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1.
A method was developed for the synthesis of 2-alkyl(aryl)-1,2-dihydro-2,3-biquinolines, based on the addition of organolithium compounds to 2,3-biquinoline in the presence of tetramethylethylenediamine. Their oxidation with manganese dioxide led to 2-alkyl(aryl)-2,3-biquinolines.For Communication 2, see [1].Stavropol State University, Stavropol 355009, Russia. Russian Chemical-Technology University, Moscow 125190. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 350–354, March, 1998. 相似文献
2.
4,5-Dimethyl-1,3-bis(pyridin-2-ylmethyl)-1H-imidazolium chloride (1) was synthesized and characterized by IR and NMR spectroscopy and X-ray diffraction. An attempt to prepare the free tridentate N-heterocyclic carbene pincer ligand by the reaction of 1 with KN(SiMe3)2 resulted in the formation of 1,1′-bis(pyridin-2-ylmethyl)-2,2′-bis(4,5-dimethylimidazole) as a product of dimerization of the target carbene followed by the rearrangement accompanied by the elimination of dipyridylethane. 相似文献
3.
The reaction of M(OAc)2 with 2,2′-bis(2-hydroxybenzylideneamino)-4,4′-dimethyl-1,1′-biphenyl (H2L1) allows the synthesis of 2,2′-bis(2-oxidobenzylideneamino)-4,4′-dimethyl-1,1′-biphenyl complexes of Cu(II) (CuL1), Co(II) (CoL1) and Ni(II) (NiL1) that were characterized by elemental analysis, FTIR spectroscopy and for CuL1 also by X-ray crystallography verifying a tetradentate binding mode of L1 via an (ONNO) motif of the two phenolic oxygen atoms and two azomethine nitrogen atoms. Recrystallization from a solvent mixture of dichloromethane and methanol promotes the formation of methanol adducts. Different binding modes of the methanol–complex were investigated using density functional theory calculations and binding energies, and thermodynamic data of the interaction are reported. The results show that the favored interaction occurs when the methanol molecule acts as a Lewis acid weakly binding via an O–H···O hydrogen bridge to a phenoxide moiety leading to an elongation of the respective M–O bond. 相似文献
4.
Some 1-arylsulfonylthiosemicarbazides have been reported as fungicides1 and bacterio-static agents2. Recently, it is well documented that thiosemicarbazide is a novel class ofnon-peptide antagonists for bradykinin B2 , which is beneficial in the symptomat… 相似文献
5.
The 1,4-dihydro-2,3-biquinolyl reacts with organolithium compounds to form the mixture of 4-R-1,4-dihydro-2,3-biquinolyls and 2-R-1,2-dihydro-2,3-biquinolyls in the ratio analogous to the conversion in the series of 2,3-biquinolyl. The utilization of the complex, the organolithium compound-TMEDA, in this process leads, after treatment of the reaction mixture with water, exclusively to 2-R-1,2-dihydro-2,3-biquinolyls. Treatment with methyl iodide leads to 1-methyl-2-R-1,2-dihydro-2,3-biquinolyls. 相似文献
6.
A general method has been proposed for synthesizing 3-(3-acetyl-5-aroyl-1,3,4-oxadiazolyl-2)-chromones that has been based on conversion of 3-formylchromones to acylhydrazones and of theacylhydrazones into the heterocyclic chromones. 相似文献
7.
Summary Binuclear metal complexes of the type [M(HMTE)-(H 2O) 2] 2, where HMTE=1-(-hydroxynaphthyl)-2-(3-methyl-5-mercapto-1,2,4-triazolc)2-aza-ethane and M-Cu II, Co II, Ni II and Mn II have been prepared and characterized. An octahedral geometry around the metals is proposed. The complexes have been screened as possible fungicides. 相似文献
8.
An X-ray structural examination is carried out for 2,3-dimethyl-5-(2′-methylprop-1′-enyl)-6-(morpholyl-4′-carbonyl)-cyclohex-3-en-1-carboxlic acid that is one of the products of the Diels-Alder reaction of an acyclic monoterpene alloocimene with maleic and citraconic anhydrides followed by the ring opening of adducts with morpholine to corresponding amides. The crystals are triclinic; a = 10.619(1) ?, b = 12.784(2) ?, c = 14.328(2) ?; α = 65.752(1)°, β = 87.932(1)°, γ = 78.120(1)°; V = 1733.0(3) ? 3, P-1 space group, Z = 4 (two independent molecules). In both molecules, the anti-conformation of the carboxylic group is observed, the conformation being stabilized by an intramolecular hydrogen bond involving the carboxylic hydrogen atom and ketonic oxygen. 相似文献
9.
Synthesis of 3,4-Biheterylthieno[2,3-b]-thiophenes. Part I: Synthesis of 3,4-Bi(1′,3′,4′-thiadiazolyl-, s-triazolyl-,1′,3′,4′-thiadiazinyl-, 1′,3′,4′-triazinyl-, thiazolyl-, 1′,3′-thiazinyl- and primidinyl)-thieno[2,3-b]thiophenes
3,4-Diamino-2,5-dicarbethoxythieno[2,3-b]thiophene ( 1 ) was allowed to react with NaNO 2 and active methylenes to afford the corresponding azo compounds 2a-c . Hydrazonyl chloride 2a was treated with carbon disulfide, phenyl isothiocyanate, benzonitrile, benzyl cyanide, malononitrile, benzalaniline, ethyl mercaptoacetate, and ethyl glycinate to give 1,3,4-thiadiazolyl-, s-triazolyl-, 1,3,4-thiadiazinyl-, 1,3,4-triazinylthieno[2,3-b]thiophenes 3-6 respectively. The reaction of 2b,c with urea, thiourea, and guanidine afforded pyrimidinyl- and thiazinylazothieno [2,3-b]thiophenes 7-10 respectively. Bithiazolylthieno[2,3-b]thiophenes 11 and 13 were synthesized by treating compound 1 with CS 2 along with halo compounds. The addition of S,S-, N,S-, and N,O-acetals to the Schiff base 14 afforded compounds 15-17 respectively. 相似文献
10.
A series of novel 2,3-dihydro-2-phenylsulfonylhydrazono-3-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl) thiazoles were designed and synthesized via the reaction of thiosemicarbazide with chloroaldehyde.Their chemical structures were characterized by 1H and 13C NMR spectroscopy and elemental analysis.The bioassay results indicate that some of these compounds exhibit moderate fungicidal and herbicidal activities. 相似文献
11.
A method has been developed for the synthesis of 1′-R-1′,4′-dihydro-2,3′-biquinolin-4′-ones based on the interaction of quinaldine
with N-alkyl-N-formylanthranilic acid methyl esters under the conditions of the Claisen condensation.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 409–410, March 2008. 相似文献
12.
The title compound 3, an intermediate in the synthesis of fluorocarbapenems, is obtained with high stereocontrol by the condensation of ( R)-(+)-ethyl 4,4,4-trifluoro-3-hydroxybutanoate with N-trimethylsilyl cinnamylidenimine. X-Ray diffraction analysis of the condensation product and chemical correlations allowed the unambiguous determination of the absolute configuration. 相似文献
13.
Five-membered 2,3-dioxo heterocycles: LXIII. Cascade recyclization of isopropyl 2-(1-aryl-4,5-dioxo-2-phenyl-4,5-dihydro-1H-pyrrol-3-yl)-2-oxoacetates with cyclic enamines. Crystalline and molecular structure of 1′-benzyl-6′,6′-dimethyl-3-[(Z)-phenyl(phenylamino)methylidene]-6′,7′-dihydro-3H-spiro[furan-2,3′-indole]-2′,4,4′,5(1′H,5′H)-tetraone
Isopropyl 2-(1-aryl-4,5-dioxo-2-phenyl-4,5-dihydro-1 H-pyrrol-3-yl)-2-oxoacetates reacted with N-substituted 3-amino-5,5-dimethylcyclohex-2-en-1-ones to give the corresponding 1′-substituted ( Z)-6′,6′-dimethyl-3-[phenyl(arylamino)methylidene]-6′,7′-dihydro-3 H-spiro[furan-2,3′-indole]-2′,4,4′,5(1′ H,5′ H)-tetraones. The structure of 1′-benzyl-6′,6′-dimethyl-3-[( Z)-phenyl(phenylamino)methylidene]-6′,7′-dihydro-3 Hspiro[furan-2,3′-indole]-2′,4,4′,5(1′ H,5′ H)-tetraone was proved by X-ray analysis. 相似文献
14.
3,3-Dimethyl- and 3-methyl-1-(4,4-dimethyl-2,6-dioxocyclohex-1-yl)-3,4-dihydroisoquinolines have been synthesized. Crystal and molecular structures of the 3,3-dimethyl derivative have been determined. In the crystalline state this compound exists as a tautomeric form where a hydrogen atom is located at the N atom of the dihydroisoquinoline fragment of the molecule. The tautomeric equilibrium does not shift noticeably in solutions, as shown by IR, UV, and NMR spectroscopy.Translated from Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 331–336, February, 1993. 相似文献
15.
Steroidal ketone thiosemicarbazones (4–6), obtained from the corresponding ketones(1–3), on oxidative cyclization with H 2O 2 at 0°C provide title compounds (7–9), respectively. The structures of these compounds have been established on the basis of their elemental analytical and spectral data. 相似文献
16.
Specific features of the molecular and crystal structures of 1,5- bis-(4′,4′,4′-trifluoro-1′-methyl-3′-oxo-but-1′-enylamino)-3-oxapentane are determined by single crystal XRD. 相似文献
17.
Summary Ten derivatives of 1,1- bis(diphenylphosphine)ferrocene (BDPF) are described in this paper. The first three, [BDPF·SnCl 4] ( 1), [BDPF·MeSnCl 3] ( 2) and [BDPF·PhSnCl 3] ( 3), present the two phosphorus atoms of the ligand directly bonded to a Sn centre. Two others, [BDPF-PdCl 2 ( 4) and [BDPF·PtCl 2] ( 5), similarly have the ligand BDPF acting as a bidentate species towards a transition metal. The crystal and molecular structures of ( 4) and ( 5) are presented here. Two other BDPF complexes were obtained with Pd and Pt, with the transition metals in the zerovalent state, namely [Pd(BDPF) 2] ( 6) and [Pt(BDPF) 2] ( 7). Finally, three trimetallic complexes are also described; [BDPF·Pd( -Cl) 2SnCl 2] ( 8), [BDPF· Pt(-Cl) 2SnCl 2] ( 9) and [BDPF·PdClSnCl 3] ( 10). 相似文献
18.
1,1′-Bis[(alkyl- or phenyl-)thio]- and 1,1′-bis(diphenylphosphino)-ferrocenes react with (CH 3CN) 4Pd(BF 4) 2 in the presence of triphenylphosphine to give 1/1 complexes in good yields. Spectral data have confirmed the presence of an FePd dative bond in these complexes. 相似文献
19.
Thiolation of 1-alkyl-3-(2-quinolyl)quinolinium halides by a mixture of sulfur with KOH in DMF leads to formation of 1-alkyl-1,4-dihydro-2,3-biquinolyl-4-thiones, rearrangement of which in boiling ethylene glycol makes it possible to obtain 4-alkylthio-2,3-biquinolyls. 相似文献
20.
以2-苯基-1,2,3-三唑-4甲酰肼为原料合成了几种新的1-(2′-苯基-1′,2′,3′-三唑-4′-甲酰基)-4芳基氨基硫脲,在不同条件下环化,制得一系列新的1,3,4-噻二唑、1,3,4- 二唑和1,2,4-均三唑衍生物.化合物的结构经元素分析、IR、1HMR和MS确证,并对其波谱性质进行了讨论. 相似文献
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