共查询到20条相似文献,搜索用时 171 毫秒
1.
2.
3.
4.
5.
5-氟尿嘧啶(5-FU)是抗代谢类抗癌药,但由于其脂溶性小,选择性较差,毒副作用较大,限制了它的广泛使用.为了提高其疗效,降低毒副作用,人们向5-FU分子内引入亲脂性基团,合成了前药替加氟[1-(四氢呋喃-2-基)-5-氟尿嘧啶]和HCFU(1-己基氨基甲酰基-5-氟尿嘧啶).有机磷化合物是一类生命过程中极其重要的物质,生命体内进行的各种变化甚至在生命过程中,都必须有磷化合物的参与,甚至起调控作用.采用含磷物质对5-氟尿嘧啶类药物进行改性已有不少文献报道,主要有羟基膦酸、氨基膦酸和含磷肽等.本文将α-羟基膦酸酯引入至5-氟尿嘧啶的N3,合成了一系列目标化合物,合成路线如下: 相似文献
6.
7.
奥沙利铂又名草酸铂(L-OHP),是继顺铂和卡铂之后问世的铂类第三代抗癌药物。具有抗瘤谱广,对大肠癌、卵巢癌疗效好,对胃癌、非霍奇金氏淋巴瘤、非小细胞肺癌和头颈部肿瘤有一定疗效,对5氟脲嘧啶(5-FU)治疗无效的大肠癌病人、对铂类耐药者有效。奥沙利铂中的银为杂质,其最大限量为5,0mg·kg~(-1)。准确测定银含量对该药的 相似文献
8.
功能化纳米粒子作为药物载体的研究 总被引:1,自引:0,他引:1
将合成的含有羧基侧基官能团的己内酯类聚合物, 用溶剂挥发与超声乳化相结合的方法制备成表面可供修饰的纳米粒子. 利用扫描电镜(SEM)研究了纳米粒子在水溶液中的形态. 使用5-氟脲嘧啶(5-FU)作为模型药物制备了载药纳米粒子, 利用紫外分光光度计法、差示扫描量热法(DSC)、X射线衍射法(XRD)研究了纳米粒子的载药及释放性能. 研究表明, 载药纳米粒子可以控制5-FU的释放速率. 释放时间可持续至96 h 以上, 符合Higuchi 动力学方程. 相似文献
9.
以N-异丙基-9H-咔唑为起始原料,经取代、氧化、环合、酰化4步反应合成了7个新型2-取代氨基-5-(N-异丙基-9H-咔唑-2-基)-1,3,4-噻二唑类化合物(1a~1g),其结构经~1H NMR,~(13)C NMR, MS(ESI)和元素分析表征。采用MTT法测定了1a~1g对5种肿瘤细胞的体外抗增殖活性。结果表明:1a~1g对人正常VEC细胞的抑制活性弱于5-FU。1d和1e对人白血病细胞(K562)和人结肠癌细胞(HCT-8),1e对人肺癌细胞(A549细胞),以及1g对人结肠癌细胞(HCT-8)的抑制活性(IC_(50)≤9.28μmol·L~(-1))均与5-FU相当。 相似文献
10.
以N-异丙基-9H-咔唑为起始原料,经取代、氧化、环合、酰化4步反应合成了7个新型2-取代氨基-5-(N-异丙基-9H-咔唑-2-基)-1,3,4-噻二唑类化合物(1a~1g),其结构经1H NMR, 13C NMR, MS(ESI)和元素分析表征。采用MTT法测定了1a~1g对5种肿瘤细胞的体外抗增殖活性。结果表明:1a~1g对人正常VEC细胞的抑制活性弱于5-FU。 1d和1e对人白血病细胞(K562)和人结肠癌细胞(HCT-8), 1e对人肺癌细胞(A549细胞),以及1g对人结肠癌细胞(HCT-8)的抑制活性(IC50≤9.28 μmol·L-1)均与5-FU相当。 相似文献
11.
用凝胶法培养了由18-冠-6钡与硫氰酸钴组成的配合物[Ba(C12H24O6)·(H2O)2][Co(NCS)4]的单晶。对配合物进行了熔点测定、元素分析和X-射线结构分析。 相似文献
12.
The RbI-SmI2 , binary system was studied with DTA and X-ray powder diffraction. Its phase diagram shows that it has a congruently melting compound,RbSm2I5 , with a melting point 524℃; an incongru-ently melting compound, Rb2SmI4 , with an inconsruently point 467℃ and two compounds, RbSmI3, and Rb3SmI5, being decomposed at 433℃ and 460℃, respectively. The measured structure of RbSm2I5 shows that it is isomorphous with NH4 Pb2 Cl5 space group P21/c, a=10 . 063(3)A, b=9.003(3)A. c =14 . 242(5)A°,β=90.23(3)°;z = 4, MVx= 1 94 . 3cm3/mol;D=5.255g/cm3 and Do =5. 334g/cm3 (25. 0℃).The structural, investigation ofRbSmI3 shows that it belongs to the orthorhombic system with a = 15.914(6)A, b=8.898(3)A c =12.193(5)A; Z=8, MVx =130.0cm3/mol, Dx =4 . 743g/cm3,Do = 4.597g/cm3(25.0℃). 相似文献
13.
The transition metal element substitutions of the industrial catalytic material ortho-borophosphate, BPO4, can lead to either new type of structure for Cr[1] or stabilize low cristobalite structure for Mn, Fe,Co, Ni and Cu[2] Here we report our results on the substitution by main group elements Zn and Ga. The two title compounds were synthesized by high temperature solid state reactions and the structure were refined by powder diffraction methods.The structure parameters:(B0.25Ga0.75)PO4:Tetragonal, P-4, a=4.727(1), c=7.078(1) Å,V=158.17(1) Å3, Z=2, R(P)=0.0965, R(I)=0.0426; (B0.61Zn0.39)PO4:Orthorhombic, C2221 a=7.080(1), b=7.087(1),c=6.990(1) Å, V=350.71(2) Å3, Z=4,R(P)=0.0904,R(I)=0.0438. Pure GaPO4 were found three kinds of structures, low- and high-cristobalite and high -quartz with an observation of an unknown unstable high cristobalite at high temperature[3] The boron substitution of the high-cristobalite GaPO4 with space group I-A leads to lower symmetry space group(P-4). We assume the low symmetry structure related to the unknown unstable phase. The structures of both compounds are similar to very well known cristobalite (see figure below). 相似文献
14.
目前,Mo-S化合物的化学,特别是以多硫基为配体的铟硫化合物的化学是一个活跃的研究领域。这里我们报道含S22-、S42-两种多硫基的二核钼原子簇化合物〔Et4N〕2〔Mo2O2(S2)(S4)(u3-S)2]的合成和单晶结构。 相似文献
15.
Abstract The crystal and molecular structure of the title compound 4 have been determined by single crystal X-ray crystallography. The structure shows the typical S,-ruffled conformation observed for Ni(II) tetrapyrroles. Compared to the structure of the methyl ester of (132 -demethoxycarbonyl-pheophorbidato a)nickel(II), 4 shows a smaller Ca -Cm -Cm angle and a higher degree of conformational distortion at the methyl-substituted C20 position. This local distortion of the macrocycle might account for the bathochromic shifted absorption spectra of the bacteriochlorophylls c compared to the d-series. Crystal data: C35 H38 N4 NiO3 ; tetragonal, P43 21 2, a = 15.335(7) Å, c = 25.11(2) Å, V = 5904, Z = 8, λ(Mo Kα) = 0.71069 Å, μ= 0.701 mm−1 , P(000) = 2624, 130 K, R = 0.058 for 5700 reflections with F > 4.0σ(F). 相似文献
16.
(η5-C6H5)2Nb[CH2Si(CH3)3]2has been prepared and characterized by X-ray diffraction method and solution and frozen-glass EPR.The compound crystallizes in a monoclinic space group P21/Owith lattice parameters a=13.291(Å),b=12.406(Å),σ=13.901Å,β=115.40,V=2070Å5and Z=4 Full-matrix least-squares refinement of the diffractometry data led to final discrepancy indices of K(F0)=0.043,R(F02)=0.057,Rw(F02)=0.071.From computer simulation of the frozen-glass spec trum of the compound,the principal components of the g and Ttensors are gx=1.9840.gy=2.0075,gz=2.0020,Tx=-89.2G,Ty=-136.9G,Tz=-50.0G.The observed anisotropy for the hyperfine interaction arises from the admixture of 4dz2 and 4dx2-y2 character in the HOMO.The ratio of mixing coefficients a2/b2=10.3. 相似文献
17.
采用1,6-二氯十二甲基六硅烷与对溴苯甲醚的格氏试剂反应制得了标题化合物。对其进行了结构分析。X射线衍射分析表明,该晶体属单斜晶系,分子是中心对称的,化合物呈交叉锯齿型稳定构象。 相似文献
18.
化合物[UO2(NO3)2(H2O)2]·(DB18C6)2晶体属单斜晶系,空间群为P21/k。晶体学参数:a=11.782(2)Å,b=8.584(2)Å,c=22.631(2),β=98.29(2)Å°,Z=2.用3024个I≥3σ(I)的三维X射线独立衍射数据进行结构解析,最终的R=0.066。结构分析表明,两个双齿配体硝酸根及两个水分子配位于线型铀酰离子的赤道平面上,铀的配位数是8,配位几何构型为稍有扭曲的六方双锥。配位水分子的4个氢原子分别与上下两层冠醚环上的氧原子生成氢键。形成夹心式分子缔合物。 相似文献
19.
Synthesis,crystal structure and thermal behavior of 4-amino-3,5-dinitropyrazole copper salt 总被引:1,自引:0,他引:1
A novel energetic combustion catalyst, 4-amino-3,S-dinitropyrazole copper salt ([Cu(adnp)2(H2O)2]), was synthesized in a yield of 93.6% for the first time. The single crystal of [Cu(adnp)2(H2O)2] was determined by single crystal X-ray diffraction. It crystallizes in a triclinic system, space group p^-1 with crystal parameters a = 5.541(3) A, b = 7.926(4) A, c = 10.231(5) A,β = 101.372(8)°, V = 398.3(3) A3, Z = 1, μ = 1.467 mm^-1, F(0 0 0) = 243, and Dc = 2.000 g cm^-3. The thermal behavior and non-isothermal decomposition reaction kinetics of [Cu(adnp)2(H2O)2] were studied by means of different heating rate differential scanning calorimetry (DSC). The kinetic equation of major exothermic decomposition reaction for [Cu(adnp)2(H2O)2] was obtained. The entropy of activation (△S≠), enthalpy of activation (△H≠), free energy of activation (△G≠), the self-accelerating decomposition temperature (TSADT) and the critical temperature of thermal explosion (Tb) are 59.42 j mol^-1 K^-1, 169.5 kJ mol^-1, 1141.26 kJ mol ^-1 457.3 K and 468.1 K, respectively. 相似文献
20.
Borophosphates, as potential microporous materials, have drawn much attention in recent years and show rich chemistry[1-3]. Although many compounds with transition metals have been reported, compounds with the p-block main group elements participating in the framework are rare[4] The title compound has been synthesized by mild hydrothermal methods and crystal structure characterized by X-ray single crystal methods. Crystallographic data:monoclinic,C2/c (No. 15), a=10.408(3), b=8.094(2),c=9.099(2) Å, β=116.64(2), Z=4, R=0.0246,Rw=0.0676. The crystal structure contains isolated anions[(OH)O2P1/2-O1/2B(OH)2O1/2-O1/2PO3]4-. Geometrically, four GaO6 groups with four PO4 groups form an eight-member ring by sharing comers resulting to a two dimensional layer in be plane. The layers are joined by BO4 group through comer sharing with GaO6 and PO4 and result to a three dimensional network structure. A 350pm x 600pm open channel along c-axis can be seen (figure below) and occupied by Na cations. 相似文献