共查询到20条相似文献,搜索用时 46 毫秒
1.
Ahmad Shaabani Afshin Sarvary Sajjad Mousavi-Faraz Seik Weng Ng 《Monatshefte für Chemie / Chemical Monthly》2012,9(5):1061-1065
Abstract
A facile stereoselective synthesis of 1,2-dihydroquinolin-2-ylphosphonate and 1,2-dihydroisoquinolin-1-ylphosphonate derivatives by the three-component reactions of quinoline or isoquinoline, dialkyl acetylenedicarboxylates, and hydrogen phosphonates is described. 相似文献2.
Wael A. El-Sayed Farag A. El-Essawy Omar M. Ali Barsis S. Nasr Mohamed M. Abdalla Adel A.-H. Abdel-Rahman 《Monatshefte für Chemie / Chemical Monthly》2010,20(4):1021-1028
Abstract
A number of new 5-[(naphthalen-1-yloxy)-methyl]-1,3,4-oxadiazole derivatives were synthesized. Sugar 2-[5-[(naphthalen-1-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio]acetohydrazones were prepared by condensation of the hydrazide with the corresponding monosaccharides. Cyclization of the sugar hydrazones with acetic anhydride afforded the substituted oxadiazoline derivatives. The synthesized compounds displayed different degrees of antiviral activities or inhibitory actions against HCV and HIV viruses. 相似文献3.
Grzegorz Zi?ba Marcin Rojkiewicz Violetta Kozik Krystyna Jarzembek Anna Jarczyk Aleksander Sochanik Piotr Ku? 《Monatshefte für Chemie / Chemical Monthly》2012,58(4):153-159
Abstract
A series of mono-alkylcarboxylic acid derivatives of tetraphenylporphyrin have been prepared. All the porphyrins were completely characterized by use of mass, 1H NMR, UV–visible, and fluorescence spectroscopy. Experimental log P were determined by use of reversed-phase thin-layer chromatography with use of log P Rekker. These porphyrins are potential photosensitizers in photodynamic therapy. 相似文献4.
Zhiyong Weng Wei Wei Xiaowu Dong Yongzhou Hu Shufang Huang Tao Liu Xin Xie 《Monatshefte für Chemie / Chemical Monthly》2012,17(8):303-308
Abstract
A series of novel piperidin-4-ol derivatives were designed, synthesized, and evaluated for potential treatment of HIV. The compounds were obtained via an efficient synthetic route in excellent yields and have been characterized by 1H NMR, 13C NMR, MS, and elemental analysis. The CCR5 antagonistic activities of the compounds have also been evaluated. 相似文献5.
Madhukar N. Jachak Sandeep M. Bagul Bhausaheb K. Ghotekar Raghunath B. Toche 《Monatshefte für Chemie / Chemical Monthly》2009,20(5):655-662
Abstract
A series of (2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-1-(4-aryl)prop-2-en-1-ones (chalcones) have been synthesized by a new synthetic route. The 3-pyridinecarbonitrile derivatives were synthesized by the Michael reaction of malononitrile (in base) and aroylacetonitriles (in acid) with chalcones in one pot. The fluorescent properties and quantum yields of these compounds were studied. 相似文献6.
Jan Zawadiak Barbara Hefczyc Henryk Janeczek Marek Kowalczuk 《Monatshefte für Chemie / Chemical Monthly》2009,36(11):303-308
Abstract
New azo-perester derivatives of tert-butyl and tert-amyl hydroperoxides were obtained in reactions of azo acid chlorides with hydroperoxides in the presence of an inorganic base. Obtained azo-peresters possess two kinds of the labile functional groups: the azo group and also the perester group. The data from DSC experiments indicate that in the case of azo-perester derivatives of tert-amyl hydroperoxide, the perester group decomposes at a somewhat lower temperature than in the case of tert-butyl derivatives, whereas azo groups decompose at somewhat higher temperature in the case of derivatives with tert-amyl substituent. 相似文献7.
Abstract
Succinimide sulfonic acid (SuSA) as a stable reagent is easily prepared by the reaction of succinimide with neat chlorosulfonic acid. This compound is able to catalyze the chemoselective conversion of amines to their corresponding N-Boc protected derivatives with (Boc)2O. All reactions were performed under mild conditions, giving the desired products in good to high yields. 相似文献8.
Abstract
N-Arylquinoline derivatives are obtained in excellent yields by a rapid, easy, and efficient one-pot multicomponent reaction of aromatic aldehydes, 3-arylamino-5,5-dimethylcyclohex-2-enone, and active methylene compounds utilizing 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as a catalyst in ethanol under microwave irradiation. 相似文献9.
Abstract
An efficient one-pot synthesis of ketenimine derivatives is described. It involves a four-component reaction between benzylamines, 2,2-dichloroethanoyl chloride, alkyl isocyanide, and dialkyl acetylenedicarboxylates under mild conditions at ambient temperature. 相似文献10.
Wafaa M. Abdou Reham F. Barghash Mohamed S. Bekheit 《Monatshefte für Chemie / Chemical Monthly》2011,81(2):649-656
Abstract
Schiff-base Kabachnik–Fields intermediates generated in situ from substituted pyrazole-4-carbaldehyde and 2-aminothiophene derivatives were trapped by dialkyl phosphites to produce the corresponding α-aminophosphonates in moderate yields. The latter products could be also obtained in excellent yields (≥75%) by directly applying the phosphorus reagents to the Schiff bases. Next, dialkyl phosphites were applied to one of the parent aldehydes to give the expected α-hydroxyphosphonate derivatives. Applying hexaalkyl triamidophosphites to the Schiff base in ethanol afforded methylphosphonic diamide derivatives, whereas ring attack on the pyrazole ring occurred when the same amidophosphites were applied to the parent aldehyde to give the corresponding alkylidenephosphorane ylides in an open structure form in good yields. Some of the new compounds exhibited considerable anti-inflammatory properties. 相似文献11.
Mino R. Caira Emilian Georgescu Florentina Georgescu Florin Albota Florea Dumitrascu 《Monatshefte für Chemie / Chemical Monthly》2011,62(2):743-748
Abstract
Structural elucidation of the dihydro derivatives obtained as by-products in the classic salt method synthesis of pyrrolo[2,1-a]phthalazines and acetylenic dipolarophiles was achieved by X-ray diffraction analysis of a representative compound. In addition, new pyrrolo[2,1-a]phthalazines were obtained by a one-pot three-component reaction that avoids the formation of the dihydro derivative intermediates. 相似文献12.
Afshin Rajabi Khorrami Parvin Kiani Ayoob Bazgir 《Monatshefte für Chemie / Chemical Monthly》2011,9(6):287-295
Abstract
l-Proline was found to be a versatile organocatalyst for the synthesis of new spirooxindole derivatives in good yields under mild reaction conditions using 1-propanol as a solvent. 相似文献13.
S. Makarem A. R. Fakhari Ali A. Mohammadi 《Monatshefte für Chemie / Chemical Monthly》2009,38(12):645-649
Abstract
Electrochemical oxidation of 2,3-dimethylhydroquinone has been studied in the presence of β-diketones as nucleophiles in aqueous solution using cyclic voltammetry and controlled-potential coulometry. The results indicate that the derivatives of 2,3-dimethylhydroquinone participate in a Michael addition reaction to form the corresponding benzofuran derivatives. The electrochemical synthesis has been successfully performed at pH 7.0 and E = 0.1 V versus an Ag|AgCl|KCl (3 M) in an undivided cell in good yield and purity. 相似文献14.
Abstract
A facile and environmentally benign procedure for the synthesis of octahydroquinazolinone and biscoumarin derivatives in ionic liquids is reported. Octahydroquinazolinones were synthesized in the presence of trimethylsilyl chloride (TMSCl) while the synthesis of biscoumarins required no additive. The ability to reuse the ionic liquid, the high yields, and ease of purification are the important features of this process. 相似文献15.
Robabeh Baharfar Seyed M. Vahdat Fatemeh G. Hakimabadi 《Monatshefte für Chemie / Chemical Monthly》2009,10(1):489-493
Abstract
An efficient one-pot reaction of dialkyl acetylenedicarboxylates with 2,4-dihydroxybenzo(or aceto)phenones in the presence of triphenylphosphine produces 5-hydroxy- and 7-hydroxycoumarin derivatives. The novel procedure features short reaction time, fairly good yields, and simple workup. 相似文献16.
Patchreenart Saparpakorn Ratsupa Thammaporn Supa Hannongbua 《Monatshefte für Chemie / Chemical Monthly》2009,15(7):587-594
Abstract
Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) based on the docked conformation were performed for 24 pyrazinone derivatives. All compounds were docked into the wild-type HIV-1 RT binding pocket and the lowest-energy docked configurations were used to construct the 3D QSAR models. The CoMFA and CoMSIA models enable good prediction of inhibition by the pyrazinones, with r\textcv2 r_{\text{cv}}^{2} = 0.703 and 0.735. Results obtained from CoMFA and CoMSIA based on the docking conformation of the pyrazinones are, therefore, powerful means of elucidating the mode of binding of pyrazinones and suggesting the design of new potent NNRTIs. 相似文献17.
Barbara Hefczyc Jan Zawadiak Henryk Janeczek Marek Kowalczuk Beata Orlińska 《Monatshefte für Chemie / Chemical Monthly》2011,288(2):271-276
Abstract
New asymmetrical azo-perester derivatives of tert-butyl and tert-amyl hydroperoxides were obtained by reacting azo acids with hydroperoxides in the presence of N,N′-carbonyldiimidazole. The obtained azo-peresters possess two labile functional groups: the azo group and the perester group. Data from dynamic differential scanning calorimetry (DSC) experiments indicate that the azo groups decompose at somewhat lower temperatures than the perester groups. 相似文献18.
A. M. Khalil M. A. Berghot M. A. Gouda S. A. El Bialy 《Monatshefte für Chemie / Chemical Monthly》2010,46(2):1353-1360
Abstract
A dibenzobarrelene derivative was used as key intermediate for the synthesis of 2-(4-(methyl/phenylthiaz-ol-2-yl)-2,3,4a,5,10,10a-hexahydro-5,10-benzenobenzo[g]phthalazine-1,4-diones. These compounds were coupled with the appropriate diazonium chlorides to give the corresponding 5-(arylazo)thiazole derivatives. The synthesized dyes were applied to polyester as disperse dyes, and their antibacterial, color measurement, and fastness properties were evaluated. 相似文献19.
Kasthuri Balasubramani Packianathan Thomas Muthiah Daniel E Lynch 《Chemistry Central journal》2007,1(1):28
Background
Pyrimethamine [2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine] is an antifolate drug used in anti-malarial chemotherapy. Pyrimidine and aminopyrimidine derivatives are biologically important compounds owing to their natural occurrence as components of nucleic acids. 相似文献20.
Minoo Dabiri Peyman Salehi Mahboobeh Bahramnejad Mohsen Alizadeh 《Monatshefte für Chemie / Chemical Monthly》2010,46(6):877-881