共查询到20条相似文献,搜索用时 15 毫秒
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Back Cover: Cofactor‐Free Light‐Driven Whole‐Cell Cytochrome P450 Catalysis (Angew. Chem. Int. Ed. 3/2015) 下载免费PDF全文
Jong Hyun Park Dr. Sahng Ha Lee Gun Su Cha Da Som Choi Dong Heon Nam Jae Hyung Lee Prof. Dr. Jung‐Kul Lee Prof. Dr. Chul‐Ho Yun Prof. Dr. Ki Jun Jeong Prof. Dr. Chan Beum Park 《Angewandte Chemie (International ed. in English)》2015,54(3):1042-1042
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碳氢键选择氧化是合成化学领域的重要课题,其中烷烃选择性羟化反应更是面临着化学选择性、区域选择性和立体选择性等多重挑战.细胞色素P450酶广泛分布于动植物和微生物体内,是公认的多功能生物氧化催化剂. P450酶对惰性C—H键的选择性氧化具有独特优势,在催化烷烃选择性羟化反应方面拥有巨大潜力.本综述简述了P450单加氧酶及其催化烷烃选择性羟化的反应机理,梳理了来自CYP153家族、CYP52家族和其他家族的天然P450酶催化各类烷烃底物的氧化反应和选择性,讨论了理性设计和定向进化策略在开发烷烃羟化P450突变酶过程中的经典案例,介绍了底物工程、诱饵分子、双功能小分子协同催化等几种化学活化P450酶的策略及其在烷烃羟化上的应用,探讨了P450酶在烷烃选择性羟化方面所面临的挑战和解决途径,并展望了其应用前景. 相似文献
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Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis‐β‐Methylstyrenes 下载免费PDF全文
Dr. Chun Zhang Ping‐Xian Liu Lu‐Yi Huang Dr. Si‐Ping Wei Dr. Li Wang Prof. Sheng‐Yong Yang Prof. Xiao‐Qi Yu Prof. Lin Pu Prof. Qin Wang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(31):10969-10975
P450 119 peroxygenase and its site‐directed mutants are discovered to catalyze the enantioselective epoxidation of methyl‐substituted styrenes. Two new site‐directed P450 119 mutants, namely T213Y and T213M, which were designed to improve the enantioselectivity and activity for the epoxidation of styrene and its methyl substituted derivatives, were studied. The T213M mutant is found to be the first engineered P450 peroxygenase that shows highly enantioselective epoxidation of cis‐β‐methylstyrenes, with up to 91 % ee. Molecular modeling studies provide insights into the different catalytic activity of the T213M mutant and the T213Y mutant in the epoxidation of cis‐β‐methylstyrene. The results of the calculations also contribute to a better understanding of the substrate specificity and configuration control for the regio‐ and stereoselective peroxygenation catalyzed by the T213M mutant. 相似文献
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Inside Cover: Esterase‐Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide (Angew. Chem. Int. Ed. 14/2016) 下载免费PDF全文
Yueqin Zheng Bingchen Yu Dr. Kaili Ji Zhixiang Pan Vayou Chittavong Prof. Binghe Wang 《Angewandte Chemie (International ed. in English)》2016,55(14):4370-4370
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