共查询到19条相似文献,搜索用时 78 毫秒
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含2,4-咪唑啉二酮的环十二酮衍生物的合成及杀菌活性 总被引:2,自引:0,他引:2
以环十二酮为原料合成α-取代环十二酮和α-取代环十二二酮,再与2,4-咪唑啉二酮膦酸酯和2-硫代-2,4-咪唑啉二酮分别发生Wittig-Horner反应和Knoevenagel缩合反应,合成了一系列目标化合物,它们的化学结构通过IR,1HNMR,13C NMR和元素分析进行了表征.初步生物活性测试结果表明,部分化合物10,11A,11B,12A,12B,13A,14B和16在50μg/mL浓度时对芦笋茎枯、茄绵疫以及油菜菌核病菌均有优良的抑制活性,抑制率在70%~98%之间,进一步的生物测试结果表明,化合物12B,13A和14B对芦笋茎枯的EC50值分别为15.80,31.34和44.26 μg/mL. 相似文献
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以4,4′-二羟基查尔酮为原料,和环氧氯丙烷反应合成了主链含有双键结构的查尔酮环氧树脂(CER),其结构经1H NMR和FT-IR确证。采用非等温DSC法研究了甲基四氢邻苯二甲酸酐和4,4′-二氨基二苯基砜两种固化剂对CER的固化反应热行为,通过动态热机械分析和热失重分析对CER的热性能进行了研究。结果表明:甲基四氢邻苯二甲酸酐体系固化的CER的Tg为152.73 ℃,初始热分解温度为350.6 ℃, 800 ℃时的残碳率为19.29%; 4,4′-二氨基二苯基砜体系固化的CER的Tg为251.94 ℃,初始分解温度为365.7 ℃, 800 ℃时的残碳率为46.44%。 相似文献
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以廉价的4-羟基苯甲醛为原料,在温和条件下先后经硼氢化钠还原和与乙酰氯反应,合成了乙酸4-氯甲基苯酯,其结构经元素分析,IR,1H NMR和13C NMR确证。 相似文献
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一种新的WO3纳米管的制备方法 总被引:6,自引:1,他引:6
一维纳米材料因可用来构造高性能纳米器件的结构单元而成为纳米材料研究的热点.目前的研究重点集中在材料的制备和结构性能表征方面,已发展了多种制备方法,主要有模板法、V-L-S法、L-L-S法和V-S法等,其中阳极氧化铝(AAO)模板法是制备一维材料的好方法.AAO模板的制备工艺已相当成熟, 相似文献
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Starting from tetraacetylribofuranose (Ⅰ) and 6-chloropurine (Ⅲ), in the presence ofp-toluenesulfonic acid as catalyst, the intermediate 2',3',5'-tri-O-acetyl-6-chloropurine nucleoside (Ⅲ) was synthesized for the first time under microwave irradiation in the yield of 80.1%. The title compounds 6-chloro-9-β-D-purinenucleoside (Ⅳ) and 6-methoxy9-β-D-purinenucleoside (Ⅴ) were easily obtained by treatment the intermediate (Ⅲ) with NH3/CH3OH and Na2CO3/CH3OH in the yields of 78.8% and 76.9%, respectively. Structures of Ⅳ and Ⅴ have been identified by 1H NMRand elementary analysis. The optimal conditions for condensation were as follows: n(Ⅰ): n(Ⅱ)= 1: 1, m(TsOH):m(6-chloropurine)=3 × 10-2, microwave irradiation at 595 W for 4.5 min, at 462 W for 1 min, at 119 W for 0.5 min;aminolysis condition for Ⅳ: room temperature for 5 min; alkaline hydrolysis conditions for Ⅴ: reflux for 5 h. 相似文献
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Starting from tetraacetylribofuranose and 6-chloropurine, in the presence of was synthesized for the first time under microwave irradiation. The title compound 6-chloro-9-β-D-purinenucleoside (Ⅳ) and 6-methoxy-9-β-D-purinenucleoside (Ⅴ) was easily obtained by treatment of the intermediate (Ⅲ) with Na2CO3 in CH3OH solution refluxing for 8min and 2hr respectively. 相似文献
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合成联苯衍生物的改良方法 总被引:4,自引:0,他引:4
联苯衍生物可以通过Ullmann反应和Gomberg-Bachmann反应来合成。后者是芳香胺的重氮盐在苯中于低温经NaOH(NaOAc)分解来完成的,属于非均相反应,且重氮盐不稳定,故产率很低(15~35%)。Hey发展了该反应,将芳香胺转变为亚硝基乙酰芳胺后与苯加热即得目的物,收率提高至40~70%,但手续复杂。为了克服上述缺点,1962年,Cadogan将芳胺、苯、亚硝酸戊酯一起加热即得产物,产率较高(30~35%)。新近,又有人用芳胺的氟硼酸重氮盐在苯中分解偶联,而 相似文献
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A novel one‐pot synthesis of biaryl derivatives has been developed starting from bromobenzaldehyde and phenylboronic acid in the presence of activated methylene compounds via sequential Suzuki coupling/Knoevenagel condensation in aqueous isopropanol medium at room temperature. Significantly, this strategy afforded a straightforward and efficient approach to construct original biaryls in which a new carbon double bond bound to activated moieties such as nitrile, ester and amide is formed from three simple substrates in a one‐pot procedure. Moreover, a wide scope of substrates could effectively participate in the process affording the target products in moderate to excellent yields. 相似文献
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本文报道了一种通过微波辅助合成5-亚甲基-2,3-二苯基-4-噻唑酮类衍生物的新型方法。在以K2CO3 为碱、H2O 为溶剂、四丁基溴化铵(TBAB)为催化剂的条件下,2,3-二苯基-4-噻唑酮与取代醛在微波辅助下发生Knoevenagel 反应,生成5-亚甲基-2,3-二苯基-4-噻唑酮类衍生物,产率最高可达85%。 相似文献
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Faryal Chaudhry Sadia Naureen Fatima Ijaz Munawar Ali Munawar Misbahul Ain Khan 《合成通讯》2017,47(4):310-318
This newly designed route assembled a pyrazole ring with an aldehydic functionality over another pyrazole moiety. Further, formyl group was exploited in different routes such as condensation reactions, imidazole and pyrimidone/thione synthesis. The present reactions were performed with glycine, a facile catalyst, and the results were compared well with those of conventional methods. 相似文献