyst in boiling 2-propanol.
16.
Facile Protocol for Catalytic Frustrated Lewis Pair Hydrogenation and Reductive Deoxygenation of Ketones and Aldehydes 下载免费PDF全文
Tayseer Mahdi Prof. Dr. Douglas W. Stephan 《Angewandte Chemie (International ed. in English)》2015,54(29):8511-8514
A series of ketones and aldehydes are reduced in toluene under H2 in the presence of 5 mol % B(C6F5)3 and either cyclodextrin or molecular sieves affording a facile metal‐free protocol for reduction to alcohols. Similar treatment of aryl ketones resulted in metal‐free deoxygenation yielding aromatic hydrocarbons. 相似文献
17.
Zack M. Strater Michael Rauch Steffen Jockusch Tristan H. Lambert 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(24):8133-8136
Single electron oxidation of 2,3‐diaminocyclopropenones is shown to give rise to stable diaminocyclopropenium oxyl (DACO) radical cations. Cyclic voltammetry reveals reversible oxidations in the range of +0.70–1.10 V (vs. SCE). Computational, EPR, and X‐ray analysis support the view that the oxidized species is best described as a cyclopropenium ion with spin density located on the heteroatom substituents, including 23.5 % on oxygen. The metal–ligand behavior of the DACO radical is also described. 相似文献
18.
Mild Deoxygenation of Aromatic Ketones and Aldehydes over Pd/C Using Polymethylhydrosiloxane as the Reducing Agent 下载免费PDF全文
Alexey Volkov Karl P. J. Gustafson Dr. Cheuk‐Wai Tai Dr. Oscar Verho Prof. Dr. Jan‐E. Bäckvall Prof. Dr. Hans Adolfsson 《Angewandte Chemie (International ed. in English)》2015,54(17):5122-5126
Herein, a practical and mild method for the deoxygenation of a wide range of benzylic aldehydes and ketones is described, which utilizes heterogeneous Pd/C as the catalyst together with the green hydride source, polymethylhydrosiloxane. The developed catalytic protocol is scalable and robust, as exemplified by the deoxygenation of ethyl vanillin, which was performed on a 30 mmol scale in an open‐to‐air setup using only 0.085 mol % Pd/C catalyst to furnish the corresponding deoxygenated product in 93 % yield within 3 hours at room temperature. Furthermore, the Pd/C catalyst was shown to be recyclable up to 6 times without any observable decrease in efficiency and it exhibited low metal leaching under the reaction conditions. 相似文献
19.
报道了一种小分子酮、酯与富电子杂环芳烃的高度选择性的自由基脱氢交叉偶联反应. 酯、酮作为溶剂, 过氧化物加热条件下发生裂解与酯、酮作用产生α羰基碳中心自由基, 进而与富电子杂环芳烃发生交叉脱氢偶联, 得到一系列C-2官能化富电子杂环产物. 该反应成功地运用自由基的极性效应, 从而精确控制自由基反应的化学选择性. 此外, 该体系还具有反应迅速、操作简便、官能团兼容性较好、区域选择性单一等优点. 预期它将在合成有机化学上得到较广泛的应用. 相似文献
20.
Methyl ketones are oxidatively transformed into α-keto esters by metal ion assisted alcoholysis of the corresponding β-keto-α, α-dichloroalkyl sulfides. 相似文献