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通过紫外光谱、荧光光谱、zeta电位、电导率、高效液相色谱和影像分析等方法研究了Triton X-100对血红蛋白/利巴韦林/H2O体系中血红蛋白性质和药物控制释放的影响. 研究结果表明, 随着Triton X-100浓度的增大, 荧光强度、荧光偏振、zeta电位和蛋白的形貌均发生较大的变化, Triton X-100能使增溶定位在蛋白表面中的利巴韦林逐渐游离出来. 当Triton X-100浓度大于1×10-5 mol·L-1 时, Triton X-100 与血红蛋白的作用占主导地位, 血红蛋白开始明显变性. 少量Triton X-100能保护蛋白免受药物的影响. 相似文献
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Semidifferential electroanalysis is used as an effective method for investigating microstructure and structural transition of Triton X-100 microemulsions. 相似文献
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QIANJun-hong GUORong ZHUJun 《高等学校化学研究》2004,20(6):785-789
The hydrolysis of cephanone in Triton X-100 micelle and Triton X-100/n-C5H11OH/H2O(O/W) microemulsion were studied by means of UV-Vis absorption spectroscopy. The results show that compared with water, Triton X-100 micelle and Triton X-100/n-C5H11OH/H2O (O/W) microemulsion can inhibit the hydrolysis of cephanone. The inhibition effects of Triton X-100 micelle and Triton X-100/n-C5H11OH/H2O (O/W) microemulsion on the hydrolysis of cephanone are related to the location of cephanone in the interphases of Triton X-100 miceUes and Triton X-100/n-C5H11OH/H2O(O/W) microemulsion droplets. 相似文献
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Effects of Triton X-100 on the properties of hemoglobin (Hb) and on the controlled release of ribavirin were studied using the methods of UV-Vis spectrum, fluorescence spectrum, zeta potential, conductivity, high-performance liquid chromatographic (HPLC), and image morphology in Hb/ribavirin/H2O system. With the increase of concentration of Triton X-100 in the system, the intrinsic fluorescence intensity, synchronous fluorescence intensity, fluorescence polarization, zeta potential, and morphology of Hb all changed gradually, and the ribavirin located on the Hb surface was dissociated and released out. When the concentration of Triton X-100 was higher than 1×10−5 mol·L−1, the stronger interaction of Triton X-100 with Hb was predominant. Hb was unfolded and denaturized. A little Triton X-100 can protect Hb from the effects of ribavirin. 相似文献
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The effects of Triton X-100 molecule and micelle on the microstructure and properties of HSA are studied by the some methods of UV spectrum, fluorescence spectrum, fluorescence polarization, circular dichroism, conductivity, and zeta potential. With the increase of Triton X-100 concentration, the UV absorbance, fluorescence intensity of HSA, and the system conductivity all first decrease and then increase. The zeta potential of HSA first goes up and then down. The percents of the β-sheet, random, turn structures, and the polarization of HSA increase but the percent of the α-Helix of HSA decreases. When Triton X-100 concentration is more than 1.0×10−3 mol l−1, the structure parameters change obviously especially for the percents of random and turn structures. 相似文献
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AOT/Triton X-100混合反胶束体系中假丝酵母脂肪酶催化蓖麻油水解的活性 总被引:2,自引:0,他引:2
研究了二(2-乙基己基)琥珀酸磺酸钠(AOT)/Triton X-100混合反胶束体系中假丝酵母脂肪酶(candida rugosa lipase)催化蓖麻油水解的反应. 考察了Triton X-100占总表面活性剂的摩尔分数(x(Triton X-100))、水与总体表面活性剂的摩尔比(ω0)、pH值、反应温度以及底物蓖麻油的浓度等因素对酶活性的影响. 研究结果表明, 加入非离子表面活性剂Triton X-100可以使假丝酵母脂肪酶的活性得到显著提高, 但是当底物蓖麻油的浓度大于0.24 mol·L-1时, 会对假丝酵母脂肪酶产生抑制作用. 相似文献
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TritonX-100-5-Br-PADAP光度法测定发样中铁 总被引:2,自引:0,他引:2
在表面活性剂Triton X-100存在下,以5-Br-PADAP作显色剂,光度法测定发样中铁,结果在所选浓度范围内线性关系良好,稳定时间长,回收率平均为98.14%。 相似文献
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G. Geeraerts P. Joos 《Colloids and surfaces. A, Physicochemical and engineering aspects》1994,90(2-3):149-154
Considering surfactant solutions at concentrations exceeding the CMC, another relaxation process besides diffusion occurs, also affecting the dynamic surface tension. The latter equilibration process concerns a micellisation/demicellisation process, representing the disintegration of micelles into monomers. The micellisation kinetics are accounted for by adding a single source term to the diffusion equation of the free monomers.
In the present paper the integration of the diffusion equation is avoided by using the concept of the diffusion penetration depth. Nevertheless, when this approximation is made, good agreement is achieved between experiment and theory for micellar Triton X-100 solutions. Moreover, it follows that diffusion of micelles may not be neglected. 相似文献
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Triton X—100——n—C6H13OH/c—C6H12/H2O体系W/O微乳液的稳定条件 总被引:13,自引:1,他引:13
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表面活性剂在非水溶剂中聚集态的研究所见的报导与水体系相比要少得多.然而近年来对非水体系的研究日益增多.这是因为表面活性剂在非水溶剂中的应用日趋增加,但与水体系相反,对非水体系的性质了解甚少.对表面活性剂非水体系的研究还有助于对其聚集体的共溶剂效应有更深的认识.TritonX-100(以下简写为TX-100)是典型的非离子表面活性剂,在工业上有着广泛的应用.乙二醇在多醇中与水的化学结构最相近问,然而它却是水结构的破坏剂,加入少量的乙二醇会使水的冰点急剧下降.乙二醇又是蛋白质的变性溶剂.表面活性剂在乙二醇中的胶… 相似文献
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Triton X-100/C10H21OH/H2O体系微乳液与溶致液晶 总被引:1,自引:0,他引:1
关于离子型表面活性剂生成的微乳液与溶致液晶已有不少研究,非离子型表面活性剂生成的微乳液与港致液晶的应用正在引起人们的重视,但由于药物提纯的困难,对其物理化学性质的研究还不多见.本文以非离子表面活性剂TritonX-100/C10H21OH/H2O体系为例,研究了非离子型表面活性剂微乳液和溶致液晶的生成及其结构特性.1实验部分试剂ThitonX-100(Aldrich公司,分析纯)正癸醇(分析纯)、水为一次蒸馏水微乳液区域和层状液晶区域的确定方法及小角x射线衍射测定方法同文献,实验温度20±0.1℃.2结果与讨论2·IThtonX-100、CIOH… 相似文献
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Triton X-100增敏光度法测定铝土矿中的微量钪 总被引:1,自引:0,他引:1
研究了在HCl溶液中微量钪(Ⅲ)-偶氮氯膦Ⅲ(CPAⅢ)之间的配合反应。结果表明,在0.5mol/LHCl溶液中和TritonX 100的存在下,有色溶液的最大吸收波长为680nm,表观摩尔吸光系数为2.62×104L·mol-1·cm-1。钪(Ⅲ)质量浓度在0~0.45mg/L范围内符合比耳定律,钪(Ⅲ)的加标回收率在98.0%~105.1%之间,RSD(n=6)为2.1%~2.6%。可用于铝土矿中的微量钪的测定。 相似文献
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In this communication,we report four component condensations of acetophenone,arylaldehydes,arylthiol,and malononitrile in the presence of Triton X-100(5 mol%) aqueous micelles.This reaction led to the formation of 4,6-diaryl-2-(arylthio)nicotinonitrile new derivatives in good yields.The FT-IR,19F NMR,1H NMR,13C NMR spectra and elemental analysis confirm the structure of compounds. 相似文献