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《Journal of heterocyclic chemistry》2018,55(8):1917-1925
Ten new isoxazoline derivatives were synthesized from the reactions of benzonorbornadiene and homonorbornadiene derivatives with nitrile oxides formed from benzaldehyde and 4‐substituted benzaldehyde. Two new pyridazine derivatives were also synthesized from the reaction of the homonorbornadiene derivatives with 3,6‐di (2‐pyridyl)‐s‐tetrazine. It was seen that all cycloaddition reactions were realized as exo selectivity. Finally, γ‐Gauche effect in the isoxazoline derivatives was discussed. 相似文献
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通过糖单元6-位羟基的保护和去保护,运用区域选择性方法合成了6种新型多糖类氨基甲酸酯衍生物,分别为纤维素/直链淀粉-[2,3-二(3,5-二甲基苯基)-6-环己基]氨基甲酸酯、[2,3-二(3,5-二氯苯基)-6-环己基]氨基甲酸酯及[2,3-二(4-氯苯基)-6-环己基]氨基甲酸酯,并将其涂敷在氨丙基硅胶的表面制备HPLC手性固定相.利用1H-NMR与FTIR光谱技术对所合成衍生物进行结构表征和分析,并应用HPLC法评价其对于9种手性化合物的手性识别能力.通过与以手性识别能力高而著称且含有单一取代基的纤维素/直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)等手性固定相的对比分析表明,所合成新型手性固定相对于某些对映体显示出更优的手性识别能力.由进一步分析表明,糖单元2-、3-和6-位取代基的性能对于纤维素和直链淀粉氨基甲酸酯类衍生物的手性识别能力均具有较大影响. 相似文献
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A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1H-, 13C-, 1?F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified trifluoromethyl-substituted derivatives to be the best lead compounds for new antimalarial drug development. 相似文献
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利用相转移催化剂十六烷基三甲基溴化铵(CTMAB)催化的连二亚硫酸钠引发的苯酚衍生物与含氟碘代烷的氟烷基化反应, 合成了含氟烷基取代的酚类化合物. 研究了双酚A与含氟碘代烷的氟烷基化反应, 得到了一类重要的含氟单体, 即含氟烷基取代的双酚A衍生物. 通过改变含氟碘代烷与双酚A的摩尔比, 可以得到单取代、二取代和四取代的含氟烷基双酚A衍生物. 相似文献
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用手性的丙烯酸薄荷醇酯与原位生成的1,3-偶极试剂发生Diels-Alder反应, 得到一系列新的手性2,4-二酯基四氢吡咯衍生物,经氢化铝锂还原得到纯的手性 2,4-二羟甲基吡咯衍生物。并首次发现,在用Oxone氧化烯时,2,4-二羟甲基四 氢吡咯衍生物能有效地诱导烯烃发生环氧化反应,转化率达到定量。 相似文献
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Yoshihiro Ohba Yasuo Murakami Tyo Sone Hiroshi Awano 《Journal of heterocyclic chemistry》1997,34(3):781-787
A series of new type of benzo[b]thiophene-fused 1,4-benzoquinones and their tetracyanoquinodimethane derivatives were synthesized. The cyclic voltammetric data of new type quinones and tetracyanoquinodimethane derivatives displayed different behavior. All new quinones exhibit two reduction waves corresponding to the radical anion and dianion. On the other hand, most tetracyanoquinodimethane derivatives display a singlewave reduction to the dianion. The benzo[b]thiophene moiety fused tetracyanoquinodimethane derivatives reveal more negative reduction potentials than that of tetracyanoquinodimethane. 相似文献
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大黄素衍生物的合成及细胞毒性研究 总被引:7,自引:0,他引:7
以天然大黄素为母体, 经化学修饰得到一系列新的含氮衍生物6~14. 通过1H NMR, IR, MS和元素分析确定了结构. 选择口腔底癌(KB)和乳腺癌(MFC-7)两种人癌细胞株, 采用标准MTT法测定了这类大黄素衍生物的细胞毒性. 研究表明大多数衍生物都有较强的抗癌活性, 其中位置异构体7a和7b的混合物表现出最强的活性, 与母体大黄素相比较, 活性分别提高了174倍(KB)和133倍(MFC-7). 相似文献
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Gui-Rong C Li-Ping C De-Qiang D Ting-Guo K Hong-Fu L Fu-Rui L Ning J 《Natural product research》2012,26(2):177-181
The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin, which was prepared from fructus arctii, showed obvious anticancer activity. The synthesis of four new (-)-arctigenin derivatives and their anticancer bioactivities were examined. The structures of the four new synthetic derivatives were elucidated. 相似文献
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《Journal of heterocyclic chemistry》2018,55(9):2123-2129
Two new series of pyrazoles and bipyrazoles were synthesized, and their structures were elucidated according to all data results from spectral and elemental analyses. The pathway of the formation of the new bipyrazole derivatives was discussed. Further, all the synthesized derivatives were screened for their antitumor activity on human lung (A‐549) and hepatocellular cancer (HepG‐2) cell lines. The results of antitumor screening have exhibited that several derivatives are more potent than the reference drug. 相似文献
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Y Nagao S Sano M Ochiai K Fuji S Nishimoto T Kagiya C Murayama T Mori Y Shibamoto K Sasai 《Chemical & pharmaceutical bulletin》1989,37(7):1951-1953
The new regioisomer derivatives 4a-f and 5a-f of 3-nitro-1,2,4-triazole (3-NTR) were synthesized for the development of new radiosensitizers of hypoxic cancer cells for radiotherapy. N(2)-Substituted 3-NTR derivatives 5a-f were stronger radiosensitizers of hypoxic cells in vitro (Chinese hamster V79 cells) than N(1)-substituted 3-NTR derivatives 4a-f, but in vivo they were weaker (SCCVII carcinoma cells inoculated into C3H/He mouse). 相似文献
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Rahman AU Choudhary MI Alam MN Ndognii PO Badarchiin T Purevsuren G 《Chemical & pharmaceutical bulletin》2000,48(5):738-739
Two new benzoquinone derivatives, bungeiquinone (1) and dihydrobungeiquinone (2), and two known derivatives, 3-hydroxyirisquinone (3) and 3-hydroxydihydroirisquinone (4), were isolated from the roots of Iris bungei. The structures of the new compounds were established on the basis of spectroscopic methods. 相似文献
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Some hymecromone derivatives containing chiral 1,1'-bi-2-naphthyl moiety were synthesized and their photodimerizations were investigated. It was found that fluorescence intensity and optical rotation of the new chiral hymecromone derivatives could be regulated by light. This property has potential significance for developing a new type of dual-mode molecular switch. 相似文献
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Nagy M. Khalifa Mostafa M. Ramla Abd El-Galil E. Amr Mohamed M. Abdulla 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):3046-3062
A series of some new acetylated S-glycosides of pyridine-2-thione derivatives, including D-glucose, D-galactose, D-xylose and L-arabinose derivatives were synthesized. Oxidation of some formed S-glycosides derivatives with H2O2 afforded the corresponding sulfones. S-Alkylation of pyridine-2-thione derivatives was performed to furnish the S-acyclo deazauridine derivatives. The entire tested compound showed potent anti-inflammatory activity were potent against edema and in the same time inhibited the prostaglandine formation. It is work mention that all the tested compounds showed high safety margin. The structures of the new synthesized compounds have been proved by IR, 1 HNMR, mass spectra and elemental analysis. 相似文献
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合成了16种2,2-二苯并(口恶)唑衍生物,测定了化合物的熔点、红外光谱、紫外吸收光谱、荧光发射光谱以及荧光量子产率,与1,4-二(苯并(口恶)唑1′,3′-基-2′)苯和1,4-二(苯并(口恶)唑-1′,3′-基-2′)乙烯衍生物进行了比较,讨论了它们之间光谱特性的差异. 相似文献
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Goreti Pereira Elisabete M.S. Castanheira Peter Schellenberg M. Belsley Paula M.T. Ferreira Luís S. Monteiro 《Tetrahedron》2013
Two new pyrenylamino acid derivatives were synthesized from β-bromodehydroalanine derivatives in good yields using addition and elimination reactions. 相似文献
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Suyou Liu Xuhong Qian Jing Chen Gonghua Song 《Monatshefte für Chemie / Chemical Monthly》2000,415(2):953-957
Thiatetraazaindenone derivatives were synthesized by reaction of 3-substituted 1,2,4-triazole-5-thiols with N-substituted N-chloromethyl carbamoyl chlorides. A series of thiatriazafluorenone derivatives were also prepared by reaction of benzimidazole derivatives with the same substrate. Some of the new compounds show fungicidal, herbicidal, and insecticidal activity. 相似文献