共查询到20条相似文献,搜索用时 31 毫秒
1.
Photocyclization of 3-chloro-N-phenylbenzo[b]thiophene-2-carboxamide 10 afforded [1]benzothieno[2,3-c]-quinolin-6(5H)-one 11 which was chlorinated to 6-chloro[1]benzothieno[2,3-c]quinoline 12 followed by dechlorination to give [1]benzothieno[2,3-c]quinoline 5 . A series of 6-substituted alkoxy and thioalkoxy[1]benzothieno[2,3-c]quinoline derivatives were prepared along with the N-methyl quaternary salt 13 of 5 . 6-Chloro[1]-benzothieno[2,3-c]quinoline 12 was converted into 6-hydrazino[1]benzothieno[2,3-c]quinoline 23 which upon treatment with formic acid yielded [1]benzothieno[2,3-c][1,2,4]triazolo[4,3-a]quinoline 6 . Treatment of 23 with nitrous acid resulted in [1]benzothieno[2,3-c]tetrazolo[1,5-a]quinoline 7 . Compounds 6 and 7 are novel heterocyclic ring systems. 相似文献
2.
S. V. Tolkunov S. Yu. Suikov M. Yu. Zubritskii V. I. Dulenko 《Chemistry of Heterocyclic Compounds》1998,34(8):983-985
A study has been made of the reaction of 1,3-disubstituted bezothieno[2,3-c]pyrylium salts with hydrazine. It has been shown that 1,3-dialkyl-substituted benzothieno[2,3-c]pyrylium salts interact with hydrazine to give N-amino-1,3-dialkylbenzothieno[2,3-c]pyridines. The presence of a pyrylium ring on one of the positions of the phenyl group leads to a mixture of N-amino derivatives and 5H-[2,3]benzothieno[2,3-e]diazepines. In contrast, 1,3-diphenylbenzothieno[2,3-c]pyrylium perchlorate gives exclusively 5H-[2,3]benzothieno[2,3-e]diazepine.L. M. Litvinenko Institute of Physical Organic Chemistry and Coal Tar Chemistry, National Academy of Sciences of Ukraine, Donetsk 340114. Translate from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp 1137–1140, August, 1998. 相似文献
3.
The synthesis of two new heterocycles is described: pyrido-[2,3-d]-.s-triazolo[ 3,4-f] pyrimidine and pyrido[3,2-d]-.s-triayzolo-[3,4-f] pyrimidine. 4-[I'-Pyrazolyl]pyrido[2,3-d]pyrimidines and 4-[1′-pyrazoly1] pyrido[ 3,2-d] pyrimidine are obtained by the action of 4-hydrazinopyrido[2,3-d]pyrimidine and 4-hydrazinopyrido-[3,2-d]pyrimidine with several β-diketones. 相似文献
4.
T. E. Khoshtariya T. O. Dzhashi L. N. Kurkovskaya 《Chemistry of Heterocyclic Compounds》1999,35(5):557-560
The synthesis and some properties of the isomeric 2,3-dioxo-2,3-dihydro-1H-benzo[b]furo[2,3-g]- and 2,3-dioxo-2,3-dihydro-1H-benzo[b]furo[3,2-g]indoles
are described.
Georgian Technical University, Tbilisi 380075. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, 627–630, May,
1999. 相似文献
5.
Steven L. Castle Phillip J. Buckhaults Larry J. Baldwin J. Dew McKenney Raymond N. Castle 《Journal of heterocyclic chemistry》1987,24(4):1103-1108
A series of monomethoxy[1]benzothieno[2,3-c]quinolines 24-28 were prepared by photocylization of the appropriate 3-chloro-N-phenylbenzo[b]thiophene-2-carboxamides 9–13 to [1]benzothieno[2,3-c]quinolin-6(5H)-ones 14-18 followed by chlorination to 6-chloro[1]benzothieno[2,3-c]quinolines 19-23 then dechlorination resulting in the title compounds except for 25 which was achieved by direct reduction of 15 . Reaction of 24-28 with methyl iodide provided the corresponding N-methyl quaternary salts 29-33 . Also, conversion of 4-meth-oxy[1]benzothieno[2,3-c]quinolin-6(5H)-one 16 to 4-methoxy-6-methylthio[1]benzothieno[2,3-c]quinoline 35 and 4,6-dimethoxy[1]benzothieno[2,3-c]quinoline 36 is described. 相似文献
6.
S. V. Tolkunov M. N. Kal'nitskii E. A. Zemskaya 《Chemistry of Heterocyclic Compounds》1991,27(11):1253-1256
The reaction of 1,7-dimethyl-3(2H)-benzo[b]furo[2,3-c]pyridone with phosphoric acid amides gave 1,7-dimethyl-3-dimethylamino (morpholino)benzo[b]furo[2,3-c]pyridines. A method for the synthesis of 3-amino derivatives of 4-nitrobenzo[b]furo[2,3-c]pyridines, which consists in heating 1,7-dimethyl-4-nitro-3(2H)-benzo[b]furo[2,3-c]pyridone with hexamethyldisilazane and secondary or primary amines in pyridine, was developed.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1552–1555, November, 1991. 相似文献
7.
The synthesis of 1,2-dihydro[1]benzofuro[2,3-d]pyridazin-1-one and 3,4-dihydro [1]benzofuro[2,3-d]pyridazin-4-one was accomplished by the eyclization of appropriately carbonyl-substituted benzofuran derivatives. Another successful synthetic route was provided using 1,2,3,4-tetrahydro[1]benzofuro[2,3-d]pyridazine-1,4 dione and 1,2,3,4-tetrahydro[1]benzofuro[2,3-d]pyridazin-4-one. The structure of a nitrobenzofuropyridazin-4-one was established using nmr and the nuclear Overhauser effect. 相似文献
8.
The reaction of benzo[b]thieno[2,3-b]benzo[b]thiophene S,S,S′,S′-tetroxide with primary and secondary amines and with alcohols gave 10 b-amino- and 10 b-alkoxy-5a, 10b-dihydro-benzo[b]thieno[2,3-b]benzo[b]thiophene S,S,S′,S′-tetroxides. These nucleophilic reagents do not add to benzo[b]thieno[2,3-b]benzo[b]thiophene S,S-dioxide. 相似文献
9.
It is shown that 2-methyl-3-carbethoxy-4H,8H,5,6-dihydrothieno[2,3-d]thia[1]pyrano [4,3-b]pyrrole and 8-methyl-9-carbethoxy-10H,5,6-dihydrothieno[2,3-d]thia[1]chromeno[4,3-b]pyrrole and their S,S-dioxides, respectively, are obtained in the reaction of 2-methyl-3-carbethoxy-4-thienylhydrazine with tetrahydro-4-thiopyrone, tetrahydro-4-thiopyrone S, S-dioxide, 4-thiochromanone, and 4-thiochromanone S,S-dioxide in the presence of an acid catalyst.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 195–196, February, 1979. 相似文献
10.
Richa Gupta Ram Pal Chaudhary 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6):735-742
Abstract 8-Methoxy-4-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thione, obtained by the condensation of 2-benzylidene-6-methoxy-3,4-dihydronapthalene-1(2H)-one with thiourea, on reaction with chloroacetic acid and 3-chloropropanoic acid in the presence of the ionic liquid N-methylpyridinium tosylate furnishes 3-methoxy-7-phenyl-7,10-dihydro-5H- benzo[h]thiazolo[2,3-b]quinazoline-9(6H)-one and 3-methoxy-7-phenyl-5,6,10,11-tetrahydro- benzo[h][1,3]thiazino[2,3-b]quinazoline-9(7H)-one. Further, condensation of the thione with 1,2-dibromoethane and 1,3-dibromopropane yields 3-methoxy-7-phenyl-6,7,9,10-tetrahydro-5 H-benzo[h]thiazolo[2,3-b]quinazoline and 3-methoxy-7-phenyl-5,6,7,9,10,11-hexahydrobenzo [h][1,3]thiazino[2,3-b]quinazoline respectively. Arylidene derivatives have been obtained by two routes. The structures of the cyclized compounds have been established on the basis of elemental analysis and spectroscopic data. The synthesized compounds were screened for antimicrobial activity. Some of the compounds showed promising antimicrobial activities. 相似文献
11.
The base promoted four-component reaction of hydrated hydrazine, dimethyl acetylenedicarboxylate, isatines and malononitrile (ethyl cycanoacetate) in ethanol afforded polysubstituted spiro[indoline-3,4‘-pyrano[2,3-c]pyrazoles] and spiro[acenaphthyl-3,4-pyrano[2,3-c]pyrazoles] 相似文献
12.
The previously unknown polycyclic heterocyclic ring systems, namely, [1]benzothieno[2,3-c]naphtho[1,2-h]-quinoline and [1]benzothieno[2,3-c]naphtho[1,2-h][1,2,4]triazolo[4,3-a]quinoline were synthesized via photocyclization of 3-chloro-N-(1′-phenanthryl)benzo[b]thiophene-2-carboxamide. 相似文献
13.
John G. Stuart Shinya Khora J. Dew McKenney Raymond N. Castle 《Journal of heterocyclic chemistry》1987,24(6):1589-1594
Three dimethoxy[1]benzothieno[2,3-c]quinolines 24–26 were prepared by photocyclization of the appropriate 3-chloro-N-phenylbenzo[b]thiophene-2-carboxamides 15–17 to [1]benzothieno[2,3-c]quinolin-6(5H)-ones 18–20 followed by chlorination to 6-chloro[1]benzothieno[2,3-c]quinolines 21–23 and then dechlorination resulting in the title compounds. Reaction of 24–26 with methyl iodide furnished the corresponding N-methyl quaternary salts 27–29 . Sodium methoxide readily converted 21–23 to trimethoxy[1]benzothieno[2,3-c]quinolines 30–32 . 相似文献
14.
Keith Brewster John M. Harrison Thomas D. Inch 《Journal of heterocyclic chemistry》1978,15(8):1497-1499
Synthetic routes to pyrido[2,3-b]-, pyrido[4,3-b]-, pyrido[3,2-f] [1,4]benzoxazepines and dipyrido[2,3-b:2,3-f] [1,4]oxazepine are described. The applicability of one of the methods to dibenz[b,f] [1,4]oxazepine synthesis is discussed. 相似文献
15.
Hirotaka Kudo Kazufumi Takahashi Raymond N. Castle Milton L. Lee 《Journal of heterocyclic chemistry》1987,24(4):1009-1011
3-Chlorobenzo[b]thiophene-2-carbonyl chloride reacted readily with 2-amino-, 3-amino-, or 4-aminopyridine to give the corresponding amides. Photocyclization of the amides afforded the following lactams: [1]ben-zothieno[2,3-c][1,5]naphthyridin-6(5H)-one ( 14 ), [1]benzothieno[2,3-c][1,6]naphthyridin-6(5H)-one ( 7 ), [1]benzo-thieno[2,3-c][1,7]naphthyridin-6(5H)-one ( 11 ), and [1]benzothieno[2,3-c][1,8]naphthyridin-6(5H)-one ( 3 ). These lactams have been converted to other derivatives including in two instances the unsubstituted ring system. 相似文献
16.
The synthesis of [1,4]dioxino[2,3-c]quinolines and [1,4]dioxepino[2,3-c]quinolines with restrained conformation of the piperidine ring, which represent 1,2,3,4-tetrahydroquinolines containing two heteroatom substituents at positions 3 and 4, is described. In addition, the application of this approach for the synthesis of 1-sulfur analogues is discussed. Both series are helpful tools for three-dimensional quantitative structure-activity relationship studies in the field of modulators of multidrug resistance. 相似文献
17.
Mohamed Hassan Magda A. Barsy Eman A. El Rady Abdullah Sulaiman Al-Ayed Mona Frempong Kamal U. Sadek 《Journal of heterocyclic chemistry》2024,61(4):543-549
An efficient synthesis of novel benzo[f]Chromeno[2,3-d]pyrimidine and unknown benzo[f]chromeno[2,3-d][1,2,4]triazolopyrimidine derivatives is described utilizing ethyl-2-amino-4-phenyl-4H-benzo[f]chromene-3-carboxylate as precursor via aza-Wittig reaction. The process proved to be simple, high-yielding, and efficient. 相似文献
18.
Polymethine dyes — benzofuro[2,3-b]pyridine and selenonaphtheno[2,3-b]pyridine derivatives — were synthesized, and their spectral properties are discussed. Replacement of a vinylene group by an oxygen or selenium atom in one benzene ring of the 2-benzo[h]quinoline residue in the cyanines causes a large bathochromic shift of the absorption maxima of the dyes as compared with replacement by a sulfur atom. The dyes derived from benzofuro[2,3-b]pyridine derivatives are more deeply colored than the derivatives of both thionaphtheno[2,3-b]-pyridine and selenonaphtheno[2,3-b]pyridine.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp.1611–1614, December, 1972. 相似文献
19.
Afshin Yazdani-Elah-Abadi Malek-Taher Maghsoodlou Razieh Mohebat Reza Heydari 《中国化学快报》2017,28(2):446-452
A green, convenient, high yielding and one-pot procedure for the synthesis of novel spiro[benzo[a]pyrano[2,3-c]phenazine] derivatives by domino multi-component condensation reaction between 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, ninhydrine, and malononitrile in the presence of a catalytic amount of 1,3-dimethyl-7H-purine-2,6-dione (theophylline) as an expedient, eco-friendly and reusable solid base catalyst under thermal, microwave irradiation and solvent-free conditions. This procedure has also been applied successfully for the synthesis of benzo[a]pyrano[2,3-c]phenazines. 相似文献
20.
Hexasubstituted 2,3-diaza-bicyclo[3.1.0]hex-2-enes containing large substituents at C-4 and C-6 upon irradiation undergo a novel [4+2]cycloreversion reaction leading to 2,3-diazahexatriens besides the normal [3+2]cycloreversion. 相似文献