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Polysubstituted cyclopropane derivatives (3a-3h) could be obtained by reaction of activate olefinic compounds (2) with the cyanophosphates (1) aldehydes (benzaldehyde, cinnamaldehyde and croton-aldehyde) in the presence of butyllithium and tetra-methylethylenediamine in tetrahydrofuran via a Michael addition followed by 1,3-elimination. 相似文献
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The Michael addition of α-chloro esters to α,β-unsaturated systems was catalyzed by phase transfer catalyst, and the some polysubstituted cyclopropanes were facilly synthesized. 相似文献
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ZHAO Pan LU Cui-fen YANG Gui-chun CHEN Zu-xing DONG Nian-guo SHI Jia-wei 《高等学校化学研究》2011,27(6):984-987
Polysubstituted cyclopropanes were efficiently prepared with poly(ethylene glycol)(PEG) as soluble support. The reaction of PEG-supported pyridinium ylide with arylidenemalononitrile(R=CN) or ethyl arylidenecyanoacetate(R=COOEt) in the presence of triethylamine(TEA) afforded PEG-supported cyclopropanecarboxylates, which were cleaved by 1% KCN/EtOH to obtain polysubstituted cyclopropanes with exclusive trans-selectivity and good yields. 相似文献
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Min Wen William Erb Florence Mongin Yury S. Halauko Oleg A. Ivashkevich Vadim E. Matulis Thierry Roisnel 《Molecules (Basel, Switzerland)》2022,27(6)
The purpose of the study is to design synthetic methodologies, especially directed deprotometalation using polar organometallic reagents, to access polysubstituted ferrocenesulfoxides. From enantiopure 2-substituted (SiMe3, PPh2) S-tert-butylferrocenesulfoxides, a third substituent was first introduced at the 5 position (SiMe3, I, D, C(OH)Ph2, Me, PPh2, CH2NMe2, F) and removal of the trimethylsilyl group then afforded 2-substituted ferrocenesulfoxides unreachable otherwise. Attempts to apply the “halogen dance” reaction to the ferrocenesulfoxide series led to unexpected results although rationalized in light of calculated pKa values. Further functionalizations were also possible. Thus, new enantiopure, planar chiral di- and trisubstituted ferrocenes have been obtained, in addition to several original 2-substituted, 2,3- and 2,5-disubstituted, 2,3,5-trisubstituted and even 2,3,4,5-tetrasubstituted ferrocenesulfoxides, also enantiopure. 相似文献
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G. N. Sakhabutdinova G. Z. Raskil’dina S. S. Zlotskii R. M. Sultanova 《Doklady Chemistry》2018,482(2):233-236
It has been revealed that the copper(II) triflate catalyzed reaction of ethyl-2-diazo-3-oxobutanoate with phenols followed by cyclization of the intermediate enol in the presence of polyphosphoric acid is a simple and efficient method of synthesis of polysubstituted benzofurans. The use of pyrocatechol leads to the corresponding substituted 1,4-benzodioxine-2-carboxylates as major products. 相似文献
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A regioselective synthesis of deuterated aliphatic cyclopropanes has been developed to furnish labeled substrates for gas-phase ion-molecule reaction studies. 相似文献
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2′-Benzoxazolyl substituted cyclopropane derivatives were synthesized in the yield of 73-89% from the reaction of telluronium ylides with chalcones. 相似文献
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Chechina Nataliia V. Kolos Nadezhda N. Omelchenko Irina V. 《Chemistry of Heterocyclic Compounds》2019,55(12):1190-1196
Chemistry of Heterocyclic Compounds - A series of novel fused pyrrole derivatives was synthesized by one-pot three-component reaction of β-enaminoketones, derived from cyclohexane-1,3-dione or... 相似文献
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开发了一种以吲哚为起始原料,合成具有多个反应位点的多取代3-烯基吲哚的新方法,合成了9个目标化合物,其中8个为新化合物,其结构经1H NMR, 13C NMR和HR-MS(ESI)表征。 相似文献
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V. Pavlov V. Gazizova G. Shamov V. Moskva H. Winsel A. De Meijere 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1)
Abstract The report presents the study of cycloaddition reactions of phosphorylnitrile xides to dipolarophils of cyclopropene senes and development of a new methods for synthesis of cyclopropanols and cyclopropylamines bearing phospharyl moiety. 相似文献
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《Journal of heterocyclic chemistry》2017,54(1):301-304
An efficient and novel approach to the synthesis of dialkyl 1‐nitroindolizine‐2,3‐dicarboxylates has been described. A one‐pot reaction between a pyridine, dialkyl acetylendicarboxylate, and bromonitromethane leads to dialkyl 1‐nitroindolizine‐2,3‐dicarboxylates in good yields. 相似文献
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S. Z. Vatsadze Yu. V. Krainova M. A. Kovalkina N. V. Zyk 《Chemistry of Heterocyclic Compounds》2000,36(10):1185-1191
A series of tri- and tetrasubstituted 4-piperidones and their bicyclic analogs has been synthesized. It was established by 1H NMR spectroscopy that all the piperidones obtained have the chair conformation in solution with equatorially disposed substituents. 相似文献
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具有环丙烷结构的化合物是一种重要的生物代谢中间体,广泛存在于许多植物霉菌和细菌等微生物体内。三元环是一种具有很好生物活性的结构单元。三元环的反应活性不仅因为它具有类似于链状双键的化学性质,同时还具有易重排的特点,例如,由三元碳环到四元碳环、五元碳环和七元碳环的扩环反应及四元碳环到三元碳环的环收缩反应,据文献报道,给体-受体同碳取代的三元环和多取代的三元环也是一种重要的合成单元。 相似文献
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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(43):13504-13508
The first catalytic asymmetric synthesis of highly functionalized difluoromethylated cyclopropanes is described. The method, based on a rhodium‐catalyzed cyclopropanation of difluoromethylated olefins, gives access to a broad range of cyclopropanes bearing ester, ketone, or nitro functional groups. By using Rh2((S )‐BTPCP)4 as a catalyst, the corresponding products were obtained in high yields and high diastereo‐ and enantioselectivities (up 20:1 d.r. and 99 % ee ). This methodology allowed preparation of enantioenriched difluoromethylcyclopropanes for the first time. 相似文献
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以4,6-二甲基-2-甲氧基-1,3-苯二甲酸二乙酯为原料,经Micheal加成、环化、溴化、消除等5步反应,合成新型的多取代2,7-萘二甲酸二乙酯.该合成路线步骤少,收率高,反应条件温和.产物中的4个新化合物的结构均经元素分析、核磁共振、红外光谱和质谱确证. 相似文献