共查询到20条相似文献,搜索用时 15 毫秒
1.
LUO San-Zhong WANG Peng G. CHENG Jin-Pei 《有机化学》2003,23(Z1):166-166
β-Substituted enones have been considered less reactive in Baylis-Hillman reaction. The reaction of cyclic enones is sluggish or does not occur at all under traditional conditions. Various catalysts have been developed to pro mote the reaction of cyclic enones but with limited success. In previous study, we found that imidazole can catalyze the Baylis-Hillman reaction involving cyclic enones in aqueous THF solution.[1] In our continued efforts, we screened a variety of imidazoles to develop superior catalyst, and we found that the reaction could be greatly accelerated by adjusting the pH value of the water solution. 相似文献
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LUO San-Zhong WANG Peng G. CHENG Jin-Pei 《有机化学》2003,23(Z1):169-169
β-Substituted enones have been considered less reactive in Baylis-Hillman reaction. The reaction of cyclic enones is sluggish or does not occur at all under traditional conditions. Various catalysts have been developed to pro mote the reaction of cyclic enones but with limited success. In previous study, we found that imidazole can catalyze the Baylis-Hillman reaction involving cyclic enones in aqueous THF solution. [1] In our continued efforts, a variety of azole compounds were examined in Baylis-Hillman reaction. We found that the azoles act as effective catalysts in properly adjusted water solution. 相似文献
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Aqueous trimethylamine mediated Baylis-Hillman coupling of alkyl acrylates with aldehydes is described. 相似文献
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Siegfried E. Drewes Owen L. Njamela Neville D. Emslie Niyum Ramesar John S. Field 《合成通讯》2013,43(20):2807-2815
The acrylate ester of salicylaldehyde, in the presence of DABCO, affords a crystalline coumarin salt. Formation of this derivative confirms a vital intermediate in the mechanism of the reaction. Salicylaldehyde, suitably protected, reacts with methyl acrylate to afford a novel coumarin not unlike the vasodilator chromonar. 相似文献
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Francesco De Vincentiis Giorgio Bencivenni Dr. Fabio Pesciaioli Andrea Mazzanti Dr. Giuseppe Bartoli Prof. Patrizia Galzerano Dr. Paolo Melchiorre Prof. Dr. 《化学:亚洲杂志》2010,5(7):1652-1656
The first catalytic method for the asymmetric aziridination of cyclic enones is described. The presented organocatalytic strategy is based on the use of an easily available organocatalyst that is able to convert a wide range of cyclic enones into the desired aziridines with very high enantiomeric purity and good chemical yield. Such a method may very well open up new opportunities to stereoselectively prepare complex chiral molecules that possess an indane moiety, a framework that is found in a large number of bioactive and pharmaceutically important molecules 相似文献
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The Michael addition of ethyl acetoacetate, acetyl acetone and ethyl cyanoacetate to cycloalkenones and β -substituted enones and enal has been accomplished efficiently on the surface of alumina under microwave irradiation in dry media. 相似文献
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A highly enantio‐ and diastereoselective Mannich reaction of cyclic N‐acyl ketimines generated in situ from 3‐hydroxyisoindolin‐1‐ones with cyclic enones has been accomplished using a chiral phosphoric acid catalyst to afford the chiral isoindalinone derivatives in high yields with excellent enantioselectivities (upto 97 % ee). This is the first report on the synthesis of chiral isoindolin‐1‐ones bearing adjacent quaternary and tertiary stereogenic centers. 相似文献
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Russian Journal of General Chemistry - A mechanochemical method was developed for the synthesis of ferromagnetic Pd–Fe–Co–Ni composites based on the natural biopolymer chitosan,... 相似文献
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CunLiuZHOU YuQingZHOU ZhiYongWANG 《中国化学快报》2003,14(4):355-358
The chemoselective addition of aldehydes in aquoues medium was obtained under mild condition using improved Henry reaction. 相似文献
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Four titanocene complexes were prepared in aqueous or two-phase medium by the reaction of benzoylacetone titanocene with substituted salicylic acid, respectively. Based on the UV-Vis spectra, we studied the accelerating effect of the benzoylacetone on the reaction rate quantificationally. The results demonstrated that the presence of it not only stabilizes the “Cp2Ti” species and accordingly makes pH value of the aqueous solution of substituted salicylic acid increased but also prompts the reaction due to the presence of its conjugation structure and oleophyllic group. Furthermore, the presence of benzoylacetone is in favor of the simplification of the products. 相似文献
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Yuki Nakano Satoki Shimizu Chihiro Takeda Satoshi Sakaguchi 《Molecules (Basel, Switzerland)》2021,26(11)
Hydroxyamide-functionalized azolium salt (NHC•HI 4) was evaluated for dual enantioselective control in a Cu-catalyzed asymmetric conjugate addition (ACA) reaction. This investigation was based on our previously reported ACA reaction catalyzed using CuOTf combined with NHC•AgI complex 1. It was revealed that the stereocontrol of the catalytic ACA reaction depended on the order of the addition of the substrates. Additionally, the chiral NHC ligand precursors, substrates, the relationship between the catalyst ee (eecat) and product ee (eepro), and halogen counter anion were completely evaluated. These results suggested that the catalytic performance of the CuOTf/4 system was comparable with that of the CuOTf/1 system. Furthermore, to gain knowledge of the Cu species generated using CuOTf and NHC ligand precursor, the reaction of CuOTf with 1 was investigated. Although obtaining the corresponding NHC•CuX species failed, the corresponding NHC•AuCl complex 11 could be synthesized by allowing 1 to react with AuCl•SMe2. 相似文献
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报道了一种简便、有效的水相噤呐偶合反应。在含有少量季铵盐或季磷盐的氯化铵水溶液中.用金属锌促进羰基化合物进行水相噘呐偶合反应,其中加入的少量季铵盐或季磷盐有助于显著提高反应产率,噘呐醇产率由53%提高到87%。但噘呐偶合反应的产率受羰基周围环境的立体位阻影响较大,在此条件下,金属锌可有效地促进芳香族醛化合物进行水相噘呐偶合反应,得到产率较高的噘呐醇,但非对映异构体选择性差,而脂肪族醛化合物得到的噘呐醇产率较低,在同样条件下,酮类化合物不能顺利进行噘呐偶合反应。 相似文献