Simple Three-Component Synthesis of 4-Acyl-1-(2-aminoethyl)-5-aryl-3-hydroxy-2,5-dihydropyrrol-2(1H)-ones

Russian Journal of General Chemistry -     

Synthesis of 3-S-hetaryl-substituted pyridin-2(1H)-ones and 5,6-dihydropyridin-2(1H)-ones*

A method has been developed for the synthesis of 3-S-hetaryl-substituted pyridin-2(1H)-ones and 5,6-dihydropyridin-2(1H)-ones based on the base catalyzed cyclization of N-(3-oxoalkyl)- and N-(3-oxoalkenyl)amides which contain a divalent sulfur atom in an α-position to a carbamoyl group and bound to the heterocycle.     

Synthesis of 4-Acyl-5-aryl-3-hydroxy-1-(3-picolyl)-3-pyrroline-2-ones

Russian Journal of General Chemistry - Reaction of methyl esters of acylpyruvic acids with a mixture of aromatic aldehyde and 3-picolylamine gave...     

Synthesis of (hetero)arylated pyridazin-3(2H)-ones via Negishi reaction involving zincated pyridazin-3(2H)-ones

Zincated pyridazin-3(2H)-ones generated via bromine-magnesium exchange followed by transmetalation using ZnCl(2) or via lactam-directed ortho C4-H zincation with TMPZnCl·LiCl have been synthesized. These in situ created organometallics can be used in Negishi reactions with iodo(hetero)arenes delivering a new approach toward (hetero)arylpyridazin-3(2H)-ones.     

Synthesis of 5-Formyl and 5-Acyl-1,2-dithiole-3-ones

The preparation of new 5-formyl-, 5-acetyl- and 5-propionyl-1,2-dithiole-3-ones by oxidation of the corresponding 1,2-dithiole-3-thiones with mercuric acetate is described.     

Synthesis of 2-Phosphono Alkyl 1,2-Benzisoselenazol-3(2H)-ones

A series of 2-phosphonoalkyl 1,2-benzisoselenazol-3(2H)-ones were designed and synthesized via reaction 2-chloroselenobenzoyl chloride with 1-hydrazinobenzyl phosphonate. The structures of all new compounds were confirmed by spectroscopic methods and microanalyses.     

Cyclocondensation of 3-acetylfuran-2(5H)-ones with benzylidenemalononitrile. Synthesis of 3-(5-amino-4,6-dicyanobiphenyl-3-yl)furan-2(5H)-ones

Russian Journal of Organic Chemistry -     

Synthesis of 5,6-dimethoxyquinazolin-2(1H)-ones

Synthesis of 5,6-dimethoxyquinazolin-2(1H)-one derivatives was the subject of investigations leading to the preparation of title compounds 11, 13, 14 and 26 . Target quinazolines 1 were synthesized in three ways; the route starting from o-vanillin via the intermediacy of 6-amino-2,3-dimethoxyacetophenone ( 19 ) was used for most of the preparative work. The unexpected formation of an acid-labile dimer of 13 was discovered and solid state ¹³C nmr was used for structural assignment. The 5-methoxy substituent in these systems shows anomalous spectral characteristics and, in one case, was cleaved in acid media to 22 .     

三唑席夫碱苯并吡喃酮衍生物的合成及其抗病毒活性

设计并合成了6个未见文献报道的三唑席夫碱苯并吡喃酮类化合物,其结构经1H NMR,IR和元素分析表征。初步生物活性测试结果表明,用量为500 mg·L-1时,部分化合物对黄瓜花叶病毒有一定的抑制作用。     

A Short Synthesis of 4- and 6-Azaindol-2(3H)-ones

Although indol-2(3H)-ones possess a wide range of pharmacological¹ and microbiological² activities, the corresponding azaindol-2(3H)-ones have stimulated little interest. Successful syntheses have been reported for the title compounds^3,4 involving several stages which in our hands gave a variety of side products, especially in the hydrogenation stage.     

Synthesis of 3-nitropyrid-2(1H)-ones fromC-nitroacetamide and 1,3-dicarbonyl compounds

The reaction of nitroacetamide with 1,3-dicarbonyl compounds afforded 3-nitropyrid-2(1H)-ones. The chemical reactivities of nitroacetamide and nitroacetohydrazide were compared.     

Synthesis and Luminescent Properties of 3-Acyl-6,8,8,9-tetramethyl-2H-pyrano[3,2-g]hydroquinolin-2-ones

Russian Journal of General Chemistry - A series of 3-R-6,8,8,9-tetramethyl-2H-pyrano[3,2-g]quinolin-2-ones was obtained by condensation of...     

Novel One-Pot Synthesis for 2,5-Diaryl and 5-Aryl-pyridazin-3(2H)-ones

A novel method for the synthesis of 2-phenyl-5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones and 5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones has been found during the reaction of 4-bromomethylcoumarins with phenylhydrazine and hydrazinehydrate, respectively, under controlled alkaline conditions.

Reaction of 2-(2-oxoethylidene)furan-3(2H)-ones with isopropylidenehydrazides of aromatic carboxylic acids: Synthesis of 3-hydroxy-3-(2-oxoethyl)-2,3-dihydropyridazin-4(1H)-ones

3-Hydroxy-3-(2-oxoethyl)-6-phenyl-2,3-dihydropyridazin-4(1H)-ones were obtained by the reaction of methyl 3-oxo-5-phenylfuran-2(3H)-ylideneacetate or 2-[2-(4-chlorophenyl)-2-oxoethylidene]-5-phenylfuran-3(2H)-one with benzoic or p-nitrobenzoic isopropylidenehydrazides. Equilibrium C₍₅₎H and C₍₅₎H₂ tautomeric forms were detected in solutions of the 4-chlorophenyl derivatives in DMSO-d₆. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1156–1158, August, 2007.