Three new caffeoyl glycosides from the roots of Picrorhiza scrophulariiflora

From the underground parts of Picrorhiza scrophulariiflora, three new caffeoyl glycosides, scrocaffeside A-C (1-3), together with two caffeic acid derivates, 4-O-beta-D-glucopyranosyl caffeic acid (4) and 4-methoxy caffeic acid (5) and a phenylethanoid glycoside, scroside D (6), were isolated. Their structures were elucidated on the basis of chemical and spectroscopic evidence and comparisons with literature data of related compounds.     

Antioxidative phenylethanoid and phenolic glycosides from Picrorhiza scrophulariiflora

One new phenylenthanoid glycoside, scroside D (2), was isolated from the roots of Picrorhiza scrophulariiflora (Scrophulariaceae), together with nine known phenylethanoid and phenolic glycosides: 2-(3,4-dihydroxyphenyl)-ethyl-O-beta-D-glucopyranoside (1), 2-(3-hydroxy-4-methoxyphenyl)-ethyl-O-beta-D-glucopyranosyl (1-->3)-beta-D-glucopyranoside (3), scroside B (4), hemiphroside A (5), plantainoside D (6), scroside A (7), androsin (8), piceoside (9), and 6-O-feruloyl-beta-D-glucopyranoside (10). The structures of these compounds were elucidated using spectroscopic methods. The antioxidative activities of these isolated compounds were evaluated based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. Compounds 1, 2, and 6 showed potent antioxidative effects as those of ascorbic acid and the structure-activity relationship is discussed.     

Two new abietane diterpenoid glycosides from Clinopodium chinense

Two new abietane diterpenoid glycosides, named clinopoditerpenes B (1) and C (2), were isolated from Clinopodium chinese. The structures of the new compounds were determined on the basis of extensive spectral analysis. Compound 1 exhibited cardioprotective effect against H₂O₂-induced apoptosis in H9c2 cells.     

A new flavonol glycoside from Hydrangea macrophylla (Thunb.) Seringe

<正>A new kaempferol glycoside,named kaempferol 3-O-[6″-O-β-D-glucopyranosyl-6′′′-O-α-L-rhamnopy ranosyl-2′′′′-O-α-L-rhamnopyranosyl]-β-D-glucopyranoside,was isolated from Hydrangea macrophylla(Thunb.) Seringe.Its structure was establishedby spectroscopic techniques including MS,IR,UV,and 2D NMR.     

A new phenylethanoid glycoside from Rabdosia lophanthoides （Buch.-Ham.ex D.Don） Hara.

A new phenylethanoid glycoside,3-hydroxy-4-methoxy-β-phenylethoxy-O-α-L-rhamnopyranosyl-(1→3)-2-O-acetyl-O-β-D-glucopyranoside, named lophanthoside A,was isolated from Rabdosia lophanthoides(Buch.-Ham.ex D.Don) Hara.Its structure was determined by spectroscopic evidences.     

A new lathyrane diterpene glycoside from Euphorbia helioscopia L.

<正>A new lathyrane diterpene glycoside,named 3β,7β,15β-trihydroxy-14-oxolathyra-5E,12E-dienyl-16-O-β-D-glucopyranoside, was isolated from Euphorbia helioscopia L.Its structure was established by spectroscopic techniques including 2D NMR.     

A new 3-(3,4-methylenedioxyphenyl)-propane-1,2-diol glycoside from the roots of Cinnamomum camphora

A new 3-(3,4-methylenedioxyphenyl)-propane-1,2-diol glycoside,named cinnamomdiol A(1),together with two known compounds,3-(3,4-methylenedioxyphenyl)-propane-1,2-diol(2) and taxifolin(3),was isolated from the roots of Cinnamomum camphora.Their structures were determined on the basis of spectroscopic evidences.Compounds 2 and 3 were isolated from the title plant for the first time.     

Two new steroidal glycosides from the root of Cynanchum auriculatum

Two new steroidal glycosides named cyanoauriculoside A(1) and B(2),have been isolated from the roots of Cynanchumauriculatum Royle ex Wight.The structure of cyanoauriculoside A(1) was determined to be 20-O-acetyl-penupogenin-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopy-ranosyl-(1→4)-β-D-cymaropyranoside.Cyanoauriculoside B(2) was characterized as 20-O-acetylpenupogenin-3-O-β-D-gluco-pyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside.The structures of these compounds were elucidated based on the chemical and spectroscopic evidence.     

金果榄化学成分的研究 I: 新呋喃三萜苷-金果榄苷的结构

从金果榄中分离得到十余种化学成分, 鉴定了其中一个新的配糖体, 经鉴定为呋喃二萜苷—金果榄苷(异非洲防己苦素4-β-D-葡萄糖苷), 还鉴定了异非洲防己苦素和药根碱等化合物.     

A new prenylated xanthone from Garcinia xipshuanbannaensis Y.H. Li

A new prenylated xanthone, named bannaxanthone I, has been isolated from the leaves of Garcinia xipshuanbannaensis, along with five other known compounds, bannaxanthone E, mangostinone, tovophyllin A, garcinone E, and γ-mangostin. The structure of the new compound was elucidated on the basis of high-resolution fast atom bombardment mass spectra (HRFABMS), 1D-and 2D-NMR experiments, including heteronuclear multiple bond connectivity (HMBC), heteronuclear single quantum coherence (HSQC) and 1H-1H-COSY (correlated spectroscopy, COSY).     

Phenyl and Phenylethyl Glycosides from Picrorhiza scrophulariiflora

Three new phenyl glycosides, scrophenoside A ( 1 ), B ( 2 ), and C ( 3 ), and two new phenylethyl glycosides, scroside D ( 4 ) and scroside E ( 5 ), were isolated from the stem of Picrorhiza scrophulariiflora Pennell (Scrophularlaceae), besides five known compounds. On the basis of spectroscopic evidence, the structures of the new compounds were elucidated as 4‐acetyl‐2‐methoxyphenyl 6‐O‐[4‐(β‐D ‐glucopyranosyloxy)vanilloyl]‐β‐D ‐glucopyranoside ( 1 ), 4‐acetylphenyl 6‐O‐[(E)‐p‐coumaroyl]‐β‐D ‐glucopyranoside ( 2 ), 4‐[(1R)‐ and (1S)‐1‐hydroxyethyl]‐2‐methoxyphenyl β‐D ‐glucopyranoside ( 3a and 3b , resp.), 2‐(3,4‐dihydroxyphenyl)ethyl O‐β‐D ‐glucopyranosyl‐(1→3)‐4‐O‐[(E)‐feruloyl]‐β‐D ‐glucopyranoside ( 4 ), and 2‐(3,4‐dihydroxyphenyl)ethyl O‐β‐D ‐glucopyranosyl‐(1→3)‐6‐O‐[(E)‐feruloyl]‐β‐D ‐glucopyranoside ( 5 ).     

Complete 1H and 13C NMR assignments of four new oligosaccharides and two new glycosides from Periploca forrestii

Four new oligosaccharides (1–4), one new pregnane glycoside (5), and one new cardiac glycoside (6) were isolated from the roots of Periploca forrestii Schltr. (Asclepiadaceae), a traditional Chinese medicine used for the treatment of rheumatoid arthritis and wounds. Their structures were characterized on the basis of extensive analysis of NMR (¹H, ¹³C NMR, ¹H‐¹H COSY, HSQC, HMBC, TOCSY and ROESY) spectra. Copyright © 2009 John Wiley & Sons, Ltd.     

New lignan glycosides from Glehnia littoralis

From the roots ethanol extract of Glehnia littoralis, two new lignan glycosides, named glehlinoside E (1) and F (2), were obtained. Their structures were determined to be (-)-secoisolariciresinol 4-O-β-D-(6-O-feruloyl) glucopyranoside (1) and (-)-secoisolariciresinol 4-O-β-D-(6-O-caffeloyl) glucopyranoside (2) by analysis of their spectral data, respectively.     

A new iridoid glycoside from Veronica sibirica

A new iridoid glycoside,versibirioside（1）,and a known iridoid glycoside,verbaspinoside（2）,were isolated from the whole plant of Veronica sibirica L.Their structures were elucidated by spectroscopic methods,including 2D-NMR spectra.     

A new spirostanol saponin from the rhizomes of Paris mairei

A new spirostanol steroidal saponin,named maireioside A(1),together with three known steroidal saponins,hypoglaucin G(2), parisaponin I(3),and diosgenin-3-O-α-L-rhamnopyranosyl(1→4)-[α-L-rhamnopyranosyl(1→2)]-β-D-glucopyranoside(4),were isolated from the rhizomes of Paris mairei.The structure elucidation was accomplished by 1D and 2D NMR methods,HR-ESI-MS, and hydrolysis.     

Three new compounds from Sarcandra glabra

One new sesquiterpene lactone,1 α,8 α,9 α-trihydroxyeudesman-3(4),7(11)-dien-8 β,12-olide(1) and two new phenylpropanoidsubstituted catechin glycosides,glabraoside C(2) and glabraoside D(3) were isolated from the whole plant of Sarcandra glabra. Their structures were established by the analyses of spectral and chemical evidences.     

Two new polyporusterones from Polyorus umbellatus

Two new polyporusterones named as porusterone I and polyprosterone II were isolated from polyourus umbellatus. Their structures have been established on the basis of spectroscopic analysis.     

Eight new clerodane diterpenoids from the bark of Ptychopetalum olacoides

Eight new clerodane type diterpenoids, named 7-oxo-kolavelool (1), 7alpha-hydroxykolavelool (2), 6alpha,7alpha-dihydroxykolavenol (3), 12-oxo-hardwickiic acid (4), ptycholide I (5), ptycholide II (6), ptycholide III (7), and ptycholide IV (8) were isolated from the MeOH extract of the bark of a Brazilian medicinal plant, Ptychopetalum olacoides. The structures of 1-8 were elucidated by analyzing spectroscopic data and by comparing their NMR data with those of the previously reported compounds kolavelool (la), kolavenol (3a), hardwickiic acid (4a), and ptychonolide (5a). Compounds 5 and 6 existed as a 1:1 mixture of inseparable epimers at C-15.     

Two new secoiridoid glycosides from the roots of Picrorhiza scrophulariiflora

From the roots ofPicrorhiza scrophulariiflora, two new secoifidoid glycosides, named picrosecosides Ⅰ and Ⅱ （1, 2） have been isolated. Their structures were elucidated on the basis of chemical and spectropic evidences.     

A new C27-steroidal glycoside from Ophiopogon japonicus

A new C27-steroidal glycoside with three known compounds were isolated from the tuber of Ophiopogonjaponicus （Thunb.） Ker-Gawl. Based on the spectral analysis, including HRMS, 1H NMR, 13C NMR, DEPT, 1H-1H COSY, HMQC and HMBC, their chemical structures were determined as pennogenin-3-O-α-L-rhamnopyranosyl-（1→ 2）-β-D-xylopyranosyl-（1→ 4）-13-D-gluco- pyranoside （1）, pennogenin-3-O-α-L-rhamnopyranosyl-（1→ 2）-β-D-glucopyranoside （2）, ophiopojaponin C （3） and ophiopogonin D （4）. 2007 Jian Zhong Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.