Indole derivatives CXVI. Preparation and some properties of 3-aminoindoles

Reactions in which 3-aminoindole displays the properties of 3-imino-2H-indole were carried out. Condensation of aromatic amines (in the case of 3-aminoindole, p-toluidine, and p-nitrophenylamine) and of pyridoxamine with 1-acetylindoxyl is proposed as a convenient method for the preparation of secondary amines of the indole series.See [1] for communication CXV.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 939–943, July, 1978.     

Preparation of trimethylsilyl derivatives of amino acids and peptides for peptide synthesis

Russian Chemical Bulletin -     

Preparation and properties of some derivatives of perfluoropropyl vinyl ether

Conclusions It has been shown that it is possible to synthesize phenoxy derivatives of perfluoroalkyl ethers from perfluoropropyl vinyl ether. Some reactions of the products have been studied.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2319–2321, October, 1984.     

Preparation and properties of pure lithio esters of some carboxylic acids

Lithio esters of carboxylic acids have been prepared in pure state and their properties are described. Interaction between the lithio esters with alkali metals alkoxides has been demonstrated, and some adducts have been isolated. The IR and UV spectra of these compounds are described, and their structures are discussed.     

Isopropenyldihydrofuran derivatives. Preparation and reactions of some isopropenyldihydrofurandicarboxylates

Diethyl 5-isopropenyl-4,5-dihydrofuran-2,3-dicarboxylate 1a and methyl 5-isopropenyl-3-methoxy-carbonyl-4,5-dihydrofuran-2-acetate 2a were prepared by cylization of diethyl 2-oxosuccinate or dimethyl 3-oxoglutarate with (E)-1,4-dibromo-2-methyl-2-butene. Their chemical properties were studied.     

Studies in the quinoxaline series. 17. Preparation and properties of some derivatives of 2-sulfonylmethylquinoxaline

Ketimines of 2-methylthiomethyl- and 2-methylsulfonylmethyl-3-oxodihydroquinoxaline have been prepared with the object of studying their tautomeric forms. The enaminoester of 1,3-bis(ethoxycarbonyl)-4,9-dihydrothienol[3,4-b]-quinoxaline-2,2-dioxide is very stable: it does not eliminate sulfur dioxide on boiling in diphenyl ether, under UV irradiation, or under electron bombardment. Reductive decomposition does not lead to the expected dienaminoester.For communication 16, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 352–355, March, 1987.     

Preparation of hydrazides of amino acids and peptides

A new method of synthesizing hydrazides of amino acids and peptides is considered which involves the hydrazinolysis of the silyl esters of the corresponding compounds. A number of hydrazides of derivatives of amino acids and peptides has been obtained in high purity with yields close to quantitative. The physicochemical characteristics of the compounds synthesized are given.All-Union Scientific-Research Institute of the Technology of Blood Substitutes and Hormones Preparations, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 684–686, September–October, 1979.     

Preparation of hydrazides of amino acids and peptides

A new method of synthesizing hydrazides of amino acids and peptides is considered which involves the hydrazinolysis of the silyl esters of the corresponding compounds. A number of hydrazides of derivatives of amino acids and peptides has been obtained in high purity with yields close to quantitative. The physicochemical characteristics of the compounds synthesized are given.     

Organoboron compounds. Communication 118. Ethanediboronic acids and some of their derivatives

Summary In the hydroboration of dibutyl ethyleneboronate with subsequent treatment with alcohols 1,2- and 1, 1-ethanediboronic esters are formed in relative amounts of 1 1.3–1.75. From these esters the corresponding acids and the products of their condensation with o-phenylenediamine were prepared.     

Amino acids and peptides. XXVII. Synthesis of phytochelatin-related peptides and examination of their heavy metal-binding properties

Phytochelatin (PC)-related peptides were prepared by a conventional solution method and their heavy metal-binding properties were examined. Different from the Cu2+ and Cu+ -binding properties of metallothionein (MT)-related peptides, the Cu2+ and Cu+ -binding properties of PC-related peptides were fairly dependent on structure. It is of interest that gamma-Glu-Cys-Gly (glutathione) exhibited quite different Cu2+ and Cu+ -binding properties from those of other PC-related peptides and its binding abilities were comparable to those of MT-related peptides. The Cd2+ -binding properties of glutathione were similar to those of Cys, and the Cd2+ -binding abilities of PC-related peptides increased in proportion to the increase of gamma-Glu-Cys peptide unit.