A HYDROGEN BONDING ASSISTED CATALYST SCREENED OUT VIA COMBINATORIAL CHEMISTRY STRATEGY

Possibilities for enhancement of catalytic reaction rate by combining phase transfer catalysis and hydrogen bonding of the catalyst with the substrate and reagent were studied.A phase transfer catalyst library with sixty polystyrene-supported quaternary ammonium salt catalysts was synthesized.The reduction of acetophenone by NaBH4 was used as the probing reaction to select out the ost active catalyst in the library by using iterative method.which was the gel-type triethanolamine aminsating strongly asic anion exchange resin with the crosslinking degeree of 2% A hydrogen bonding assisted catalytic mechanism was proposed to explain the high catalytic activity of the catalyst.     

三丁胺胺化强碱性阴离子交换树脂催化合成羧酸苄酯

用组合化学方法筛选出的对无外加碱条件下的亲核取代催化活性最高的聚合物季铵盐-三丁胺胺化强碱性阴离子交换树脂为相转移催化剂,催化合成了乙酸苄酯、丙酸苄酯、丁酸苄酯、戊酸苄酯等羧酸苄酯。讨论了各种反应条件对合成丙酸苄酯的产率的影响,并对传统合成方法进行了改进。在优化反应条件下,反应产率接近100%。     

三丁胺胺化强碱性阴离子交换树脂催化合成苄叉丙酮

以用组合化学方法筛选出的在有外加碱条件下的亲核取代催化活性最高的聚合物季铵盐-大孔型苯乙烯系三丁胺胺化强碱性阴离子交换树脂为相转移催化剂,催化合成苄叉丙酮,考察了各种反应条件对苄叉丙酮收率的影响,在优化反应条件下,苄叉丙酮的收率高达98%,且催化剂可重复使用。     

三丁胺胺化强碱性阴离子交换树脂催化苯乙腈的α-丁基化反应

以大孔型苯乙烯系三丁胺胺化强碱性阴离子交换树脂为催化剂，催化苯乙腈的α-丁基化反应，研究了反应温度，催化剂用量和反应时间等因素对反应产率的影响。并考察了催化剂的重复使用性能，结果表明：在优化条件下，该催化剂催化苯乙腈的α-丁基化反应产率高达88%以上，且催化剂具有良好的重复使用性能。