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1.
《Tetrahedron letters》1988,29(15):1799-1802
Pd(II) catalyzed reaction of N-carbomethoxy-2-alkynylanilines with allyl chlorides produces 2-alkyl-3-allyl-N-carbomethoxyindoles in the presence of oxirances; Aminopalladation of a N-carbomethoxy-2-alkynylaniline gives 3-(N-carbomethoxyindolyl)palladium intermediate, which regioselectively attacks on the γ position of chlorides to give 3-allyl-2-alkylindoles with concurrent regeneration of Pd(II) catalyst. 相似文献
2.
Shchepin V. V. Sazhneva Yu. Kh. Russkikh N. Yu. Vakhrin M. I. 《Russian Journal of General Chemistry》2003,73(5):760-764
Zinc enolates of 3-alkyl-6-aryl-5,5-dimethyl-2,3,5,6-tetrahydropyrane-2,4-diones react with acyl chlorides to form O-acylation products, 4-acyloxy-3-alkyl-6-aryl-5,5-dimethyl-5,6-dihydropyrane-2-ones. Sodium enolates of these pyranediones react in DMSO with substituted benzyl bromides to give mainly C-alkylation products, 3-alkyl-6-aryl-3-(4-R-benzyl)-5,5-dimethyl-2,3,5,6-tetrahydropyrane-2,4-diones, as single geometric isomers. In some cases, O-alkylation products, 4-alkoxy-3-alkyl-6-aryl-5,5-dimethyl-5,6-dihydropyrane-2-ones, are formed as by-products (10-15%). 相似文献
3.
Da Qiang Zhang Gao Fei Xu Zhi Jin Fan Dao Quan Wang Xin Ling Yang De Kai Yuan 《中国化学快报》2012,23(6):669-672
In order to investigate the biological activity of novel bis-pyrazole compounds,a series of N-(3-alkyl-5-(N-methylcarbamyl)- 1H-pyrazol-4-yl)-3-alkyl-4-substituted-1H-pyrazole-5-carboxamides were designed and synthesized with ethyl 3-alkyl-1H-pyrazole -5-carboxylate 1 as starting materials.N-Methyl-3-alkyl-4-amino-1H-pyrazole-5-carboxamides 6 were obtained from 1 via 5 steps.3-Alkyl-4-substitued-1H-pyrazole-5-carboxyl chlorides 4a,4b,11a,11b,11c or 12 were also obtained from 1 via several steps.Target compounds 7a-7g were obtained after the reaction of 6 with the above 1H-pyrazole-5-carboxyl chlorides.Preliminary bioassay showed some compounds possessing good inactivation effect against TMV(tobacco mosaic virus).Compound 7a showed higher activity superior to ningnanmycin at a concentration of 5.0×10-4 g/mL and equal activity at 1.0×10-4 g/mL;7b and 7c showed equal activity to virazole both at concentrations of 5.0×10-4 g/mL and 1.0×10-4 g/mL. 相似文献
4.
On the basis of our synthetic methodologies employing mesoionic synthons, the nucleophilic character of 2-alkyl-1,3-thiazolium-4-olates (2-alkylthioisomünchnones) has been envisaged and developed, at the expenses of their common role as masked 1,3-dipoles. Reactions with aliphatic acid chlorides lead to monoketones derived from thiazolidin-4-ones, whose structure can be rationalized in terms of orbital interactions by computational studies. Aromatic acid chlorides invariably produce 1,3-dicarbonyl compounds, yet maintaining the mesoionic core. Unlike [3+2]-cycloadditions reported previously for thioisomünchnones with isocyanates and isothiocyanates, these heterocumulenes react with 2-alkylthioisomünchnones affording conjugated amides or thioamides. 相似文献
5.
Elzbieta Radzyminska-Lenarcik 《Chemical Papers》2011,65(2):226-232
Extraction experiments are presented dealing with the partition of Cu(II) complexes of 1-alkyl-2-methylimidazoles, 1-alkyl-2-ethylimidazoles,
1-alkyl-2-propylimidazoles, 1-alkyl-2-butylimidazoles, and 1-alkyl-2-pentylimidazoles (where alkyl = ethyl, butyl, hexyl)
between water and an immiscible organic solvent (chloroform, methylene chloride, 2-ethylhexanol, isoamyl alcohol, benzyl alcohol,
methyl propyl ketone, and toluene). It has been shown that the partition ratios of Cu(II) complexes are dependent on the donor
number (DN) of the solvent and the partition ratios increase distinctly with their increase in DN. 相似文献
6.
A method was developed for the preparation of new liquid-crystalline substances, pyrazole derivatives, through the corresponding 2-isoxazolines and isoxazoles. The hydrogenolysis of the heterocycle in 3-(4-hydroxyphenyl)-5-amylisoxazole afforded 1-amino-1-(4-hydroxyphenyl)-1-octen-3-one. The acid hydrolysis of the compound followed by treating with hydrazine hydrate resulted in 5-amyl-3-(4-hydroxyphenyl)-1H-pyrazole, whose benzylation and esterification with the corresponding mesogenous benzyl chlorides and benzoyl chlorides provided liquid-crystalline 5-alkyl-3-aryl-1H-pyrazoles. 相似文献
7.
《Liquid crystals》2000,27(7):935-941
The synthesis and chemical transformations of various diketones into liquid crystalline compounds are discussed. The diketones were prepared by the interaction of cyclohexene with acid chlorides and benzene in the presence of aluminium chloride (Nenitzescu method) or by Friedel Crafts reaction of trans-4-alkanoyl-1-phenylcyclohexanes or trans-2-alkyl-5-phenylcyclohexanones with acid chlorides, or by the condensation of corresponding Mannich salts with 2-substituted acetoacetates or acetylacetone. 相似文献
8.
N. M. Tsizorik A. I. Vas’kevich E. B. Rusanov A. B. Rozhenko M. V. Vovk 《Russian Journal of Organic Chemistry》2014,50(10):1397-1408
2-(Cyclohex-2-en-1-yl)acetanilides react with arylsulfanyl chlorides in chloroform to give 2-(2-arylsulfanyl-3-chlorocyclohexyl)acetanilides which undergo isomerization into 2-chloro-3-arylsulfanylsubstituted derivatives in polar solvents. According to the results of quantum chemical calculations, the addition of arylsulfanyl chlorides to 2-(cyclohex-2-en-1-yl)acetanilides is characterized by negative Gibbs energy. Specific conformation of the isomerization products is stabilized by weak (non-covalent) interactions which make them more energetically favorable than the initial compounds. The reactions of 2-(cyclohex-2-en-1-yl)acetanilides with arylsulfanyl chlorides in nitromethane in the presence of lithium perchlorate lead to the formation of mixtures of the corresponding addition products and electrophilic intramolecular cyclization products, N-[7-(arylsulfanyl)octahydro-1-benzofuran-2-ylidene]anilinium perchlorates, which are converted into free bases by treatment with sodium ethoxide. 相似文献
9.
Aihua Zhou 《Tetrahedron letters》2005,46(22):3801-3805
2-Ethylthiazolines react with 2-halobenzoyl chlorides to form N-(2-halobenzoyl)-cyclic ketene-N,S-acetals, which undergo stereo-controlled radical cyclizations to afford (R,S,S)-3-alkyl-10-methyl-2,3,10,10a-tetrahydrothiazolo[3,2-b]isoquinolin-5-one and (R,R,S)-3-alkyl-10-methyl-2,3,10,10a-tetrahydrothiazolo[3,2-b]isoquinolin-5-one. 相似文献
10.
The synthesis and chemical transformations of various diketones into liquid crystalline compounds are discussed. The diketones were prepared by the interaction of cyclohexene with acid chlorides and benzene in the presence of aluminium chloride (Nenitzescu method) or by Friedel Crafts reaction of trans-4-alkanoyl-1-phenylcyclohexanes or trans-2-alkyl-5-phenylcyclohexanones with acid chlorides, or by the condensation of corresponding Mannich salts with 2-substituted acetoacetates or acetylacetone. 相似文献
11.
12.
Alkyl halides underwent unique cross-coupling reaction with vinylmagnesium chloride in the presence of Ni catalyst to give 2-alkyl-3-butenyl Grignard reagent (1) in high yields. This reaction proceeded efficiently at 25 degrees C in THF using primary and secondary alkyl fluorides. On the other hand, PhCH=CHMgBr gave double alkylative vinyl coupling product 4 in good yield as the sole coupling product. Alkyl fluorides react as the most suitable alkylating reagent in comparison to the corresponding chlorides, bromides, and iodides. 相似文献
13.
B. F. Kukharev V. K. Stankevich V. A. Lopyrev G. R. Klimenko B. N. Gutsalyuk V. A. Kukhareva 《Russian Journal of Applied Chemistry》2006,79(4):683-684
Aklylation of 1,1-dimethylhydrazine with higher alkyl chlorides was studied. The resulting 1-alkyl-1,1-dimethylhydrazinium chlorides were tested as modifiers of oil asphalt for preparation of asphalt concrete. 相似文献
14.
K. B. Abdireimov N. S. Mukhamedov M. Zh. Aiymbetov Kh. M. Shakhidoyatov 《Chemistry of Heterocyclic Compounds》2010,46(8):941-946
2-Alkylbenzimidazoles have been obtained from o-nitroaniline and aliphatic carboxylic acids by reductive cyclization. Interaction
of the former with arenesulfonyl chlorides led to the synthesis of 2-alkyl-1-arylsulfonylbenzimidazoles, the yield of which
depended on the structure of the substituent in position 2. 相似文献
15.
On the Structure of Two Isothiazolium Polyiodides (C19H16FeNS)I5 and (C15H12NS)2I8 By oxidation of 3‐phenylamino thiopropenones with iodine two isothiazolium polyiodides were obtained, whose structures have been determined by X‐ray structure analysis. 2‐Phenyl‐5‐ferrocenyl‐isothiazolium pentaiodide(C19H16FeNS)I5 forms a layer structure with isothiazolium cations and polyiodide anions. The polyiodide layers contain pentaiodide ions I5–, triiodide ions I3– and iodine molecules I2. Bis(2,5‐diphenyl‐isothiazolium) octaiodide (C15H12NS)2I8 also forms a layer structure with isothiazolium cations and polyiodide anions. The polyiodide layers are built up by octaiodide ions I82–, pentaiodide ions I5– and triiodide ions I3–. 相似文献
16.
2-Alkyl-3-(1-methyl-2-benzimidazolyl)-7-acyloxychromones were synthesized by the reaction of substituted or unsubstituted
2-(2,4-dihydroxyphenacyl)-1-methylbenzimidazoles with the acid chlorides and anhydrides of carboxylic acids. The products
were converted into 2-alkyl-7-hydroxychromones as a result of acid hydrolysis.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 26–30, January, 2008. 相似文献
17.
Blesic M Lopes A Melo E Petrovski Z Plechkova NV Canongia Lopes JN Seddon KR Rebelo LP 《The journal of physical chemistry. B》2008,112(29):8645-8650
The aggregation behavior in aqueous solution of a number of ionic liquids was investigated at ambient conditions by using three techniques: fluorescence, interfacial tension, and (1)H NMR spectroscopy. For the first time, the fluorescence quenching effect has been used for the determination of critical micelle concentrations. This study focuses on the following ionic liquids: [Cnmpy]Cl (1-alkyl-3-methylpyridinium chlorides) with different linear alkyl chain lengths (n=4, 10, 12, 14, 16, or 18), [C12mpip]Br (1-dodecyl-1-methylpiperidinium bromide), [C12mpy]Br (1-dodecyl-3-methylpyridinium bromide), and [C12mpyrr]Br (1-dodecyl-1-methylpyrrolidinium bromide). Both the influence of the alkyl side-chain length and the type of ring in the cation (head) on the CMC were investigated. A comparison of the self-aggregation behavior of ionic liquids based on 1-alkyl-3-methylpyridinium and 1-alkyl-3-methylpyridinium cations is provided. It was observed that 1-alkyl-3-methylpyridinium ionic liquids could be used as quenchers for some fluorescence probes (fluorophores). As a consequence, a simple and convenient method to probe early evidence of aggregate formation was established. 相似文献
18.
Arylsulfochlorination of β-aminopropioamidoximes giving 2-aminospiropyrazolylammonium arylsulfonates
Kayukova L. A. Praliyev K. D. Myrzabek A. B. Kainarbayeva Zh. N. 《Russian Chemical Bulletin》2020,69(3):496-503
Russian Chemical Bulletin - The reaction of P-(morpholin-1-yl)propioamidoxime with aromatic sulfonyl chlorides (p-XC6H4SO2Cl; X = CH3O, CH3, H, Br, Cl, NO2) in chloroform in the presence of... 相似文献
19.
苯并咪唑类化合物在杀菌剂研究中已取得可喜的结果,如苯菌灵、多菌灵,具有生物活性的酰基苯并咪唑类化合物已见报道,Richmond等研究发现保护性杀菌剂克菌丹在植物体内被代谢成具有内吸活性的含酰基硫代噻唑烷酮的氨基酸,杀菌和杀线虫剂N-244的结 相似文献
20.
Synthesis of 6-substituted 1-alkoxy-5-alkyluracils 2a-c have been achieved from readily accessible 2-alkyl-3,3-di(methylthio)acryloyl chlorides 4a,b in high overall yields. Treatment of 4a,b with silver cyanate followed by reaction of the resulting isocyanates 5a,b with an appropriate alkoxyamine afforded N-alkoxy-N′-[2-alkyl-3,3-di(methylthio)acryloyl]ureas 6a,b in 85–88% yields. Cyclization of 6a,b in acetic acid containing methanesulfonic acid followed by oxidation with 3-chloroperoxybenzoic acid gave high yields of 1-alkoxy-5-alkyl-6-(methylsulfonyl)uracils 9a,b. Nucleophillic addition-elimination reaction of 9a,b with sodium azide, phenylthiol, or phenylselenol produced 6-azido-1-butoxythymine ( 2a , 98%), 5-ethyl-1-(2-phenoxyethoxy)-6-(phenylthio)uracil ( 2b , 95%), or 5-ethyl-1-(2-phenoxyethoxy)-6-(phenylselenenyl)uracil ( 2c , 91%). 相似文献