A New Triterpenoid Saponin: Se-saponin A

In continuation of our studies on the constituents of Clerodendrum serratum var.amplexghlium Moldenke'-"', a new triterpenoid saponin, sc-saponin A (l), was isolated.To the best of our knowledge, it is the second instance oftriterpenoid saponin from theClerodendrum genus. This paper deals with the structural elucidation of the newcompound.Se-saponin A (l) an amorphous powder, gave positive Liebermann-Burchardreaction. It was deduced to have a molecular formula of C58H,,O,, by high resoluti…     

A Triterpenoid Saponin from Polycarpon prostratum

FromPo{1'cal'Ponproslraluln(Forssk.)Aschers.etSchwein.ExAscherswhichissaidtobetoxicandhasanti-inflammatoryandanodynicactivities',anewtriterpenoidsaponin.namedprostratosideA.wasisolated.ProstratosideA1.mpf250-252"C,[a]5'= 4.3(c0.88,MeOH).0.0018%yield.ItsHRFAB-MSgavea[M-1]'ionatm/zI117.>505,inagreementwiththemolecularformulaC..H,.O:.(cafed."l/zI117.5431).TheiRspectrumshowedabsorptionbandsat3371.1717.1646and1046cm-'.AcomparisonofIwith22a-hydroxy-saikogeninG=showedIwasverysimilarto22a-…     

A New Triterpenoid Saponin and a New Glycoside from Epigynum aurilum

A new triterpenoid saponin with novel sugar moiety (1), a new trisaccharide derivative (2), as well as a known monosaccharide derivative (3), were isolated from the dried stem of Epigyhum aurilum. The structures of compounds 1 and 2 were determined by MS and NMR spectram analyses.     

A New Triterpenoid Saponin from Aralia subcapitata

The plants of Aralia genus are used as folk medicines for rheumathism, hepatitis and bruise in China 1. Aralia subcapitata Hoo is distributed in Anhui Province of China and also used for the treatment of diabetes. Yang et al. 2 reported the isolation of four known triterpenoids from this plant. In this paper, we report the structural elucidation of a new triterpenoid saponin, subcapitatoside A, isolated from the roots of this plant. Figure 1: structure of compound 1 Subcapitatoside A (1), …     

A New Triterpenoid Saponin from Codonopsis lanceolata

A new triterpenoid saponin, named codonolaside (1) was isolated from the root of Codonopsis lanceolata.Its structure was determined by analysis of its spectral and chemical data.     

Two Glycosides and Other Constituents from Anemone tomentosa Roots

Two new natural products, i.e., 1‐O,2‐O‐[(1S,2S)‐1‐(3‐acetyl‐2,4,6‐trihydroxyphenyl)‐3‐hydroxypropane‐1,3‐diyl]‐β‐D ‐glucopyranose (=tomentoside I; 1 ) and (3β)‐3‐(acetyloxy)ferruginol 12‐[6‐O‐(4‐hydroxy‐3,5‐dimethoxybenzoyl)‐β‐D ‐glucopyranoside] (=tomentoside II; 2 ), were isolated from the EtOH extract of the root of Anemone tomentosa, together with five known compounds. Their structures were characterized by means of spectroscopic methods, especially by ¹H‐, ¹³C‐, and 2D‐NMR and HR‐MS, as well as by chemical methods and comparison with literature data.     

Two New Oleanene-Type Triterpenoid Saponins from Pueraria peduncularis

Pueraria pedllncltlaris Grab. (Leguminosae) is a plant growing in the southwest of China.The plants of Pueraria DC. are important oriental crude drugs used as a perspiration,antipyretic and antispasmodic agents. Various isoflavonoids and triterpenoidsaponins"' have been discovered from them. Since P pedunculariS is toxic. it hasnever been used as a source for medicines. There are only scarce reports on its chemicalconstituents.In the preceding paper', we reported the isolation of a new …     

A New Triterpenoid Saponin from the Seeds of Deccaria segetalis

The seeds of Vaccaria segetalis (Neck) Garcke, which is distributed all over China,except southern China, are used in Chinese folk medicine for promoting diuresis,activating blood circulation and relieving carbuncles 1. Previous studies on the seeds ofthis plant have led to the isolation of seven cyclic peptides 2-5 and several saponins 6-]o.We have repoyted the isolation and structural elucidation of Segetosides A, C-E from theseeds of Vaccaria segetalis I I-13. FuFther investigation of…     

A New Triterpenoid Spaonin Isolated from the Seeds of Aesculus assamica Griff

The Aesculus genus consists of about thirty species distributed in Asia, Europe andAmerica. There are sixteen species distributed in China, and most of them are used asherbal medicines for the treatment of distention and pain in the chest and abdomen. Anu…     

Two New Oleanane Saponins from Anemone anhuiensis

Two new oleanane triterpene saponins, named as anhuienside C (1) and D (2), were isolated from the rhizomes of Anemone anhuiensis (Ranunculaceae). The structures of the new compounds were elucidated as 3-O-α-L-rhamnopyranosyl (1→ 2)-β -D-xylopyranosyl oleanolic acid 28-O-b -D-glucopyranosyl (1→ 6)-b -D-glucopyranosyl ester (1) and 3-O-β-D-xylopyranosyl oleanolic acid 28-O-α-L-rhamnopyranosyl (1→ 4)-β-D-glucopyranosyl (1→6)-β-D-gluco-pyranosyl ester (2), respectively.     

Segetoside L, A New Triterpenoid Saponin from Vaccaria segetalis

A new triterpenoid saponin, named segetoside L, was isolated from the seeds of Vaccaria segetalis. On the basis of spectral data and chemical reaction, its structure was established as 28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl oleanolic acid 3-O-β-D-glucopyranosyl-(1→3)- [β-D-galactopyranosyl-(1→2)]-β-D-galactopyranoside.     

A New Triterpenoid from "Gualou-xiebai-baijiu-tang" Consisting of Fructus trichosanthis and Bulbus allii mtacrostemi

A new triterpenoid saponin was isolated by bioactivity-guided isolation from "Gualou-xiebai-baijiu-tang" consisting ofFructus trichosanthisi and Bulbus allii macrostemi. Its structure was determined as 3-O-β-D-galactopyranosyl-hederagenin 28-O-β-D-xylopyranosyl (1→6)- β-D-galactopyranosyl ester by means of chemical evidences and spectral analysis.     

A New Triterpenoid Saponin from the Seeds of Vaccaria segetalis

A new triterpenoid saponin, named segetoside k, has been isolated from the seeds of Vaccaria segetalis.On the basis of chemical reaction and spectral analysis, the structure of segetoside K was established as: olean-12-ene-23a ,28b -dioic acid 3b , 16a -dihydroxy-28-O-[b -D-glucopyranosyl-(1→ 3)]-b -D-glucopyra-nosyl-(1→ 2)-b -D-glucopyranosyl-(1→ 6)-b -D-gluco-pyranoside(1).     

A new triterpenoid saponin from Anemone raddeana

A new triterpenoid bisglycoside, named raddeanoside R19, was isolated from the roots of Anemone raddeana. Its structure was elucidated on the basis of ESI-MS, ^13C NMR, and chemical methods.     

冻地银莲花中三萜皂苷的HPLC/MSn分析

药用植物冻地银莲花(Anemone rupestris ssp. gelida)的全草中含有丰富的三萜皂苷, 经HPLC-MSⁿ分析, 发现其总皂苷中共含有10余个三萜皂苷成分. 除由总离子流色谱图给出各皂苷成分的相对含量外, 从每个色谱峰的正负离子ESI-MS获得相应皂苷的分子量, 进而由多级质谱给出糖链连接的信息, 结合文献报道, 将11个主要三萜皂苷成分分别鉴定为革叶常春藤皂苷F (1), 牡丹草皂苷D (2), 刺楸皂苷B (3), 革叶常春藤皂苷E (4), 红毛七皂苷D (5), 常春藤皂苷B(6), 刺五加皂苷C₃ (7), 牡丹草皂苷B (8), 刺楸皂苷A (9), 木通皂苷D (10)和齐墩果酸-3-鼠李糖基-(12)-[葡萄糖基-(14)]-阿拉伯糖苷(11). 其中微量成分2, 5, 7, 10和11为首次从冻地银莲花中分离鉴定. 最后通过与标准品的HPLC保留时间对照证实了他们的存在.     

Diacylated Triterpenoid Saponin from Silene szechuensis

TherootofSileneszechuensisisaChinesetTaditionalmedicinewhichcanbeusedtotreatgaStralgia'.Fromethanolicextractoftheplantanewdiacylatedtriterpenoidsaponin,silenosidel,wasisolated.Thestructureofthesaponinwaselucidatedafterderivatives2~10wereobtained.Sele...     

A New Taraxastane-type Triterpenoid from Potentilla multicaulis

The genus Potentilla (Rosaceae) consists of about 200 species distributed in many countries, among them about 90 species grow in China1. Some species of Potentilla plants have long been used as traditional Chinese medicinal herbs for anti-rheumatism, deto…     

A Cytotoxic Saponin with Two Monoterpenoids from Albizia julibrissin

The dried stem barks of Albl'ziajulibrissin have been specified in Chinese Pharmacopeiaas a sedative agent. In the previous research several novel saponins were reported'-'.T.Ikeda. at al' isolated three similar saponins almost at the same time. In our further studieson the 95O/O etllanol extract from the plant, a new saponin I was obtained. This paper'involves the isolation and structural elucidation of the new saponin.Air-dried powdered stem barks (13.5 kg.) were extracted with 95% ethan…     

A New Triterpenoid from Doellingeria scaber

A new oleanane-type triterpene was isolated from the roots ofDoellingeria scaber. Itsstructure was identified as 3-oxo-16ct-hydroxy-olean-12-en-28-oic acid based on 1D and 2D NMRspectroscopy and X-ray analysis.     

A New Cyclopropyl‐Triterpenoid from Ochradenus arabicus

One new cyclopropyl‐triterpenoid ( 1 ), along with four known constituents including octacosan‐1‐ol ( 2 ), pentacosanoic acid ( 3 ), β‐sitosterol ( 4 ), and β‐sitosterol 3‐O‐β‐D ‐glucopyranoside ( 5 ) were isolated from the aerial parts of Ochradenus arabicus for the first time. These compounds were isolated by repeated column chromatography followed by further purification through recycling HPLC. The structure of the new secondary metabolite 1 was established on the basis of UV, IR, 1D‐ (¹H‐ and ¹³C‐) and 2D‐NMR (HMBC and HSQC), and MS spectral data. The molecular mass was determined by HR‐MS, and hence the molecular formula was deduced. The configurations of stereogenic centers in the molecule were assigned by NOESY experiments, along with biogenetic considerations. The structures of the known compounds were confirmed by comparison of their physical and spectroscopic data with those reported in literature.