共查询到20条相似文献,搜索用时 15 毫秒
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N. N. Kolos V. D. Orlov B. V. Paponov O. V. Shishkin S. V. Baumer N. A. Kvashnitskaya 《Chemistry of Heterocyclic Compounds》1999,35(6):708-715
2,3-Diamino-5,7-diaryl-1,2,4-triazolo[1,5-a]pyrimidinium salts have been synthesized by the cyclocondensation of 3,4,5-triamino-1,2,4-triazole with 1,3-diaryl-2,3-propanes, and their structures and chemical properties have been studied.Kharkov State University, Kharkov 310077, Ukraine. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, 796–804 June, 1999. 相似文献
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Dupuy M Pinguet F Chavignon O Chezal JM Teulade JC Chapat JP Blache Y 《Chemical & pharmaceutical bulletin》2001,49(9):1061-1065
Access to the original series of pyrido[1',2':1,2]imidazo[4,5-h]quinazoline was developed from a 1,3-dicarbonyl unit with some "N-C-N" bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytotoxic activities against HL60 and A2780 cells. All compounds exhibited cytotoxic activities on resistant cell lines (MDR+; HL60R and A2780R) with no resistance phenomena. 相似文献
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9-Methyl-di-s-triazolo[4,3-a:4,3-c]pyrimidine and 9-methyl-s-triazolo[4,3-c]tetrazolo[1,5-a]pyrimidine have been synthetized from 4-hydrazino-7-methyl-s-triazolo[4,3-c]pyrimidine. Structural assignments based on nmr, ir and chemical manipulations are discussed. 相似文献
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Flash vacuum thermolyses of tetrazolo[1,5- a]pyridine and pyrido[2,3- a][1,2,4]oxadiazol-2-one generate 2-pyridylnitrene, which was detected by Ar matrix ESR spectroscopy. The thermolysis products are 2-aminopyridine, Z- and E-glutacononitriles, and 2- and 3-cyanopyrroles. The products are formed in the same ratios from the two precursors. 相似文献
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Fabrizio Bruni Silvia Selleri Annarella Costanzo Gabriella Guerrini Maria Lucia Casilli 《Journal of heterocyclic chemistry》1994,31(5):1193-1198
A series of 7-methylpyrazolo[1,5-a]pyrimidines were reacted with dimethylformamide dimethylacetal to give the corresponding dimethylaminovinyl derivatives. These were reacted with ammonium acetate affording, through a ring closure, a number of 6-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidines bearing various substituents on the pyrazole ring. The 6-acetyl-2-hydroxy-7-methylpyrazolo[1,5-a]pyrimidine was used as starting material for obtaining some O-alkyl derivatives. Catalytic transfer hydrogenation of 2-benzyloxy-6-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine led to the 2-hydroxy derivative. 相似文献
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Methods are proposed for the synthesis of previously unknown pyrido[1,2-a]benzimidazoles via the cyclocondensation of 2-acylmethyl-1H-benzimidazoles
with malononitrile, triethylorthoformate ester, or ethoxymethylenemalononitrile.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1073–1079, July, 2006. 相似文献
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Fabrizio Bruni Silvia Selleri Annarella Costanzo Gabriella Guerrini Maria Lucia Casilli Laura Giusti 《Journal of heterocyclic chemistry》1995,32(1):291-298
A series of pyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-6-ones was obtained by reaction of ammonium acetate with ethyl 7-dimethylaminovinylpyrazolo[1,5-a]pyrimidine-6-carboxylates and these had been prepared from ethyl 7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylates by reaction with dimethylformamide dimethylacetal. Under these conditions the compounds bearing a 2-hydroxy group were also O-alkylated. During the preparation of the ethyl 2-hydroxy-7-methyl-3-phenylpyrazolo[1,5-a]pyrimidine-6-carboxylate the corresponding 5-methyl isomer was isolated and identified. 相似文献
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V. I. Terenin E. A. Sumtsova E. V. Kabanova A. P. Pleshkova N. V. Zyk 《Chemistry of Heterocyclic Compounds》2004,40(4):436-445
Esters, nitriles, and amides of dipyrrolo[1,2-a:2',1'-c]pyrazines have been synthesized by the acylation of dipyrrolo[1,2-a:2',1'-c]pyrazines and 5,6-dihydrodipyrrolo[1,2-a:2',1'-c]pyrazines with trichloroacetic acid chloride, p-tosyl isocyanate, and isocyanatophosphoric acid dichloride (Kirsanov isocyanate). 相似文献
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Agheli Z. Pordel M. Davoodnia A. Beyramabadi S. A. 《Russian Journal of General Chemistry》2020,90(7):1345-1350
Russian Journal of General Chemistry - New fluorescent heterocyclic compounds pyrido[1',2':1,5]pyrazolo[4,3-b]quinolines have been synthesized by the reaction of... 相似文献
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L. Kosychova Z. Stumbreviciute L. Pleckaitiene R. Janciene B. D. Puodziunaite 《Chemistry of Heterocyclic Compounds》2004,40(6):811-815
A one-pot synthetic approach to the novel 5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepines by thermal cyclization of 4-acylhydrazino-2,3-dihydro-1H-1,5-benzodiazepines is described. 相似文献
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The chemical reactivity of the [1,2,3]triazolo[1,5-a]- and [1,5-c]-pyrimidinium salts towards morpholine, water and sodium methoxide have been studied. Among others, new 1-aza and 2-azabutadienes substituted by a [1,2,3]-triazole ring were obtained in the course of the opening of the positively charged pyrimidine ring. 相似文献
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<正>Reactions of the 6-hydroxy-thiopyrano[3,4-c]pyridine-5-carbonitrile derivative 1 withα-halo-carbonyl compounds gave the ortho-substituted intermediates 2a-c which were converted into furo[2,3-b]thiopyrano[4,3-d]pyridines 3a-c by fusion of a furan moiety under basic conditions.Further cyclization of 3a-c led to a fusion of a pyrimidine ring,yielding the tetracyclic products 6,7 and 8.In addition,condensation of 6 with various aromatic aldehydes afforded the corresponding imines 9a,b.Mannich reaction of 7 gave products 10a,b. 相似文献
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Treatment of 5-methylmercapto-1,4-benzodiazepine (I) with hydrazine hydrate gave the 5-hydrazino derivative (II, R = H) which, in turn, was conveniently cyclized to the title compounds. Another method for the synthesis of triazolo [4,3-d] [1,4] benzodiazepines (III) is also described. 相似文献
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I. Krężel 《Chemistry of Heterocyclic Compounds》1987,23(11):1233-1235
In the reaction of 1-ethoxycarbonyl-2-methylthio-1,4,5,6-tetrahydropyrimidine with thiosemicarbazide, 2-aminothiocarbonyl-3-oxo-2,3,5,6,7,8-hexahydro-sym-triazolo[4,3-a]pyrimidine is formed, which as a result of the successive action of methyl iodide, K2CO3 solution, and cyclic amines, converts into 2,3,5,6,7,8-hexahydro-8-oxo-sym-triazolo[4,3-a]pyrimidine.For Communication 3, see [1]Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1540–1542, November, 1987. 相似文献
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Giorgio Stefancich Romano Silvestri Marino Artico 《Journal of heterocyclic chemistry》1993,30(2):529-532
Reaction of 2-nitrobenzyl iodide with 1H-imidazole, in the presence of potassium tert-butoxide and 18-crown-6, gave 1-(2-nitrobenzyl)-1H-imidazole. Trichloroacetylation of this compound furnished trichloroacet-ylimidazole 8 , which on treatment with sodium ethoxide was transformed into the corresponding ethoxycarbonyl derivative 9 . Catalytic reduction of the nitro group to the amino group yielded 10 , which was then cyclized to 10,11-dihydro-11-oxo-5H-imidazo[2,1-c][1,4]benzodiazepine 11. Treatment of this lactam with di-4-morpholinylphosphinic chloride followed by reaction of the intermediate 12 with formylhydrazine gave the title compound or its 1-derivatives when acetylhydrazine or isonicotinoylhydrazine were used instead of formylhydrazine. 相似文献