共查询到20条相似文献,搜索用时 15 毫秒
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With increase in the reactivity, the amidine carbon becomes more susceptible to nucleophiles. However, the H2SOCH3 and AgNO3 the α-CH2 group is more activated. 相似文献
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A simple and general method has been developed for the synthesis of various4(3H)-quinazolinone derivatives by the treatment of the appropriate 3-amino-2-aryl-4(3H)-quinazolinone with a substituted benzaldehyde in ethanol. The structures of the compoundswere characterized by elemental analysis, IR, (1)H-NMR and (13)C-NMR spectra. The title 2-aryl- or 2-methyl-3-(substituted-benzalamino)-4(3H)-quinazolinone compounds III-1~III-31 were found to possess moderate to good antiviral activity. Semi-quantitative PCR andReal Time PCR assays were used to ascertain the target of action of compound III-31against TMV. The studies suggest that III-31 possesses antiviral activity due to inductionof up-regulation of PR-1a and PR-5, thereby inhibiting virus proliferation and movementby enhancement of the activity of some defensive enzyme. 相似文献
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New derivatives of 5(4H)-quinazolinone containing 2-imidazolin-5-one rings have been prepared from 5(4H)-oxazolone derivatives. 相似文献
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V. A. Kovtunenko T. T. Kucherenko R. I. Zubatyuk O. V. Shishkin D. A. Yushchenko 《Chemistry of Heterocyclic Compounds》2007,43(10):1301-1306
A method has been developed for the reaction of 2-cyanomethylbenzoic acid with N-methylanthranilic acid to give 2-[(1-methyl-4-oxo-1,4-dihydro-2-quinazolin-2-yl)methyl]benzoic
acid, its esters were synthesized. The spectroscopic chracteristics of the isomeric compounds have been studied and compared
in solution and in the solid state.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1532–1538, October, 2007. 相似文献
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Yu. L. Zborovskii V. V. Orysyk A. A. Dobosh V. I. Staninets V. V. Pirozhenko A. N. Chernega 《Chemistry of Heterocyclic Compounds》2003,39(8):1099-1106
Reaction of the potassium salt of 2-thioquinazolin-4-one with propargyl halides leads to formation of 2-propargylthioquinazolin-4-one derivatives, which undergo heterocyclization when they are treated with electrophilic or nucleophilic reagents and, depending on the nature of the cyclization agent, leads to formation of tricyclic systems with angular or linear structure. 相似文献
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F. M. Avotin'sh M. V. Petrova P. V. Pastors A. Ya. Strakov 《Chemistry of Heterocyclic Compounds》1999,35(6):722-728
Anthranilic acid and its 5-bromo and 4-chloro derivatives react with pinanoic and pinonoic acid chlorides to give the corresponding N-acyl derivatives. The pinanoyl derivatives give the corresponding 2-(3-ethyl-2,2-dimethyl-cyclobutylmethyl)-4-(3H)-quinazolinones when refluxed in formamide. Pinanoylanthranilic acid reacts with dicyclohexylcarbodiimide to give 2-(3-ethyl-2,2-dimethylcyclobutylmethyl)benz-3,1-oxazin-4(H)-one and subsequently with hydrazine hydrate to give 3-amino-2-(3-ethyl-2,2-dimethylcyclobutylmethyl)-4(3H)-quinazolinone. Refluxing of the pinanoyl- and pinonoylanthranilic acids with acetic anhydride gives acetylanthranilic acid, and pinonoylanthranilic acid gives 4(3H)-quinazolinone with formamide.Riga Technical University, Riga LV-1658, Latvia; e-mail: marina@osi.lanet.lv. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 811–817, June, 1999. 相似文献
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Chandresh L. Jagani Natvar A. Sojitra Satish F. Vanparia Tarosh S. Patel Ritu B. Dixit Bharat C. Dixit 《Journal of Saudi Chemical Society》2012,16(4):363-369
The present paper describes an optimized reaction condition for the microwave promoted synthesis of newer 3-thiazole substituted 2-styryl-4(3H)-quinazolinone derivatives, which in turn were prepared in good yield by the treatment of various 2-styryl benzoxazinone derivatives with various 2-aminothiazoles using co-solvent under microwave irradiation. All the compounds were characterized by various spectroscopic techniques and analytical methods. All newly synthesized compounds have been screened for their in vitro antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus megaterium,Bacillus subtilis, and Aspergillus niger. 相似文献
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Cyril Prknyi Hui Liang Yuan Bo H. E. Strmberg Ariella Evenzahav 《Journal of heterocyclic chemistry》1992,29(4):749-753
The synthesis of ten new substituted 1,3,4-thiadiazolyl-4(3H)-quinazolinones 8–11, 13, 17 , and 20–23 is reported. Compounds 8–11 were prepared by condensation of 5-fluoro-2-methyl-3,1-benzoxazin-4-one (3) and 5-substituted 2-amino-1,3,4-thiadiazoles 4–7. Compound 13 was obtained by condensation of 5-fluoro-2-methyl-3,1-benzoxazin-4-one (3) with DL-α-amino-?-caprolactam (12) . Compound 17 was synthesized by condensation of 6-bromo-2-methyl-3,1-benzoxazin-4-one (16) and 2-amino-5-t-butyl-1,3,4-thiadiazole (5) . Compounds 20–23 were obtained by condensation of 5-chloro-6,8-dibromo-2-methyl-3,1-benzoxazin-4-one (19) and 5-substituted 2-amino-1,3,4-thiadiazoles 4–7, respectively. The substituted 3,1-benzoxazin-4-ones 3, 16, and 19 were obtained in good yield by refluxing the appropriate anthranilic acid, 1,15 , and 18 with acetic anhydride (2) . 相似文献
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Hashimoto M Andersson I Pettersson L 《Dalton transactions (Cambridge, England : 2003)》2007,(1):124-132
The speciation in the phosphitomolybdate system, H+-MoO4(2-)-(HP)O(3)2-, has been determined from combined potentiometric and 31P NMR measurements in 0.600 M Na(Cl) medium at 298(1) K. Potentiometric titration data were collected in the ranges 2.5<-log[H+]<6.2, 40.0相似文献
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Alkyl 2-methyl-4-(diethoxyphosphorylmethyl)-5-tert-butylfuran-3-carboxylates are selectivelybrominated with N-bromosuccinimide at the methyl group in position 2 of the ring. The resulting bromo-methyl derivatives react with secondary amines to form tertiary amines, with sodium butylthiolate inmethanol to form the corresponding sulfide. The reaction with potassium thiocyanate in DMF at 80°C givesa mixture of thiocyanate and isothiocyanate. When treated with phenolate or alcoholate ions, the bromomethylfurans decompose. 相似文献