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1.
JIN Tong-Shou YANG Mi-Na FENG Guo-Liang LI Tong-Shuang 《有机化学》2003,23(Z1):94-94
Pentaerythritol diacetals are useful in many fields. They can be applied as plasticizers and vulcanizers of various polymeric materials, as raw materials for production of valuable resins and lacquers, as physiologically active substances and as defoamers for washing solution containing anionic surfactants. [ 1 ~ 4] Synthsis of diacetals from 2,2bis(hydroxymethyl)-1, 3-propanediol with aldehydes and ketones in refluxing toluene using ZrO2/S2O2- 8 solid superacid as catalyst in 85% ~ 99% yields has been described. The catalysts are easily regenerated by washing with ethanol followed by drying at 120 ℃ for 4 h and could be reused 5 times for the synthesis pentaerythritol diacetal 3e without significant loss of activity. This method possesses the advantages of the operational simplicity, short reaction time, use of inexpensive materials, non-corrosion, non-polluting, high yields and reusable catalysts. 相似文献
2.
A novel and efficient method is developed for the selective mono nitration of anthraquinone (1). A mixture of fuming nitric acid, sulfuric acid and phosphoric acid in carbon tetrachloride is introduced as a new nitrating system for the high yield preparation of 1-nitroanthraquinone. 相似文献
3.
The introduction of the “isoprene unit” is an important key step in terpene synthesis and to this end, several basic routes employing organometallics have been utilised. 相似文献
4.
In the Fmoc-strategy of solid phase peptide synthesis, 1M trimethylsilyl bromide-thioanisole/trifluoroacetic acid in the presence of 1,2-ethanedithiol as scavenger was found to be an efficient deprotecting procedure for a full cleavage and side chains deprotection of the peptide resin involving t-butyl protected cysteine. In addition, selective deprotection of the peptide resin containing protected cysteine was also described based on this method. 相似文献
5.
Poly(4-vinylpyridinium tribromide) is an efficient catalyst for the conversion of various alcohols to their corresponding acetate derivatives with acetic anhydride.This method has some advantages such as mild reaction conditions,good to excellent yields,and ease of work-up. 相似文献
6.
A fast, general, environmentally friendly, and facile method for preparation of 5, 5-disubstituted hydantoins from the reaction between ketone (or aldehyde) derivatives with KCN and ammonium carbonate under microwave irradiation is presented. The microwaves remarkably accelerated this reaction, the reaction times decreased dramatically, the reaction conditions were milder, and the yields were also greater. Also a comparative study of microwave versus classical conditions has been done. All the products were characterized by infrared, NMR, and CHN analysis, and their melting points are identical to those of the known compounds reported in the literature. This method might be useful in the future for the preparation of similar derivatives. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resources: Full experimental and spectral details.] 相似文献
7.
Alkylamino derivatives of naphthazarine, juglone, and naphthoquinone have been synthesized via their corresponding bromo-analogues, in high yields, especially in the case of naphthazarins. 相似文献
8.
Vincent J. Kalish Robert L. Shone Steven W. Kramer Paul W. Collins Kevin A. Babiak Kathleen T. McLaughlin 《合成通讯》2013,43(11):1641-1645
Hydrozirconation-iodination of a terminal acetylene followed by lithium-iodide exchange and finally dilithio cyanocuprate mediated conjugate addition to an appropriate cyclopentenone is reported as an efficient method for the synthesis of prostaglandin analogues. 相似文献
9.
Hassan Y. Aboul-enein 《合成通讯》2013,43(5):255-258
Ethylglycidate (1), is a useful intermediate which can be used in several reactions involving epoxide ring opening with the introduction of an ester function and in co-polymer chemistry (1,2). Emmons and Pagano (3) described the preparation of I by epoxidation of ethyl acrylate with peroxytrifluoroacetic acid in 54% yield. 相似文献
10.
Conditions for preparing acetophenone azine via the oxidative dimerization of acetophenone imine anion are investigated. 相似文献
11.
Yanyan Huang Ying Feng Wensheng Gao Chao Zhang Ligong Chen 《Journal of heterocyclic chemistry》2016,53(2):437-440
Laquinimod, 5‐chloro‐1,2‐dihydro‐N‐ethyl‐4‐hydroxy‐1‐methyl‐2‐oxo‐N‐ phenyl‐3‐quinoline carboxamide, is an oral drug in clinical trials for the treatment of multiple sclerosis. An efficient synthetic method for laquinimod from 2‐amino‐6‐chlorobenzoic acid via four steps was established. The overall yield of laquinimod is up to 82% as compared with 70% reported in literature. It has also been demonstrated that green reagent dimethyl carbonate is not suitable for the N‐methylation of 5‐chloroisatoic anhydride owing to the ring‐cleavage reaction induced by the generated methanol. The ring‐cleavage by‐products were isolated and characterized by 1H‐NMR and 13C‐NMR. In addition, in the study of laquinimod derivatives, we found that 5‐chloro‐1,2‐dihydro‐N‐ethyl‐4‐hydroxy‐1‐methyl‐2‐oxo‐N‐phenyl‐3‐quinoline carboxamide (laquinimod) was obtained in much higher yield than 7‐chloro‐1,2‐dihydro‐N‐ethyl‐4‐hydroxy‐1‐methyl‐2‐oxo‐N‐phenyl‐3‐quinoline carboxamide under the same reaction conditions, and it is possibly attributed to a neighboring group effect. 相似文献
12.
13.
超声波辐射可有效地促进溴仿和镁产生二溴卡宾的反应.当n(溴仿)/n(镁)/n(烯烃)=2/1/1时,以无水乙醚反应可在15~25min内以较高的产率反应生成偕二溴环丙烷衍生物.该方法具有反应速度快、产率高等优点,是一种产生二溴卡宾的新的实用方法.探讨了溴仿与镁的单电子转移(SET)和自由基链循环的反应机理. 相似文献
14.
Summary. The environment-friendly one-pot three-component condensation reactions of 4-hydroxycoumarin or 4-hydroxy-6-methylpyrone, p-substituted benzaldehyde, and alkyl or aryl isocyanides to afford furocoumarines or furopyranones in water in good yields after about one hour at 75°C are reported. 相似文献
15.
Ahmad Shaabani Mohammad Bagher Teimouri Hamid Reza Bijanzadeh 《Monatshefte für Chemie / Chemical Monthly》2004,9(2):589-593
The environment-friendly one-pot three-component condensation reactions of 4-hydroxycoumarin or 4-hydroxy-6-methylpyrone, p-substituted benzaldehyde, and alkyl or aryl isocyanides to afford furocoumarines or furopyranones in water in good yields after about one hour at 75°C are reported. 相似文献
16.
In 1975, we have described the first synthesis of the aryloxysulfonyl azides (aryl azidosulfates),1 the interest of which is confirmed to be varied, especially about the elaboration of molecules such that sulfamates2 (Ar-O-SO2-NH2), not easily accessible by other methods and endowed with very important biological properties.3–5 Their cycloaddition on bicyclic olefinic systems gives a new family of N-substituted aziridines, the N-aryloxy-3-aza-tricyclo[3,2,1,02,4 exo]octanes.6 They react with trivalent phosphorus compounds to afford some very interesting phosphine-imides.7 相似文献
17.
Chun GUO Xiao Dan LIU Zhen Gang XIE Chu Jun LI 《中国化学快报》2006,17(2):180-182
Ozagrel 1 is a 1-alkylimidazole derivative that acts as a selective inhibitor ofthromboxane A2 (TXA2) with an IC50 of 11mol/L. The beneficial effects of TXA2inhibition by ozagrel include improved motor coordination after experimental stroke, andantihypert… 相似文献
18.
尿素催化的高效绿色Knoevenagel缩合反应 总被引:4,自引:0,他引:4
An efficient and green procedure for the urea catalyzed Knoevenagel condensation was developed. In the presence of a catalytic ammount of urea, stoichiometric aldehyde and active methylene compound reacted under sol-vent-free conditions at 100℃ for 5-60 min to give nearly quantitative yield of product. 相似文献
19.
Chun Mei LI Zhi Li MIAO Lei SHI Qi SUN Yu Hong HE 《中国化学快报》2006,17(12):1540-1542
N-Phenylpyrrolidine is an important N-heterocycle compound used in the fields of medicine, the material chemistry and the synthesis of fine chemicals1-3. There are a lot of methods to produce N-phenylpyrrolidine4-6. However, One of the most promising rout… 相似文献
20.
1-Arylalkynes are prepared from propiophenones in good yield via the sequence a) 2 equiv PCl5/Δ b) DBN or Δ and c) Mg metal. 相似文献