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Mironovich L. M. Salistaya G. S. Promonenkov V. K. 《Russian Journal of General Chemistry》2001,71(6):991-992
Russian Journal of General Chemistry - 相似文献
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Some 5-aryl(or benzyl)-2-oxo-1,3,4-oxadiazole-3(2H)-acetones or acetophenones 2 were easily prepared. These compounds reacted with hydrazine derivatives to give 4,5-dihydro-1,2,4-triazin-3(2H)-one derivatives 3 , 4 and 6 in good yields. With phenylhydrazine, the intermediate hydrazones 5 were obtained. Their conversion into triazinones necessitated the presence of sodium ethylate. 相似文献
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Yoshinori Nakayama Yuzuru Sanemitsu Masato Mizutani Hirosuke Yoshioka 《Journal of heterocyclic chemistry》1981,18(3):631-632
A facile synthesis of 4,5-dihydro-1,2,4-triazin-3-(2H)one (2a) from 5-methylthio-1,2,4-triazin-3-(2H)one (1a) with sodium borohydride is described. The reaction provides a convenient method for its 6-substituted derivatives (2b-h). 相似文献
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Alkylation of the sodium salt and the trimethyl silylated derivatives of 6-methyl-1,2,4-triazin-3(4H)-one 1-oxide with chloromethoxyethyl acetate, n-hexyl chloride and benzyl bromide gave the 4-substituted products. However, attempts to achieve the ring closure of N4-(2-acetoxyethoxymethyl)thiosemicarbazide with bicarbonyl compounds to the corresponding as-triazines under different reaction conditions was not possible without disruption of the acetoxyethoxymethyl moiety. Although the as-triazine nucleoside analog II did not show antileukemic activity, this and other 4-alkylated as-triazine 1-oxides revealed good growth inhibitory effects against a representative spectrum of microorganisms. 相似文献
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Alfredo Camparini Angela Maria Celli Fabio Ponticelli Piero Tedeschi 《Journal of heterocyclic chemistry》1978,15(8):1271-1276
Reactions of the iminoesters 3a-c with hydrazine or 1,2-dimethylhydrazine gave 4,5-dihydro- 4a-c or 2,5-dihydro-1,2,4-triazin-6(1H) ones 7a-c , respectively. When methylhydrazine was employed, 1-methyl-4, 5-dihydro- 5a-c and 2-methyl-2,5-dihydro-1,2,4-triazin-6(1H) ones 6a-c were obtained. Compounds 6a-c exist as zwitterions in the solid state and in polar aprotic solvents. 相似文献
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The reaction of 6-(tert-butyl)-3-hydrazino-1,2,4-triazin-5(2H)-one with acetone and benzaldehyde yields the corresponding hydrazones. In the presence of thionyl chloride the benzaldehyde hydrazone is converted to 3-(tert-butyl)-6-phenyl-1,2,4-triazolo[4,3-b]-1,2,4-triazin-2(1H)-one and this can also be formed via the acylation of the starting hydrazinotriazinone using benzoyl chloride. 相似文献
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Reaction of 6-tert-butyl-3-hydrazino-2,5-dihydro-1,2,4-triazin-5-one with excess benzoyl chloride or formic acid afforded 6-tert-butyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-7(8H)-ones. 相似文献
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A new and easy protocol for the formation of substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones was developed on solid support. The heterocyclic compounds were formed by nucleophilic reaction of hydrazine on thioamide esters. As cyclization was concomitant with cleavage from the support, substituted 4,5-dihydrotriazinones were obtained in high purity. 相似文献
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A. F. Prokof'eva Zh. Z. Sapozhnikova V. N. Volkova V. V. Negrebetskii L. A. Pokrovskaya N. N. Mel'nikov 《Chemistry of Heterocyclic Compounds》1991,27(7):772-778
A study was carried out of alkylation, acylation and aminomethylation reactions were studied in the 5-alkyl-4,5-dihydro-1,2,4-triazin-4-one series. Alkylation by alkyl halides proceeds in the presence of sodium methylate at the N
(1)
and N
(4)
atoms with the formation of a mixture of alkylated compounds of three types: derivatives of 4,5-dihydrotriazine, unsaturated triazine, and their dimers. Acylation with isocyanates leads to the formation of heterocyclic ureas — derivatives at the N
(4)
atom. Mono- and bisaminals were obtained by the reaction of triazines with ethoxymethyldiethylamine.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 963–970, July, 1991. 相似文献
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Treatment of methyl α-(dimethylarninomethyleneamino)carboxylates 1 (from α-amino acids and dimethylformamide dimethylacetal) with hydrazine gives 5-substituted-4,5-dihydro-1,2,4-triazin-6-ones 2 , which are smoothly dehydrogenated to 5-substituted-1,2,4-triazin-6-ones 3 with potassium permanganate in acetone/acetic acid. 相似文献
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Journal of Structural Chemistry - 相似文献
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Zyryanov G. V. Rusinov V. L. Chupakhin O. N. Krasnov V. P. Levit G. L. Kodess M. I. Shtukina T. S. 《Russian Chemical Bulletin》2004,53(6):1290-1294
The reaction of 3-phenyl-1,2,4-triazin-5(4H)-one (1) with l-menthol in the presence of aliphatic acid anhydrides results in (6S)- and (6R)-1-acyl-6-(l-menth-3-yl)-1,6-dyhydro-3-phenyl-1,2,4-triazin-5(4H)-ones. The reaction is diastereoselective with predominant formation of (6S)-isomers. The reaction diastereoselectivity increases with enhancement of the steric hindrance in the vicinity of the reaction center of the azine. 相似文献
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The novel synthesis of 4,5-dihydro-1,2,4-triazin-6-(1H)ones, 2 , from 2-isocyanoacetates is described. This synthetic method allows the first synthesis of the unsubstituted parent ring sytem and, in general, gives 2 substituted in only the five position. The assignment of tautomeric structures ( 2 or 3 ) to the triazinone products was resolved by spectroscopic means. 相似文献
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