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Phormidolides B and C,Cytotoxic Agents from the Sea: Enantioselective Synthesis of the Macrocyclic Core 下载免费PDF全文
Dr. Adriana Lorente Alejandro Gil Dr. Rogelio Fernández Dr. Carmen Cuevas Prof. Fernando Albericio Prof. Mercedes Álvarez 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(1):150-156
New cytotoxic polyketide macrolides named phormidolides B and C were isolated from a marine sponge of the Petrosiidae family collected off the coast of Pemba (Tanzania). The isolation, structure elucidation, and enantioselective synthesis of three diastereomers of the macrocyclic core is described herein. The described synthetic methodology started from 2‐deoxy‐D ‐ribose or 2‐deoxy‐L ‐ribose and afforded the desired macrocycles with high enantiomeric purity. The key step of the synthesis is the formation of the Z‐trisubstituted double bond using a Julia–Kocienski olefination. The versatility of the synthetic methodology may provide access to other enantiopure macrocycles by making changes in the starting materials or chiral inductors. 相似文献
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Takamasa Oguchi Kazuhiro Watanabe Dr. Kôichi Ohkubo Hideki Abe Dr. Tadashi Katoh Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(12):2826-2845
Potential immunosuppressive agents : Candelalides A, B and C (see figure), novel blockers of the voltage‐gated potassium channel Kv1.3, have been efficiently synthesized for the first time in a convergent and unified manner starting from (+)‐5‐methyl‐Wieland–Miescher ketone. The method explored has potential for preparing various types of candelalide analogues for the structure–activity relationship studies.
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Cover Picture: Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring (Chem. Eur. J. 50/2015) 下载免费PDF全文
Dr. Daniele Lo Re Dr. Ying Zhou Dr. Joanna Mucha Dr. Leigh F. Jones Lorraine Leahy Prof. Corrado Santocanale Prof. Magdalena Krol Prof. Paul V. Murphy 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(50):17989-17989
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