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近年来,活性钛,活性镍等金属试剂正被用于有机合成并引起人们的关注。最近,对活性钴引起有机反应的研究也日益增多。例如在活性钴试剂作用下,卤代芳烃脱卤偶联得到联苯化合物,α,α—二氯二苯基甲烷脱卤得到四苯乙烯,富马酸与二溴甲烷可以发生不对称环丙烷化反应等。本文报道活性钴试剂引起α—溴代酮的反应。 相似文献
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研究了在低价钛(TiCl~4-Ga)试剂作用下,α,α,α-三卤甲基芳烃的还原偶联反应,得到了脱卤偶联产物-二卤代烯烃、炔烃。 相似文献
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刘开建 《高等学校化学学报》2014,(6):1236-1240
发展了一种简单、高效、温和的卤代炔烃水合反应体系.在阳离子金催化剂的催化作用下,以二氯乙烷为溶剂,室温下卤代炔烃发生水合反应,高收率、高区域选择性地得到单一的α-卤代甲基酮化合物(收率≥91%).该方法具有底物适用范围广、反应条件温和和环境友好等优点,为含α-卤代甲基酮结构单元的天然产物及复杂药物分子的合成提供了新方法. 相似文献
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α-卤代酮与芳香二胺经氧化-缩合过程一锅法合成喹喔啉衍生物 总被引:2,自引:0,他引:2
在二甲亚砜作用下, α-卤代酮与芳香1,2-二胺反应, 得到较高产率的喹喔啉衍生物. 结果表明反应经历一个串联的氧化-缩合过程. 二甲亚砜现场氧化α-卤代酮, 生成的二羰基化合物与芳香1,2-二胺缩合成喹喔啉衍生物. 相似文献
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在铜体系催化的卤原子转移自由基聚合反应中 ,已有多种卤化物被作为引发剂使用 ,如α-卤代酯、α-卤代腈、多卤代烃、卤代苄基化合物及芳磺酰氯等 [1] ,最近又有报道称 N-氯代磺酰胺也可以作为引发剂使用 [2 ] .但以 α-卤代酮作引发剂只在钌系 [3~ 7]、铁系 [8]及镍系 [9]催化的原子转移自由基聚合中进行了研究 ,尤其是 Swawamoto等 [3~ 6] 对 Ru Cl2 (PPh3 ) 3 作催化剂 ,α,α-二氯苯甲酮和 1 ,1 ,1 -三氯丙酮作引发剂进行的甲基丙烯酸甲酯的原子转移自由基聚合进行了非常系统的研究 .由于羰基的吸电子能力较强 ,α-卤代酮的卤原子… 相似文献
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用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%. 相似文献
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Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction
Laurent Gavara Thomas Boisse Jean-Pierre Hénichart Adam Daïch Philippe Gautret 《Tetrahedron》2010,66(38):7544-5571
In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments. 相似文献
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The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula. 相似文献
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Rebecca J. Burton Mandy L. CrowtherNeal J. Fazakerley Shaun M. FilleryBarry M. Hayter Jason G. KettleCaroline A. McMillan Paula PerkinsPeter Robins Peter M. SmithEmma J. Williams Gail L. Wrigley 《Tetrahedron letters》2013
The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines. 相似文献
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KMnO4-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields. 相似文献
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N. A. Nedolya 《Chemistry of Heterocyclic Compounds》2008,44(10):1165-1219
The review contains a concise historical account and information on the most significant researches undertaken by the staff
at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry
of Heterocyclic Compounds.
Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008. 相似文献
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Regiospecific and direct imidation of the methyl C(sp3)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products. 相似文献
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《Tetrahedron》2014,70(21):3377-3384
The Rh(II)-catalyzed reaction of 2-carbonyl-substituted 2H-azirines with ethyl 2-cyano-2-diazoacetate or 2-diazo-3,3,3-trifluoropropionate provides an easy access to 2H-1,3-oxazines and 1H-pyrrol-3(2H)-ones. These compounds can be selectively prepared from the same starting material using temperature as the only varied parameter. The 2-azabuta-1,3-diene intermediate, a common precursor for both heterocyclic products, isomerizes into 2H-1,3-oxazine under kinetic control, while 1H-pyrrol-3(2H)-one is the sole product of the reaction at elevated temperatures. According to DFT-calculations a one-atom oxazine ring contraction involving ring-opening to a 2-azabuta-1,3-diene intermediate, followed by a 1,5- and 1,2-prototropic shift leads to the consecutive formation of imidoylketene and azomethine ylide, which then further undergo cyclization to the pyrrole derivative. 相似文献
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Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields. 相似文献