新型酸性离子液体催化的 Knoevenagel缩合反应

研究了一类新型酸性离子液体催化的Knoevenagel缩合反应, 结果表明, 该催化剂适用于一系列芳香/杂环醛与α-取代活性亚甲基化合物间的反应, 反应可在室温下进行, 反应时间短且收率良好(92% ~98%). 该反应体系操作简单, 产物易分离. 提出了可能的反应机理并对机理进行了验证. 该离子液体重复使用5次后仍具有较高的反应活性.     

功能化离子液体氯化1-(2-羟乙基)-3-甲基咪唑噁盐催化的Knoevenagel缩合反应

在无溶剂条件下 ,采用催化量的功能化离子液体氯化 1 甲基 3 羟乙基咪唑盐作为催化剂 ,在 80℃条件下顺利地催化一系列芳醛和活泼亚甲基化合物进行Knoevenagel缩合反应 ,以 82 %～ 97%的产率生成相应E 式烯烃 .反应在中性条件下进行 ,条件温和 ,产率高 ,操作和后处理简单方便     

酸功能化离子液体催化合成2-叔丁基蒽醌

以N-甲基咪唑、吡啶、1,4-丁烷磺内酯、对甲苯磺酸及硫酸为主要原料,经两步反应合成了4种酸功能化离子液体［MIM-BS］［TsO］(IL1)、 ［MIM BS］［HSO₄］(IL2)、 ［PY-BS］［TsO］(IL3)和［PY-BS］［HSO₄］(IL4),其结构和性能经¹H NMR, IR和TGA表征。以［MIM-BS］［TsO］为催化剂,催化2-(4-叔丁基苯甲酰基)苯甲酸(BB酸)合成2-叔丁基蒽醌,并对反应条件进行了优化。结果表明：IL1 0.4 g,n(IL)/n(BB酸)=0.5,于120 ℃反应9 h, 2-叔丁基蒽醌产率最高达90%,离子液体循环使用5次后催化活性无明显降低。     

新型无毒离子液体催化“一锅煮”合成3,4-二氢嘧啶-2(1H)-酮

利用新型无毒离子液体(BMImSac)作催化剂, 芳香醛、1, 3-二羰基化合物和尿素或硫脲三组分“一锅煮”合成了3,4-二氢嘧啶-2(1H)-酮. 与传统方法相比, 该法是一种操作简单、产率高、用时少的环境友好方法.     

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Acidic Ionic Liquids Under Solvent-Free Conditions

The acidic ionic liquids were new catalysts for the one-pot Biginelli reaction coupling of aldehyde, 1,3-dicarbonyl compound, and urea to afford the corresponding dihydropyrimidinones in good yields under solvent-free conditions. The catalysts could be recycled and reused five times without a noticeable decrease in catalytic activity.     

Condensation Reactions of Aromatic Aldehydes with Active Methylene Compounds Catalyzed by Alkaline Ionic Liquid

The Knoevenagel condensation reactions of aromatic aldehydes with active methylene compounds catalyzed by the functionalized ionic liquid, 1-n-butyl-3-methylimmidazolium hydroxide ([bmim]OH), were carried out under grinding, heating, and microwave irradiation conditions, respectively. It is shown that the proposed method is fast, efficient, and environmentally benign.      

3-Amino-5,5-dimethylcyclohex-2-enone in the synthesis of heterocyclic compounds (review)

Methods for the synthesis of various heterocyclic compounds based on 3-amino-5,5-dimethylcyclohex-2-enone are discussed.     

Heck Arylation of Cyclohexene Promoted by Ultrasonic and Micro wave in Ionic Liquid： a Novel Method of the Synthesis of 3-Naphthylcyclohexene

Palladium catalyzed arylation or vinylation of olefins by aryl halides are well known as the Mizoroki-Heck reaction and have proved to be of genuine synthetic utility for C-C bond formation1. Although a lot of progress has been made in Heck coupling react…     

离子液体中Yb(OTf)_3催化下喹唑啉酮衍生物的绿色合成

以邻氨基苯甲酰胺和芳醛为原料,离子液体[BMIm]Br为溶剂,Yb(OTf)3为催化剂室温下合成了一系列的2-芳基-2,3-二氢化喹唑啉-4-(1H)-酮衍生物.和其他方法相比,该方法具有反应条件温和、产率高(85%～96%)、环境友好等优点.产物的结构通过熔点,IR,1H NMR和高分辨质谱分析确证.     

酸性离子液体催化合成1,5-苯并二氮衍生物

以邻苯二胺和酮为原料,酸性离子液体[hmim]HSO4和乙醇为催化体系,合成了一系列1,5-苯并二氮衍生物,其结构经1^H NMR,IR和元素分析表征。催化体系可循环使用3次。     

InCl3·4H2O Promoted Green Preparation of Xanthenedione Derivatives in Ionic Liquids

Xanthenediones derivatives have attracted considerable interests in recent times because they constitute a structural unit in a number of natural products1 and have been used as versatile synthons due to the inherent reactivity of the inbuilt pyran ring2. The conventional syntheses of xanthenediones were acid or base catalyzed condensation of appropriate active methylene carbonyl compounds with aldehydes3. However, many of these procedures involved longer reaction times,low yields and side reactions of aldehydes. In recent years, room temperature ionic liquids (RTILs) have been used as novel green reaction media4. Considering that InCl3 is an efficient Lewis acid catalyst used in promoting many organic reactions, especially in several condensation processes, we herein wish to report a very simple and green method for the preparation of poly-hydrogenated xanthenediones through InCl3·4H2O promoted cascade reaction of aldehydes and 5,5-dimethyl-l,3-cyclohexanedione in ionic liquid,1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4]). The preparative process presented here is operationally simple, environmentally benign and has the advantage of enhanced atom utilization. Furthermore, the solvent and the catalyst used can be recovered easily and reused efficiently.     

碱性离子液体催化的5-芳亚甲基-2-硫代-4-噻唑酮衍生物的合成

以碱性离子液体[bmim]OH为溶剂和催化剂, 由芳香醛与2-硫代-4-噻唑酮在沸水浴中反应30～75 min, 以89%～ 96%的产率制备了5-芳亚甲基-2-硫代-4-噻唑酮. 结果表明该方法简便易行, 产率较高, 所使用的离子液体对环境友好, 并可循环使用. 产物结构经¹H NMR和IR确证.     

Catalysis by L-Lysine:A Green Method for the Condensation of Aromatic Aldehydes with Acidic Methylene Compounds in Water at Room Temperature

The condensation of aromatic aldehydes with acidic methylene compounds such as ethyl benzoylacetate, 2,4‐pentanedione and dimedone proceeded efficiently in pure water in the presence of L‐lysine at room temperature. Interestingly, there are two different reaction mechanisms taking place under the same green catalyst system. This provides a green and mild synthetic method for the preparation of these two classes of compounds.     

Ultrasound Promoted and Ionic Liquid Catalyzed Cyclocondensation Reaction for the Synthesis of 4(3H)-Quinazolinones

4(3H)‐Quinazolinones were synthesized in high yields by one‐pot three‐component condensation of anthranilic acid, carboxylic acid and aniline in the presence of ionic liquid such as 1‐n‐butyl‐3‐methylimidazolium tetrafluoroborate (BMImBF₄) as catalyst under solvent free and neutral conditions.     

水相中十二烷基苯磺酸催化合成双吲哚甲烷衍生物

本文报道了一种环境友好的合成双吲哚烷烃衍生物的方法。在十二烷基苯磺酸催化下，吲哚与醛或酮在水相中迅速反应，高产率生成相应的双吲哚烷烃衍生物（60-97%）。本方法因催化剂廉价易得、反应条件温和、后处理简单和环境友好，将有很好的应用前景。     

Green and Efficient Protocol for the Synthesis of N-(2-Hydroxyethyl)anilines by the Alkylation Reaction in Ionic Liquid

A green and efficient protocol for the synthesis of N-(2-hydroxyethyl)anilines by the selective alkylation reaction in ionic liquid [BMIM]BF₄ (1-butyl-3-methylimidazolium tetrafluoroborate) has been developed, eliminating the need for toxic and expensive catalysts and volatile organic solvents. The effects of the amount of ionic liquid, temperature, time, and substrate structure on the reaction were investigated. The conversion and selectivity of N-(2-hydroxyethyl)anilines obtained in ionic liquid [BMIM]BF₄ are significantly increased in comparison to those traditional methods. Furthermore, the ionic liquid could be easily separated and reused at least five times. It provided a simple and efficient alternative way for the industrial synthesis of N-(2-hydroxyethyl)anilines.     

新型离子液体体系催化苯与1-己烯的烷基化反应

氯化铁;盐酸三乙胺;新型离子液体体系催化苯与1-己烯的烷基化反应     

离子液体中乙酸异山梨醇酯的合成

以1-丁基-3-甲基咪唑六氟磷酸盐离子液体为溶剂,对新一代长效抗心绞痛药物单硝酸异山梨酯中间体异山梨醇进行了萃取分离,避免了使用高真空高温蒸馏;以酸性离子液体N-甲基咪唑硫酸氢盐为溶剂和催化剂,合成了中间体2-乙酸异山梨醇酯,产物结构经红外光谱确证.异山梨醇收率80%,2-乙酸异山梨醇酯收率86%.     

A Novel Green Synthesis of Quinolines through Acid-catalyzed Friedlander Reaction in Ionic Liquids

Quinoline derivatives were efficiently prepared through acid-catalyzed Friedlander reaction in ionic liquid ([bmim] [BF4]). It is shown that the proposed method is operationally simple and environmentally benign in that the reaction media and the catalyst can be recovered and be reused effectively for at least four times.     

Synthesis of Tetrahydrofuran and Tetrahydropyran Derivatives Catalyzed by Tungstophosphoric Acid in Ionic Liquid

Synthesis of tetrahydrofuran and tetrahydropyran derivatives catalyzed by tungstophosphoric acid （H3PW12040） were conveniently performed with high yield from the corresponding unsaturated alcohols in ionic liquid. Sufuric acid （H2SO4）, trifluoromathanesulfonic acid （TfOH） and p-toluenesulfonic acid （TsOH） were also explored for preparing these products in ionic liquid. The catalysts and ionic liquid can be easily recovered and reused.