Preparation and X—ray Crystal Structure of Di—chloro—bis（p—t—butylphen

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2，3—二氰基—2，3—二（p—X苯基）丁二酸二乙酯的分子构型和取代基电子效应对613 NMR谱的影响

测定了meso-和dl-2,3－二氰基－2，3－二（p-X苯基）丁二酸二乙酯（X＝OCH3，CH3，H，Cl,NO2)的^13C NMR谱。结果表明，，中心碳－碳键两端相连基团的各碳原子的化学位移值相同，与dl-异构体相比，所有相应meso-异构体的乙氧羰基^13C NMR吸附峰均处于高场，苯环对位取代基的Hammett基团常数σ与氰基碳原子和乙氧羰基中的羰基碳及次甲基碳的化学位移间线性相关，而且meso-异构体比dl-异构体有更好的线性关系。     

通过α—重氮—β—二酮与醛酮的环加成反应合成4H—1,3—二恶环已—5—烯 …

研究了α-重氮-β-二酮与各类羰基化合物的环加成反应,合成了一系列4H-1,3-二噁环己-5-烯-4-酮衍生物.     

Crystal Structure of 2—[（P,P—Diphenoxy）phosphono（p—methyl）benzyl]—1,2—

The crystal structure of the title compound 2-[(P, P-Diphenoxy)phosphono(p-methyl)benzyl]-1, 2-benzisoselenazol-3(2H)-one, C27H22NO4PSe, was determined by single crystal X-ray diffraction. It crystallizes in the triclinic system, space group P(No. 2) with Mr=534.41, a=9.761(2), b=10.304(2), c=13.396(3), α=110.97(3), β=107.70(3). γ=90.02(3)°, V=1190(1) 3, Z=2, Dx=1.492 g/cm3, λ=0.71073, μ=1.6596 mm-1 and F(000)=544. The structure was solved by direct methods. The final R factor is 0.068 and Rw is 0.074 for 2500 unique observed reflections [I≥3σ(I)]. The results presented herein indicate that the selenium-containing bicyclic moiety is a coplanar structure and that two adjacent molecules are symmetrically linked to each other forming a dimer through the Se(1c)...O=P(1) bonding interaction with an intermolecular Se(1c)...O distance of 2.797 .     

Synthesis of 5—Aryl—1,2—dihydro—1—pyrrolizinones

In order to search for new potent anti-inflammatory and analgesic agents in pyrrolizinones,the title compounds were designed and synthesized.A series of the compounds were prepared with two different synthetic schemes.Some of the compounds showed remarkable anti-inflammatory and/or analgesic activities on mice.     

Synthesis of 3,7—Disubstituted 1,4—Benzodiazepin—2—one

A series of 3-methoxycarbonylpropoxy-7-(imidazol-4-ylpropinamide)-1,3-dihydrogen-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-ones,as farnesyltransferase(Ftase) inhibitors,were synthesized. The preparation of the key intermediate,7-amino-3-methoxycabonylpropoxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one,was improved.     

5，5—二甲基—2—氧代—2—（N，N‘—对苯二胺基—二苄基）—二—1，3，2—氧磷杂环已烷的合成及表征

以新戊二醇、三氯化磷和乙醇为原料制得中间体5,5-二甲基-1,3,2-二氧磷杂环已烷-2-氧（DPDO）,用DPDO与由芳醛和对苯二胺缩合制得的席夫碱SBⅠ-SBⅡ加成,合成了膨胀型阻燃剂5,5-二甲基-2-氧代-2-（N,N‘-对苯二胺基-二苄基）-二-1,3,2-氧磷杂环已烷（DPPOⅠ-DPPOⅡ）,通过元素分析,IR,NMR和MS对其结构进行表征,并对其在醇酸清漆中的应用进行了讨论。     

Molecular and Crystal Structure of 7—Hydroxy—6,8—dimethoxyl—coumarin

1　ＩＮＴＲＯＤＵＣＴＩＯＮＣｏｕｍａｒｉｎｉｓｏｎｅｋｉｎｄｏｆｔｈｅｌａｃｔｏｎｅｏｆｏｒｔｈｏ ｈｙｄｒｏｘｙｌｃａｓｓｉａａｃｉｄ .Ｉｔｃｏｍｐｏｓｅｓａｌａｒｇｅｎｕｍｂｅｒｏｆｃｏｕｍａｒｉｃｄｅｒｉｖａｔｅｓｅｒｉｅｓｂｅｃａｕｓｅｏｆｔｈｅｄｉｆｆｅｒｅｎｔｐｏｓｉｔｉｏｎｓ,ｋｉｎｄｓａｎｄｎｕｍｂｅｒｓｏｆｔｈｅｓｕｂｓｔｉｔｕｅｎｔｇｒｏｕｐｓｗｈｉｃｈｌｉｎｋｕｐｗｉｔｈｔｈｅａｒｏｍａｔｉｃａｎｄｌａｃｔｏｎｅｒｉｎｇｓ[1 ,2 ,3] .Ｔｈｉｓｋｉｎｄｏｆｃｏｍｐｏｕｎｄｓｅｘ…