共查询到20条相似文献,搜索用时 15 毫秒
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Data on the synthesis and chemical properties of the phosphorus-containing derivatives of indoles and pyrroles, published in 1976-1998, are reviewed. The introduction of substituents containing tri- and tetracoordinated phosphorus atom into the heterocycle and the side chain is discussed. Information on the biological activity is presented. 相似文献
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Mátyás Milen Péter Ábrányi-Balogh György Balogh László Drahos György Keglevich 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):1091-1100
Abstract N-Heterocycles including indolecarbaldehyde, substituted benzimidazoles, and methylimidazole could be efficiently phosphorylated by diethyl chlorophosphate at room temperature in different solvents using alkali carbonate or triethylamine as the base. However, the phosphorylation of N-heterocycles with a lower reactivity at the NH function, such as carbazole and phenothiazine, could not be conducted to complete conversion under the conditions applied. 相似文献
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An Efficient Ultrasound‐Assisted Synthesis of N‐Alkyl Derivatives of Carbazole,Indole, and Phenothiazine 下载免费PDF全文
Sanhu Zhao Jin Kang Yuting Du Jingyan Kang Xiaoni Zhao Yinfeng Xu Ruixi Chen Qianqian Wang Xitao Shi 《Journal of heterocyclic chemistry》2014,51(3):683-689
Heterocyclic compounds bearing an acidic hydrogen atom attached to nitrogen such as carbazole, indole, and phenothiazine can be efficiently alkylated in DMSO or N,N‐DMF under ultrasonic irradiation in the presence of potassium hydroxide as a base. In almost all cases, a dramatic reduction of the reaction time results and a clear yield increase accompanied by an improved quality of the products occurs. 相似文献
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《Analytical letters》2012,45(6):1139-1157
Abstract The use of p-dimethylaminocinnamaldehyde (p-DAC) has been described for the colorimetric determination of diphenylamine (DPA), Pyrrole (Py) and Indole (In) in acidic media. The kinetics of the reactions were studied and a mechanism for the reactions has been proposed. The reaction products were isolated, and identified using IR, NMR and elemental analysis. 相似文献
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I. N. Okhtemenko A. I. Khlebnikov V. D. Ogorodnikov 《Russian Journal of Organic Chemistry》2001,37(1):112-115
Reactions of 9-(2,2-dichlorocyclopropyl)carbazole, 10-(2,2-dichlorocyclopropyl)phenothiazine, and 10-(2,2-dichlorocyclopropyl)phenoxazine with alcohols in the system t-BuOK-DMSO yield the corresponding N-(1-alkoxy-2-propynyl) derivatives. Hydrolysis of 9-(1-methoxy-2-propynyl)carbazole and 10-(1-methoxy-2-propynyl)phenothiazine in 60% aqueous dioxane in the presence of sulfuric acid gives the corresponding heterocyclic amine and 2-propynal. 相似文献
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Siddappa A. Patil Shivaputra A. Patil Ever A. Ble-Gonzlez Stephen R. Isbel Sydney M. Hampton Alejandro Bugarin 《Molecules (Basel, Switzerland)》2022,27(19)
Microbial infection is a leading cause of death worldwide, resulting in around 1.2 million deaths annually. Due to this, medicinal chemists are continuously searching for new or improved alternatives to combat microbial infections. Among many nitrogen-containing heterocycles, carbazole derivatives have shown significant biological activities, of which its antimicrobial and antifungal activities are the most studied. In this review, miscellaneous carbazole derivatives and their antimicrobial activity are discussed (articles published from 1999 to 2022). 相似文献
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以N-烷基咔唑作为电子给体和共轭桥中心, 二米基硼作为端基电子受体, 合成了两个V形A-π-D-π-A型新化合物: 3,6-二{[(E)-2-(5-二米基硼)噻吩]乙烯基}-N-丁基-咔唑 {N-butyl-3,6-bis{(E)-2-[5-(dimesitylboryl)thiophen-2-yl]-vinyl}-carbazole, BBTC}和3,6-二[(E)-(4-二米基硼)苯乙烯基]-N-己基-咔唑, {N-hexyl-3,6-bis[(E)-4-(dimesitylboryl)-styryl]-carbazole, BBSC}. 这两个化合物在蓝绿光波段都有较强的荧光发射. 光谱数据表明, 扩大共轭体系并在端基引入含硼基团导致吸收谱和发射谱显著红移, 并增大分子内电荷转移. 相似文献
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以吲哚和酰氯(苯甲酰氯及苯磺酰氯)为原料,合成了7个N-酰基取代吲哚类化合物(a~g),其结构经1H NMR和元素分析确证。研究了化合物对球等鞭金藻、亚心形扁藻和舟形藻以及藤壶幼虫的生长抑制活性。结果表明:当吲哚结构连接电负性较高的基团时,化合物对藻类和藤壶幼虫的生长抑制性较好,其中以连接苯磺酰基化合物的抑制效果最佳。目标化合物对藤壶幼虫12 h和24 h的半致死浓度(LC50)明显低于底物吲哚,其中以苯磺酰基取代的化合物最低。采用目标化合物制备的海洋防污涂料,浅海挂板90 d后,对海洋污损生物的附着表现出明显的抑制作用。 相似文献
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A simple and highly efficient three-component method using easily available amines, nitrostyrene, and diketones in one pot has been developed for synthesis of pyrroles in the presence of catalytic amounts of iodobenzene and Oxone as oxidant. The protocol has been used to afford wide range of pyrroles in moderate to good yields. 相似文献
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《Analytical letters》2012,45(2):81-91
Abstract Indole amines and indole alcohols were converted to heptafluoro-butyryl (HFB) derivatives by an acyl transfer reaction with heptafluoro-butyrylimidazole. The indole NH group as well as all amino and hydroxyl groups were acylated. The HFB derivatives have excellent gas chroma-tographic properties and can be used with either hydrogen flame or electron capture detection systems. Mass spectra of the HFB derivatives of biologic N, N-dialkyl indole amines are very characteristic; these compounds can be identified easily by GLC-MS methods. 相似文献