Alkaloids of Stephania hernandifolia VI. Hernandifoline

Summary A new hasubanan alkaloid with the composition C₂₉H₃₃O₉N, mp 128–129°C₉ from ether), [] _D ²⁰ – 25° (c 2; ethanol) containing an ester group has been isolated from the herbStephania hernandifolia and has been called hernandifoline.All-Union Scientific-Research Institute for Medicinal Plants. Translated from Khimiya Prirodynkh Soedinenii, No. 2, pp. 158–164, March, 1971.     

Alkaloids of Stephania hernandifolia VIII. Methylhernandine

Summary A new hasubanan alkaloid with the composition C₂₀H₂₇O₆N, mp 152–153°C (ether-methanol) has been isolated from the herbStephania hernandifolia and has been called methylhernandine. The alkaloid has been shown to be identical with the methylamino alcohol obtained in the hydrolysis of hernandifoline.All-Union Scientific Research Institute of Medicinal Plants. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 455–457, July–August.     

Three New Hasubanan Alkaloids from Stephania hernandifolia (Willd.) Walp.

Three new hasubanan alkaloids, hernsubanines A–C ( 1 – 3 , resp.), were isolated from the whole plants of Stephania hernandifolia. Their structures were elucidated on the basis of physical and spectroscopic data. In in vitro tests for cytotoxic activity against two human cancer cell lines, A 549 and K 562, compound 1 did not exhibit any cytotoxicity.     

Alkaloids ofStephania hernandifolia. III

Chemistry of Natural Compounds - 1. A new alkaloid hernandoline with the composition C20H25O5N has been isolated from the herbStephania herandifolia Walp. 2. The Hofmann degradation of the...     

Alkaloids ofStephania hernandifolia

Chemistry of Natural Compounds -     

Alkaloids of Stephania delovayi III. Stephodeline

Summary From the epigeal part ofStephania delovayi Diels (Menispermaceae) have been isolated cycleanine and a new amorphous alkaloid, stephodeline, with the composition C₂₁H₂₇O₅N, a structure for which is proposed.All-Union Scientific-Research Institute of Medicinal Plants. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 650–653, September–October, 1973.     

Alkaloids of Stephania delavayi IV. Isostephodeline

Summary The structure of the new alkaloid isostephodeline isolated from the roots ofStephania delavayi Diels has been established. The most probable relative configurations of isostephodeline and of the stephodeline isolated previously have been proposed.All-Union Scientific-Research Institute of Medicinal Plants. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 188–193, March–April, 1975.     

New Stephaoxocane Alkaloids from Stephania longa

Three new stephaoxocane‐type alkaloids, stephalonganines A–C ( 1 – 3 ), together with the known eletefine ( 4 ), were isolated from the whole plant of Stephania longa. Their structures were fully characterized spectroscopically, and the absolute configurations of the new alkaloids were assigned by comparison of their circular‐dichroism (CD) data with those of 1,2‐dihydrostephaoxocanine ( 5 ), in combination with 2D‐NMR experiments.     

粪箕笃中两个新颖的含硝基莲花氏烷型生物碱

Two unusual nitro-substituted hasubanan-type alkaloids, stephalonines J （1） and K （2）, together with ten known alkaloids, protostephanine, dehydrostephanine, （-）-stephanine, （-）-isolaureline, R-roemeroline, （＋）-pronuciferine, （ ＋）-stephafine, （ ＋ ）-N-acetylstephafine, （ ＋ ）-lirioferine, and （ ＋ ）-norlirioferine, were isolated from the whole plant of Stephania longa. Their structures were characterized mainly by spectroscopic methods including IR, MS, and NMR experiments, and the structures of 1 and 2 were further confirmed through chemical correlations with the known alkaloids stephalonines A （1a） and B （2a）, respectively.     

Alkaloids ofNitraria komarovii. VII. Structure and synthesis of komarovinine

The new alkaloid komarovinine has been isolated from the total ether-extracted alkaloids of the epigeal part ofNitraria komarovii. It has also been found among the products of the dehydrogenation of nitrarine by selenium and sulfur. On the basis of the available facts, the structure of one of the isomers of 1-quinolinyl-β-carboline was proposed for komarovinine. A direct comparison with synthetic samples shows the identity of the alkaloid to 1-(quinolin-6′-yl)-β-carboline. 1-(Quinolin-7′-yl)-β-carboline, not previously described in the literature, has been characterized.     

Separation of Alkaloids Extracted from Stephania Tetranda S. Moore by Analytical High-Speed Countercurrent Chromatography

Abstract

High-Speed countercurrent chromatography is a recently developed separation method which has been remarkably improved in both partition efficiency and separation time. In the present study, this advanced countercurrent chromatographic method was applied to separation of sample mixture containing tetrandrine, fangchinoline, and cyclanoline originally extracted from

Stephania tetrandra S. Moore. Separations were performed with a two-phase solvent system composed of n-hexane/ethyl acetate/methanol/water in two different elution modes. Sample mixture containing 3 mg of alkaloids was efficiently separated in 100 min. The peak fraction of each component was analyzed with a mass spectrometer for structure identification.