Probing local innate immune responses after mucosal immunisation

Background  

Intranasal immunisation is potentially a very effective route for inducing both mucosal and systemic immunity to an infectious agent.     

Growth Cone Pathfinding: a competition between deterministic and stochastic events

Background  

Growth cone migratory patterns show evidence of both deterministic and stochastic search modes.     

A novel and facile synthesis of N-cyclohexyl-benzofurans by one-pot three-component reaction

Abstract  

A simple and efficient synthesis of N-cyclohexyl-benzofuran derivatives was achieved via a one-pot three-component reaction of cyclohexylisocyanide, an aromatic aldehydes, and phenols in DMF for 10 h with good yields.     

Levamizole enhances immune responsiveness to intra-dermal and intra-muscular hepatitis B vaccination in chronic hemodialysis patients

Background  

Hemodialysis patient are at high risk for hepatitis B virus (HBV) infection.     

Breakup modes of a laminar hollow water jet

Graphical Abstract  

     

Flow visualization of supersonic transverse jet over Mach 2 freestream of a sharp cone

Graphical abstract  

     

Visualizations of the flow around a swimmer in turbulent regime

Graphical abstract  

     

Sex-dependent gene expression in early brain development of chicken embryos

Background  

Differentiation of the brain during development leads to sexually dimorphic adult reproductive behavior and other neural sex dimorphisms. Genetic mechanisms independent of steroid hormones produced by the gonads have recently been suggested to partly explain these dimorphisms.     

Pattern of distribution and cycling of SLOB,Slowpoke channel binding protein,in <Emphasis Type="Italic">Drosophila</Emphasis>

Background  

SLOB binds to and modulates the activity of the Drosophila Slowpoke (dSlo) calcium activated potassium channel. Recent microarray analyses demonstrated circadian cycling of slob mRNA.     

Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation

Background  

Long non-protein-coding RNAs (ncRNAs) are emerging as important regulators of cellular differentiation and are widely expressed in the brain.     

Effects of monoclonal anti-PcrV antibody on <Emphasis Type="Italic">Pseudomonas aeruginosa</Emphasis>-induced acute lung injury in a rat model

Background  

The effects of the murine monoclonal anti-PcrV antibody Mab166 on acute lung injury induced by Pseudomonas aeruginosa were analyzed in a rat model.     

Coherent structures of the turbulent round jet in different focal lengths

Graphical abstract  

     

Temperature distribution on an isoflux surface cooled by an impinging liquid jet with a 40° Wall Jet Swirl Generator

Graphical Abstract  

     

A Canadian national survey of attitudes and knowledge regarding preventive vaccines

Background  

Vaccines have virtually eliminated many diseases, but public concerns about their safety could undermine future public health initiatives.     

Photodynamic action of LED-activated nanoscale photosensitizer in nasopharyngeal carcinoma cells

Background  

Photodynamic therapy has been confirmed to an efficient therapeutic modality of malignant tumors. The aim of the present study was to explore the photodynamic action of LED-activated nanoscale photosensitizer-loading hypocrellin in nasopharyngeal carcinoma cells.     

Serotonin-mediated modulation of Na<Superscript>+</Superscript>/K<Superscript>+</Superscript> pump current in rat hippocampal CA1 pyramidal neurons

Background  

The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na⁺/K⁺ pump in rat hippocampal CA1 pyramidal neurons.     

Entry of inclined hydrophobic and hydrophilic circular cylinders into water

Graphical Abstract  

     

Two-layer exchange flows over a dune: effect of large-scale bottom roughness

Graphical Abstract  

     

Evidence for non-independent gating of P2X<Subscript>2</Subscript> receptors expressed in <Emphasis Type="Italic">Xenopus</Emphasis>oocytes

Background  

P2X₂ receptor is an ATP-activated ion channel which is widely expressed in the nervous system, and mediates synaptic transmission.     

Slowing of axonal regeneration is correlated with increased axonal viscosity during aging

Background  

As we age, the speed of axonal regeneration declines. At the biophysical level, why this occurs is not well understood.