A new picrotoxane sesquiterpene from the berries of Baccaurea ramiflora with antifungal activity against Colletotrichum gloeosporioides

Three picrotoxane sesquiterpenes including one new glycoside and two known constituents, sapidolide A (2) and picrotoximaesin (3), were isolated from the berries of Baccaurea ramiflora. The structure of the new sesquiterpene glycoside, ramifloside (1), was elucidated as 2-one-6α-hydroxy-13-nor-11-picrotoxen-3(15β)-olide 10-O-β-d-glucopyranoside on the basis of extensive spectroscopic analysis. Compounds 1–3 exhibited antifungal activity against Colletotrichum gloeosporioides with MICs of 12.5, 12.5 and 50 μg/mL.     

Iridoids and sesquiterpenoids with NGF-potentiating activity from the rhizomes and roots of Valeriana fauriei

A new iridoid glycoside, 10-isovaleryl kanokoside C (1), and a new sesquiterpene (2) together with two known compounds (3, 4) were isolated from the rhizomes and roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2 and 4 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.     

Chemical Constituents of Yucca gloriosa Flowers

Chemistry of Natural Compounds - Four new sesquiterpene glycosides and one triterpene glycoside were isolated from flowers of Yucca gloriosa L. introduced into Georgia.     

A New Sesquiterpene Glycoside from Leaves of Bombax ceiba

Chemistry of Natural Compounds - A new sesquiterpene glycoside, ceibanoside (1), was isolated from the leaves of Bombax ceiba, together with the previously-reported quercetin (2), kaempferol (3),...     

A New Calamenene Sesquiterpene Glycoside from the Bark of Thespesia populnea

Chemistry of Natural Compounds - One new calamenene sesquiterpene glycoside, (1R,2R,3S,4S)-4-isopropyl-1,6-dimethyl-1,2,3,4- tetrahydronaphthalene-2,7-diol 3-O-β-D-glucopyranoside (1), along...     

Constituents from the roots of Taraxacum platycarpum and their effect on proliferation of human skin fibroblasts

A MeOH extract from the roots of Taraxacum platycarpum has shown significant effects on the proliferation of normal human skin fibroblasts. Chemical analysis of the extract resulted in the isolation of 26 compounds, including eight new triterpenes, one new sesquiterpene glycoside, and seventeen known compounds. The structure of each new compound was established using NMR spectroscopy. Some triterpenes had a significant effect on the proliferation of normal human skin fibroblasts.     

Structure elucidation and complete NMR spectral assignments of a novel sesquiterpene glycoside from Ixeris sonchifolia

A novel sesquiterpene glycoside was isolated from the whole plant of Ixeris sonchifolia. The structure was established as 1(10)E-4Z-3alpha-hydroxy-germacra-1(10),4,11(13)-trien-6, 12-olide-14-O-beta-D-glucopyranoside (1) on the basis of spectroscopic techniques and chemical analysis.     

Three sesquiterpene compounds biosynthesised from artemisinic acid using suspension-cultured cells of Averrhoa carambola (Oxalidaceae)

A new sesquiterpene glycoside, artemisinic acid 3-β-O-β-D-glucopyranoside (3, 31.24%) and other two biotransformation products, 3-β-hydroxyartemisinic acid (2, 36.69%) and 3-β-hydroxyartemisinic acid β-D-glucopyranosyl ester (4, 7.03%), were biosynthesised after artemisinic acid (1) was administered to the cultured cells of Averrhoa carambola. The three biotransformation products were obtained for the first time by using the suspension-cultured cells of A. carambola as a new biocatalyst system, and their structures were identified on the basis of the physico-chemical properties, NMR and mass spectral analyses. The results indicate that the cultured cells of A. carambola have the abilities to hydroxylate and glycosylate sesquiterpene compounds in a regio- and stereoselective manner. Furthermore, the anti-tumour activity of compounds 3 and 4 was evaluated against K562 and HeLa cell lines. Compound 4 showed strong activity against HeLa cell line, with the IC?? value of 0.56?μmol?mL?1.     

A new eudesmane sesquiterpene glycoside from Parepigynum funingense

A new eudesmane sesquiterpene glycoside,1α,6β-dihydroxy-5,10-bis-epi-eudesm-4(15)-ene-6-O-β-D-glucopyranoside(2), together with a known analogue compound,1α,6β-dihydroxy-5,10-bis-epi-eudesm-3-ene-6-O-β-D-glucopyranoside(1),were isolated from the roots of Parepigynumfuningense.The structure of 2 was determined by 1D and 2D NMR spectroscopy.Compound 1 was isolated from this plant for the first time.     

Chemical constituents from the submerged plant Potamogeton crispus and their effects on NAD(P)H:quinone oxidoreductase 1

A new isopimarane-type diterpene(liwariverol,1) and eight known compounds were isolated and characterized from the EtOAc extract of the whole plant oi Potamogeton crispus.The structure of 1 was elucidated to be 17-hydroxy-8αH-isopimara-9(11),15- diene by means of spectroscopic methods.Among the isolates,crenulatoside A(2),an acyclic sesquiterpene glycoside,was found to have anti-oxidative activity with enhancement of the expression of the NAD(P)H:quinone oxidoreductase 1(NQO1) in human neuroblastoma SH-SY5Y cells at 100μmol/L after a 24-h incubation.     

南蛇藤昆虫拒食倍半萜成分的研究(Ⅱ)

南蛇藤昆虫拒食倍半萜成分的研究（Ⅱ）王明安,陈馥衡（北京农业大学应用化学系,北京,１０００９４）关键词南蛇藤,倍半萜,结构分析卫矛科植物含多种类型β－二氢沉香呋喃倍半萜多醇酯衍生物和生物碱［１］,有些化合物显示了良好的昆虫拒食和抗肿瘤活性［２～４］．...     

Acetylated triterpene saponins from the Thai medicinal plant, Sapindus emarginatus

From the pericarps of Sapindus emarginatus (Sapindaceae), three new acetylated triterpene saponins were isolated together with hederagenin and five known triterpene saponins, as well as one known sweet acyclic sesquiterpene glycoside, mukurozioside IIb. The structures of new compounds were elucidated as hederagenin 3-O-(2-O-acetyl-beta-D-xylopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside, 23-O-acetyl-hederagenin 3-O-(4-O-acetyl-beta-D-xylopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside and oleanolic acid 3-O-(4-O-acetyl-beta-D-xylopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside by chemical and spectroscopic data.     

Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov

Five new drimane-type sesquiterpenoids were isolated from cultures of the tropical basidiomycetes, Perenniporia centrali-africana (originating from Kenya) and Cerrena sp. nov. (originating from Thailand). A new pereniporin A derivative (1), a new drimane-type sesquiterpene lactam (2), and the new 6,7-Dehydro-isodrimenediol (3) were isolated from P. centrali-africana. In parallel, the two new drimane-type sesquiterpene lactams 5 and 6 were isolated together with known isodrimenediol (4) from Cerrena sp. This is the first report of drimane-type sesquiterpene lactams from basidiomycetes. The structures were elucidated based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. The compounds were devoid of significant antimicrobial and cytotoxic activities.     

Struktur und stereochemie eines sesquiterpen-esters und dreier sesquiterpen-alkaloide von Celastrus paniculatus Willd

A new sesquiterpene ester (Malkangunin) and three sesquiterpene alkaloids (Celapanin, Celapanigin, Celapagin) were isolated from Celastrus paniculatus Willd. The complete structure and stereochemistry of Malkangunin, a sesquiterpene tetra-ol of the β-dihydroagarofurane type two of whose hydroxyls being esterified with acetic and benzoic acids, is discussed. The alkaloids described here are derived from a new sesquiterpene tetra-ol (Celapanol) which is alternately esterified with acetic, benzoic, nicotinic and β-furoic acids.     

Structure of the sequiterpene lactones fromCyclachaena xanthifolia

Conclusions The racemes ofCyclachaena xanthifolia Fresen. have yielded four sesquiterpene lactones, two of which are new, not having been described in the literature previously, and these have been called ivoxanthin and 1,2-anhydrocoronopilin. Structures II and IV have been proposed for these.The plant also contains the sesquiterpene lactones coronopilin and ambrosin.Khimiya Prirodnykh Soedinenii, Vol. 5, No. 6, pp. 487–490, 1969     

Sesquiterpene Lactones from Daucus glaber

Six new sesquiterpene lactone esters, daucoguaianolactones A–F ( 1 – 6 ), and one new sesquiterpene lactone, daucoeudesmanolactone A ( 7 ) were isolated from the leaves and stems of Daucus glaber (Forssk .) Thell ., along with the known sesquiterpene lactones talasins A and B and badkhysin. The structures of 1 – 6 were established on the basis of extensive 1D‐ and 2D‐NMR spectroscopic studies and that of 7 by X‐ray crystallography. Compounds 4, 7 , and talasins A and B showed moderate cytotoxicity against P‐388 leukemia cells.     

Melledonal and melledonol,sesquiterpene esters from armillaria mellea

Isolation of two new sesquiterpene aryl esters melledonal (6) and melledonol (8) from culture broth extract of Armillaria mellea are reported. Their structures were deduced from spectral and chemical data.     

New Sesquiterpenes from Chloranthus japonicus

Chemical investigation of the roots of Chloranthus japonicus Sieb . has resulted in the isolation and characterization of four new eudesmane‐type sesquiterpenes including two new sesquiterpene cinnamates, along with one new and two known sesquiterpene dimers. Their structures were established by spectroscopic means and by comparison with the respective literature values.     

Steroidal glycosides from Agave utahensis

Three new spirostanol glycosides (1-3) and a new furostanol glycoside (4), together with two known spirostanol glycosides (5 and 6) were isolated from the whole plants of Agave utahensis (Agavaceae). The structures of the new compounds were determined by spectroscopic analysis and the results of hydrolytic cleavage.     

Constituents of the underground parts of Glehnia littoralis

From the underground parts of Glehnia littoralis FR. Schmidt ex Miquel (Umbelliferae), 26 compounds, including two new lignan glycosides [giehlinosides A (1) and B (2)], a new neolignan glycoside [glehlinoside C (3)], and a new phenylpropanoid glycoside 14-[beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranosyloxyl-3-methoxypropiophenone (4)1, were obtained and their structures were determined by analysis of their spectral data. The 1,1-diphenyl-2-picrylhydrazyl radical-scavenging assay disclosed quercetin (8), isoquercetin (9), rutin (10), chlorogenic acid (11), and caffeic acid (24) as the major antioxidative constituents in this crude drug.