微量热法测定细菌的最低生长温度

微量热法测定细菌的最低生长温度南照东，刘永军，孙海涛，张洪林（曲阜师范大学化学系曲阜２７３１６５）关键词微量热法，细菌的生长热谱，最低生长温度，生长速率常数我们应用微量热法测定了大肠杆菌（Ｅ．ｃｏｌｉ），白色葡萄球菌（Ｓ．ａｌｂｕｓ），金黄色葡萄球菌...     

线粒体热化学研究──Ⅳ．鱼类肝脏线粒体代谢的微量热学研究

线粒体热化学研究──Ⅳ．鱼类肝脏线粒体代谢的微量热学研究谭安民，刘义，谢昌礼，屈松生，顾贫，邓凤姣（武汉大学化学系武汉４３００７２）（武汉大学生命科学院武汉）关键词鱼肝脏，线粒体，微量热学，热化学线粒体在能量代谢的过程中，除一部分能量用于合成ＡＴＰ外...     

黄芪促菌作用的微量热法研究

黄芪促菌作用的微量热法研究李志萍，杭瑚，陆懋荪于秀芳，张洪林袁久荣（青岛大学化学系青岛２６６０７１）（曲阜师范大学化学系曲阜）（山东中医学院中药系济南）关键词黄芪，促菌作用，量热法前文［１～３］已报道合成药物及中草药黄连对细菌生长的抑制作用。本文研究...     

微量热法研究Schiff碱药物的抗菌作用

微量热法研究Ｓｃｈｉｆｆ碱药物的抗菌作用冯英，刘义，谢昌礼，屈松生，乐芝凤，冯长建，沈昊宇，张香才（武汉大学化学系武汉４３００７２）（华中师范大学化学系武汉）关键词Ｓｃｈｉｆｆ碱药物，微量热法，产气杆菌Ｓｃｈｉｆｆ碱及其金属配合物具有抗病毒抗菌等生物...     

用微量热法研究漆酶和3,4—二羟基苯甲醛的反应

用微量热法研究漆酶和３，４－二羟基苯甲醛的反应望天志＊吴鼎泉万洪文＊＊屈松生（武汉大学化学系，武汉４３００７２，＊＊华中师范大学化学系武汉）关键词漆树漆酶，微量热法，３，４－二羟基苯甲醛１９９６－０８－０８收稿，１９９６－１０－１７修回国家自然科学基...     

黄连抗菌作用的量热测定

黄连抗菌作用的量热测定孙海涛，刘永军，南照东，张洪林，袁久荣（曲阜师范大学化学系曲阜２７３１６５）（山东中医学院中药系济南）关键词黄连，抗菌作用，量热法一切生物活体在生长和代谢过程中都产生一定的热效应。近年人们已应用微量量热法测定了合成药物对细菌的抑...     

微量热法研究Schiff碱钴配合物的抗菌活性

微量热法研究Ｓｃｈｉｆｆ碱钴配合物的抗菌活性黄在银＊屈松生冯英俞芸（武汉大学化学系武汉４３００７２）关键词二羟基苯甲醛葡萄糖Ｓｃｈｉｆ碱配合物，微量热法，抗菌活性，大肠杆菌１９９７－０８－１８收稿，１９９７－１１－０３修回国家自然科学基金及高等学校博...     

2－杂萘满并喹啉的合成及抑菌活性的微量量热法研究

２－杂萘满并喹啉的合成及抑菌活性的微量量热法研究刘永军，丁养军，刘英（曲阜师范大学化学系曲阜２７３１６５）关键词２－杂萘满酮，抑菌活性，微量量热２－杂萘满酮具有（Ｉ）所示的化学结构，最常见的杂原子为Ｏ、Ｓ、Ｎ，关于Ｓｅ原子报道不多，分别俗称异色满酮、...     

药物对福氏志贺氏菌代谢抑制的微量热法研究

药物抑制细菌生长的热化学研究是当今热化学法研究的一个活跃领域．在这项研究中，Boling[1]、Nordmark[2]、屈松生[3]等人已做了不少有意义的工作．在前人工作的基础上，我们用热活性检测系统测定了福氏志贺氏菌属中五株细菌在药物抑制下生长的完整的热谱曲线．按指数生长模型计算出细菌代谢抑制下的生长速车常数，并用计算机拟会出生长速率常数与不同浓度药物之间的关系式，进一步得到生长速率常数为零（临界生长参数[4]）时的用药物浓度．此项研究工作的开展对于深入研究药物对细菌的抑制作用，筛选对某细菌抑制的特效药提供了一种新的…     

邻苯二甲酸锌配合物的合成,红外光谱和晶体结构

邻苯二甲酸锌配合物的合成、红外光谱和晶体结构孙聚堂＊王东利张克立王春林（武汉大学化学系武汉４３００７２）（武汉大学测试中心武汉）关键词邻苯二甲酸，锌，晶体结构，红外光谱１９９６－１２－１６收稿，１９９７－０６－１６修回国家自然科学基金资助课题掺杂微量...     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Selective syntheses of 2H-1,3-oxazines and 1H-pyrrol-3(2H)-ones via temperature-dependent Rh(II)-carbenoid-mediated 2H-azirine-ring expansion

The Rh(II)-catalyzed reaction of 2-carbonyl-substituted 2H-azirines with ethyl 2-cyano-2-diazoacetate or 2-diazo-3,3,3-trifluoropropionate provides an easy access to 2H-1,3-oxazines and 1H-pyrrol-3(2H)-ones. These compounds can be selectively prepared from the same starting material using temperature as the only varied parameter. The 2-azabuta-1,3-diene intermediate, a common precursor for both heterocyclic products, isomerizes into 2H-1,3-oxazine under kinetic control, while 1H-pyrrol-3(2H)-one is the sole product of the reaction at elevated temperatures. According to DFT-calculations a one-atom oxazine ring contraction involving ring-opening to a 2-azabuta-1,3-diene intermediate, followed by a 1,5- and 1,2-prototropic shift leads to the consecutive formation of imidoylketene and azomethine ylide, which then further undergo cyclization to the pyrrole derivative.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.